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MetaCyc Reactions Class: Composite Reactions

Summary:
A composite reaction R is represented both as a net chemical transformation, and a set of sub-reactions of which R is comprised. Those sub-reactions represent finer grained details of the reaction. Thus, composite reactions may have their mechanistic details recorded, when such information is available. The relationships among the sub-reactions are stored in the same way as are the relationships of reactions within a pathway (i.e. using the Reaction-List/In-Pathway and Predecessors slots). As a result, composite reactions exhibit hybrid properties: internally, they are constructed like pathways, and externally, they look like reactions.

The LEFT and RIGHT slots of composite reactions reflect the overall inputs and outputs of the composite transformation. At a later point in time, these slots should be automatically kept in synch with the sub-reactions. However, currently the Reaction Editor will have the burden of updating the LEFT and RIGHT slots.

An enzyme that is linked to a composite reaction may or may not also be linked to its sub-reactions -- cases when we might not want to link the enzyme to sub-reactions might be if one or more sub-reactions are spontaneous (so the enzyme would only be linked to the non-spontaneous sub-reactions), or if the enzyme were a complex with each of its subunits catalyzing a different sub-reaction (in which case it should be the subunit that is linked to each corresponding sub-reaction, not the complex).

Parent Classes:
Chemical Reactions

Child classes:
Electron-Transfer-Reactions (71)

Instances:
1.1.1.23: histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+,
1.1.1.42: D-threo-isocitrate + NADP+ ↔ 2-oxoglutarate + CO2 + NADPH,
1.1.1.85: (2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH,
1.1.1.103: L-threonine + NAD+ = aminoacetone + CO2 + NADH,
1.1.1.262: 4-phospho-hydroxy-L-threonine + NAD+ = 3-amino-1-hydroxyacetone 1-phosphate + CO2 + NADH,
1.1.1.276: L-serine + NADP+ = 2-aminoacetaldehyde + CO2 + NADPH,
1.1.1.314: germacra-1(10),4,11(13)-trien-12-ol + 2 NADP+ + H2O = germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+,
1.1.1.324: (6E)-8-hydroxygeraniol + 2 NADP+ → (6E)-8-oxogeranial + 2 NADPH + 2 H+,
1.1.1.331: (-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 NADH + 2 H+,
1.1.1.367: UDP-N-acetyl-β-L-pneumosamine + NAD(P)+ = UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hexul-4-ose + NAD(P)H + H+,
1.1.1.381: L-allo-threonine + NADP+ = aminoacetone + CO2 + NADPH,
1.1.1.387: L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH,
1.1.1.-: dTDP-β-L-rhamnose + NAD+ ↔ dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + NADH + H+,
1.1.1.-: 2-benzyl-3-hydroxybutanedioate + NAD+ = 2-oxo-4-phenylbutanoate + CO2 + NADH,
1.1.3.6: cholesterol + oxygen → cholest-4-en-3-one + hydrogen peroxide,
1.1.3.8: L-gulono-1,4-lactone + oxygen → L-ascorbate + hydrogen peroxide + H+,
1.1.3.17: choline + 2 oxygen + H2O → glycine betaine + 2 hydrogen peroxide + H+,
1.1.3.28: inosine + oxygen → 9-riburonosylhypoxanthine + H+ + H2O,
1.1.3.39: adenosine + 2 oxygen + H2O → adenin-9-yl riburonosate + 2 hydrogen peroxide + H+,
1.1.3.47: 5-hydroxymethylfurfural + 3 oxygen + 2 H2O → furan-2,5-dicarboxylate + 3 hydrogen peroxide + 2 H+,
1.2.1.25: 3-methyl-2-oxobutanoate + coenzyme A + NAD+ → isobutanoyl-CoA + CO2 + NADH,
1.2.1.31: (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O → L-2-aminoadipate + NAD(P)H + 2 H+,
1.2.1.95: (S)-2-amino-6-oxohexanoate + AMP + NADP+ + diphosphate ← L-2-aminoadipate + ATP + NADPH + H+,
1.2.1.-: pyruvate + coenzyme A + NAD+ ↔ acetyl-CoA + CO2 + NADH,
1.2.1.-: (S)-3-methyl-2-oxopentanoate + coenzyme A + NAD+ ↔ 2-methylbutanoyl-CoA + CO2 + NADH,
1.2.1.-: 4-methyl-2-oxopentanoate + coenzyme A + NAD+ → isovaleryl-CoA + CO2 + NADH,
1.2.1.-: (S)-2-amino-6-oxohexanoate + NAD+ + H2O = L-2-aminoadipate + NADH + 2 H+,
1.2.4.1: pyruvate + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + H+ ↔ a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + CO2,
1.2.99.-: carbon monoxide + H2O = CO2 + H2,
1.3.1.83: phytyl diphosphate + 3 NADP+ ← geranylgeranyl diphosphate + 3 NADPH + 3 H+,
1.3.2.3: L-galactono-1,4-lactone + 4 an oxidized c-type cytochrome = L-dehydro-ascorbate + 4 a reduced c-type cytochrome + 4 H+,
1.3.2.-: L-gulono-1,4-lactone + 4 an oxidized c-type cytochrome = L-dehydro-ascorbate + 4 a reduced c-type cytochrome + 4 H+,
1.3.3.13: cyclo(L-leucyl-L-phenylalanyl) + 2 oxygen → albonoursin + 2 hydrogen peroxide,
1.3.5.5: 15-cis-phytoene + 2 a plastoquinone = 9,15,9'-tri-cis-ζ-carotene + 2 a plastoquinol,
1.3.5.6: 9,9'-di-cis-ζ-carotene + 2 an electron-transfer quinone = prolycopene + 2 an electron-transfer quinol,
1.3.8.2: 15-cis-4,4'-diapophytoene + 4 FAD + 4 H+ = all-trans-4,4'-diapolycopene + 4 FADH2,
1.3.8.6: glutaryl-CoA + an oxidized electron-transfer flavoprotein + 2 H+ = crotonyl-CoA + CO2 + a reduced electron-transfer flavoprotein,
1.3.8.o: 15-cis-4,4'-diapophytoene + 3 FAD + 3 H+ = all-trans-4,4'-diaponeurosporene + 3 FADH2,
1.3.99.26: all-trans-ζ-carotene + 2 an oxidized unknown electron acceptor = all-trans-lycopene + 2 an reduced unknown electron acceptor,
1.3.99.28: 15-cis-phytoene + 3 an oxidized unknown electron acceptor = all-trans neurosporene + 3 an reduced unknown electron acceptor,
1.3.99.29: 15-cis-phytoene + 2 an oxidized unknown electron acceptor = all-trans-ζ-carotene + 2 an reduced unknown electron acceptor,
1.3.99.30: 15-cis-phytoene + 5 an oxidized unknown electron acceptor = all-trans-3,4-didehydrolycopene + 5 an reduced unknown electron acceptor,
1.3.99.31: 15-cis-phytoene + 4 an oxidized unknown electron acceptor = all-trans-lycopene + 4 an reduced unknown electron acceptor,
1.4.1.13: 2 L-glutamate + NADP+ ← L-glutamine + 2-oxoglutarate + NADPH + H+,
1.4.1.18: L-lysine + NAD+ = 1-piperideine 6-carboxylate + ammonium + NADH + 2 H+,
1.4.3.19: glycine + oxygen + H2O → ammonium + hydrogen peroxide + glyoxylate,
1.4.7.1: 2 L-glutamate + 2 an oxidized ferredoxin [iron-sulfur] cluster ← 2-oxoglutarate + L-glutamine + 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H+,
1.4.99.6: D-arginine + an oxidized unknown electron acceptor + H2O = 5-guanidino-2-oxo-pentanoate + ammonium + an reduced unknown electron acceptor,
1.5.1.31: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+,
1.5.3.5: (S)-6-hydroxynicotine + oxygen + H2O → 6-hydroxypseudooxynicotine + hydrogen peroxide,
1.5.3.6: (R)-6-hydroxynicotine + oxygen + H2O → 6-hydroxypseudooxynicotine + hydrogen peroxide,
1.7.3.6: hydroxylamine + oxygen → nitrite + H2O + H+,
1.8.99.5: hydrogen sulfide + a [DsrC protein] with an intramolecular disulfide bond + 2 an oxidized unknown electron acceptor + 3 H2O ↔ sulfite + a [DsrC protein]-dithiol + 2 an reduced unknown electron acceptor + 2 H+,
1.8.99.5: a [DsrC]-S-sulfanyl-L-cysteine + 3 an oxidized unknown electron acceptor + 3 H2O = sulfite + a [DsrC protein] with an intramolecular disulfide bond + 3 an reduced unknown electron acceptor + 2 H+,
1.10.3.4: 4 2-aminophenol + 3 oxygen → 2 isophenoxazine + 6 H2O,
1.11.1.11: 2 L-ascorbate + hydrogen peroxide + H+ → L-ascorbate + L-dehydro-ascorbate + 2 H2O,
1.11.1.14: veratryl alcohol + hydrogen peroxide = veratraldehyde + 2 H2O,
1.13.11.18: S-sulfanylglutathione + oxygen + H2O → glutathione + sulfite + 2 H+,
1.13.11.34: arachidonate + oxygen → leukotriene A4 + H2O,
1.13.11.64: 5-nitrosalicylate + oxygen → 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite + H+,
1.13.11.-: all-trans-β-carotene + 2 oxygen → 2 β-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial,
1.14.11.27: a [protein] N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 oxygen + H+ → a [protein]-L-lysine + 2 succinate + 2 formaldehyde + 2 CO2,
1.14.11.34: 2-oxoglutarate + L-arginine + oxygen → succinate + CO2 + guanidinium + (S)-1-pyrroline-5-carboxylate + H2O + H+,
1.14.11.36: pentalenolactone D + 2 2-oxoglutarate + 2 oxygen → pentalenolactone F + 2 succinate + 2 CO2 + H2O,
1.14.11.-: 3 2-oxoglutarate + L-arginine + 3 oxygen + 3 H+ → 2 ethylene + 7 CO2 + succinate + guanidinium + (S)-1-pyrroline-5-carboxylate + 3 H2O,
1.14.13.39: 2 L-arginine + 3 NADPH + H+ + 4 oxygen → 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O,
1.14.13.41: L-tyrosine + 2 NADPH + 2 oxygen + 2 H+ → (Z)-[(4-hydroxyphenyl)acetaldehyde oxime] + CO2 + 2 NADP+ + 3 H2O,
1.14.13.68: (Z)-[(4-hydroxyphenyl)acetaldehyde oxime] + NADPH + H+ + oxygen → (S)-4-hydroxymandelonitrile + NADP+ + 2 H2O,
1.14.13.70: lanosterol + 3 NADPH + 3 oxygen + 2 H+ → 14-demethyllanosterol + formate + 3 NADP+ + 4 H2O,
1.14.13.70: 24,25-dihydrolanosterol + 3 NADPH + 3 oxygen + 2 H+ → 4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol + formate + 3 NADP+ + 4 H2O,
1.14.13.72: 4,4-dimethyl-5α-cholest-7-en-3β-ol + 3 NAD(P)H + 3 oxygen + 2 H+ → 3β-hydroxy-4β-methyl-5α-cholest-7-ene-4α-carboxylate + 3 NAD(P)+ + 4 H2O,
1.14.13.72: 4α-methyl-cholesta-8-enol + 3 NAD(P)H + 3 oxygen + 2 H+ → 4α-carboxy-5α-cholesta-8-en-3β-ol + 3 NAD(P)+ + 4 H2O,
1.14.13.72: 4α-methyl-zymosterol + 3 NAD(P)H + 3 oxygen + 2 H+ → 4α-carboxy-5α-cholesta-8,24-dien-3β-ol + 3 NAD(P)+ + 4 H2O,
1.14.13.72: 4,4-dimethylzymosterol + 3 NAD(P)H + 3 oxygen + 2 H+ → 4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol + 3 NAD(P)+ + 4 H2O,
1.14.13.72: 4,4-dimethyl-5α-cholesta-8-en-3-β-ol + 3 NAD(P)H + 3 oxygen + 2 H+ → 4α-carboxy-4β-methyl-5α-cholesta-8-en-3β-ol + 3 NAD(P)+ + 4 H2O,
1.14.13.78: ent-kaurene + 3 NADPH + 3 oxygen + 2 H+ent-kaur-16-en-19-oate + 3 NADP+ + 4 H2O,
1.14.13.79: ent-kaur-16-en-19-oate + 3 NADPH + 3 oxygen + 2 H+ → gibberellin A12 + 3 NADP+ + 4 H2O,
1.14.13.81: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 2 H+ + 3 oxygen → 2,4-divinyl protochlorophyllide a + 3 NADP+ + 5 H2O,
1.14.13.88: (2S)-naringenin + 2 NADPH + 2 oxygen + H+ → (2S)-dihydrotricetin + 2 NADP+ + 2 H2O,
1.14.13.88: (+)-dihydrokaempferol + 2 NADPH + 2 oxygen + H+ → dihydromyricetin + 2 NADP+ + 2 H2O,
1.14.13.88: a flavanone + 2 NADPH + 2 oxygen + 2 H+ → a 3',5'-dihydroxy isoflavanone + 2 NADP+ + 2 H2O,
1.14.13.90: zeaxanthin + 2 NAD(P)H + 2 H+ + 2 oxygen → violaxanthin + 2 NAD(P)+ + 2 H2O,
1.14.13.105: (1S,4R)-1-hydroxymenth-8-en-2-one + NADPH + oxygen → (3S)-3-isopropenyl-6-oxoheptanoate + NADP+ + H2O,
1.14.13.105: a 1-hydroxymenth-8-en-2-one + NADPH + oxygen → a 3-isopropenyl-6-oxoheptanoate + NADP+ + H2O,
1.14.13.105: (1R,4S)-1-hydroxymenth-8-en-2-one + NADPH + oxygen → (3R)-3-isopropenyl-6-oxoheptanoate + NADP+ + H2O,
1.14.13.106: (+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 oxygen → albaflavenone + 2 NADP+ + 3 H2O,
1.14.13.109: abieta-7,13-dien-18-ol + NADPH + H+ + oxygen → abieta-7,13-diene-18-al + NADP+ + 2 H2O,
1.14.13.117: L-isoleucine + 2 NADPH + 2 oxygen + 2 H+ → (E)-2-methylbutanal oxime + CO2 + 2 NADP+ + 3 H2O,
1.14.13.118: L-valine + 2 NADPH + 2 oxygen + 2 H+ → (E)-2-methylpropanal-oxime + CO2 + 2 NADP+ + 3 H2O,
1.14.13.119: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 oxygen → capsidiol + 2 NADP+ + 2 H2O,
1.14.13.121: (-)-vetispiradiene + 2 NADPH + 2 H+ + 2 oxygen → solavetivone + 2 NADP+ + 3 H2O,
1.14.13.122: chlorophyllide a + 2 NADPH + 2 oxygen + 3 H+ → chlorophyllide b + 2 NADP+ + 3 H2O,
1.14.13.124: L-phenylalanine + 2 NADPH + 2 oxygen + 2 H+ → (E)-phenylacetaldehyde oxime + CO2 + 2 NADP+ + 3 H2O,
1.14.13.125: L-tryptophan + 2 NADPH + 2 oxygen + 2 H+ → (E)-indol-3-ylacetaldoxime + CO2 + 2 NADP+ + 3 H2O,
1.14.13.129: all-trans-β-carotene + 2 NADH + 2 H+ + 2 oxygen → zeaxanthin + 2 NAD+ + 2 H2O,
1.14.13.133: pentalenene + 2 NADPH + 2 H+ + 2 oxygen → pentalen-13-al + 2 NADP+ + 3 H2O,
1.14.13.134: β-amyrin + 2 NADPH + 2 oxygen + 2 H+ → 11-oxo-β-amyrin + 2 NADP+ + 3 H2O,
1.14.13.144: 9β-stemod-13(17)-ene + 3 NADPH + 3 oxygen + 3 H+ → 9β-stemod-13(17)-en-19-oate + 3 NADP+ + 4 H2O,
1.14.13.144: (-)-9β-pimara-7,15-diene + 3 NADPH + 3 oxygen + 2 H+ → (-)-9β-pimara-7,15-dien-19-oate + 3 NADP+ + 4 H2O,
1.14.13.151: linalool + 2 NADH + 2 H+ + 2 oxygen → (6E)-8-oxolinalool + 2 NAD+ + 3 H2O,
1.14.13.158: amorpha-4,11-diene + 3 NADPH + 3 oxygen + 2 H+ → artemisinate + 3 NADP+ + 4 H2O,
1.14.13.165: 2 L-arginine + 3 NAD(P)H + H+ + 4 oxygen → 2 L-citrulline + 2 nitric oxide + 3 NAD(P)+ + 4 H2O,
1.14.13.173: 11-oxo-β-amyrin + 3 NADPH + 3 oxygen + 2 H+ → glycyrrhetinate + 3 NADP+ + 4 H2O,
1.14.13.187: dTDP-β-L-evernosamine + 2 NADPH + H+ + 2 oxygen → dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-β-L-arabino-hexopyranose + 2 NADP+ + 3 H2O,
1.14.13.197: dihydromonacolin L acid + NADPH + oxygen + H+ → monacolin L acid + NADP+ + 2 H2O,
1.14.13.201: β-amyrin + 3 NADPH + 3 oxygen + 2 H+ → oleanolate + 3 NADP+ + 4 H2O,
1.14.13.-: adonixanthin + 2 NADH + 2 H+ + 2 oxygen = 2,3,2',3'-tetrahydroxy-β,β-caroten-4-one + 2 NAD+ + 2 H2O,
1.14.13.-: candicinolide + NADPH + 2 oxygen → 18-carboxy candicinolide + NADP+ + 2 H2O,
1.14.13.-: zeaxanthin + 2 NADH + 2 H+ + 2 oxygen → nostoxanthin + 2 NAD+ + 2 H2O,
1.14.13.-: pentahomomethionine + 2 NADPH + 2 oxygen + 2 H+ → 8-methylthiooctanaldoxime + CO2 + 2 NADP+ + 3 H2O,
1.14.13.-: aminopyrrolnitrin + NAD(P)H + 2 oxygen + H+ → pyrrolnitrin + NAD(P)+ + 2 H2O,
1.14.13.-: 3S,3'S-astaxanthin + 2 NADH + 2 H+ + 2 oxygen = 2,3,2',3'-tetrahydroxy-β,β-carotene-4,4'-dione + 2 NAD+ + 2 H2O,
1.14.13.-: hexahomomethionine + 2 NADPH + 2 oxygen + 2 H+ → CO2 + 9-methylthiononanaldoxime + 2 NADP+ + 3 H2O,
1.14.13.-: (Z)-2-methylbutanal oxime + NADPH + oxygen + H+ → 2-hydroxy-2-methylbutyronitrile + NADP+ + 2 H2O,
1.14.14.14: testosterone + 3 a reduced flavoprotein + 3 oxygen → 17β-estradiol + 3 an oxidized flavoprotein + formate + 4 H2O + H+,
1.14.14.14: androst-4-ene-3,17-dione + 3 a reduced flavoprotein + 3 oxygen → estrone + 3 an oxidized flavoprotein + formate + 4 H2O + H+,
1.14.14.-: 20-hydroxyecdysone + 3 a reduced flavoprotein + 3 oxygen → 20-hydroxyecdysonate + 3 an oxidized flavoprotein + 4 H2O + H+,
1.14.14.-: 3,5,6-trichloro-2-pyridinol + FADH2 + oxygen + 2 H2O → 3,6-dihydroxypyridine-2,5-dione + 3 chloride + FAD + H2O + 4 H+,
1.14.14.-: dimethyl sulfone + 2 FMNH2 + 2 oxygen → methanesulfonate + formaldehyde + 2 FMN + 2 H2O + 3 H+,
1.14.15.6: cholesterol + 6 a reduced adrenodoxin + 3 oxygen + 6 H+ → pregnenolone + 4-methylpentanal + 6 an oxidized adrenodoxin + 4 H2O,
1.14.15.9: 2-oxospirilloxanthin + 4 a reduced ferredoxin [iron-sulfur] cluster + 2 oxygen + 4 H+ → 2,2'-dioxospirilloxanthin + 4 an oxidized ferredoxin [iron-sulfur] cluster + 3 H2O,
1.14.15.9: spheroidene + 4 a reduced ferredoxin [iron-sulfur] cluster + 2 oxygen + 4 H+ → spheroiden-2-one + 4 an oxidized ferredoxin [iron-sulfur] cluster + 3 H2O,
1.14.15.9: spirilloxanthin + 4 a reduced ferredoxin [iron-sulfur] cluster + 2 oxygen + 4 H+ → 2-oxospirilloxanthin + 4 an oxidized ferredoxin [iron-sulfur] cluster + 3 H2O,
1.14.15.12: a long-chain acyl-[acyl-carrier protein] + 2 a reduced flavodoxin + 3 oxygen → a pimeloyl-[acp] + an n-alkanal + 2 an oxidized flavodoxin + 3 H2O + H+,
1.14.15.h: 5β-cholestane-3α,7α-diol + 6 a reduced adrenodoxin + 5 H+ + 3 oxygen → (25R)-3α,7α-dihydroxy-5-β-cholestanate + 6 an oxidized adrenodoxin + 4 H2O,
1.14.15.h: 5β-cholestane-3α,7α,12α-triol + 6 a reduced adrenodoxin + 5 H+ + 3 oxygen → (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate + 6 an oxidized adrenodoxin + 4 H2O,
1.14.18.1: L-tyrosine + oxygen → dopaquinone + H2O,
1.14.99.1: arachidonate + an reduced unknown electron acceptor + 2 oxygen → prostaglandin-H2 + an oxidized unknown electron acceptor + H2O,
1.14.99.42: zeaxanthin + 2 oxygen → crocetin dialdehyde + 2 (3S)-3-hydroxycyclocitral,
1.16.3.2: 4 Fe2+ + oxygen + 6 H2O → 4 [FeO(OH)] monomer + 8 H+,
1.17.1.-: magnesium-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine + H2O = 2,4-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 3 L-methionine + 4 H+,
1.17.99.1: 4-methylphenol + 2 an oxidized unknown electron acceptor + H2O = 4-hydroxybenzaldehyde + 2 an reduced unknown electron acceptor,
1.17.99.-: 2,4-xylenol + 2 an oxidized unknown electron acceptor + H2O = 4-hydroxy-3-methylbenzaldehyde + 2 an reduced unknown electron acceptor,
1.21.1.1: L-tyrosine + 2 iodide + 2 NADP+ ← 3,5-diiodo-L-tyrosine + 2 NADPH + H+,
1.23.5.1: violaxanthin + 2 L-ascorbate + 2 H+ = zeaxanthin + 2 L-dehydro-ascorbate + 2 H2O,
2.1.1.44: L-histidine + 3 S-adenosyl-L-methionine → hercynine + 3 S-adenosyl-L-homocysteine + 3 H+,
2.1.1.98: a 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] + 3 S-adenosyl-L-methionine → a diphthine-[translation elongation factor 2] + 3 S-adenosyl-L-homocysteine + 3 H+,
2.1.1.107: 2 S-adenosyl-L-methionine + uroporphyrinogen-III → 2 S-adenosyl-L-homocysteine + precorrin-2 + H+,
2.1.1.132: precorrin-6B + 2 S-adenosyl-L-methionine → precorrin-8x + 2 S-adenosyl-L-homocysteine + CO2 + H+,
2.1.1.156: 2 S-adenosyl-L-methionine + glycine → 2 S-adenosyl-L-homocysteine + dimethylglycine + 2 H+,
2.1.1.157: 2 S-adenosyl-L-methionine + sarcosine → 2 S-adenosyl-L-homocysteine + glycine betaine + 2 H+,
2.1.1.162: 3 S-adenosyl-L-methionine + glycine → 3 S-adenosyl-L-homocysteine + glycine betaine + 3 H+,
2.1.1.169: 3 S-adenosyl-L-methionine + tricetin → 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin + 3 H+,
2.1.1.175: tricetin + 2 S-adenosyl-L-methionine → 3',5'-O-dimethyltricetin + 2 S-adenosyl-L-homocysteine + 2 H+,
2.1.1.213: a guanine10 in tRNA + 2 S-adenosyl-L-methionine → N2-dimethylguanine10 in tRNA + 2 S-adenosyl-L-homocysteine + 2 H+,
2.1.1.216: a guanine26 in tRNA + 2 S-adenosyl-L-methionine → an N2dimethylguanine26 in tRNA + 2 S-adenosyl-L-homocysteine + 2 H+,
2.1.1.240: 2 S-adenosyl-L-methionine + trans-resveratrol → 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+,
2.1.1.244: 3 S-adenosyl-L-methionine + an N-terminal-(A/S)PK-[protein] → 3 S-adenosyl-L-homocysteine + an N terminal N,N,N-trimethyl-(A/S)PK-[protein] + 3 H+,
2.1.1.244: 2 S-adenosyl-L-methionine + an N-terminal-PPK-[protein] → 2 S-adenosyl-L-homocysteine + an N terminal N,N-dimethyl-PPK-[protein] + 2 H+,
2.1.1.251: methanethiol + coenzyme M = methyl-CoM + HS- + H+,
2.1.1.262: squalene + 2 S-adenosyl-L-methionine → 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 S-adenosyl-L-homocysteine + 2 H+,
2.1.1.263: C30 botryococcene + 2 S-adenosyl-L-methionine → 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 S-adenosyl-L-homocysteine + 2 H+,
2.1.1.272: S-adenosyl-L-methionine + cobalt-factor III + an reduced unknown electron acceptor → S-adenosyl-L-homocysteine + cobalt-precorrin-4 + an oxidized unknown electron acceptor,
2.1.1.-: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose → 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose + 2 H+,
2.1.1.fn: 2 S-adenosyl-L-methionine + a [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-ω-NG,N'G-dimethyl-arginine + 2 H+,
2.1.1.fm: 2 S-adenosyl-L-methionine + a [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-ω-NG,NG-dimethyl-arginine + 2 H+,
2.1.1.-: tetrahydrosarcinapterin + acetyl-CoA + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O ↔ 5-methyl-tetrahydrosarcinapterin + CO2 + 2 a reduced ferredoxin [iron-sulfur] cluster + coenzyme A + 2 H+,
2.3.1.164: isopenicillin N + phenylacetyl-CoA + H2O = L-2-aminoadipate + penicillin G + coenzyme A + H+,
2.3.1.206: hexanoyl-CoA + 3 malonyl-CoA + 3 H+ = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 coenzyme A,
2.3.1.235: 10 malonyl-CoA + 9 H+ = tetracenomycin F2 + 10 CO2 + 10 coenzyme A + 2 H2O,
2.3.2.24: an S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + a [protein]-L-lysine = an [E1 ubiquitin-activating enzyme]-L-cysteine + an N6-monoubiquitinyl-[protein]-L-lysine + H+,
2.3.2.25: an S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + a [protein] N-terminal amino acid = an N-terminal-monoubiquitinyl-[protein] + an [E1 ubiquitin-activating enzyme]-L-cysteine + H+,
2.4.1.249: 2 UDP-α-D-glucose + delphinidin 3-O-(6''-O-malonyl)-β-glucoside = ternatin C5 + 2 UDP + 2 H+,
2.4.1.276: zeaxanthin + 2 UDP-α-D-glucose = zeaxanthin bis(β-D-glucoside) + 2 UDP + 2 H+,
2.4.1.287: 2 UDP-α-D-galactofuranose + α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 2 UDP + β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol + 2 H+,
2.4.99.20: nicotinate + NADP+ = nicotinate-adenine dinucleotide phosphate + nicotinamide,
2.5.1.21: 2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ → squalene + NAD(P)+ + 2 diphosphate,
2.5.1.32: 2 2-cis,6-trans,10-trans-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate,
2.5.1.46: spermidine + an [eIF5A-precursor]-lysine = an [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine + H+,
2.5.1.96: 2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate,
2.5.1.99: 2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate,
2.5.1.128: 2 S-adenosyl 3-(methylthio)propylamine + spermidine = 2 S-methyl-5'-thioadenosine + N4-bis(aminopropyl)spermidine + 2 H+,
2.6.1.82: putrescine + 2-oxoglutarate ↔ L-glutamate + 1-pyrroline + H2O,
2.7.1.151: D-myo-inositol (1,4,5)-trisphosphate + 2 ATP = D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H+,
2.7.7.86: ATP + GTP = cyclic Gp(2'-5')Ap(3'-5') + 2 diphosphate,
2.8.1.7: L-cysteine + an unsulfurated [sulfur carrier] → L-alanine + a sulfurated [sulfur carrier],
2.8.1.7: a ThiI sulfur-carrier protein + L-cysteine = an S-sulfanyl-[ThiI sulfur-carrier protein] + L-alanine,
2.8.4.3: N6-dimethylallyladenosine37 in tRNA + 2 S-adenosyl-L-methionine + a sulfurated [sulfur carrier] + an reduced unknown electron acceptor → 2-methylthio-N6-dimethylallyladenosine37 in tRNA + S-adenosyl-L-homocysteine + an unsulfurated [sulfur carrier] + 5'-deoxyadenosine + L-methionine + an oxidized unknown electron acceptor + 2 H+,
3.1.1.82: pheophorbide a + H2O → pyropheophorbide a + methanol + CO2,
3.1.1.M1: pedunculagin = 2 ellagic acid + D-glucopyranose,
3.1.1.-: enterobactin + 3 H2O → 3 N-(2,3-dihydroxybenzoyl)-L-serine + 3 H+,
3.1.3.77: 5-(methylthio)-2,3-dioxopentyl 1-phosphate + H2O → 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate + H+,
3.1.7.10: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O → (13E)-labda-7,13-dien-15-ol + diphosphate,
3.2.1.191/3.2.1.z: ginsenoside Rd + 2 H2O → ginsenoside C-K + 2 D-glucopyranose,
3.2.1.191: (20S)-ginsenoside Rg3 + 2 H2O → protopanaxadiol + 2 D-glucopyranose,
3.2.1.191/3.2.1.z: ginsenoside Rb3 + 2 H2O → ginsenoside Mx + 2 D-glucopyranose,
3.2.1.191/3.2.1.z: ginsenoside Rc + 2 H2O → ginsenoside Mc + 2 D-glucopyranose,
3.2.1.191: ginsenoside Rb1 + 2 H2O → gypenoside LXXV + 2 D-glucopyranose,
3.2.1.191/3.2.1.z: ginsenoside Rb2 + 2 H2O → ginsenoside C-Y + 2 D-glucopyranose,
3.2.1.192: ginsenoside Rb1 + 2 H2O → (20S)-ginsenoside Rg3 + 2 D-glucopyranose,
3.2.1.193/3.2.1.z: a protopanaxadiol-type ginsenoside with two glucosyl residues at position 3 + 2 H2O → a protopanaxadiol-type ginsenoside with no glycosidic modification at position 3 + 2 D-glucopyranose,
3.2.1.194: ginsenoside R1 + 2 H2O → ginsenoside F1 + D-xylopyranose + D-glucopyranose,
3.2.1.194: ginsenoside Rg2 + 2 H2O → protopanaxatriol + L-rhamnopyranose + D-glucopyranose,
3.2.1.194: ginsenoside Rf + 2 H2O → protopanaxatriol + 2 D-glucopyranose,
3.2.1.194: a protopanaxatriol-type ginsenoside with two glycosyl residues at position 6 + 2 H2O → a protopanaxatriol-type ginsenoside with no glycosidic modification at position 6 + a monosaccharide + D-glucopyranose,
3.2.1.194: ginsenoside Re + 2 H2O → ginsenoside F1 + L-rhamnopyranose + D-glucopyranose,
3.2.1.z: ginsenoside Rb1 + 3 H2O → ginsenoside C-K + 3 D-glucopyranose,
3.2.2.6: NAD+ + H2O → ADP-D-ribose + nicotinamide + H+,
3.5.1.110: (Z)-2-methylureidoacrylate peracid + H+ + H2O → (Z)-2-methyl-peroxyaminoacrylate + ammonium + CO2,
3.5.1.110: (Z)-3-ureidoacrylate peracid + H+ + H2O → (Z)-3-peroxyaminoacrylate + ammonium + CO2,
3.5.3.21: methylenediurea + 2 H+ + 2 H2O = N-(hydroxymethyl)urea + 2 ammonium + CO2,
3.5.5.4: 3-cyano-L-alanine + H+ + 2 H2O → ammonium + L-aspartate,
3.5.99.7: 1-aminocyclopropane-1-carboxylate + H2O → ammonium + 2-oxobutanoate,
3.6.1.5: CTP + 2 H2O → CMP + 2 phosphate + 2 H+,
3.6.1.5: dGTP + 2 H2O → dGMP + 2 phosphate + 2 H+,
3.6.1.5: dATP + 2 H2O → dAMP + 2 phosphate + 2 H+,
3.6.1.5: dCTP + 2 H2O → dCMP + 2 phosphate + 2 H+,
3.6.1.5: GTP + 2 H2O → GMP + 2 phosphate + 2 H+,
3.6.1.5: a nucleoside triphosphate + 2 H2O → a nucleoside 5'-monophosphate + 2 phosphate + 2 H+,
3.6.1.5: UTP + 2 H2O → UMP + 2 phosphate + 2 H+,
3.6.1.5: ATP + 2 H2O → AMP + 2 phosphate + 2 H+,
3.6.1.5: dTTP + 2 H2O → dTMP + 2 phosphate + 2 H+,
3.6.1.5: dUTP + 2 H2O → dUMP + 2 phosphate + 2 H+,
3.7.1.21: 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O ↔ 3-hydroxypimeloyl-CoA + H+,
4.1.1.68: (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H+ → (4Z)-2-oxohept-4-enedioate + CO2,
4.1.3.6: citrate → acetate + oxaloacetate,
4.1.99.1: L-tryptophan + H2O = indole + pyruvate + ammonium,
4.1.99.2: L-tyrosine + H2O = phenol + pyruvate + ammonium,
4.2.1.3: citrate = D-threo-isocitrate,
4.2.1.20: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine → L-tryptophan + D-glyceraldehyde 3-phosphate + H2O,
4.2.1.33: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate,
4.2.1.87: octopamine → (4-hydroxyphenyl)acetaldehyde + ammonium,
4.2.1.88: (R)-synephrine → (4-hydroxyphenyl)acetaldehyde + methylamine,
4.2.1.104: cyanate + hydrogen carbonate + 3 H+ → ammonium + 2 CO2,
4.2.1.110: 1,5-anhydro-D-fructose = microthecin + H2O,
4.2.1.114: (2R)-homocitrate = (1R,2S)-homoisocitrate,
4.2.1.155: 3-(methylthio)acryloyl-CoA + 2 H2O → methanethiol + acetaldehyde + CO2 + coenzyme A,
4.2.1.az: dTDP-4-dehydro-6-deoxy-α-D-glucopyranose = dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose + H2O,
4.2.1.bb: bacterioruberin = bisanhydrobacterioruberin + 2 H2O,
4.3.1.9: D-glucosaminate = ammonium + 2-dehydro-3-deoxy-D-gluconate,
4.3.1.13: O-carbamoyl-L-serine + H2O + H+ = pyruvate + CO2 + 2 ammonium,
4.3.1.17: L-serine → pyruvate + ammonium,
4.3.1.18: D-serine = pyruvate + ammonium,
4.3.1.19: L-threonine → 2-oxobutanoate + ammonium,
4.3.1.-: O-succinyl-L-homoserine + H2O → 2-oxobutanoate + succinate + ammonium + H+,
4.3.3.6: keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine → pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H+,
4.4.1.1: L-cystine + H2O → thiocysteine + pyruvate + ammonium,
4.4.1.1/4.4.1.28: L-cysteine + H2O → pyruvate + hydrogen sulfide + ammonium,
4.4.1.1: L-cystathionine + H2O → 2-oxobutanoate + L-cysteine + ammonium,
4.4.1.1: L-homoserine → 2-oxobutanoate + ammonium,
4.4.1.2: L-homocysteine + H2O → hydrogen sulfide + 2-oxobutanoate + ammonium,
4.4.1.6: an S-alkyl-L-cysteine + H2O = an alkyl-thiol + pyruvate + ammonium,
4.4.1.8: L-selenocystathionine + H2O → ammonium + pyruvate + seleno-L-homocysteine,
4.4.1.8: L-cystathionine + H2O → ammonium + pyruvate + L-homocysteine,
4.4.1.11: L-methionine + H2O → methanethiol + 2-oxobutanoate + ammonium,
4.4.1.13: an L-cysteine-S-conjugate + H2O → a thiol + pyruvate + ammonium,
4.4.1.25: L-cysteate + H2O → sulfite + pyruvate + ammonium + H+,
4.4.1.27: carbon disulfide + 2 H2O = CO2 + 2 hydrogen sulfide,
4.5.1.2: 3-chloro-D-alanine + H2O = pyruvate + ammonium + chloride + H+,
5.4.2.2: α-D-glucopyranose 1-phosphate ↔ D-glucopyranose 6-phosphate,
5.4.2.3: N-acetyl-D-glucosamine 6-phosphate ↔ N-acetyl-α-D-glucosamine 1-phosphate,
5.4.2.6: β-D-glucose 1-phosphate ↔ β-D-glucose 6-phosphate,
5.4.2.10: D-glucosamine 6-phosphate ↔ D-glucosamine 1-phosphate,
5.4.2.11: 2-phospho-D-glycerate ↔ 3-phospho-D-glycerate,
6.1.2.2: carbamoyl phosphate + kanamycin A + ATP + H2O → 6''-O-carbamoylkanamycin A + AMP + diphosphate + phosphate + H+,
6.1.2.2: carbamoyl phosphate + tobramycin + ATP + H2O → nebramycin 5' + AMP + diphosphate + phosphate + H+,
6.1.2.2: carbamoyl phosphate + kanamycin B + ATP + H2O → 6''-O-carbamoylkanamycin B + AMP + diphosphate + phosphate + H+,
6.1.2.-: carbamoyl phosphate + HypE + ATP + H2O → a HypE hydrogenase maturation protein-S-carboxamide + AMP + diphosphate + phosphate,
6.2.1.-: a holo-[tryptophanyl-carrier protein] + L-tryptophan + ATP → an L-tryptophanyl-[tryptophanyl-carrier protein] + AMP + diphosphate,
6.2.1.-: a holo-[seryl-carrier protein] + L-serine + ATP → an L-seryl-[seryl-carrier protein] + AMP + diphosphate,
6.3.1.h: [glycine cleavage system lipoyl-carrier protein]-L-lysine + ATP + (R)-lipoate → AMP + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + diphosphate + H+,
6.3.1.h: a [lipoyl-carrier protein]-L-lysine + ATP + (R)-lipoate = a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + AMP + diphosphate + H+,
6.3.2.14: 3 L-serine + 3 2,3-dihydroxybenzoate + 6 ATP → enterobactin + 6 AMP + 6 diphosphate + 3 H+,
6.3.4.2: ATP + UTP + L-glutamine + H2O → ADP + CTP + L-glutamate + phosphate + 2 H+,
6.3.4.16: 2 ATP + hydrogen carbonate + ammonium → 2 ADP + carbamoyl phosphate + phosphate + 2 H+,
6.3.5.2: XMP + L-glutamine + ATP + H2O → L-glutamate + GMP + AMP + diphosphate + 2 H+,
6.3.5.4: L-glutamine + L-aspartate + ATP + H2O → L-glutamate + L-asparagine + AMP + diphosphate + H+,
6.3.5.5: 2 ATP + L-glutamine + hydrogen carbonate + H2O → L-glutamate + carbamoyl phosphate + 2 ADP + phosphate + 2 H+,
6.3.5.11: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O → cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 phosphate + 2 H+,
2-oxepin-2(3H)-ylideneacetyl-CoA + NADP+ + 2 H2O = 3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+,
meso-diaminopimelate + NADP+ = (S)-2,3,4,5-tetrahydrodipicolinate + ammonium + NADPH + 2 H+,
(S)-1-pyrroline-5-carboxylate + NAD+ + 2 H2O → L-glutamate + NADH + H+,
glycine + a tetrahydrofolate + NAD+ ↔ a 5,10-methylene-tetrahydrofolate + ammonium + CO2 + NADH,
strictosamide = camptothecin,
2-oxoglutarate + coenzyme A + NAD+ → succinyl-CoA + CO2 + NADH,
3-hydroxypropanoate + ATP + coenzyme A + NADPH + H+ → propanoyl-CoA + AMP + NADP+ + diphosphate + H2O,
methanol + coenzyme M ↔ methyl-CoM + H2O


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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