Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Homo sapiens Reaction: 2.1.1.49

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.1.1.49

Enzymes and Genes:
indolethylamine N-methyltransferase Inferred from experiment : INMT

In Pathway: nicotine degradation IV

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: amine N-methyltransferase

Enzyme Commission Synonyms: nicotine N-methyltransferase, tryptamine N-methyltransferase, arylamine N-methyltransferase, tryptamine methyltransferase

Enzyme Commission Summary:
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.

Citations: [Crooks88, Crooks88a, Ansher86]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.1.1.49 , ENZYME:EC:2.1.1.49 , IUBMB-ExplorEnz:EC:2.1.1.49


References

Ansher86: Ansher SS, Jakoby WB (1986). "Amine N-methyltransferases from rabbit liver." J Biol Chem 261(9);3996-4001. PMID: 3949799

Crooks88: Crooks PA, Godin CS (1988). "N-methylation of nicotine enantiomers by human liver cytosol." J Pharm Pharmacol 40(2);153-4. PMID: 2897456

Crooks88a: Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB (1988). "Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases." Biochem Pharmacol 37(9);1673-7. PMID: 3377829


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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13A.