Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Enzyme: tetrahydrothiophene 1-oxide reductase

Summary:
There has been no gene isolated for this enzyme and no information on the enzyme's structure.

Gene-Reaction Schematic: ?


Enzymatic reaction of: tetrahydrothiophene 1-oxide reductase

Synonyms: THTO reductase

tetrahydrothiophene 1-oxide[periplasmic space] + a reduced electron acceptor[periplasmic space] <=> tetrahydrothiophene[periplasmic space] + an oxidized electron acceptor[periplasmic space] + H2O[periplasmic space]

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

The reaction is irreversible in the direction shown.

Summary:
It has recently been discovered that E. coli can use tetrahydrothiophene 1-oxide as an electron acceptor for anaerobic growth with glycerol as a carbon source. It appears that the enzyme is membrane-bound and can use NADH, NADPH, formate, lactate, BVH2, or dithionite as the electron donor. The reaction also seems to be menaquinone dependent. [Meganathan87]

Cofactor Binding Comment: Several compounds can serve as cofactor electron donors.


References

Meganathan87: Meganathan R, Schrementi J (1987). "Tetrahydrothiophene 1-oxide as an electron acceptor for Escherichia coli." J Bacteriol 1987;169(6);2862-5. PMID: 3294808


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc14.