There has been no gene isolated for this enzyme and no information on the enzyme's structure.
Synonyms: THTO reductase
tetrahydrothiophene 1-oxide[periplasmic space] + a reduced electron acceptor[periplasmic space] <=> tetrahydrothiophene[periplasmic space] + an oxidized electron acceptor[periplasmic space] + H2O[periplasmic space]
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.
The reaction is irreversible in the direction shown.
It has recently been discovered that E. coli can use tetrahydrothiophene 1-oxide as an electron acceptor for anaerobic growth with glycerol as a carbon source. It appears that the enzyme is membrane-bound and can use NADH, NADPH, formate, lactate, BVH2, or dithionite as the electron donor. The reaction also seems to be menaquinone dependent. [Meganathan87]
Cofactor Binding Comment: Several compounds can serve as cofactor electron donors.
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