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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Homo sapiens Enzyme: Histone-lysine N-methyltransferase MLL5

Gene: MLL5 Accession Number: HS00145 (HumanCyc)

Synonyms: KMT2E, Lysine N-methyltransferase 2E, Myeloid/lymphoid or mixed-lineage leukemia protein 5

Citations: [Emerling02, Kratz01, Johnson97a]

Map Position: [103,138,378 -> 103,238,235] (65.51 centisomes) on Chromosome 7
Length: 99858 bp / 33285 aa

Unification Links: Ensembl:ENSG00000005483 , Entrez-gene:55904 , Entrez-Nucleotide:AC005065 , Entrez-Nucleotide:AF067804 , Entrez-Nucleotide:AF519459 , Entrez-Nucleotide:AF520790 , Entrez-Nucleotide:AF520791 , Entrez-Nucleotide:AF520792 , Entrez-Nucleotide:AF520794 , Entrez-Nucleotide:AK000940 , Entrez-Nucleotide:AK024088 , Entrez-Nucleotide:AY113691 , Entrez-Nucleotide:AY147037 , Entrez-Nucleotide:AY157990 , Entrez-Nucleotide:BC001296 , Entrez-Nucleotide:BC009061 , Entrez-Nucleotide:BC016382 , Entrez-Nucleotide:BC024658 , Entrez:AAD04721 , Entrez:AAF75564 , Entrez:AAM74947 , Entrez:AAN17675 , Entrez:AAN76325 , Entrez:BAA91435 , Entrez:BAB14821 , GeneCards:MLL5 , MOPED:Q8IZD2 , RefSeq:NM_018682 , RefSeq:NP_061152 , UCSC Human Genome:NM_018682 , UniGene:333300 , UniProt:Q8IZD2

Gene-Reaction Schematic: ?

GO Terms:

Biological Process: GO:0006355 - regulation of transcription, DNA-templated
Molecular Function: GO:0003677 - DNA binding


Enzymatic reaction of: Histone-lysine N-methyltransferase MLL5

EC Number: 2.1.1.43

a [histone]-L-lysine + S-adenosyl-L-methionine <=> a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the direction shown.


Gene Local Context (not to scale): ?


References

Emerling02: Emerling BM, Bonifas J, Kratz CP, Donovan S, Taylor BR, Green ED, Le Beau MM, Shannon KM (2002). "MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia." Oncogene 21(31);4849-54. PMID: 12101424

Johnson97a: Johnson E, Cotter FE (1997). "Monosomy 7 and 7q--associated with myeloid malignancy." Blood Rev 11(1);46-55. PMID: 9218106

Kratz01: Kratz CP, Emerling BM, Donovan S, Laig-Webster M, Taylor BR, Thompson P, Jensen S, Banerjee A, Bonifas J, Makalowski W, Green ED, Le Beau MM, Shannon KM (2001). "Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies." Genomics 77(3);171-80. PMID: 11597142


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14B.