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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Escherichia coli K-12 substr. MG1655 Enzyme: propionyl-CoA carboxylase

Summary:
There has been no gene associated with this enzymatic activity and the subunit structure is unknown.

Gene-Reaction Schematic: ?


Enzymatic reaction of: propionyl-CoA carboxylase

Synonyms: methylmalonyl-CoA carboxyltransferase, propanoyl-CoA:carbon-dioxide ligase (ADP-forming)

EC Number: 6.4.1.3

ATP + hydrogen carbonate + propanoyl-CoA <=> ADP + (S)-methylmalonyl-CoA + phosphate + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is physiologically favored in the direction shown.

In Pathways: propionyl CoA degradation

Summary:
E. coli may utilize propionate via two pathways, oxidation to pyruvate and carboxylation to succinate. Both of these intermediates are further metabolized via the TCA cycle. The major route of propionate metabolism appears to be the carboxylase pathway. [Evans93] However very little is known of the actual mechanism or genetics of the pathway. This enzyme is a biotinyl-protein. [Webb92]

Cofactors or Prosthetic Groups: biotin


References

Evans93: Evans CT, Sumegi B, Srere PA, Sherry AD, Malloy CR (1993). "[13C]propionate oxidation in wild-type and citrate synthase mutant Escherichia coli: evidence for multiple pathways of propionate utilization." Biochem J 1993;291 ( Pt 3);927-32. PMID: 8098211

Webb92: Webb EC "Enzyme Nomenclature 1992." Academic Press, Inc., San Diego, 1992.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC14A.