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Homo sapiens Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
SET and MYND domain-containing protein 3 : SMYD3
Histone-lysine N-methyltransferase SETD2 : SETD2
Mariner transposase Hsmar1 : SETMAR
Histone-lysine N-methyltransferase MLL2 : MLL2
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific : NSD1
Histone-lysine N-methyltransferase PRDM9 : PRDM9
Histone-lysine N-methyltransferase NSD3 : WHSC1L1
Histone-lysine N-methyltransferase SETD1B : SETD1B
Histone-lysine N-methyltransferase SETDB2 : SETDB2
Histone-lysine N-methyltransferase SUV420H2 : SUV420H2
Probable histone-lysine N-methyltransferase PRDM7 : PRDM7
Histone-lysine N-methyltransferase HRX : MLL
PR domain zinc finger protein 2 : PRDM2
Probable histone-lysine N-methyltransferase ASH1L : ASH1L
Histone-lysine N-methyltransferase SUV420H1 : SUV420H1
Probable histone-lysine N-methyltransferase NSD2 : WHSC1
Histone-lysine N-methyltransferase EZH1 : EZH1
Histone-lysine N-methyltransferase EZH2 : EZH2
Histone-lysine N-methyltransferase MLL4 : WBP7
Histone-lysine N-methyltransferase SETD1A : SETD1A
Putative histone-lysine N-methyltransferase PRDM6 : PRDM6
Histone-lysine N-methyltransferase MLL3 : MLL3
Histone-lysine N-methyltransferase MLL5 : MLL5
Histone-lysine N-methyltransferase SUV39H1 : SUV39H1
Histone-lysine N-methyltransferase, H3 lysine-79 specific : DOT1L
Histone-lysine N-methyltransferase SUV39H2 : SUV39H2
histone-lysine N-methyltransferase, H3 lysine-9 specific 5 : Eu-HMTase1
Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 : EHMT1
Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 : EHMT2
Histone-lysine N-methyltransferase SETD7 : SETD7
Histone-lysine N-methyltransferase SETD8 : SETD8
Histone-lysine N-methyltransferase SETDB1 : SETDB1

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: histone-lysine N-methyltransferase

Enzyme Commission Synonyms: protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase

Enzyme Commission Summary:
One of a group of enzymes methylating proteins; see also EC, [cytochrome-c]-lysine N-methyltransferase and EC, calmodulin-lysine N-methyltransferase.

Citations: [Paik70, Venkatesan79]

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Paik70: Paik WK, Kim S (1970). "Solubilization and partial purification of protein methylase 3 from calf thymus nuclei." J Biol Chem 245(22);6010-5. PMID: 5484460

Venkatesan79: Venkatesan M, McManus IR (1979). "Partial purification and characterization of a protein lysine methyltransferase from plasmodia of Physarum polycephalum." Biochemistry 18(24);5365-71. PMID: 391266

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 19.0 on Wed Sep 2, 2015, biocyc12.