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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc EC 1.14 -- Acting on paired donors, with incorporation or reduction of molecular oxygen

Parent Class: EC-Numbers 1 -- Oxidoreductases

Child Classes:
1.14.3 -- With reduced pteridine as one donor (deleted sub-subclass) (1) ,
1.14.11 -- With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (137) ,
1.14.12 -- With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor (48) ,
1.14.13 -- With NADH or NADPH as one donor, and incorporation of one atom of oxygen (564) ,
1.14.14 -- With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (42) ,
1.14.15 -- With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (27) ,
1.14.16 -- With reduced pteridine as one donor, and incorporation of one atom of oxygen (9) ,
1.14.17 -- With reduced ascorbate as one donor, and incorporation of one atom of oxygen (4) ,
1.14.18 -- With another compound as one donor, and incorporation of one atom of oxygen (6) ,
1.14.19 -- With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (80) ,
1.14.20 -- With 2-oxoglutarate as one donor, and the other dehydrogenated (3) ,
1.14.21 -- With NADH or NADPH as one donor, and the other dehydrogenated (19) ,
1.14.99 -- Miscellaneous (requires further characterization) (79)

Unofficial Reactions:
fluorene + NADH + oxygen + H+ → 9-fluorenol + NAD+ + H2O ,
6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen → 3-demethylubiquinol-8 + an oxidized electron acceptor + H2O ,
adamantanone + NADH + H+ + oxygen → 5-hydroxyadamantan-2-one + NAD+ + H2O ,
4-oxahomoadamantan-5-one + NADH + H+ + oxygen → 1-hydroxy-4-oxahomoadamantan-5-one + NAD+ + H2O ,
2-methylthio-N6-dimethylallyladenosine37 in tRNA + a reduced electron acceptor + oxygen → 2-methylthio-6-dimethylallyl-(cis-hydroxy)-adenosine37 in tRNA + an oxidized electron acceptor + H2O ,
tricoumaroyl spermidine + 3 a reduced electron acceptor + 3 oxygen → tricaffeoyl spermidine + 3 an oxidized electron acceptor + 3 H2O ,
triferuloyl spermidine + 3 a reduced electron acceptor + 3 oxygen → trihydroxyferuloyl spermidine + 3 an oxidized electron acceptor + 3 H2O ,
gibberellin A4 + NAD(P)H + oxygen + H+ → 16α,17-epoxy gibberellin A4 + NAD(P)+ + H2O ,
gibberellin A12 + NAD(P)H + oxygen + H+ → 16α, 17-epoxy gibberellin A12 + NAD(P)+ + H2O ,
gibberellin A9 + NAD(P)H + oxygen + H+ → 16α, 17-epoxy gibberellin A9 + NAD(P)+ + H2O ,
solavetivone + a reduced electron acceptor + oxygen → 15-hydroxysolavetivone + an oxidized electron acceptor + H2O ,
11α,30-dihydroxy-β-amyrin + NADPH + oxygen + H+ → 30-hydroxy-11-oxo-β-amyrin + NADP+ + 2 H2O ,
betulin + NADPH + H+ + oxygen → betulinic aldehyde + NADP+ + 2 H2O ,
uvaol + NADPH + oxygen + H+ → ursolic aldehyde + NADP+ + 2 H2O ,
fluorene + 2 NADH + oxygen → (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene + 2 NAD+ ,
6-deoxotyphasterol + oxygen → typhasterol + H2O ,
lubimin + a reduced electron acceptor + oxygen → 3-hydroxylubimin + an oxidized electron acceptor + H2O ,
campestanol + a reduced electron acceptor + oxygen → (6α)-hydroxycampestanol + an oxidized electron acceptor + H2O ,
cathasterone + a reduced electron acceptor + oxygen → teasterone + an oxidized electron acceptor + H2O ,
typhasterol + a reduced electron acceptor + oxygen → castasterone + an oxidized electron acceptor + H2O ,
gibberellin A14 + NADPH + oxygen → gibberellin A4 + CO2 + NADP+ + 4 H+ ,
gibberellin A12 + NADPH + oxygen → gibberellin A9 + CO2 + NADP+ + 4 H+ ,
6-deoxocathasterone + a reduced electron acceptor + oxygen → 6-deoxoteasterone + an oxidized electron acceptor + H2O ,
6-deoxotyphasterol + a reduced electron acceptor + oxygen → 6-deoxocastasterone + an oxidized electron acceptor + H2O ,
6-deoxocastasterone + a reduced electron acceptor + oxygen → 6α-hydroxy-castasterone + an oxidized electron acceptor + H2O ,
deoxypodophyllotoxin + NADPH + H+ + oxygen → podophyllotoxin + NADP+ + H2O ,
demecolcine + NADPH + oxygen + H+ → deacetylcolchicine + formaldehyde + NADP+ + H2O ,
6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen → 3-demethylubiquinol-10 + an oxidized electron acceptor + H2O ,
6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen → 3-demethylubiquinol-9 + an oxidized electron acceptor + H2O ,
6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen → 3-demethylubiquinol-6 + an oxidized electron acceptor + H2O

Enzymes and Genes:
5-demethoxyubiquinol hydroxylase : COQ7 ( Saccharomyces cerevisiae )
5-demethoxyubiquinol hydroxylase : PA0655 ( Pseudomonas aeruginosa )
5-demethoxyubiquinol hydroxylase : clk-1 ( Caenorhabditis elegans )
ubiquinone biosynthesis protein COQ7 homolog : COQ7 ( Homo sapiens )
gibberellin 20-oxidase : P450-2 ( Fusarium fujikuroi )
6-deoxotyphasterol C-23 hydroxylase [multifunctional] : CYP90D1 ( Arabidopsis thaliana col )
3-epi-6-deoxocathasterone C-23 hydroxylase [multifunctional] : CYP90C1 ( Arabidopsis thaliana col )
23α hydroxylase : CYP90A1 ( Arabidopsis thaliana col )
brassinolide synthase : CYP85A2 ( Arabidopsis thaliana col )
brassinosteroid-6-oxidase : CYP85A1 ( Arabidopsis thaliana col )
α/β-amyrin 28-monooxygenase : CYP716AL1 ( Catharanthus roseus )
ursolic aldehyde 28-monooxygenase [multifunctional] : CYP716A15 ( Vitis vinifera )
β-amyrin 28-oxidase : CYP716A12 ( Medicago truncatula )
11-oxo-β-amyrin 30-oxidase : CYP72A154 ( Glycyrrhiza uralensis )
gibberellin 16α, 17-epoxidase : CYP714D1 ( Oryza sativa Japonica Group )
CYP98A8 : At1G74540 ( Arabidopsis thaliana col )
cytochrome P-450cam : camC ( Pseudomonas putida ATCC 17453 )
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase : ubiF ( Escherichia coli K-12 substr. MG1655 )
naphthalene 1,2-dioxygenase multicomponent enzyme : nahAd , nahAc , nahAb , nahAa ( Pseudomonas sp. NCIB9816-4 )


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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