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Homo sapiens Enzyme: Histone-lysine N-methyltransferase EZH2

Gene: EZH2 Accession Number: HS02911 (HumanCyc)

Synonyms: KMT6, Enhancer of zeste homolog 2, ENX-1, Lysine N-methyltransferase 6

Citations: [Varambally02, OConnell01, Cardoso00, Cardoso98, Laible97, Chen96a, Abel96, Bonaldo96]

Locations: nucleus

Map Position: [146,750,916 <- 146,827,855] (93.22 centisomes) on Chromosome 7
Length: 76940 bp

Unification Links: Ensembl:ENSG00000106462 , Entrez-gene:2146 , Entrez-Nucleotide:AC006323 , Entrez-Nucleotide:AK092676 , Entrez-Nucleotide:BC010858 , Entrez-Nucleotide:BG829016 , Entrez-Nucleotide:BM974565 , Entrez-Nucleotide:U61145 , Entrez-Nucleotide:X95653 , Entrez:AAC50591 , Entrez:AAC51520 , Entrez:AAH10858 , Entrez:CAA64955 , GeneCards:EZH2 , MOPED:Q15910 , OMIM:601573 , RefSeq:NM_004456 , RefSeq:NM_152998 , RefSeq:NP_004447 , RefSeq:NP_694543 , UCSC Human Genome:NM_004456 , UniGene:77256 , UniProt:Q15910

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Biological Process: GO:0006325 - chromatin organization
GO:0006355 - regulation of transcription, DNA-templated
Molecular Function: GO:0003677 - DNA binding
Cellular Component: GO:0005634 - nucleus

Enzymatic reaction of: Histone-lysine N-methyltransferase EZH2

EC Number:

a [histone]-L-lysine + S-adenosyl-L-methionine <=> a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

Gene Local Context (not to scale): ?

Gene local context diagram


Schematic showing introns, exons and/or isoforms of EZH2


Abel96: Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL (1996). "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1." Genomics 37(2);161-71. PMID: 8921387

Bonaldo96: Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery." Genome Res 6(9);791-806. PMID: 8889548

Cardoso00: Cardoso C, Mignon C, Hetet G, Grandchamps B, Fontes M, Colleaux L (2000). "The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders." Eur J Hum Genet 8(3);174-80. PMID: 10780782

Cardoso98: Cardoso C, Timsit S, Villard L, Khrestchatisky M, Fontes M, Colleaux L (1998). "Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein." Hum Mol Genet 7(4);679-84. PMID: 9499421

Chen96a: Chen H, Rossier C, Antonarakis SE (1996). "Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2." Genomics 38(1);30-7. PMID: 8954776

Laible97: Laible G, Wolf A, Dorn R, Reuter G, Nislow C, Lebersorger A, Popkin D, Pillus L, Jenuwein T (1997). "Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres." EMBO J 16(11);3219-32. PMID: 9214638

OConnell01: O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS (2001). "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein." J Biol Chem 276(46);43065-73. PMID: 11571280

Varambally02: Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM (2002). "The polycomb group protein EZH2 is involved in progression of prostate cancer." Nature 419(6907);624-9. PMID: 12374981

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 19.0 on Mon Aug 31, 2015, biocyc13.