|Gene:||micC||Accession Numbers: G0-8901 (EcoCyc), b4427, ECK1373|
Synonyms: IS063, tke8
Superclasses: a regulatory RNA
MicC is a small RNA that regulates expression of OmpC at the post-transcriptional level [Chen04, Urban07]. Overexpression of MicC causes a 60% reduction of OmpC expression, while deletion of micC causes a 1.5-2 fold increase in OmpC expression. 22 nucleotides at the 5' end of MicC are able to base pair with a sequence located upstream of the ribosome binding site in the ompC mRNA and represses OmpC expression by inhibiting binding of the 30S ribosomal subunit to ompC mRNA [Chen04].
Expression of MicC is induced by growth at low temperature or on minimal media [Chen04].
|Map Position: [1,435,145 -> 1,435,253] (30.93 centisomes)||Length: 109 bp|
|Biological Process:||GO:0040033 - negative regulation of translation, ncRNA-mediated
GO:0045947 - negative regulation of translational initiation [Chen04]
|Molecular Function:||GO:0048027 - mRNA 5'-UTR binding [Chen04]|
|MultiFun Terms:||information transfer → RNA related → antisense RNA|
|regulation → type of regulation → posttranscriptional → antisense RNA|
Position corrected based on Chen et al., J. Bacteriol. 186:6689-6697 (2004).
Suzanne Paley on Thu Oct 21, 2004:
Position updated based on U00096.2 release of genome
Chen02: Chen S, Lesnik EA, Hall TA, Sampath R, Griffey RH, Ecker DJ, Blyn LB (2002). "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome." Biosystems 65(2-3);157-77. PMID: 12069726
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