Homo sapiens Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: type III protein arginine methyltransferase

Enzyme Commission Synonyms: PRMT7

Enzyme Commission Summary:
Type III protein arginine methyltransferases catalyse the single methylation of one of the terminal nitrogen atoms of the guanidino group in an L-arginine residue within a protein. Unlike type I and type II protein arginine methyltransferases, which also catalyse this reaction, type III enzymes do not methylate the substrate any further. c.f. EC, type I protein arginine methyltransferase, EC, type II protein arginine methyltransferase and EC, type IV protein arginine methyltransferase.

Citations: [Miranda04, Gonsalvez07]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Gonsalvez07: Gonsalvez GB, Tian L, Ospina JK, Boisvert FM, Lamond AI, Matera AG (2007). "Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins." J Cell Biol 178(5);733-40. PMID: 17709427

Miranda04: Miranda TB, Miranda M, Frankel A, Clarke S (2004). "PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity." J Biol Chem 279(22);22902-7. PMID: 15044439

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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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