Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
twitter

Homo sapiens Reaction: 2.1.1.77

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.1.1.77

Enzymes and Genes:
protein-L-isoaspartate(D-aspartate) O-methyltransferase : PCMT1

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: protein-L-isoaspartate(D-aspartate) O-methyltransferase

Enzyme Commission Synonyms: protein-L-isoaspartate O-methyltransferase, protein-β-aspartate O-methyltransferase, D-aspartyl/L-isoaspartyl methyltransferase, L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase, protein (D-aspartate) methyltransferase, protein D-aspartate methyltransferase, protein L-isoaspartate methyltransferase, protein L-isoaspartyl methyltransferase, protein O-methyltransferase (L-isoaspartate), L-aspartyl/L-isoaspartyl protein methyltransferase

Enzyme Commission Summary:
D-Aspartate (but not L-aspartate) residues in proteins can also act as acceptors. Previously also listed as EC 2.1.1.24.

Citations: [Clarke85, Kim70, Ota87]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.1.1.77 , ENZYME:EC:2.1.1.77 , IUBMB-ExplorEnz:EC:2.1.1.77


References

Clarke85: Clarke S (1985). "Protein carboxyl methyltransferases: two distinct classes of enzymes." Annu Rev Biochem 54;479-506. PMID: 3896126

Kim70: Kim S, Paik WK (1970). "Purification and properties of protein methylaase II." J Biol Chem 245(7);1806-13. PMID: 5438363

Ota87: Ota IM, Ding L, Clarke S (1987). "Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase." J Biol Chem 262(18);8522-31. PMID: 3597386


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 19.0 on Thu Sep 3, 2015, biocyc13.