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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc EC 1.13.11 -- With incorporation of two atoms of oxygen

Parent Class: EC-Numbers 1 -- Oxidoreductases 1.13 -- Acting on single donors with incorporation of molecular oxygen

Instances:
1.13.11.1 -- catechol 1,2-dioxygenase ,
1.13.11.2 -- catechol 2,3-dioxygenase ,
1.13.11.3 -- protocatechuate 3,4-dioxygenase ,
1.13.11.4 -- gentisate 1,2-dioxygenase ,
1.13.11.5 -- homogentisate 1,2-dioxygenase ,
1.13.11.6 -- 3-hydroxyanthranilate 3,4-dioxygenase ,
1.13.11.8 -- protocatechuate 4,5-dioxygenase ,
1.13.11.9 -- 2,5-dihydroxypyridine 5,6-dioxygenase ,
1.13.11.10 -- 7,8-dihydroxykynurenate 8,8a-dioxygenase ,
1.13.11.11 -- tryptophan 2,3-dioxygenase ,
1.13.11.12 -- linoleate 13S-lipoxygenase ,
1.13.11.14 -- 2,3-dihydroxybenzoate 3,4-dioxygenase ,
1.13.11.15 -- 3,4-dihydroxyphenylacetate 2,3-dioxygenase ,
1.13.11.16 -- 3-carboxyethylcatechol 2,3-dioxygenase ,
1.13.11.17 -- indole 2,3-dioxygenase ,
1.13.11.18 -- sulfur dioxygenase ,
1.13.11.19 -- cysteamine dioxygenase ,
1.13.11.20 -- cysteine dioxygenase ,
1.13.11.22 -- caffeate 3,4-dioxygenase ,
1.13.11.23 -- 2,3-dihydroxyindole 2,3-dioxygenase ,
1.13.11.24 -- quercetin 2,3-dioxygenase ,
1.13.11.25 -- 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase ,
1.13.11.26 -- peptide-tryptophan 2,3-dioxygenase ,
1.13.11.27 -- 4-hydroxyphenylpyruvate dioxygenase ,
1.13.11.28 -- 2,3-dihydroxybenzoate 2,3-dioxygenase ,
1.13.11.29 -- stizolobate synthase ,
1.13.11.30 -- stizolobinate synthase ,
1.13.11.31 -- arachidonate 12-lipoxygenase ,
1.13.11.33 -- arachidonate 15-lipoxygenase ,
1.13.11.34 -- arachidonate 5-lipoxygenase ,
1.13.11.35 -- pyrogallol 1,2-oxygenase ,
1.13.11.36 -- chloridazon-catechol dioxygenase ,
1.13.11.37 -- hydroxyquinol 1,2-dioxygenase ,
1.13.11.38 -- 1-hydroxy-2-naphthoate 1,2-dioxygenase ,
1.13.11.39 -- biphenyl-2,3-diol 1,2-dioxygenase ,
1.13.11.40 -- arachidonate 8-lipoxygenase ,
1.13.11.41 -- 2,4′-dihydroxyacetophenone dioxygenase ,
1.13.11.43 -- lignostilbene αβ-dioxygenase ,
1.13.11.45 -- linoleate 11-lipoxygenase ,
1.13.11.46 -- 4-hydroxymandelate synthase ,
1.13.11.47 -- 3-hydroxy-4-oxoquinoline 2,4-dioxygenase ,
1.13.11.48 -- 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase ,
1.13.11.49 -- chlorite O2-lyase ,
1.13.11.50 -- acetylacetone-cleaving enzyme ,
1.13.11.51 -- 9-cis-epoxycarotenoid dioxygenase ,
1.13.11.52 -- indoleamine 2,3-dioxygenase ,
1.13.11.53 -- acireductone dioxygenase (Ni2+-requiring) ,
1.13.11.54 -- acireductone dioxygenase [iron(II)-requiring] ,
1.13.11.55 -- sulfur oxygenase/reductase ,
1.13.11.56 -- 1,2-dihydroxynaphthalene dioxygenase ,
1.13.11.57 -- gallate dioxygenase ,
1.13.11.58 -- linoleate 9S-lipoxygenase ,
1.13.11.59 -- torulene dioxygenase ,
1.13.11.60 -- linoleate 8R-lipoxygenase ,
1.13.11.61 -- linolenate 9R-lipoxygenase ,
1.13.11.62 -- linoleate 10R-lipoxygenase ,
1.13.11.63 -- β-carotene 15,15′-dioxygenase ,
1.13.11.64 -- 5-nitrosalicylate dioxygenase ,
1.13.11.65 -- carotenoid isomerooxygenase ,
1.13.11.66 -- hydroquinone 1,2-dioxygenase ,
1.13.11.67 -- 8′-apo-β-carotenoid 14′,13′-cleaving dioxygenase ,
1.13.11.68 -- 9-cis-β-carotene 9′,10′-cleaving dioxygenase ,
1.13.11.69 -- carlactone synthase ,
1.13.11.70 -- all-trans-10′-apo-β-carotenal 13,14-cleaving dioxygenase ,
1.13.11.71 -- carotenoid-9′,10′-cleaving dioxygenase ,
1.13.11.72 -- 2-hydroxyethylphosphonate dioxygenase ,
1.13.11.73 -- methylphosphonate synthase ,
1.13.11.74 -- 2-aminophenol 1,6-dioxygenase ,
1.13.11.75 -- all-trans-8′-apo-β-carotenal 15,15′-oxygenase ,
1.13.11.76 -- 2-amino-5-chlorophenol 1,6-dioxygenase ,
1.13.11.77 -- oleate 10S-lipoxygenase ,
1.13.11.78 -- 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) ,
1.13.11.79 -- 5,6-dimethylbenzimidazole synthase ,
1.13.11.v

Unofficial Reactions:
3-sulfocatechol + oxygen → a sulfo-aldehyde intermediate + H+ ,
3-O-methylgallate + oxygen → 2-pyrone-4,6-dicarboxylate + methanol + H+ ,
2,2',3-trihydroxydiphenyl-ether + oxygen → 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate ,
2,2',3-trihydroxybiphenyl + oxygen → 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate + H+ ,
4,6-dichloro-3-methylcatechol + oxygen → 3,5-dichloro-2-methyl-muconate + 2 H+ ,
protocatechuate + oxygen → (2Z,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde + H+ ,
salicylate + oxygen → 2-oxohepta--3,5-dienedioate + H+ ,
gallate + oxygen → 2-pyrone-4,6-dicarboxylate + H2O + H+ ,
trans-resveratrol + oxygen → protocatechualdehyde + 4-hydroxybenzaldehyde ,
4-amino-3-hydroxybenzoate + oxygen → (2Z,4Z)-2-amino-5-carboxymuconate-6-semialdehyde + H+ ,
3-propylcatechol + oxygen → 2-hydroxy-6-oxo-nona-2,4-dienoate + H+ ,
3-isopropylcatechol + oxygen → 2-hydroxy-6-oxo-7-methyl-octa-2,4-dienoate + H+ ,
2,2',3,3'-tetrahydroxybiphenyl + oxygen → 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H+ ,
trans-neoxanthin + oxygen → 2-trans,4-trans-xanthoxin + (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-β-caroten-12'-al ,
4-methyl-2-oxopentanoate + oxygen → 3-hydroxyisovalerate + CO2 ,
all-trans-10'-apo-β-carotenal + oxygen → β-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial ,
3-dimethylallyl-4-hydroxyphenylpyruvate + oxygen → 3-dimethylallyl-4-hydroxymandelate + CO2 ,
3-mercaptopropionate + oxygen → 3-sulfinopropionate + H+ ,
4,2'-dihydroxy-3,3'-dimethoxy-5'-(2''-carboxyvinyl)stilbene + oxygen → 5-formylferulate + vanillin ,
a 2,3,4-saturated fatty acid + oxygen → a 2(R)-hydroperoxy fatty acid ,
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + oxygen → 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H+ ,
p-cumate + NADH + H+ + oxygen → cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ ,
2,3-dihydroxy-p-cumate + oxygen → 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate + H+ ,
all-trans-β-carotene + 2 oxygen → 2 β-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial ,
lutein + 2 oxygen → 3-hydroxy-β-ionone + 3-hydroxy-9-apo-δ-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial ,
violaxanthin + 2 oxygen → 2 5,6-epoxy-3-hydroxy-9-apo-β-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial ,
α-linolenate + oxygen → 9(S)-HPOTE ,
leukotriene A4 + a reduced electron acceptor + oxygen → lipoxin A4 + an oxidized electron acceptor ,
leukotriene A4 + a reduced electron acceptor + oxygen → lipoxin B4 + an oxidized electron acceptor

Enzymes and Genes:
arachidonate 12-lipoxygenase : ALOX12 ( Homo sapiens )
9S-lipoxygenase 1 : r9-LOX1 ( Oryza sativa )
13S/9S lipoxygenase : lox1-St-2 ( Solanum tuberosum )
9S-lipoxygenase : LOX1 ( Solanum tuberosum )
2,3-dihydroxy-p-cumate dioxygenase : cmtC ( Pseudomonas putida F1 )
p-cumate 2,3-dioxygenase : cmtAa , cmtAb , cmtAc , cmtAd ( Pseudomonas putida F1 )
fatty acid α-dioxygenase : AT3G01420 ( Arabidopsis thaliana col )
fatty aldehyde dehydrogenase [multifunctional] ( Pisum sativum )
lignostilbene α,β-dioxygenase I : isdB1 ( Sphingomonas paucimobilis )
lignostilbene α,β-dioxygenase III : isdB2 ( Sphingomonas paucimobilis )
3-mercaptopropionate dioxygenase : mdo ( Advenella mimigardefordensis DPN7 )
3-mercaptopropionate dioxygenase : cdo ( Variovorax paradoxus )
3-dimethylallyl-4-hydroxyphenylpyruvate oxygenase : novR ( Actinoalloteichus cyanogriseus )
carotenoid cleavage dioxygenase : CCD1 ( Arabidopsis thaliana col )
4-hydroxyphenylpyruvate dioxygenase : HPD ( Homo sapiens )
4-amino-3-hydroxy-benzoate 2,3-dioxygenase : ahdA ( Bordetella sp. 10d )
resveratrol cleavage oxygenase : Rco1 ( Ustilago maydis )
protocatechuate 3,4-dioxygenase : pcaH , pcaG ( Pseudomonas putida )
salicylate 1,2-dioxygenase : AY323951 ( Pseudaminobacter salicylatoxidans BN12 )
protocatechuate 2,3-dioxygenase : praA ( Paenibacillus sp. JJ-1b )
chlorocatechol 1,2-dioxygenase ( Cupriavidus sp. PS12 )
2,3-dihydroxybiphenyl-1,2-dioxygenase [multifunctional] : hbpC ( Pseudomonas nitroreducens )
2,2',3-trihydroxybiphenyl dioxygenase : dbfB ( Sphingomonas wittichii RW1 )
2,2',3-trihydroxy-biphenyl dioxygenase : dbfB ( Sphingomonas wittichii RW1 )
protocatechuate 4,5-dioxygenase : ligB , ligA ( Sphingomonas sp. SYK6 )
3-O-methylgallate 3,4-dioxygenase : desZ ( Sphingomonas sp. SYK6 )
protocatechuate 4,5-dioxygenase : PmdA , PmdB ( Comamonas testosteroni )
3-sulfocatechol 2,3-dioxygenase ( Alcaligenes sp. O-1 )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.