Homo sapiens Enzyme: Histone-lysine N-methyltransferase EZH1

Gene: EZH1 Accession Number: HS03158 (HumanCyc)

Synonyms: KIAA0388, Enhancer of zeste homolog 1, ENX-2

Citations: [Ogawa98, Nagase97, Abel96, Friedman95, OsborneLawrence95, Brody95]

Locations: nucleus

Map Position: [43,016,777 <- 43,044,267] (51.03 centisomes) on Chromosome 17
Length: 27491 bp

Unification Links: Ensembl:ENSG00000108799 , Entrez-gene:2145 , Entrez-Nucleotide:AB002386 , Entrez-Nucleotide:AB004818 , Entrez-Nucleotide:AL833159 , Entrez-Nucleotide:BC015882 , Entrez-Nucleotide:U50315 , Entrez:AAB59574 , Entrez:AAC50778 , Entrez:AAH15882 , Entrez:BAA20842 , Entrez:BAA25019 , GeneCards:EZH1 , MOPED:Q92800 , OMIM:601674 , RefSeq:NM_001991 , RefSeq:NP_001982 , UCSC Human Genome:NM_001991 , UniGene:194669 , UniProt:Q92800

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

GO Terms:

Biological Process: GO:0006355 - regulation of transcription, DNA-templated
Molecular Function: GO:0003682 - chromatin binding
Cellular Component: GO:0005634 - nucleus

Enzymatic reaction of: Histone-lysine N-methyltransferase EZH1

EC Number:

a [histone]-L-lysine + S-adenosyl-L-methionine <=> a [histone] N6-methyl-L-lysine + S-adenosyl-L-homocysteine + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

Gene Local Context (not to scale): ?

Gene local context diagram


Schematic showing introns, exons and/or isoforms of EZH1


Abel96: Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL (1996). "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1." Genomics 37(2);161-71. PMID: 8921387

Brody95: Brody LC, Abel KJ, Castilla LH, Couch FJ, McKinley DR, Yin G, Ho PP, Merajver S, Chandrasekharappa SC, Xu J (1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17." Genomics 25(1);238-47. PMID: 7774924

Friedman95: Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE (1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors." Genomics 25(1);256-63. PMID: 7774926

Nagase97: Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." DNA Res 4(2);141-50. PMID: 9205841

Ogawa98: Ogawa M, Hiraoka Y, Taniguchi K, Aiso S (1998). "Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2." Biochim Biophys Acta 1395(2);151-8. PMID: 9473645

OsborneLawrence95: Osborne-Lawrence S, Welcsh PL, Spillman M, Chandrasekharappa SC, Gallardo TD, Lovett M, Bowcock AM (1995). "Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21." Genomics 25(1);248-55. PMID: 7774925

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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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