Homo sapiens Enzyme: Histone-lysine N-methyltransferase SUV39H1

Gene: SUV39H1 Accession Number: HS02321 (HumanCyc)

Synonyms: KMT1A, SUV39H, H3-K9-HMTase 1, Histone H3-K9 methyltransferase 1, Lysine N-methyltransferase 1A, Position-effect variegation 3-9 homolog, Su(var)3-9 homolog 1, Suppressor of variegation 3-9 homolog 1

Citations: [Schotta02, Vaute02, Rea00, Aagaard99]

Locations: nucleus

Map Position: [46,815,791 -> 46,828,063] (30.2 centisomes) on Chromosome X
Length: 12273 bp

Unification Links: Ensembl:ENSG00000101945 , Entrez-gene:6839 , Entrez-Nucleotide:AF019968 , Entrez-Nucleotide:BC006238 , Entrez:AAB92224 , Entrez:AAF06805 , Entrez:AAH06238 , GeneCards:SUV39H1 , MOPED:O43463 , OMIM:300254 , RefSeq:NM_003173 , RefSeq:NP_003164 , UCSC Human Genome:NM_003173 , UniGene:37936 , UniProt:O43463

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Biological Process: GO:0006325 - chromatin organization
GO:0006333 - chromatin assembly or disassembly
GO:0016568 - chromatin modification
Molecular Function: GO:0003682 - chromatin binding
GO:0005515 - protein binding
GO:0008168 - methyltransferase activity
GO:0016740 - transferase activity
GO:0018024 - histone-lysine N-methyltransferase activity
Cellular Component: GO:0000785 - chromatin
GO:0005634 - nucleus

Enzymatic reaction of: Histone-lysine N-methyltransferase SUV39H1

EC Number:

a [histone]-L-lysine + S-adenosyl-L-methionine <=> a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

Gene Local Context (not to scale): ?

Gene local context diagram


Schematic showing introns, exons and/or isoforms of SUV39H1


Aagaard99: Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, Reuter G, Jenuwein T (1999). "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31." EMBO J 18(7);1923-38. PMID: 10202156

Rea00: Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases." Nature 406(6796);593-9. PMID: 10949293

Schotta02: Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G (2002). "Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing." EMBO J 21(5);1121-31. PMID: 11867540

Vaute02: Vaute O, Nicolas E, Vandel L, Trouche D (2002). "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases." Nucleic Acids Res 30(2);475-81. PMID: 11788710

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, biocyc13.