Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Homo sapiens Enzyme: Histone-lysine N-methyltransferase SUV39H1

Gene: SUV39H1 Accession Number: HS02321 (HumanCyc)

Synonyms: KMT1A, SUV39H, H3-K9-HMTase 1, Histone H3-K9 methyltransferase 1, Lysine N-methyltransferase 1A, Position-effect variegation 3-9 homolog, Su(var)3-9 homolog 1, Suppressor of variegation 3-9 homolog 1

Citations: [Schotta02, Vaute02, Rea00, Aagaard99]

Locations: nucleus

Map Position: [46,815,791 -> 46,828,063] (30.2 centisomes) on Chromosome X
Length: 12273 bp

Unification Links: Ensembl:ENSG00000101945 , Entrez-gene:6839 , Entrez-Nucleotide:AF019968 , Entrez-Nucleotide:BC006238 , Entrez:AAB92224 , Entrez:AAF06805 , Entrez:AAH06238 , GeneCards:SUV39H1 , MOPED:O43463 , OMIM:300254 , RefSeq:NM_003173 , RefSeq:NP_003164 , UCSC Human Genome:NM_003173 , UniGene:37936 , UniProt:O43463

Gene-Reaction Schematic: ?

GO Terms:

Biological Process: GO:0006325 - chromatin organization
GO:0006333 - chromatin assembly or disassembly
GO:0016568 - chromatin modification
Molecular Function: GO:0003682 - chromatin binding
GO:0005515 - protein binding
GO:0008168 - methyltransferase activity
GO:0016740 - transferase activity
GO:0018024 - histone-lysine N-methyltransferase activity
Cellular Component: GO:0000785 - chromatin
GO:0005634 - nucleus


Enzymatic reaction of: Histone-lysine N-methyltransferase SUV39H1

EC Number: 2.1.1.43

a [histone]-L-lysine + S-adenosyl-L-methionine <=> a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the direction shown.


Gene Local Context (not to scale): ?

Exons/Introns:


References

Aagaard99: Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, Reuter G, Jenuwein T (1999). "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31." EMBO J 18(7);1923-38. PMID: 10202156

Rea00: Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases." Nature 406(6796);593-9. PMID: 10949293

Schotta02: Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G (2002). "Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing." EMBO J 21(5);1121-31. PMID: 11867540

Vaute02: Vaute O, Nicolas E, Vandel L, Trouche D (2002). "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases." Nucleic Acids Res 30(2);475-81. PMID: 11788710


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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14B.