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Escherichia coli K-12 substr. MG1655 Pathway: propanoyl CoA degradation I
Inferred from experiment

Pathway diagram: propanoyl CoA degradation I

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Genetic Regulation Schematic

Genetic regulation schematic for propanoyl CoA degradation I

Synonyms: propionyl CoA degradation I

Superclasses: Degradation/Utilization/AssimilationCarboxylates DegradationPropanoate Degradation

Another pathway for metabolism of propionyl-CoA may proceed through acryloyl-CoA and lactoyl-CoA to lactate and pyruvate, but there is little information on it. [Kay72]

Created 20-Oct-1995 by Riley M, Marine Biological Laboratory


Kay72: Kay WW (1972). "Genetic control of the metabolism of propionate by Escherichia coli K12." Biochim Biophys Acta 264(3);508-21. PMID: 4554901

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Bobik03: Bobik TA, Rasche ME (2003). "HPLC assay for methylmalonyl-CoA epimerase." Anal Bioanal Chem 375(3);344-9. PMID: 12589497

Dayem02: Dayem LC, Carney JR, Santi DV, Pfeifer BA, Khosla C, Kealey JT (2002). "Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli." Biochemistry 41(16);5193-201. PMID: 11955068

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Evans93: Evans CT, Sumegi B, Srere PA, Sherry AD, Malloy CR (1993). "[13C]propionate oxidation in wild-type and citrate synthase mutant Escherichia coli: evidence for multiple pathways of propionate utilization." Biochem J 1993;291 ( Pt 3);927-32. PMID: 8098211

Froese09: Froese DS, Dobson CM, White AP, Wu X, Padovani D, Banerjee R, Haller T, Gerlt JA, Surette MG, Gravel RA (2009). "Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli." Microbiol Res 164(1):1-8. PMID: 18950999

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Haller00: Haller T, Buckel T, Retey J, Gerlt JA (2000). "Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli." Biochemistry 2000;39(16);4622-9. PMID: 10769117

Roy92: Roy I, Leadlay PF (1992). "Physical map location of the new Escherichia coli gene sbm." J Bacteriol 1992;174(17);5763-4. PMID: 1355087

UniProtGOA11a: UniProt-GOA (2011). "Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries."

Webb92: Webb EC "Enzyme Nomenclature 1992." Academic Press, Inc., San Diego, 1992.

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon May 2, 2016, biocyc13.