Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Protein Class: an apo aryl-carrier protein

Superclasses: all acyl-carrier proteins an apo-[acp]
all acyl-carrier proteins an aryl-carrier protein

Summary:
Aryl carrier proteins (ArCP) are a common component of non-ribosomal peptide synthetase (NRPS) complexes. The protein is expressed in the inactive apo form and the essential prosthetic group 4'-phosphopantetheine must be post-translationally attached to a conserved serine residue by the action of a phosphopantetheinyl transferase.

Child Classes: a holo-AsbD protein (0) , an apo-AsbD protein (1) , an NRPS containing an [aryl-carrier-protein] domain (0)

Alternative forms of an apo aryl-carrier protein: a holo aryl-carrier protein

Reactions known to consume the compound:

acyl carrier protein metabolism I , acyl carrier protein metabolism II (mammalian) :
an apo-[acp] + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein]

Reactions known to produce the compound:

acyl carrier protein metabolism I :
a holo-[acyl-carrier protein] + H2O → 4'-phosphopantetheine + an apo-[acp]

Enzymes inhibited by an apo aryl-carrier protein, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase [Rock81, Comment 1]

Inhibitor (Other types) of: acetyl-CoA carboxylase [Davis01a]

Gene-Reaction Schematic: ?


References

Davis01a: Davis MS, Cronan, Jr. JE (2001). "Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein." J Bacteriol. 183(4):1499-503. PMID: 11157970

Rock81: Rock CO, Goelz SE, Cronan JE (1981). "Phospholipid synthesis in Escherichia coli. Characteristics of fatty acid transfer from acyl-acyl carrier protein to sn-glycerol 3-phosphate." J Biol Chem 1981;256(2);736-42. PMID: 7005223


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, BIOCYC14B.