Escherichia coli K-12 substr. MG1655 RNA: MicC small regulatory RNA

Gene: micC Accession Numbers: G0-8901 (EcoCyc), b4427, ECK1373

Synonyms: IS063, tke8

Superclasses: a regulatory RNA

Regulation Summary Diagram: ?

Regulation summary diagram for micC

MicC is a small RNA that regulates expression of OmpC at the post-transcriptional level [Chen04, Urban07]. Overexpression of MicC causes a 60% reduction of OmpC expression, while deletion of micC causes a 1.5-2 fold increase in OmpC expression. 22 nucleotides at the 5' end of MicC are able to base pair with a sequence located upstream of the ribosome binding site in the ompC mRNA and represses OmpC expression by inhibiting binding of the 30S ribosomal subunit to ompC mRNA [Chen04].

Hfq is required for MicC function [Chen04, Urban07].

Expression of MicC is induced by growth at low temperature or on minimal media [Chen04].

Reviews: [Altuvia04, Hershberg03, Vogel06]

Citations: [Chen02]

Map Position: [1,435,145 -> 1,435,253] (30.93 centisomes, 111°)
Length: 109 bp

Unification Links: ASAP:ABE-0047248 , EchoBASE:EB4512 , EcoGene:EG31144 , EcoliWiki:b4427 , PortEco:micC , RegulonDB:G0-8901

GO Terms:

Biological Process: GO:0040033 - negative regulation of translation, ncRNA-mediated Inferred from experiment [Chen04]
GO:0045947 - negative regulation of translational initiation Inferred from experiment [Chen04]
Molecular Function: GO:0048027 - mRNA 5'-UTR binding Inferred from experiment [Chen04]

MultiFun Terms: information transfer RNA related antisense RNA
regulation type of regulation posttranscriptional antisense RNA

Regulated Transcription Units (3 total): ?


Transcription-unit diagram

Transcription-unit diagram

Transcription-unit diagram

Gene Local Context (not to scale): ?

Gene local context diagram

Transcription Unit:

Transcription-unit diagram


Position corrected based on Chen et al., J. Bacteriol. 186:6689-6697 (2004).
Suzanne Paley on Thu Oct 21, 2004:
Position updated based on U00096.2 release of genome

Last-Curated ? 30-Jul-2009 by Keseler I , SRI International


Altuvia04: Altuvia S (2004). "Regulatory small RNAs: the key to coordinating global regulatory circuits." J Bacteriol 186(20);6679-80. PMID: 15466017

Chen02: Chen S, Lesnik EA, Hall TA, Sampath R, Griffey RH, Ecker DJ, Blyn LB (2002). "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome." Biosystems 65(2-3);157-77. PMID: 12069726

Chen04: Chen S, Zhang A, Blyn LB, Storz G (2004). "MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli." J Bacteriol 186(20);6689-97. PMID: 15466019

Hershberg03: Hershberg R, Altuvia S, Margalit H (2003). "A survey of small RNA-encoding genes in Escherichia coli." Nucleic Acids Res 31(7);1813-20. PMID: 12654996

Urban07: Urban JH, Vogel J (2007). "Translational control and target recognition by Escherichia coli small RNAs in vivo." Nucleic Acids Res 35(3);1018-37. PMID: 17264113

Vogel06: Vogel J, Papenfort K (2006). "Small non-coding RNAs and the bacterial outer membrane." Curr Opin Microbiol 9(6);605-11. PMID: 17055775

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, biocyc12.