|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
protein-L-isoaspartate(D-aspartate) O-methyltransferase : PCMT1
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: protein-L-isoaspartate(D-aspartate) O-methyltransferase
Enzyme Commission Synonyms: protein-L-isoaspartate O-methyltransferase, protein-β-aspartate O-methyltransferase, D-aspartyl/L-isoaspartyl methyltransferase, L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase, protein (D-aspartate) methyltransferase, protein D-aspartate methyltransferase, protein L-isoaspartate methyltransferase, protein L-isoaspartyl methyltransferase, protein O-methyltransferase (L-isoaspartate), L-aspartyl/L-isoaspartyl protein methyltransferase
Enzyme Commission Summary:
D-Aspartate (but not L-aspartate) residues in proteins can also act as acceptors. Previously also listed as EC 22.214.171.124.
Ota87: Ota IM, Ding L, Clarke S (1987). "Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase." J Biol Chem 262(18);8522-31. PMID: 3597386
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