|Gene:||isrC||Accession Numbers: G0-8905 (EcoCyc), b4435, ECK1992|
isrC was first identified in a screen for potential small RNA genes [Chen02]. It is not clear whether IsrC simply represents the attenuated UTR of flu or whether it has an independent function [Wallecha14].
A predicted secondary structure at the 3' end of isrC functions as a rho-independent terminator in vitro. Antitermination is regulated in vivo; initiation of translation at the in-frame ATG codon within isrC enhances expression of flu [Wallecha14].
|Map Position: [2,069,341 -> 2,069,535] (44.6 centisomes, 161°)||Length: 195 bp|
|MultiFun Terms:||information transfer → RNA related|
Ingrid Keseler on Mon Aug 4, 2014:
5' and 3' end positions adjusted according to [Wallecha14 ].
Chen02: Chen S, Lesnik EA, Hall TA, Sampath R, Griffey RH, Ecker DJ, Blyn LB (2002). "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome." Biosystems 65(2-3);157-77. PMID: 12069726
Wallecha14: Wallecha A, Oreh H, van der Woude MW, deHaseth PL (2014). "Control of Gene Expression at a Bacterial Leader RNA, the agn43 Gene Encoding Outer Membrane Protein Ag43 of Escherichia coli." J Bacteriol 196(15);2728-35. PMID: 24837285
Chauhan13: Chauhan A, Sakamoto C, Ghigo JM, Beloin C (2013). "Did I pick the right colony? Pitfalls in the study of regulation of the phase variable antigen 43 adhesin." PLoS One 8(9);e73568. PMID: 24039985
Gabig02: Gabig M, Herman-Antosiewicz A, Kwiatkowska M, Los M, Thomas MS, Wegrzyn G (2002). "The cell surface protein Ag43 facilitates phage infection of Escherichia coli in the presence of bile salts and carbohydrates." Microbiology 148(Pt 5);1533-42. PMID: 11988528
Gonzalez06a: Gonzalez Barrios AF, Zuo R, Hashimoto Y, Yang L, Bentley WE, Wood TK (2006). "Autoinducer 2 Controls Biofilm Formation in Escherichia coli through a Novel Motility Quorum-Sensing Regulator (MqsR, B3022)." J Bacteriol 188(1);305-16. PMID: 16352847
Haagmans00: Haagmans W, van der Woude M (2000). "Phase variation of Ag43 in Escherichia coli: Dam-dependent methylation abrogates OxyR binding and OxyR-mediated repression of transcription." Mol Microbiol 35(4);877-87. PMID: 10692164
Henderson99: Henderson IR, Owen P (1999). "The major phase-variable outer membrane protein of Escherichia coli structurally resembles the immunoglobulin A1 protease class of exported protein and is regulated by a novel mechanism involving Dam and oxyR." J Bacteriol 181(7);2132-41. PMID: 10094691
Tani02: Tani TH, Khodursky A, Blumenthal RM, Brown PO, Matthews RG (2002). "Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis." Proc Natl Acad Sci U S A 99(21);13471-6. PMID: 12374860
Waldron02: Waldron DE, Owen P, Dorman CJ (2002). "Competitive interaction of the OxyR DNA-binding protein and the Dam methylase at the antigen 43 gene regulatory region in Escherichia coli." Mol Microbiol 44(2);509-20. PMID: 11972787
Wallecha02: Wallecha A, Munster V, Correnti J, Chan T, van der Woude M (2002). "Dam- and OxyR-dependent phase variation of agn43: essential elements and evidence for a new role of DNA methylation." J Bacteriol 184(12);3338-47. PMID: 12029051
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