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Homo sapiens EC 2.1.1 -- Methyltransferases

Parent Class: EC-Numbers2 -- Transferases2.1 -- Transferring one-carbon groups

Instances:
2.1.1.1 -- nicotinamide N-methyltransferase,
2.1.1.2 -- guanidinoacetate N-methyltransferase,
2.1.1.4 -- acetylserotonin O-methyltransferase,
2.1.1.5 -- betaine—homocysteine S-methyltransferase,
2.1.1.6 -- catechol O-methyltransferase,
2.1.1.8 -- histamine N-methyltransferase,
2.1.1.10 -- homocysteine S-methyltransferase,
2.1.1.13 -- methionine synthase,
2.1.1.17 -- phosphatidylethanolamine N-methyltransferase,
2.1.1.20 -- glycine N-methyltransferase,
2.1.1.28 -- phenylethanolamine N-methyltransferase,
2.1.1.33 -- tRNA (guanine46-N7)-methyltransferase,
2.1.1.35 -- tRNA (uracil54-C5)-methyltransferase,
2.1.1.37 -- DNA (cytosine-5-)-methyltransferase,
2.1.1.43 -- histone-lysine N-methyltransferase,
2.1.1.45 -- thymidylate synthase,
2.1.1.49 -- amine N-methyltransferase,
2.1.1.56 -- mRNA (guanine-N7)-methyltransferase,
2.1.1.57 -- methyltransferase cap1,
2.1.1.62 -- mRNA (2′-O-methyladenosine-N6-)-methyltransferase,
2.1.1.63 -- methylated-DNA—[protein]-cysteine S-methyltransferase,
2.1.1.64 -- 3-demethylubiquinol 3-O-methyltransferase,
2.1.1.67 -- thiopurine S-methyltransferase,
2.1.1.77 -- protein-L-isoaspartate(D-aspartate) O-methyltransferase,
2.1.1.100 -- protein-S-isoprenylcysteine O-methyltransferase,
2.1.1.114 -- polyprenyldihydroxybenzoate methyltransferase,
2.1.1.137 -- arsenite methyltransferase,
2.1.1.182 -- 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase,
2.1.1.183 -- 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase,
2.1.1.201 -- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase,
2.1.1.203 -- tRNA (cytosine34-C5)-methyltransferase,
2.1.1.204 -- tRNA (cytosine38-C5)-methyltransferase,
2.1.1.211 -- tRNASer (uridine44-2′-O)-methyltransferase,
2.1.1.213 -- tRNA (guanine10-N2)-dimethyltransferase,
2.1.1.216 -- tRNA (guanine26-N2)-dimethyltransferase,
2.1.1.220 -- tRNA (adenine58-N1)-methyltransferase,
2.1.1.221 -- tRNA (guanine9-N1)-methyltransferase,
2.1.1.222 -- 2-polyprenyl-6-hydroxyphenol methylase,
2.1.1.228 -- tRNA (guanine37-N1)-methyltransferase,
2.1.1.233 -- [phosphatase 2A protein]-leucine-carboxy methyltransferase,
2.1.1.244 -- protein N-terminal methyltransferase,
2.1.1.282 -- tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase,
2.1.1.290 -- tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase,
2.1.1.296 -- methyltransferase cap2

Unofficial Reactions:
a CpG site + S-adenosyl-L-methionine = a 5-methyl-CpG site + S-adenosyl-L-homocysteine + H+,
S-adenosyl-L-methionine + a [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-ω-NG-methyl-L-arginine + H+,
S-adenosyl-L-methionine + [protein]-ω-NG-methyl-L-arginine = S-adenosyl-L-homocysteine + [protein]-ω-NG,NG-dimethyl-L-arginine + H+,
S-adenosyl-L-methionine + [protein]-ω-NG-methyl-L-arginine = S-adenosyl-L-homocysteine + [protein]-ω-NG,N'G-dimethyl-L-arginine + H+,
S-adenosyl-L-methionine + a demethylated methyl donor → S-adenosyl-L-homocysteine + a methylated methyl donor + H+

Enzymes and Genes:
protein arginine N-methyltransferase 7: PRMT7
protein arginine N-methyltransferase 5: PRMT5
protein arginine N-methyltransferase 1: PRMT1


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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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