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MetaCyc Compound Class: an antibiotic

Superclasses: a secondary metabolitea xenobiotic

Child Classes: a β-lactam (41), a carbohydrate-containing antibiotic (21), a dapdiamide (10), a deamido-bleomycin (0), a δ-lactam (0), a dithiopyrrolone (30), a γ-lactam (0), a macrolide antibiotic (62), a peptide antibiotic (6), a peptidyl nucleoside (9), a polymyxin (6), a quinomycin-type antibiotic (7), a tetrahydroisoquinoline antibiotic (10), an actinomycin (3), an aminoglycoside antibiotic (72), an angucyclin (20), an anthracycline (42), an aurachin (7), an avermectin (2)

Instances:
(+)-neocarzinostatin chromophore,
(+)-neocarzinostatin chromophore aglycone,
2-(2,4-dihydroxy-6-methylbenzoyl)benzene-1,3,5-triol,
2-hydroxyphenazine,
3,5-dioxo-6-[4,5,7-trihydroxy-3-(3-oxobutanoyl)naphthalen-2-yl]hexanoate,
5-hydroxy-desmethylanthrotainin,
5-hydroxyanthrotainin,
6-demethylmitomycin A,
6-demethylmitomycin B,
8-demethyl-8-α-L-rhamnosyl-tetracenomycin C,
8-demethyl-8-(2,3-O-dimethyl-α-L-rhamnosyl)-tetracenomycin C,
8-demethyl-8-(2-O-methyl-α-L-rhamnosyl)-tetracenomycin C,
8-demethyltetracenomycin C,
10-decarboxymethylaclacinomycin T,
12-demethyl-elloramycin,
15-demethoxyaclacinomycin T,
A-90289 A,
A-90289 B,
A201A,
A47934,
aclacinomycin A,
actinorhodin,
actinorhodin intermediate,
albaflavenone,
amiclenomycin,
andrimid,
anthramycin,
anthrotainin,
aureobasidin A,
aureothin,
avilamycin A,
azinomycin B,
balhimycin,
borrelidin,
brassicicolin A,
BU-2313B,
cadeguomycin,
caprazamycin A,
capreomycin,
ciprofloxacin,
clorobiocin,
concanamycin A,
coumermycin A1,
cytomycin,
deacetylravidomycin E,
deacetylravidomycin M,
deacetylravidomycin V,
decarboxy-dehydroxy-demycosaminyl-nystatin,
decarboxy-demycosaminyl-nystatin,
dechloro-dehydrogriseofulvin,
dechlorogriseofulvin,
dehydrogriseofulvin,
demethylarginomycin,
demethylblasticidin S,
demycosaminyl-nystatin,
desmethyl-dehydro-dechlorogriseofulvin,
desmethyl-dehydro-griseofulvin,
desmethylanthrotainin,
desulfo-A47934,
desvancoaminyl vancomycin,
dihydrokalafungin,
echinosporin,
ECO-02301,
enterocin,
enviomycin,
equisetin,
evernonimycin,
fosfomycin,
fosmidomycin,
FR-33289,
FR-900098,
fusaridione A,
gramicidin S,
griseofulvin,
griseophenone B,
griseophenone C,
griseophenone D,
hygromycin A,
indolmycin,
ionomycin,
isoepoxydon,
kijanimicin,
L-leucyl-arginomycin,
L-leucyl-blasticidin S,
L-leucyl-demethyl-blasticidin S,
L-leucyl-demethylarginomycin,
lavendomycin,
liposidomycin B1,
mannopeptimycin,
mitomycin A,
mitomycin B,
mitomycin C,
moenomycin,
myxothiazol,
neopentalenolactone,
neopentalenolactone D,
neopentalenolactone E,
neopentalenolactone F,
nikkomycin Z,
nocamycin II,
nojirimycin,
norlichexanthone,
norprodigiosin,
novclobiocin 101,
novclobiocin 102,
novobiocin,
O-phosphoviomycin,
patulin,
penem CGP31608,
pentalenolactone,
pentalenolactone D,
pentalenolactone E,
pentalenolactone F,
phenazine-1-carboxylate,
phyllostine,
piericidin A,
previridicatumtoxin,
prodigiosin,
rapamycin,
ravidomycin M,
ravidomycin V,
rifamycin B,
rifamycin SV,
sangivamycin,
sibiromycin,
streptolidigin,
syringomycin E,
TAN-1612,
teicoplanin,
terpentecin,
tetracenomycin B2,
tetracenomycin B3,
tetracycline,
tetrocarcin A,
thiolactomycin,
thiostrepton,
tirandaligin,
tirandamycin A,
tirandamycin B,
tirandamycin C,
tirandamycin C2,
tirandamycin D,
tirandamycin E,
tirandamycin F,
toyocamycin,
trichosetin,
triclosan,
tuberactinomycin A,
tuberactinomycin O,
tubercidin,
undecylprodigiosin,
vancomycin,
vancomycin aglycone,
viomycin,
viridicatumtoxin,
zwittermicin A

Unification Links: ChEBI:22582

In Transport reactions:
a xenobiotic[cytosol] + ATP + H2O ↔ a xenobiotic[extracellular space] + ADP + phosphate


References

Brakhage98: Brakhage AA (1998). "Molecular regulation of beta-lactam biosynthesis in filamentous fungi." Microbiol Mol Biol Rev 62(3);547-85. PMID: 9729600

Dalgliesh49: Dalgliesh CE, Todd AR (1949). "Actinomycin." Nature 164(4176);820. PMID: 15395378

Dawlaty10: Dawlaty J, Zhang X, Fischbach MA, Clardy J (2010). "Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases." J Nat Prod 73(3);441-6. PMID: 20041689

Fayette05: Fayette J, Coquard IR, Alberti L, Ranchere D, Boyle H, Blay JY (2005). "ET-743: a novel agent with activity in soft tissue sarcomas." Oncologist 10(10);827-32. PMID: 16314293

Frei74: Frei E (1974). "The clinical use of actinomycin." Cancer Chemother Rep 58(1);49-54. PMID: 4130354

Hayashi82a: Hayashi T, Noto T, Nawata Y, Okazaki H, Sawada M, Ando K (1982). "Cyanocycline A, a new antibiotic. Taxonomy of the producing organism, fermentation, isolation and characterization." J Antibiot (Tokyo) 35(7);771-7. PMID: 7174530

Hollenhorst09: Hollenhorst MA, Clardy J, Walsh CT (2009). "The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics." Biochemistry 48(43);10467-72. PMID: 19807062

Hutchinson97: Hutchinson CR (1997). "Biosynthetic Studies of Daunorubicin and Tetracenomycin C." Chem Rev 97(7);2525-2536. PMID: 11851469

Ishiguro78: Ishiguro K, Sakiyama S, Takahashi K, Arai T (1978). "Mode of action of saframycin A, a novel heterocyclic quinone antibiotic. Inhibition of RNA synthesis in vivo and in vitro." Biochemistry 17(13);2545-50. PMID: 567065

Johnson60: Johnson AW (1960). "The chemistry of actinomycin D and related compounds." Ann N Y Acad Sci 89;336-41. PMID: 13790233

Keller05: Keller NP, Turner G, Bennett JW (2005). "Fungal secondary metabolism - from biochemistry to genomics." Nat Rev Microbiol 3(12);937-47. PMID: 16322742

Kirschning00: Kirschning A, Chen GW, Drager G, Schuberth I, Tietze LF (2000). "Syntheses and biological evaluation of new glyco-modified angucyclin-antibiotics." Bioorg Med Chem 8(9);2347-54. PMID: 11026547

Kitagawa08: Kitagawa W, Tamura T (2008). "A quinoline antibiotic from Rhodococcus erythropolis JCM 6824." J Antibiot (Tokyo) 61(11);680-2. PMID: 19168983

Kitagawa13: Kitagawa W, Ozaki T, Nishioka T, Yasutake Y, Hata M, Nishiyama M, Kuzuyama T, Tamura T (2013). "Cloning and heterologous expression of the aurachin RE biosynthesis gene cluster afford a new cytochrome P450 for quinoline N-hydroxylation." Chembiochem 14(9);1085-93. PMID: 23677853

Kocholaty48: Kocholaty W, Junowicz-Kochlaty R, Kelner A (1948). "Actinomycin A produced by a soil Actinomyces different from Actinomyces antibioticus." Arch Biochem 17(1);191-3. PMID: 18910692

Korzybski57: Korzybski T (1957). "[Actinomycin, its properties and structure]." Postepy Biochem 3(2);121-33. PMID: 13505348

Kucharczyk90: Kucharczyk N, Denisot MA, Le Goffic F, Badet B (1990). "Glucosamine-6-phosphate synthase from Escherichia coli: determination of the mechanism of inactivation by N3-fumaroyl-L-2,3-diaminopropionic derivatives." Biochemistry 1990;29(15);3668-76. PMID: 2111163

Kunze87: Kunze B, Hofle G, Reichenbach H (1987). "The aurachins, new quinoline antibiotics from myxobacteria: production, physico-chemical and biological properties." J Antibiot (Tokyo) 40(3);258-65. PMID: 3106289

Kurosu10: Kurosu M, Begari E (2010). "Vitamin K2 in electron transport system: are enzymes involved in vitamin K2 biosynthesis promising drug targets?." Molecules 15(3);1531-53. PMID: 20335999

Le15: Le VH, Inai M, Williams RM, Kan T (2015). "Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics." Nat Prod Rep 32(2);328-47. PMID: 25273374

Li14a: Li B, Wever WJ, Walsh CT, Bowers AA (2014). "Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics." Nat Prod Rep 31(7);905-23. PMID: 24835149

Lombo06: Lombo F, Velasco A, Castro A, de la Calle F, Brana AF, Sanchez-Puelles JM, Mendez C, Salas JA (2006). "Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species." Chembiochem 7(2);366-76. PMID: 16408310

Meunier95: Meunier B, Madgwick SA, Reil E, Oettmeier W, Rich PR (1995). "New inhibitors of the quinol oxidation sites of bacterial cytochromes bo and bd." Biochemistry 34(3);1076-83. PMID: 7827023

Milewski91: Milewski S, Andruszkiewicz R, Kasprzak L, Mazerski J, Mignini F, Borowski E (1991). "Mechanism of action of anticandidal dipeptides containing inhibitors of glucosamine-6-phosphate synthase." Antimicrob Agents Chemother 35(1);36-43. PMID: 1901701

Ravina53: Ravina A (1953). "[Actinomycin C and its antitumoral action]." Presse Med 61(63);1270-2. PMID: 13112124

Scott02: Scott JD, Williams RM (2002). "Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics." Chem Rev 102(5);1669-730. PMID: 11996547

Sobell85: Sobell HM (1985). "Actinomycin and DNA transcription." Proc Natl Acad Sci U S A 82(16);5328-31. PMID: 2410919

Tomita83: Tomita F, Takahashi K, Shimizu K (1983). "DC-52, a novel antitumor antibiotic. 1. Taxonomy, fermentation and biological activity." J Antibiot (Tokyo) 36(5);463-7. PMID: 6860429

Umezawa48: Umezawa H, Maeda K, Kosaka H (1948). "Isolation of a new antibiotic substance, aureothricin from a strain of Strepomyces." The Japanese Medical Journal 1(6);512-517.

Waksman40: Waksman S A, Woodruff H B (1940). "Bacteriostatic and Bactericidal Substances Produced by a Soil Actinomyces." Experimental Biology and Medicine 45(2);609-614.

Waksman46: Waksman SA, Geiger WB, Reynolds DM (1946). "Strain Specificity and Production of Antibiotic Substances: VII. Production of Actinomycin by Different Actinomycetes." Proc Natl Acad Sci U S A 32(5);117-20. PMID: 16588723

Waxman54: Waxman SA, Gregory FJ (1954). "Actinomycin. II. Classification of organism producing different forms of actinomycin." Antibiot Chemother (Northfield) 4(10);1050-6. PMID: 24543239


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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