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MetaCyc Protein Class: an apo-[aryl-carrier protein]

Superclasses: a polypeptide all acyl-carrier proteins an apo-[acyl-carrier protein]
a polypeptide all acyl-carrier proteins an aryl-carrier protein
a protein all acyl-carrier proteins an apo-[acyl-carrier protein]
a protein all acyl-carrier proteins an aryl-carrier protein

Summary:
Aryl carrier proteins (ArCP) are a common component of non-ribosomal peptide synthetase (NRPS) complexes. The protein is expressed in the inactive apo form and the essential prosthetic group 4'-phosphopantetheine must be post-translationally attached to a conserved serine residue by the action of a phosphopantetheinyl transferase.

an <i>apo</i>-[aryl-carrier protein] compound structure

Child Classes: an apo-AsbD acyl-carrier protein (1) , an apo-[EntB isochorismatase/aryl-carrier protein] (1) , an NRPS containing an [aryl-carrier-protein] domain (0)

Alternative forms of an apo-[aryl-carrier protein]: a holo-[aryl-carrier protein]

SMILES: C(O)C(N[an aryl-carrier protein])C(=O)[an aryl-carrier protein]

Reactions known to consume the compound:

acyl carrier protein metabolism I , acyl carrier protein metabolism II (mammalian) :
an acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein] + H+

Reactions known to produce the compound:

acyl carrier protein metabolism I :
a holo-[acyl-carrier protein] + H2O → 4'-phosphopantetheine + an acyl-carrier protein + H+

Enzymes inhibited by an apo-[aryl-carrier protein], sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase [Rock81, Comment 1]

Inhibitor (Other types) of: acetyl-CoA carboxylase [Davis01]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [an acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein] + H+] (2.7.8.7):
i1: [EntB aryl-carrier protein] + coenzyme A → a holo-[EntB isochorismatase/aryl-carrier protein] + adenosine 3',5'-bisphosphate + H+ (2.7.8.7)

i2: AsbD acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[AsbD acyl-carrier protein] + H+ (no EC#)


References

Davis01: Davis MS, Cronan, Jr. JE (2001). "Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein." J Bacteriol. 183(4):1499-503. PMID: 11157970

Rock81: Rock CO, Goelz SE, Cronan JE (1981). "Phospholipid synthesis in Escherichia coli. Characteristics of fatty acid transfer from acyl-acyl carrier protein to sn-glycerol 3-phosphate." J Biol Chem 1981;256(2);736-42. PMID: 7005223


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Jul 5, 2015, BIOCYC13A.