Homo sapiens Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
protein-L-isoaspartate(D-aspartate) O-methyltransferase: PCMT1

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: protein-L-isoaspartate(D-aspartate) O-methyltransferase

Enzyme Commission Synonyms: protein-L-isoaspartate O-methyltransferase, protein-β-aspartate O-methyltransferase, D-aspartyl/L-isoaspartyl methyltransferase, L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase, protein (D-aspartate) methyltransferase, protein D-aspartate methyltransferase, protein L-isoaspartate methyltransferase, protein L-isoaspartyl methyltransferase, protein O-methyltransferase (L-isoaspartate), L-aspartyl/L-isoaspartyl protein methyltransferase

Enzyme Commission Summary:
D-Aspartate (but not L-aspartate) residues in proteins can also act as acceptors. Previously also listed as EC

Citations: [Clarke85, Kim70, Ota87]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Clarke85: Clarke S (1985). "Protein carboxyl methyltransferases: two distinct classes of enzymes." Annu Rev Biochem 54;479-506. PMID: 3896126

Kim70: Kim S, Paik WK (1970). "Purification and properties of protein methylaase II." J Biol Chem 245(7);1806-13. PMID: 5438363

Ota87: Ota IM, Ding L, Clarke S (1987). "Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase." J Biol Chem 262(18);8522-31. PMID: 3597386

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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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