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Homo sapiens Reaction: 2.1.1.49

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.1.1.49

Enzymes and Genes:
indolethylamine N-methyltransferase Inferred from experiment : INMT

In Pathway: nicotine degradation IV

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: amine N-methyltransferase

Enzyme Commission Synonyms: nicotine N-methyltransferase, tryptamine N-methyltransferase, arylamine N-methyltransferase, tryptamine methyltransferase

Enzyme Commission Summary:
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.

Citations: [Crooks88, Crooks88a, Ansher86]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.1.1.49 , ENZYME:EC:2.1.1.49 , IUBMB-ExplorEnz:EC:2.1.1.49


References

Ansher86: Ansher SS, Jakoby WB (1986). "Amine N-methyltransferases from rabbit liver." J Biol Chem 261(9);3996-4001. PMID: 3949799

Crooks88: Crooks PA, Godin CS (1988). "N-methylation of nicotine enantiomers by human liver cytosol." J Pharm Pharmacol 40(2);153-4. PMID: 2897456

Crooks88a: Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB (1988). "Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases." Biochem Pharmacol 37(9);1673-7. PMID: 3377829


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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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