Synonyms: chondroitin 4-sulfate
|Superclasses:||all carbohydrates → a carbohydrate → a glycan → a glycosaminoglycan → a galactosaminoglycan → chondroitin sulfate|
Chondroitin sulfate is a sulfated glycosaminoglycan composed of alternating units of N-acetyl-β-D-galactosamine and β-D-glucuronate. It is usually found attached to proteins as part of a proteoglycan.
The saccharide units can be sulfated in variable positions and quantities - N-acetyl-β-D-galactosamine can be sulfated at positions 4 and 6 to yield N-acetyl-β-D-galactosamine 4-sulfate, N-acetyl-D-galactosamine 6-O-sulfate or N-acetyl-D-galactosamine 4,6-bissulfate, while β-D-glucuronate can be sulfated at position 2 to form 2-O-sulfo-β-D-glucuronate.
The following names have been used to define different sulfation states:
The term "chondroitin sulfate B" has been used in the past to refer to dermatan sulfate, but is not used any more.
Reactions known to consume the compound:
chondroitin sulfate degradation I (bacterial)
chondroitin sulfate A(n) → chondroitin sulfate A(n-1) + 4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate
chondroitin sulfate A → n 4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate
Not in pathways:
chondroitin sulfate + n H2O → n chondroitin sulfate disaccharide
In Reactions of unknown directionality:
Enzymes inhibited by chondroitin sulfate A, sorted by the type of inhibition, are:Inhibitor (Competitive) of: keratan galactose-6-sulfatase [Glossl79], chondroitin N-acetylgalactosamine-6-sulfatase [Glossl79]
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493