This class consists of reactions in which no covalent modification of the substrates takes place, but in which the net effect is that one substrate noncovalently binds to or unbinds from another molecule via weak bonds (e.g. hydrogen bonds). This class includes protein complex assembly and dissociation reactions. In reactions of this class, each of the substrates maintains its original molecular identity, meaning reactions of this class affect intermolecular bonds, not intramolecular bonds.
a retinoid-binding protein + (3R)-11-cis-3-hydroxyretinal → a (3R)-11-cis-3-hydroxyretinal-[retinoid-binding protein] ,
all-trans-retinol + a plasma retinol-binding protein ↔ an all-trans-retinol-(plasma-retinol-binding-protein) ,
a retinoid-binding protein + (3R)-all-trans-3-hydroxyretinal → a (3R)-all-trans-3-hydroxyretinal-[retinoid-binding protein] ,
all-trans-retinol + a cellular-retinol-binding protein → an all-trans retinol-[cellular-retinol-binding-protein]
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