Homo sapiens Enzyme: Histone-lysine N-methyltransferase MLL5

Gene: MLL5 Accession Number: HS00145 (HumanCyc)

Synonyms: KMT2E, Lysine N-methyltransferase 2E, Myeloid/lymphoid or mixed-lineage leukemia protein 5

Citations: [Emerling02, Kratz01, Johnson97a]

Map Position: [103,138,378 -> 103,238,235] (65.51 centisomes) on Chromosome 7
Length: 99858 bp / 33285 aa

Unification Links: Ensembl:ENSG00000005483 , Entrez-gene:55904 , Entrez-Nucleotide:AC005065 , Entrez-Nucleotide:AF067804 , Entrez-Nucleotide:AF519459 , Entrez-Nucleotide:AF520790 , Entrez-Nucleotide:AF520791 , Entrez-Nucleotide:AF520792 , Entrez-Nucleotide:AF520794 , Entrez-Nucleotide:AK000940 , Entrez-Nucleotide:AK024088 , Entrez-Nucleotide:AY113691 , Entrez-Nucleotide:AY147037 , Entrez-Nucleotide:AY157990 , Entrez-Nucleotide:BC001296 , Entrez-Nucleotide:BC009061 , Entrez-Nucleotide:BC016382 , Entrez-Nucleotide:BC024658 , Entrez:AAD04721 , Entrez:AAF75564 , Entrez:AAM74947 , Entrez:AAN17675 , Entrez:AAN76325 , Entrez:BAA91435 , Entrez:BAB14821 , GeneCards:MLL5 , MOPED:Q8IZD2 , RefSeq:NM_018682 , RefSeq:NP_061152 , UCSC Human Genome:NM_018682 , UniGene:333300 , UniProt:Q8IZD2

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Biological Process: GO:0006355 - regulation of transcription, DNA-templated
Molecular Function: GO:0003677 - DNA binding

Enzymatic reaction of: Histone-lysine N-methyltransferase MLL5

EC Number:

a [histone]-L-lysine + S-adenosyl-L-methionine <=> a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

Gene Local Context (not to scale): ?

Gene local context diagram


Emerling02: Emerling BM, Bonifas J, Kratz CP, Donovan S, Taylor BR, Green ED, Le Beau MM, Shannon KM (2002). "MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia." Oncogene 21(31);4849-54. PMID: 12101424

Johnson97a: Johnson E, Cotter FE (1997). "Monosomy 7 and 7q--associated with myeloid malignancy." Blood Rev 11(1);46-55. PMID: 9218106

Kratz01: Kratz CP, Emerling BM, Donovan S, Laig-Webster M, Taylor BR, Thompson P, Jensen S, Banerjee A, Bonifas J, Makalowski W, Green ED, Le Beau MM, Shannon KM (2001). "Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies." Genomics 77(3);171-80. PMID: 11597142

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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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