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MetaCyc EC 1.13.11 -- With incorporation of two atoms of oxygen

Parent Class: EC-Numbers1 -- Oxidoreductases1.13 -- Acting on single donors with incorporation of molecular oxygen

Instances:
1.13.11.1 -- catechol 1,2-dioxygenase,
1.13.11.2 -- catechol 2,3-dioxygenase,
1.13.11.3 -- protocatechuate 3,4-dioxygenase,
1.13.11.4 -- gentisate 1,2-dioxygenase,
1.13.11.5 -- homogentisate 1,2-dioxygenase,
1.13.11.6 -- 3-hydroxyanthranilate 3,4-dioxygenase,
1.13.11.8 -- protocatechuate 4,5-dioxygenase,
1.13.11.9 -- 2,5-dihydroxypyridine 5,6-dioxygenase,
1.13.11.10 -- 7,8-dihydroxykynurenate 8,8a-dioxygenase,
1.13.11.11 -- tryptophan 2,3-dioxygenase,
1.13.11.12 -- linoleate 13S-lipoxygenase,
1.13.11.14 -- 2,3-dihydroxybenzoate 3,4-dioxygenase,
1.13.11.15 -- 3,4-dihydroxyphenylacetate 2,3-dioxygenase,
1.13.11.16 -- 3-carboxyethylcatechol 2,3-dioxygenase,
1.13.11.17 -- indole 2,3-dioxygenase,
1.13.11.18 -- persulfide dioxygenase,
1.13.11.19 -- cysteamine dioxygenase,
1.13.11.20 -- cysteine dioxygenase,
1.13.11.22 -- caffeate 3,4-dioxygenase,
1.13.11.23 -- 2,3-dihydroxyindole 2,3-dioxygenase,
1.13.11.24 -- quercetin 2,3-dioxygenase,
1.13.11.25 -- 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase,
1.13.11.26 -- peptide-tryptophan 2,3-dioxygenase,
1.13.11.27 -- 4-hydroxyphenylpyruvate dioxygenase,
1.13.11.28 -- 2,3-dihydroxybenzoate 2,3-dioxygenase,
1.13.11.29 -- stizolobate synthase,
1.13.11.30 -- stizolobinate synthase,
1.13.11.31 -- arachidonate 12-lipoxygenase,
1.13.11.33 -- arachidonate 15-lipoxygenase,
1.13.11.34 -- arachidonate 5-lipoxygenase,
1.13.11.35 -- pyrogallol 1,2-oxygenase,
1.13.11.36 -- chloridazon-catechol dioxygenase,
1.13.11.37 -- hydroxyquinol 1,2-dioxygenase,
1.13.11.38 -- 1-hydroxy-2-naphthoate 1,2-dioxygenase,
1.13.11.39 -- biphenyl-2,3-diol 1,2-dioxygenase,
1.13.11.40 -- arachidonate 8-lipoxygenase,
1.13.11.41 -- 2,4′-dihydroxyacetophenone dioxygenase,
1.13.11.43 -- lignostilbene αβ-dioxygenase,
1.13.11.45 -- linoleate 11-lipoxygenase,
1.13.11.46 -- 4-hydroxymandelate synthase,
1.13.11.47 -- 3-hydroxy-4-oxoquinoline 2,4-dioxygenase,
1.13.11.48 -- 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase,
1.13.11.49 -- chlorite O2-lyase,
1.13.11.50 -- acetylacetone-cleaving enzyme,
1.13.11.51 -- 9-cis-epoxycarotenoid dioxygenase,
1.13.11.52 -- indoleamine 2,3-dioxygenase,
1.13.11.53 -- acireductone dioxygenase (Ni2+-requiring),
1.13.11.54 -- acireductone dioxygenase [iron(II)-requiring],
1.13.11.55 -- sulfur oxygenase/reductase,
1.13.11.56 -- 1,2-dihydroxynaphthalene dioxygenase,
1.13.11.57 -- gallate dioxygenase,
1.13.11.58 -- linoleate 9S-lipoxygenase,
1.13.11.59 -- torulene dioxygenase,
1.13.11.60 -- linoleate 8R-lipoxygenase,
1.13.11.61 -- linolenate 9R-lipoxygenase,
1.13.11.62 -- linoleate 10R-lipoxygenase,
1.13.11.63 -- β-carotene 15,15′-dioxygenase,
1.13.11.64 -- 5-nitrosalicylate dioxygenase,
1.13.11.65 -- carotenoid isomerooxygenase,
1.13.11.66 -- hydroquinone 1,2-dioxygenase,
1.13.11.67 -- 8′-apo-β-carotenoid 14′,13′-cleaving dioxygenase,
1.13.11.68 -- 9-cis-β-carotene 9′,10′-cleaving dioxygenase,
1.13.11.69 -- carlactone synthase,
1.13.11.70 -- all-trans-10′-apo-β-carotenal 13,14-cleaving dioxygenase,
1.13.11.71 -- carotenoid-9′,10′-cleaving dioxygenase,
1.13.11.72 -- 2-hydroxyethylphosphonate dioxygenase,
1.13.11.73 -- methylphosphonate synthase,
1.13.11.74 -- 2-aminophenol 1,6-dioxygenase,
1.13.11.75 -- all-trans-8′-apo-β-carotenal 15,15′-oxygenase,
1.13.11.76 -- 2-amino-5-chlorophenol 1,6-dioxygenase,
1.13.11.77 -- oleate 10S-lipoxygenase,
1.13.11.78 -- 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming),
1.13.11.79 -- 5,6-dimethylbenzimidazole synthase,
1.13.11.80 -- (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase,
1.13.11.ac -- 7,8-dihydroneopterin oxygenase,
1.13.11.v -- 8'-apo-carotenoid 13,14-cleaving dioxygenase

Unofficial Reactions:
(S)-β-hydroxy-L-tryptophan + oxygen → (R)-N-formyl-β-hydroxy-L-kynurenine,
leukotriene A4 + an reduced unknown electron acceptor + oxygen → lipoxin A4 + an oxidized unknown electron acceptor,
protocatechuate + oxygen → (2Z,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde + H+,
4,6-dichloro-3-methylcatechol + oxygen → 3,5-dichloro-2-methyl-muconate + 2 H+,
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + oxygen → 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H+,
3-propylcatechol + oxygen → 2-hydroxy-6-oxo-nona-2,4-dienoate + H+,
leukotriene A4 + an reduced unknown electron acceptor + oxygen → lipoxin B4 + an oxidized unknown electron acceptor,
17S-hydroxydocosahexaenoate + oxygen → 7S-hydroperoxy,17S-hydroxy-docosahexaenoate,
3-dimethylallyl-4-hydroxyphenylpyruvate + oxygen → 3-dimethylallyl-4-hydroxymandelate + CO2,
docosahexaenoate + oxygen → 17R-hydroperoxydocosahexaenoate,
all-trans-10'-apo-β-carotenal + oxygen → β-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial,
3-mercaptopropanoate + oxygen → 3-sulfinopropionate + H+,
salicylate + oxygen → 2-oxohepta--3,5-dienedioate + H+,
caffealdehyde + oxygen → (2E,4Z,5E)-2-hydroxy-7-oxo-(2-oxoethylidene)hepta-2,5-dienoate + H+,
indole + NADH + oxygen + H+cis-indole-2,3-dihydrodiol + NAD+,
(15R)-hydroxyicosapentaenoate + oxygen → 15 epi-lipoxin A4,
2,4,5-trihydroxytoluene + oxygen → 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate + H+,
2,3-dihydroxy-p-cumate + oxygen → 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate + H+,
2,2',3-trihydroxydiphenyl-ether + oxygen → 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate,
trans-resveratrol + oxygen → protocatechualdehyde + 4-hydroxybenzaldehyde,
15S-hydroxypentaenoate + oxygen → lipoxin A4,
docosahexaenoate + oxygen → 17S-hydroperoxydocosahexaenoate,
lutein + 2 oxygen → 3-hydroxy-β-ionone + 3-hydroxy-9-apo-δ-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial,
4,2'-dihydroxy-3,3'-dimethoxy-5'-(2''-carboxyvinyl)stilbene + oxygen → 5-formylferulate + vanillin,
α-linolenate + oxygen → 9(S)-HPOTE,
2,2',3-trihydroxybiphenyl + oxygen → (2Z,2E)-2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate + H+,
4-amino-3-hydroxybenzoate + oxygen → (2Z,4Z)-2-amino-5-carboxymuconate-6-semialdehyde + H+,
trans-neoxanthin + oxygen → 2-trans,4-trans-xanthoxin + (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-β-caroten-12'-al,
3-sulfocatechol + oxygen → (2Z,4E)-2-hydroxy-6-oxo-6-sulfonatohexa-2,4-dienoate + H+,
p-cumate + NADH + H+ + oxygen → cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+,
2,2',3,3'-tetrahydroxybiphenyl + oxygen → (2Z,2E)-2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H+,
17R-hydroxydocosahexaenoate + oxygen → 4S-hydroperoxy,17R-hydroxydocosahexaenoate,
all-trans-β-carotene + 2 oxygen → 2 β-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial,
caffealdehyde + oxygen → (2E,4Z,6E)-5-formyl-2-hydroxy-8-oxoocta-2,4,6-trienoate + H+,
4-methyl-2-oxopentanoate + oxygen → 3-hydroxyisovalerate + CO2,
3-isopropylcatechol + oxygen → 2-hydroxy-6-oxo-7-methyl-octa-2,4-dienoate + H+,
15S-hydroxypentaenoate + oxygen → lipoxin B4,
17S-hydroxydocosahexaenoate + oxygen → 4S-hydroperoxy,17S-hydroxy-docosahexaenoate,
violaxanthin + 2 oxygen → 2 5,6-epoxy-3-hydroxy-9-apo-β-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial,
a 2,3,4-saturated fatty acid + oxygen → a 2(R)-hydroperoxy fatty acid,
gallate + oxygen → 2-pyrone-4,6-dicarboxylate + H2O + H+,
3-O-methylgallate + oxygen → 2-pyrone-4,6-dicarboxylate + methanol + H+,
17R-hydroxydocosahexaenoate + oxygen → 7S-hydroperoxy,17R-hydroxy-docosahexaenoate,
2-mercaptosuccinate + oxygen → sulfinosuccinate + H+

Enzymes and Genes:
mercaptosuccinate dioxygenase: msdo ( Variovorax paradoxus B4 )
protocatechuate 4,5-dioxygenase: ligB, ligA ( Sphingomonas sp. SYK6 )
3-O-methylgallate 3,4-dioxygenase: desZ ( Sphingomonas sp. SYK6 )
protocatechuate 4,5-dioxygenase: PmdA, PmdB ( Comamonas testosteroni )
protocatechuate 3,4-dioxygenase: pcaH, pcaG ( Pseudomonas putida )
fatty acid α-dioxygenase: AT3G01420 ( Arabidopsis thaliana col )
fatty aldehyde dehydrogenase [multifunctional] ( Pisum sativum )
4-hydroxyphenylpyruvate dioxygenase: HPD ( Homo sapiens )
p-cumate 2,3-dioxygenase: cmtAa, cmtAb, cmtAc, cmtAd ( Pseudomonas putida F1 )
3-sulfocatechol 2,3-dioxygenase ( Alcaligenes sp. O-1 )
4-amino-3-hydroxy-benzoate 2,3-dioxygenase: ahdA ( Bordetella sp. 10d )
2,2',3-trihydroxybiphenyl dioxygenase: dbfB ( Sphingomonas wittichii RW1 )
9S-lipoxygenase: LOX1 ( Avena sativa )
9S-lipoxygenase: LOX2 ( Avena sativa )
9S-lipoxygenase 1: r9-LOX1 ( Oryza sativa )
13S/9S lipoxygenase: lox1-St-2 ( Solanum tuberosum )
9S-lipoxygenase: LOX1 ( Solanum tuberosum )
lignostilbene α,β-dioxygenase I: isdB1 ( Sphingomonas paucimobilis )
lignostilbene α,β-dioxygenase III: isdB2 ( Sphingomonas paucimobilis )
arachidonate 15-lipoxygenase: ALOX15 ( Homo sapiens )
resveratrol cleavage oxygenase: Rco1 ( Ustilago maydis )
2,2',3-trihydroxy-biphenyl dioxygenase: dbfB ( Sphingomonas wittichii RW1 )
2,3-dihydroxy-p-cumate dioxygenase: cmtC ( Pseudomonas putida F1 )
trihydroxytoluene dioxygenase: dntD ( Burkholderia sp. DNT )
naphthalene 1,2-dioxygenase complex: nahAd, nahAc, nahAb, nahAa ( Pseudomonas sp. NCIB9816-4 )
extradiol ring-cleavage dioxygenase: LigB ( Arabidopsis thaliana )
salicylate 1,2-dioxygenase: AY323951 ( Pseudaminobacter salicylatoxidans BN12 )
3-mercaptopropionate dioxygenase: mdo ( Advenella mimigardefordensis DPN7 )
3-mercaptopropionate dioxygenase: cdo ( Variovorax paradoxus )
carotenoid cleavage dioxygenase: CCD1 ( Arabidopsis thaliana col )
prostaglandin G/H synthase 2: PTGS2 ( Homo sapiens )
3-dimethylallyl-4-hydroxyphenylpyruvate oxygenase: novR ( Actinoalloteichus cyanogriseus )
arachidonate 5-lipoxygenase: ALOX5 ( Homo sapiens )
2,3-dihydroxybiphenyl-1,2-dioxygenase [multifunctional]: hbpC ( Pseudomonas nitroreducens )
chlorocatechol 1,2-dioxygenase ( Cupriavidus sp. PS12 )
protocatechuate 2,3-dioxygenase: praA ( Paenibacillus sp. JJ-1b )
arachidonate 12-lipoxygenase: ALOX12 ( Homo sapiens )
β-hydroxy-L-tryptophan 2,3-dioxygenase: ecm11 ( Streptomyces lasaliensis )
β-hydroxy-L-tryptophan 2,3-dioxygenase: swb10 ( Streptomyces sp. SNA15896 )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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