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Homo sapiens Enzyme: transmembrane O-methyltransferase

Gene: LRTOMT Accession Number: G66-31611 (HumanCyc)

Synonyms: COMT2, PP7517, TOMT, Catechol O-methyltransferase 2, Protein LRTOMT2, TOMT_HUMAN

Unification Links: Ensembl:ENST00000427369 , Ensembl:ENST00000435085 , MOPED:Q8WZ04 , UniProt:Q8WZ04

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [a catechol + S-adenosyl-L-methionine → a guaiacol + S-adenosyl-L-homocysteine + H+] (2.1.1.6):
i1: (R)-adrenaline + S-adenosyl-L-methionine → metanephrine + S-adenosyl-L-homocysteine + H+ (2.1.1.6)

i2: 3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine → 3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (2.1.1.6)

i3: (R)-noradrenaline + S-adenosyl-L-methionine → normetanephrine + S-adenosyl-L-homocysteine + H+ (2.1.1.6)

i4: S-adenosyl-L-methionine + dopamine → S-adenosyl-L-homocysteine + 3-methoxytyramine + H+ (2.1.1.6)

i5: 3,4-dihydroxymandelate + S-adenosyl-L-methionine → vanillyl mandelate + S-adenosyl-L-homocysteine + H+ (2.1.1.6)

i6: L-dopa + S-adenosyl-L-methionine → 3-O-methyldopa + S-adenosyl-L-homocysteine + H+ (2.1.1.6)

i7: 3,4-dihydroxyphenylacetate + S-adenosyl-L-methionine → homovanillate + S-adenosyl-L-homocysteine + H+ (2.1.1.6)

Gene Class: UNCLASSIFIED


Enzymatic reaction of: Transmembrane O-methyltransferase (transmembrane O-methyltransferase)

EC Number: 2.1.1.6

(R)-noradrenaline + S-adenosyl-L-methionine <=> normetanephrine + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: noradrenaline and adrenaline degradation


Enzymatic reaction of: Transmembrane O-methyltransferase (transmembrane O-methyltransferase)

EC Number: 2.1.1.6

(R)-adrenaline + S-adenosyl-L-methionine <=> metanephrine + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: noradrenaline and adrenaline degradation


Enzymatic reaction of: Transmembrane O-methyltransferase (transmembrane O-methyltransferase)

EC Number: 2.1.1.6

3,4-dihydroxymandelate + S-adenosyl-L-methionine <=> vanillyl mandelate + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: noradrenaline and adrenaline degradation


Enzymatic reaction of: Transmembrane O-methyltransferase (transmembrane O-methyltransferase)

EC Number: 2.1.1.6

orcinol + S-adenosyl-L-methionine <=> 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.


Enzymatic reaction of: Transmembrane O-methyltransferase (transmembrane O-methyltransferase)

EC Number: 2.1.1.6

a catechol + S-adenosyl-L-methionine <=> a guaiacol + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: L-dopa degradation , dopamine degradation , noradrenaline and adrenaline degradation



Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 19.0 on Sat Aug 29, 2015, biocyc11.