Homo sapiens Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
indolethylamine N-methyltransferaseInferred from experiment: INMT

In Pathway: nicotine degradation IV

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: amine N-methyltransferase

Enzyme Commission Synonyms: nicotine N-methyltransferase, tryptamine N-methyltransferase, arylamine N-methyltransferase, tryptamine methyltransferase

Enzyme Commission Summary:
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.

Citations: [Crooks88, Crooks88a, Ansher86]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Ansher86: Ansher SS, Jakoby WB (1986). "Amine N-methyltransferases from rabbit liver." J Biol Chem 261(9);3996-4001. PMID: 3949799

Crooks88: Crooks PA, Godin CS (1988). "N-methylation of nicotine enantiomers by human liver cytosol." J Pharm Pharmacol 40(2);153-4. PMID: 2897456

Crooks88a: Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB (1988). "Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases." Biochem Pharmacol 37(9);1673-7. PMID: 3377829

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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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