Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reactions Class: Composite Reactions

Summary:
A composite reaction R is represented both as a net chemical transformation, and a set of sub-reactions of which R is comprised. Those sub-reactions represent finer grained details of the reaction. Thus, composite reactions may have their mechanistic details recorded, when such information is available. The relationships among the sub-reactions are stored in the same way as are the relationships of reactions within a pathway (i.e. using the Reaction-List/In-Pathway and Predecessors slots). As a result, composite reactions exhibit hybrid properties: internally, they are constructed like pathways, and externally, they look like reactions.

The LEFT and RIGHT slots of composite reactions reflect the overall inputs and outputs of the composite transformation. At a later point in time, these slots should be automatically kept in synch with the sub-reactions. However, currently the Reaction Editor will have the burden of updating the LEFT and RIGHT slots.

An enzyme that is linked to a composite reaction may or may not also be linked to its sub-reactions -- cases when we might not want to link the enzyme to sub-reactions might be if one or more sub-reactions are spontaneous (so the enzyme would only be linked to the non-spontaneous sub-reactions), or if the enzyme were a complex with each of its subunits catalyzing a different sub-reaction (in which case it should be the subunit that is linked to each corresponding sub-reaction, not the complex).

Parent Classes:
Chemical Reactions

Child classes:
Electron-Transfer-Reactions (57)

Instances:
1.1.1.23: histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+ ,
1.1.1.42: D-threo-isocitrate + NADP+ ↔ 2-oxoglutarate + CO2 + NADPH ,
1.1.1.85: (2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH ,
1.1.1.103: L-threonine + NAD+ = aminoacetone + CO2 + NADH ,
1.1.1.262: 4-phospho-hydroxy-L-threonine + NAD+ = 3-amino-1-hydroxyacetone 1-phosphate + CO2 + NADH ,
1.1.1.314: germacra-1(10),4,11(13)-trien-12-ol + 2 NADP+ + H2O = germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+ ,
1.1.1.324: (6E)-8-hydroxygeraniol + 2 NADP+ → (6E)-8-oxogeranial + 2 NADPH + 2 H+ ,
1.1.1.331: (-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 NADH + 2 H+ ,
1.1.1.367: UDP-N-acetyl-β-L-pneumosamine + NAD(P)+ = UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hexul-4-ose + NAD(P)H + H+ ,
1.1.1.-: 2-benzyl-3-hydroxybutanedioate + NAD+ = 2-oxo-4-phenylbutanoate + CO2 + NADH ,
1.1.1.-: dTDP-β-L-rhamnose + NAD+ ↔ dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + NADH + H+ ,
1.1.3.6: cholesterol + oxygen → cholest-4-en-3-one + hydrogen peroxide ,
1.1.3.8: L-gulono-1,4-lactone + oxygen → L-ascorbate + hydrogen peroxide + H+ ,
1.1.3.17: choline + 2 oxygen + H2O → glycine betaine + 2 hydrogen peroxide + H+ ,
1.1.3.28: inosine + oxygen → 9-riburonosylhypoxanthine + H+ + H2O ,
1.1.3.39: adenosine + 2 oxygen + H2O → adenin-9-yl riburonosate + 2 hydrogen peroxide + H+ ,
1.1.3.f: 5-hydroxymethylfurfural + 3 oxygen + 2 H2O = 2,5-dicarboxyfuran + 3 hydrogen peroxide + 2 H+ ,
1.2.1.25: 3-methyl-2-oxobutanoate + coenzyme A + NAD+ → isobutanoyl-CoA + CO2 + NADH ,
1.2.1.31: (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O → L-2-aminoadipate + NAD(P)H + 2 H+ ,
1.2.1.-: pyruvate + coenzyme A + NAD+ ↔ acetyl-CoA + CO2 + NADH ,
1.2.1.-: 4-methyl-2-oxopentanoate + coenzyme A + NAD+ → isovaleryl-CoA + CO2 + NADH ,
1.2.1.-: (S)-3-methyl-2-oxopentanoate + coenzyme A + NAD+ ↔ 2-methylbutanoyl-CoA + CO2 + NADH ,
1.2.1.-: (S)-2-amino-6-oxohexanoate + NAD+ + H2O = L-2-aminoadipate + NADH + 2 H+ ,
1.2.4.1: pyruvate + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + H+ ↔ a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + CO2 ,
1.2.99.-: carbon monoxide + H2O = CO2 + H2 ,
1.3.2.3: L-galactono-1,4-lactone + 4 an oxidized c-type cytochrome = L-dehydro-ascorbate + 4 a reduced c-type cytochrome + 4 H+ ,
1.3.2.-: L-gulono-1,4-lactone + 4 an oxidized c-type cytochrome = L-dehydro-ascorbate + 4 a reduced c-type cytochrome + 4 H+ ,
1.3.3.13: cyclo(L-leucyl-L-phenylalanyl) + 2 oxygen → albonoursin + 2 hydrogen peroxide ,
1.3.5.5: 15-cis-phytoene + 2 a plastoquinone = 9,15,9'-tri-cis-ζ-carotene + 2 a plastoquinol ,
1.3.5.6: 9,9'-di-cis-ζ-carotene + 2 an electron-transfer-related quinone = prolycopene + 2 an electron-transfer-related quinol ,
1.3.8.2: 15-cis-4,4'-diapophytoene + 4 FAD + 4 H+ = all-trans-4,4'-diapolycopene + 4 FADH2 ,
1.3.8.6: glutaryl-CoA + an oxidized electron-transfer flavoprotein = crotonyl-CoA + CO2 + a reduced electron-transfer flavoprotein ,
1.3.8.o: 15-cis-4,4'-diapophytoene + 3 FAD + 3 H+ = all-trans-4,4'-diaponeurosporene + 3 FADH2 ,
1.3.99.26: all-trans-ζ-carotene + 2 an oxidized electron acceptor = all-trans-lycopene + 2 a reduced electron acceptor ,
1.3.99.28: 15-cis-phytoene + 3 an oxidized electron acceptor = all-trans neurosporene + 3 a reduced electron acceptor ,
1.3.99.29: 15-cis-phytoene + 2 an oxidized electron acceptor = all-trans-ζ-carotene + 2 a reduced electron acceptor ,
1.3.99.30: 15-cis-phytoene + 5 an oxidized electron acceptor = all-trans-3,4-didehydrolycopene + 5 a reduced electron acceptor ,
1.3.99.31: 15-cis-phytoene + 4 an oxidized electron acceptor = all-trans-lycopene + 4 a reduced electron acceptor ,
1.4.1.13: 2 L-glutamate + NADP+ ← L-glutamine + 2-oxoglutarate + NADPH + H+ ,
1.4.1.18: L-lysine + NAD+ = (S)-2,3,4,5-tetrahydropiperidine-2-carboxylate + ammonium + NADH + 2 H+ ,
1.4.3.19: glycine + oxygen + H2O → ammonium + hydrogen peroxide + glyoxylate ,
1.4.7.1: 2 L-glutamate + 2 an oxidized ferredoxin ← 2-oxoglutarate + L-glutamine + 2 a reduced ferredoxin + 2 H+ ,
1.4.99.1: D-arginine + an oxidized electron acceptor + H2O = 2-ketoarginine + ammonium + a reduced electron acceptor ,
1.5.1.31: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+ ,
1.10.3.4: 2 2-aminophenol + an oxidized electron acceptor + oxygen → isophenoxazine + a reduced electron acceptor + 2 H2O ,
1.10.99.3: violaxanthin + 2 L-ascorbate + 2 H+ = zeaxanthin + 2 L-dehydro-ascorbate + 2 H2O ,
1.11.1.11: 2 L-ascorbate + hydrogen peroxide + H+ → L-ascorbate + L-dehydro-ascorbate + 2 H2O ,
1.13.11.18: S0 + oxygen + H2O → sulfite + 2 H+ ,
1.13.11.34: arachidonate + oxygen → leukotriene A4 + H2O ,
1.13.11.64: 5-nitrosalicylate + oxygen → 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite + H+ ,
1.13.11.-: all-trans-β-carotene + 2 oxygen → 2 β-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial ,
1.14.11.27: a [protein] N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 oxygen + H+ → a [protein]-L-lysine + 2 succinate + 2 formaldehyde + 2 CO2 ,
1.14.11.34: 2-oxoglutarate + L-arginine + oxygen → succinate + CO2 + guanidinium + (S)-1-pyrroline-5-carboxylate + H2O + H+ ,
1.14.11.36: pentalenolactone D + 2 2-oxoglutarate + 2 oxygen → pentalenolactone F + 2 succinate + 2 CO2 + H2O ,
1.14.11.-: 3 2-oxoglutarate + L-arginine + 3 oxygen + 3 H+ → 2 ethylene + 7 CO2 + succinate + guanidinium + (S)-1-pyrroline-5-carboxylate + 3 H2O ,
1.14.13.15: 5β-cholestane-3α,7α,12α-triol + 3 NADPH + 2 H+ + 3 oxygen → (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate + 3 NADP+ + 4 H2O ,
1.14.13.15: 5β-cholestane-3α,7α-diol + 3 NADPH + 2 H+ + 3 oxygen → (25R)-3α,7α-dihydroxy-5-β-cholestanate + 3 NADP+ + 4 H2O ,
1.14.13.39: 2 L-arginine + 3 NADPH + H+ + 4 oxygen → 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O ,
1.14.13.41: L-tyrosine + 2 NADPH + 2 oxygen + 2 H+ → (Z)-[(4-hydroxyphenyl)acetaldehyde oxime] + CO2 + 2 NADP+ + 3 H2O ,
1.14.13.68: (Z)-[(4-hydroxyphenyl)acetaldehyde oxime] + NADPH + H+ + oxygen → (S)-4-hydroxymandelonitrile + NADP+ + 2 H2O ,
1.14.13.70: 24,25-dihydrolanosterol + 3 NADPH + 3 oxygen + 2 H+ → 4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol + formate + 3 NADP+ + 4 H2O ,
1.14.13.70: lanosterol + 3 NADPH + 3 oxygen + 2 H+ → 14-demethyllanosterol + formate + 3 NADP+ + 4 H2O ,
1.14.13.72: 4,4-dimethyl-5α-cholest-7-en-3β-ol + 3 NAD(P)H + 3 oxygen + 2 H+ → 3β-hydroxy-4β-methyl-5α-cholest-7-ene-4α-carboxylate + 3 NAD(P)+ + 4 H2O ,
1.14.13.72: 4α-methyl-zymosterol + 3 NAD(P)H + 3 oxygen + 2 H+ → 4α-carboxy-5α-cholesta-8,24-dien-3β-ol + 3 NAD(P)+ + 4 H2O ,
1.14.13.72: 4α-methyl-cholesta-8-enol + 3 NAD(P)H + 3 oxygen + 2 H+ → 4α-carboxy-5α-cholesta-8-en-3β-ol + 3 NAD(P)+ + 4 H2O ,
1.14.13.72: 4,4-dimethyl-5α-cholesta-8-en-3-β-ol + 3 NAD(P)H + 3 oxygen + 2 H+ → 4α-carboxy-4β-methyl-5α-cholesta-8-en-3β-ol + 3 NAD(P)+ + 4 H2O ,
1.14.13.72: 4,4-dimethylzymosterol + 3 NAD(P)H + 3 oxygen + 2 H+ → 4α-carboxy-4β-methyl-5α-cholesta-8,24-dien-3β-ol + 3 NAD(P)+ + 4 H2O ,
1.14.13.78: ent-kaurene + 3 NADPH + 3 oxygen + 2 H+ent-kaur-16-en-19-oate + 3 NADP+ + 4 H2O ,
1.14.13.79: ent-kaur-16-en-19-oate + 3 NADPH + 3 oxygen + 2 H+ → gibberellin A12 + 3 NADP+ + 4 H2O ,
1.14.13.81: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 2 H+ + 3 oxygen → 2,4-divinyl protochlorophyllide a + 3 NADP+ + 5 H2O ,
1.14.13.88: a flavanone + 2 NADPH + 2 oxygen + 2 H+ → a 3',5'-dihydroxy isoflavanone + 2 NADP+ + 2 H2O ,
1.14.13.88: (2S)-naringenin + 2 NADPH + 2 oxygen + H+ → (2S)-dihydrotricetin + 2 NADP+ + 2 H2O ,
1.14.13.88: (+)-dihydrokaempferol + 2 NADPH + 2 oxygen + H+ → dihydromyricetin + 2 NADP+ + 2 H2O ,
1.14.13.90: zeaxanthin + 2 NAD(P)H + 2 H+ + 2 oxygen → violaxanthin + 2 NAD(P)+ + 2 H2O ,
1.14.13.105: a 1-hydroxymenth-8-en-2-one + NADPH + oxygen = a 3-isopropenyl-6-oxoheptanoate + NADP+ + H2O ,
1.14.13.105: (1S,4R)-1-hydroxymenth-8-en-2-one + NADPH + oxygen = (3S)-3-isopropenyl-6-oxoheptanoate + NADP+ + H2O ,
1.14.13.105: (1R,4S)-1-hydroxymenth-8-en-2-one + NADPH + oxygen = (3R)-3-isopropenyl-6-oxoheptanoate + NADP+ + H2O ,
1.14.13.106: (+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 oxygen → albaflavenone + 2 NADP+ + 3 H2O ,
1.14.13.109: abieta-7,13-dien-18-ol + NADPH + H+ + oxygen → abieta-7,13-diene-18-al + NADP+ + 2 H2O ,
1.14.13.117: L-isoleucine + 2 NADPH + 2 oxygen + 2 H+ → (E)-2-methylbutanal oxime + CO2 + 2 NADP+ + 3 H2O ,
1.14.13.118: L-valine + 2 NADPH + 2 oxygen + 2 H+ → (E)-2-methylpropanal-oxime + CO2 + 2 NADP+ + 3 H2O ,
1.14.13.119: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 oxygen → capsidiol + 2 NADP+ + 2 H2O ,
1.14.13.121: (-)-vetispiradiene + 2 NADPH + 2 H+ + 2 oxygen → solavetivone + 2 NADP+ + 3 H2O ,
1.14.13.122: chlorophyllide a + 2 NADPH + 2 oxygen + 3 H+ → chlorophyllide b + 2 NADP+ + 3 H2O ,
1.14.13.124: L-phenylalanine + 2 NADPH + 2 oxygen + 2 H+ → (E)-phenylacetaldehyde oxime + CO2 + 2 NADP+ + 3 H2O ,
1.14.13.125: L-tryptophan + 2 NADPH + 2 oxygen + 2 H+ → (E)-indol-3-ylacetaldoxime + CO2 + 2 NADP+ + 3 H2O ,
1.14.13.129: all-trans-β-carotene + 2 NADH + 2 H+ + 2 oxygen → zeaxanthin + 2 NAD+ + 2 H2O ,
1.14.13.133: pentalenene + 2 NADPH + 2 H+ + 2 oxygen → pentalen-13-al + 2 NADP+ + 3 H2O ,
1.14.13.134: β-amyrin + 2 NADPH + 2 oxygen + 2 H+ → 11-oxo-β-amyrin + 2 NADP+ + 3 H2O ,
1.14.13.144: 9β-stemod-13(17)-ene + 3 NADPH + 3 oxygen + 3 H+ → 9β-stemod-13(17)-en-19-oate + 3 NADP+ + 4 H2O ,
1.14.13.144: (-)-9β-pimara-7,15-diene + 3 NADPH + 3 oxygen + 2 H+ → (-)-9β-pimara-7,15-dien-19-oate + 3 NADP+ + 4 H2O ,
1.14.13.151: linalool + 2 NADH + 2 H+ + 2 oxygen → (6E)-8-oxolinalool + 2 NAD+ + 3 H2O ,
1.14.13.158: amorpha-4,11-diene + 3 NADPH + 3 oxygen + 2 H+ → artemisinate + 3 NADP+ + 4 H2O ,
1.14.13.165: 2 L-arginine + 3 NAD(P)H + H+ + 4 oxygen → 2 L-citrulline + 2 nitric oxide + 3 NAD(P)+ + 4 H2O ,
1.14.13.173: 11-oxo-β-amyrin + 3 NADPH + 3 oxygen + 2 H+ → glycyrrhetinate + 3 NADP+ + 4 H2O ,
1.14.13.187: dTDP-β-L-evernosamine + 2 NADPH + H+ + 2 oxygen → dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-β-L-arabino-hexopyranose + 2 NADP+ + 3 H2O ,
1.14.13.cj: dihydromonacolin L acid + NADPH + oxygen + H+ = monacolin L acid + NADP+ + 2 H2O ,
1.14.13.-: zeaxanthin + 2 NADH + 2 H+ + 2 oxygen → nostoxanthin + 2 NAD+ + 2 H2O ,
1.14.13.-: hexahomomethionine + 2 NADPH + 2 oxygen + 2 H+ → CO2 + 9-methylthiononanaldoxime + 2 NADP+ + 3 H2O ,
1.14.13.-: pentahomomethionine + 2 NADPH + 2 oxygen + 2 H+ → 8-methylthiooctanaldoxime + CO2 + 2 NADP+ + 3 H2O ,
1.14.13.-: (Z)-2-methylbutanal oxime + NADPH + oxygen + H+ → 2-hydroxy-2-methylbutyronitrile + NADP+ + 2 H2O ,
1.14.13.cn: β-amyrin + 3 NADPH + 3 oxygen + 2 H+ → oleanolate + 3 NADP+ + 4 H2O ,
1.14.13.-: aminopyrrolnitrin + NAD(P)H + 2 oxygen + H+ → pyrrolnitrin + NAD(P)+ + 2 H2O ,
1.14.14.14: testosterone + 3 a reduced flavoprotein + 3 oxygen → 17β-estradiol + 3 an oxidized flavoprotein + formate + 4 H2O + H+ ,
1.14.14.14: androst-4-ene-3,17-dione + 3 a reduced flavoprotein + 3 oxygen → estrone + 3 an oxidized flavoprotein + formate + 4 H2O + H+ ,
1.14.14.-: dimethyl sulfone + 2 FMNH2 + 2 oxygen → methanesulfonate + formaldehyde + 2 FMN + 2 H2O + 3 H+ ,
1.14.14.-: 3,5,6-trichloro-2-pyridinol + FADH2 + oxygen + 2 H2O → 3,6-dihydroxypyridine-2,5-dione + 3 chloride + FAD + H2O + 4 H+ ,
1.14.14.-: 20-hydroxyecdysone + 3 a reduced flavoprotein + 3 oxygen → 20-hydroxyecdysonate + 3 an oxidized flavoprotein + 4 H2O + H+ ,
1.14.15.6: cholesterol + 6 a reduced adrenodoxin + 3 oxygen + 6 H+ → pregnenolone + 4-methylpentanal + 6 an oxidized adrenodoxin + 4 H2O ,
1.14.15.9: spheroidene + 2 a reduced ferredoxin + 2 oxygen + 4 H+ → spheroiden-2-one + 2 an oxidized ferredoxin + 3 H2O ,
1.14.15.9: spirilloxanthin + 2 a reduced ferredoxin + 2 oxygen + 4 H+ → 2-oxospirilloxanthin + 2 an oxidized ferredoxin + 3 H2O ,
1.14.15.9: 2-oxospirilloxanthin + 2 a reduced ferredoxin + 2 oxygen + 4 H+ → 2,2'-dioxospirilloxanthin + 2 an oxidized ferredoxin + 3 H2O ,
1.14.15.12: a long-chain acyl-[acp] + 2 a reduced flavodoxin + 3 oxygen → a pimeloyl-[acp] + an n-alkanal + 2 an oxidized flavodoxin + 3 H2O + H+ ,
1.14.18.1: L-tyrosine + oxygen → dopaquinone + H2O ,
1.14.99.36: all-trans-β-carotene + oxygen → 2 all-trans-retinal ,
1.16.3.2: 4 Fe2+ + oxygen + 6 H2O = 4 [FeO(OH)] monomer + 8 H+ ,
1.17.1.-: 2-oxepin-2(3H)-ylideneacetyl-CoA + NADP+ + 2 H2O = 3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ ,
1.17.1.-: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADP+ + H2O = 2,4-divinyl protochlorophyllide a + 3 NADPH + 4 H+ ,
1.21.1.a: L-tyrosine + 2 iodide + 2 NADP+ ← 3,5-diiodo-L-tyrosine + 2 NADPH + H+ ,
2.1.1.44: L-histidine + 3 S-adenosyl-L-methionine → hercynine + 3 S-adenosyl-L-homocysteine + 3 H+ ,
2.1.1.98: a 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] + 3 S-adenosyl-L-methionine → a diphthine-[translation elongation factor 2] + 3 S-adenosyl-L-homocysteine + 3 H+ ,
2.1.1.107: 2 S-adenosyl-L-methionine + uroporphyrinogen-III → 2 S-adenosyl-L-homocysteine + precorrin-2 + H+ ,
2.1.1.132: precorrin-6B + 2 S-adenosyl-L-methionine → precorrin-8x + 2 S-adenosyl-L-homocysteine + CO2 + H+ ,
2.1.1.156: 2 S-adenosyl-L-methionine + glycine → 2 S-adenosyl-L-homocysteine + dimethylglycine + 2 H+ ,
2.1.1.157: 2 S-adenosyl-L-methionine + sarcosine → 2 S-adenosyl-L-homocysteine + glycine betaine + 2 H+ ,
2.1.1.162: 3 S-adenosyl-L-methionine + glycine → 3 S-adenosyl-L-homocysteine + glycine betaine + 3 H+ ,
2.1.1.169: 3 S-adenosyl-L-methionine + tricetin → 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin + 3 H+ ,
2.1.1.175: tricetin + 2 S-adenosyl-L-methionine → 3',5'-O-dimethyltricetin + 2 S-adenosyl-L-homocysteine + 2 H+ ,
2.1.1.213: a guanine10 in tRNA + 2 S-adenosyl-L-methionine → N2-dimethylguanine10 in tRNA + 2 S-adenosyl-L-homocysteine + 2 H+ ,
2.1.1.216: a guanine26 in tRNA + 2 S-adenosyl-L-methionine → an N2dimethylguanine26 in tRNA + 2 S-adenosyl-L-homocysteine + 2 H+ ,
2.1.1.240: 2 S-adenosyl-L-methionine + trans-resveratrol → 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+ ,
2.1.1.244: 3 S-adenosyl-L-methionine + an N-terminal-(A/S)PK-[protein] → 3 S-adenosyl-L-homocysteine + an N terminal N,N,N-trimethyl-(A/S)PK-[protein] + 3 H+ ,
2.1.1.244: 2 S-adenosyl-L-methionine + an N-terminal-PPK-[protein] → 2 S-adenosyl-L-homocysteine + an N terminal N,N-dimethyl-PPK-[protein] + 2 H+ ,
2.1.1.251: methanethiol + coenzyme M = HS- + methyl-CoM + H+ ,
2.1.1.262: squalene + 2 S-adenosyl-L-methionine → 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 S-adenosyl-L-homocysteine + 2 H+ ,
2.1.1.263: C30 botryococcene + 2 S-adenosyl-L-methionine → 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 S-adenosyl-L-homocysteine + 2 H+ ,
2.1.1.272: S-adenosyl-L-methionine + cobalt-factor III + a reduced electron acceptor → S-adenosyl-L-homocysteine + cobalt-precorrin-4 + an oxidized electron acceptor ,
2.1.1.-: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose → 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose + 2 H+ ,
2.1.1.-: acetyl-CoA + 2 an oxidized ferredoxin + tetrahydrosarcinapterin + H2O ↔ CO2 + 2 a reduced ferredoxin + 5-methyl-tetrahydrosarcinapterin + coenzyme A + 2 H+ ,
2.3.1.206: hexanoyl-CoA + 3 malonyl-CoA + 3 H+ = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 coenzyme A ,
2.3.1.ax: an acetyl-[acp] + 9 malonyl-CoA + 8 H+ = tetracenomycin F2 + a holo-[acyl-carrier protein] + 9 CO2 + 9 coenzyme A + 2 H2O ,
2.3.2.j: an S-ubiquitinyl-[ubiquitin-activating protein E1]-L-cysteine + a protein = an N-terminal-ubiquitinyl-[acceptor protein] + a [ubiquitin-activating protein E1]-L-cysteine ,
2.4.1.249: 2 UDP-α-D-glucose + delphinidin 3-O-(6''-O-malonyl)-β-glucoside = ternatin C5 + 2 UDP + 2 H+ ,
2.4.1.276: zeaxanthin + 2 UDP-α-D-glucose = zeaxanthin bis(β-D-glucoside) + 2 UDP + 2 H+ ,
2.4.1.287: 2 UDP-α-D-galactofuranose + α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 2 UDP + β-D-galactofuranosyl-(1→5)-β-D-galactofuranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)-N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol + 2 H+ ,
2.4.99.20: nicotinate + NADP+ = nicotinate-adenine dinucleotide phosphate + nicotinamide ,
2.5.1.21: 2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ → squalene + NAD(P)+ + 2 diphosphate ,
2.5.1.32: 2 2-cis,6-trans,10-trans-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate ,
2.5.1.46: spermidine + an [eIF5A-precursor]-lysine = an [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine + H+ ,
2.5.1.96: 2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate ,
2.5.1.99: 2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate ,
2.5.1.bg: 2 S-adenosyl 3-(methylthio)propylamine + spermidine = 2 S-methyl-5'-thioadenosine + N4-bis(aminopropyl)spermidine + 2 H+ ,
2.6.1.82: putrescine + 2-oxoglutarate ↔ L-glutamate + 1-pyrroline + H2O ,
2.7.1.151: D-myo-inositol (1,4,5)-trisphosphate + 2 ATP = D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H+ ,
2.7.7.63: [glycine cleavage system lipoyl-carrier protein]-L-lysine + ATP + (R)-lipoate → AMP + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + diphosphate + H+ ,
2.7.7.86: ATP + GTP = cyclic 3',5'-AMP-GMP + 2 diphosphate ,
2.8.1.7: L-cysteine + an unsulfurated [sulfur carrier] → L-alanine + a sulfurated [sulfur carrier] ,
2.8.1.7: a ThiI sulfur-carrier protein + L-cysteine = an S-sulfanyl-[ThiI sulfur-carrier protein] + L-alanine ,
2.8.4.3: N6-dimethylallyladenosine37 in tRNA + 2 S-adenosyl-L-methionine + a sulfurated [sulfur carrier] → 2-methylthio-N6-dimethylallyladenosine37 in tRNA + S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + an unsulfurated [sulfur carrier] + H+ ,
3.1.1.82: pheophorbide a + H2O → pyropheophorbide a + methanol + CO2 ,
3.1.1.-: enterobactin + 3 H2O → 3 N-(2,3-dihydroxybenzoyl)-L-serine + 3 H+ ,
3.1.3.77: 5-(methylthio)-2,3-dioxopentyl 1-phosphate + H2O → 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate + H+ ,
3.1.7.10: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O → (13E)-labda-7,13-dien-15-ol + diphosphate ,
3.2.1.191/3.2.1.z: ginsenoside Rb3 + 2 H2O → ginsenoside Mx + 2 D-glucopyranose ,
3.2.1.191/3.2.1.z: ginsenoside Rb2 + 2 H2O → ginsenoside C-Y + 2 D-glucopyranose ,
3.2.1.191/3.2.1.z: ginsenoside Rc + 2 H2O → ginsenoside Mc + 2 D-glucopyranose ,
3.2.1.191: (20S)-ginsenoside Rg3 + 2 H2O → protopanaxadiol + 2 D-glucopyranose ,
3.2.1.191/3.2.1.z: ginsenoside Rd + 2 H2O → ginsenoside C-K + 2 D-glucopyranose ,
3.2.1.191: ginsenoside Rb1 + 2 H2O → gypenoside LXXV + 2 D-glucopyranose ,
3.2.1.192: ginsenoside Rb1 + 2 H2O → (20S)-ginsenoside Rg3 + 2 D-glucopyranose ,
3.2.1.193/3.2.1.z: a protopanaxadiol-type ginsenoside with two glucosyl residues at position 3 + 2 H2O → a protopanaxadiol-type ginsenoside with no glycosidic modification at position 3 + 2 D-glucopyranose ,
3.2.1.194: a protopanaxatriol-type ginsenoside with two glycosyl residues at position 6 + 2 H2O → a protopanaxatriol-type ginsenoside with no glycosidic modification at position 6 + a monosaccharide + D-glucopyranose ,
3.2.1.194: ginsenoside Rg2 + 2 H2O → protopanaxatriol + L-rhamnopyranose + D-glucopyranose ,
3.2.1.194: ginsenoside R1 + 2 H2O → ginsenoside F1 + a D-xylopyranose + D-glucopyranose ,
3.2.1.194: ginsenoside Re + 2 H2O → ginsenoside F1 + L-rhamnopyranose + D-glucopyranose ,
3.2.1.194: ginsenoside Rf + 2 H2O → protopanaxatriol + 2 D-glucopyranose ,
3.2.1.z: ginsenoside Rb1 + 3 H2O → ginsenoside C-K + 3 D-glucopyranose ,
3.2.2.6: NAD+ + H2O → ADP-D-ribose + nicotinamide + H+ ,
3.5.1.110: (Z)-2-methylureidoacrylate peracid + H+ + H2O = (Z)-2-methyl-peroxyaminoacrylate + ammonium + CO2 ,
3.5.1.110: (Z)-3-ureidoacrylate peracid + H+ + H2O = (Z)-3-peroxyaminoacrylate + ammonium + CO2 ,
3.5.3.21: methylenediurea + 2 H+ + 2 H2O = N-(hydroxymethyl)urea + 2 ammonium + CO2 ,
3.5.5.4: 3-cyano-L-alanine + H+ + 2 H2O → ammonium + L-aspartate ,
3.5.99.7: 1-aminocyclopropane-1-carboxylate + H2O → ammonium + 2-oxobutanoate ,
3.6.1.5: ATP + 2 H2O → AMP + 2 phosphate + 2 H+ ,
3.6.1.5: UTP + 2 H2O → UMP + 2 phosphate + 2 H+ ,
3.6.1.5: CTP + 2 H2O → CMP + 2 phosphate + 2 H+ ,
3.6.1.5: a nucleoside triphosphate + 2 H2O → a nucleoside 5'-monophosphate + 2 phosphate + 2 H+ ,
3.6.1.5: dATP + 2 H2O → dAMP + 2 phosphate + 2 H+ ,
3.6.1.5: dCTP + 2 H2O → dCMP + 2 phosphate + 2 H+ ,
3.6.1.5: dUTP + 2 H2O → dUMP + 2 phosphate + 2 H+ ,
3.6.1.5: dTTP + 2 H2O → dTMP + 2 phosphate + 2 H+ ,
3.6.1.5: GTP + 2 H2O → GMP + 2 phosphate + 2 H+ ,
3.6.1.5: dGTP + 2 H2O → dGMP + 2 phosphate + 2 H+ ,
3.7.1.21: 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O ↔ 3-hydroxypimeloyl-CoA + H+ ,
4.1.3.6: citrate → acetate + oxaloacetate ,
4.1.99.1: L-tryptophan + H2O = indole + pyruvate + ammonium ,
4.1.99.2: L-tyrosine + H2O = phenol + pyruvate + ammonium ,
4.2.1.3: citrate = D-threo-isocitrate ,
4.2.1.20: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine → L-tryptophan + D-glyceraldehyde 3-phosphate + H2O ,
4.2.1.33: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate ,
4.2.1.87: octopamine → (4-hydroxyphenyl)acetaldehyde + ammonium ,
4.2.1.88: (R)-synephrine → (4-hydroxyphenyl)acetaldehyde + methylamine ,
4.2.1.104: cyanate + hydrogen carbonate + 3 H+ = ammonium + 2 CO2 ,
4.2.1.110: 1,5-anhydro-D-fructose = microthecin + H2O ,
4.2.1.114: (2R)-homocitrate = (1R,2S)-homoisocitrate ,
4.3.1.9: D-glucosaminate = ammonium + 2-dehydro-3-deoxy-D-gluconate ,
4.3.1.13: O-carbamoyl-L-serine + H2O + H+ = pyruvate + CO2 + 2 ammonium ,
4.3.1.17: L-serine → pyruvate + ammonium ,
4.3.1.18: D-serine = pyruvate + ammonium ,
4.3.1.19: L-threonine → 2-oxobutanoate + ammonium ,
4.3.1.-: O-succinyl-L-homoserine + H2O → 2-oxobutanoate + succinate + ammonium + H+ ,
4.3.3.6: keto-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine → pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H+ ,
4.4.1.1: L-cystine + H2O → thiocysteine + pyruvate + ammonium ,
4.4.1.1: L-homoserine → 2-oxobutanoate + ammonium ,
4.4.1.1/4.4.1.c: L-cysteine + H2O → pyruvate + hydrogen sulfide + ammonium ,
4.4.1.1: L-cystathionine + H2O → 2-oxobutanoate + L-cysteine + ammonium ,
4.4.1.2: L-homocysteine + H2O → hydrogen sulfide + 2-oxobutanoate + ammonium ,
4.4.1.6: an S-alkyl-L-cysteine + H2O = an alkyl-thiol + pyruvate + ammonium ,
4.4.1.8: L-cystathionine + H2O → ammonium + pyruvate + L-homocysteine ,
4.4.1.8: L-selenocystathionine + H2O → ammonium + pyruvate + seleno-L-homocysteine ,
4.4.1.11: L-methionine + H2O → methanethiol + 2-oxobutanoate + ammonium ,
4.4.1.13: an L-cysteine-S-conjugate + H2O → a thiol + pyruvate + ammonium ,
4.4.1.25: L-cysteate + H2O → bisulfite + pyruvate + ammonium ,
4.4.1.27: carbon disulfide + 2 H2O = CO2 + 2 hydrogen sulfide ,
4.5.1.2: 3-chloro-D-alanine + H2O = pyruvate + ammonium + chloride + H+ ,
5.4.2.11: 2-phospho-D-glycerate ↔ 3-phospho-D-glycerate ,
6.1.2.2: carbamoyl-phosphate + tobramycin + ATP + H2O → nebramycin 5' + AMP + diphosphate + phosphate + H+ ,
6.1.2.2: carbamoyl-phosphate + kanamycin A + ATP + H2O → 6''-O-carbamoylkanamycin A + AMP + diphosphate + phosphate + H+ ,
6.1.2.2: carbamoyl-phosphate + kanamycin B + ATP + H2O → 6''-O-carbamoylkanamycin B + AMP + diphosphate + phosphate + H+ ,
6.3.4.2: ATP + UTP + L-glutamine + H2O → ADP + CTP + L-glutamate + phosphate + 2 H+ ,
6.3.5.2: XMP + L-glutamine + ATP + H2O → L-glutamate + GMP + AMP + diphosphate + 2 H+ ,
6.3.5.4: L-glutamine + L-aspartate + ATP + H2O → L-glutamate + L-asparagine + AMP + diphosphate + H+ ,
6.3.5.5: 2 ATP + L-glutamine + hydrogen carbonate + H2O → L-glutamate + carbamoyl-phosphate + 2 ADP + phosphate + 2 H+ ,
6.3.5.11: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O → cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 phosphate + 2 H+ ,
meso-diaminopimelate + NADP+ = (S)-2,3,4,5-tetrahydrodipicolinate + ammonium + NADPH + 2 H+ ,
3-hydroxypropanoate + ATP + coenzyme A + NADPH + H+ → propanoyl-CoA + AMP + NADP+ + diphosphate + H2O ,
strictosamide = camptothecin ,
(S)-1-pyrroline-5-carboxylate + NAD+ + 2 H2O → L-glutamate + NADH + H+ ,
methanol + coenzyme M ↔ methyl-CoM + H2O ,
glycine + a tetrahydrofolate + NAD+ ↔ a 5,10-methylene-tetrahydrofolate + ammonium + CO2 + NADH ,
2-oxoglutarate + coenzyme A + NAD+ → succinyl-CoA + CO2 + NADH


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc14.