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MetaCyc EC 1.14 -- Acting on paired donors, with incorporation or reduction of molecular oxygen

Parent Class: EC-Numbers1 -- Oxidoreductases

Child Classes:
1.14.3 -- With reduced pteridine as one donor (deleted sub-subclass) (1),
1.14.11 -- With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into each donors (152),
1.14.12 -- With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor (62),
1.14.13 -- With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor (686),
1.14.14 -- With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor (44),
1.14.15 -- With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor (40),
1.14.16 -- With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor (10),
1.14.17 -- With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor (5),
1.14.18 -- With another compound as one donor, and incorporation of one atom of oxygen (15),
1.14.19 -- With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (165),
1.14.20 -- With 2-oxoglutarate as one donor, and the other dehydrogenated (3),
1.14.21 -- With NADH or NADPH as one donor, and the other dehydrogenated (34),
1.14.99 -- Miscellaneous (requires further characterization) (73)

Unofficial Reactions:
gibberellin A9 + NAD(P)H + oxygen + H+ → 16α, 17-epoxy gibberellin A9 + NAD(P)+ + H2O,
6-methylthiohexylglucosinolate + an reduced unknown electron acceptor + oxygen → 6-methylsulfinylhexyl glucosinolate + an oxidized unknown electron acceptor + H2O,
6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + an reduced unknown electron acceptor + oxygen → 3-demethylubiquinol-8 + an oxidized unknown electron acceptor + H2O,
4-methyl-proline + NAD(P)H + H+ + oxygen → 4-methyl-3-hydroxy-proline + NAD(P)+ + H2O,
deoxypodophyllotoxin + NADPH + H+ + oxygen → podophyllotoxin + NADP+ + H2O,
betulin + NADPH + H+ + oxygen → betulinic aldehyde + NADP+ + 2 H2O,
tricoumaroyl spermidine + 3 an reduced unknown electron acceptor + 3 oxygen → tricaffeoyl spermidine + 3 an oxidized unknown electron acceptor + 3 H2O,
solavetivone + an reduced unknown electron acceptor + oxygen → 15-hydroxysolavetivone + an oxidized unknown electron acceptor + H2O,
uvaol + NADPH + oxygen + H+ → ursolic aldehyde + NADP+ + 2 H2O,
gibberellin A14 + 2 NADP+ + oxygen → gibberellin A4 + CO2 + 2 NADPH + H+,
lubimin + an reduced unknown electron acceptor + oxygen → 3-hydroxylubimin + an oxidized unknown electron acceptor + H2O,
gibberellin A12 + NAD(P)H + oxygen + H+ → 16α, 17-epoxy gibberellin A12 + NAD(P)+ + H2O,
pretenellin A + NAD(P)H + H+ + oxygen → pretenellin B + NAD(P)+ + 2 H2O,
5-methylthiopentylglucosinolate + an reduced unknown electron acceptor + oxygen → 5-methylsulfinylpentyl glucosinolate + an oxidized unknown electron acceptor + H2O,
2-methylthio-N6-dimethylallyladenosine37 in tRNA + an reduced unknown electron acceptor + oxygen → 2-methylthio-6-dimethylallyl-(cis-hydroxy)-adenosine37 in tRNA + an oxidized unknown electron acceptor + H2O,
11α,30-dihydroxy-β-amyrin + NADPH + oxygen + H+ → 30-hydroxy-11-oxo-β-amyrin + NADP+ + 2 H2O,
preaspyridone A + NAD(P)H + oxygen + H+ → aspyridone A + NAD(P)+ + 2 H2O,
8-methylthiooctyl glucosinolate + an reduced unknown electron acceptor + oxygen → 8-methylsulfinyloctyl glucosinolate + an oxidized unknown electron acceptor + H2O,
campestanol + an reduced unknown electron acceptor + oxygen → (6α)-hydroxycampestanol + an oxidized unknown electron acceptor + H2O,
1,4-naphthoquinone + an reduced unknown electron acceptor + oxygen → juglone + an oxidized unknown electron acceptor + H2O,
6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + an reduced unknown electron acceptor + oxygen → 3-demethylubiquinol-9 + an oxidized unknown electron acceptor + H2O,
cathasterone + an reduced unknown electron acceptor + oxygen → teasterone + an oxidized unknown electron acceptor + H2O,
6-deoxotyphasterol + an reduced unknown electron acceptor + oxygen → 6-deoxocastasterone + an oxidized unknown electron acceptor + H2O,
triferuloyl spermidine + 3 an reduced unknown electron acceptor + 3 oxygen → trihydroxyferuloyl spermidine + 3 an oxidized unknown electron acceptor + 3 H2O,
6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + an reduced unknown electron acceptor + oxygen → 3-demethylubiquinol-10 + an oxidized unknown electron acceptor + H2O,
4-methylthiobutyl glucosinolate + an reduced unknown electron acceptor + oxygen → 4-methylsulfinylbutyl glucosinolate + an oxidized unknown electron acceptor + H2O,
6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + an reduced unknown electron acceptor + oxygen → 3-demethylubiquinol-6 + an oxidized unknown electron acceptor + H2O,
gibberellin A12 + 2 NADP+ + oxygen → gibberellin A9 + CO2 + 2 NADPH + H+,
adamantanone + NADH + H+ + oxygen → 5-hydroxyadamantan-2-one + NAD+ + H2O,
7-methylthioheptyl glucosinolate + an reduced unknown electron acceptor + oxygen → 7-methylsulfinylheptyl glucosinolate + an oxidized unknown electron acceptor + H2O,
typhasterol + an reduced unknown electron acceptor + oxygen → castasterone + an oxidized unknown electron acceptor + H2O,
4-oxahomoadamantan-5-one + NADH + H+ + oxygen → 1-hydroxy-4-oxahomoadamantan-5-one + NAD+ + H2O,
demecolcine + NADPH + oxygen + H+ → deacetylcolchicine + formaldehyde + NADP+ + H2O,
6-deoxocathasterone + an reduced unknown electron acceptor + oxygen → 6-deoxoteasterone + an oxidized unknown electron acceptor + H2O,
rotenone + an reduced unknown electron acceptor + oxygen → amorphigenin + an oxidized unknown electron acceptor + H2O,
gibberellin A4 + NAD(P)H + oxygen + H+ → 16α,17-epoxy gibberellin A4 + NAD(P)+ + H2O

Enzymes and Genes:
cytochrome P-450cam: camC ( Pseudomonas putida ATCC 17453 )
5-demethoxyubiquinol hydroxylase: COQ7 ( Saccharomyces cerevisiae )
ubiquinone biosynthesis protein COQ7 homolog: COQ7 ( Homo sapiens )
6-deoxotyphasterol C-23 hydroxylase [multifunctional]: CYP90D1 ( Arabidopsis thaliana col )
3-epi-6-deoxocathasterone C-23 hydroxylase [multifunctional]: CYP90C1 ( Arabidopsis thaliana col )
23α hydroxylase: CYP90A1 ( Arabidopsis thaliana col )
5-demethoxyubiquinol hydroxylase: PA0655 ( Pseudomonas aeruginosa )
5-demethoxyubiquinol hydroxylase: clk-1 ( Caenorhabditis elegans )
glucosinolate S-oxygenase: GS-OX5 ( Arabidopsis thaliana col )
glucosinolate S-oxygenase: GS-OX4 ( Arabidopsis thaliana col )
preaspyridone A oxidase: ApdE ( Aspergillus nidulans )
11-oxo-β-amyrin 30-oxidase: CYP72A154 ( Glycyrrhiza uralensis )
glucosinolate S-oxygenase: GS-OX2 ( Arabidopsis thaliana col )
pretenellin A oxidase: TenA ( Beauveria bassiana )
gibberellin 20-oxidase: P450-2 ( Fusarium fujikuroi )
CYP98A8: At1G74540 ( Arabidopsis thaliana col )
α/β-amyrin 28-monooxygenase: CYP716AL1 ( Catharanthus roseus )
ursolic aldehyde 28-monooxygenase [multifunctional]: CYP716A15 ( Vitis vinifera )
β-amyrin 28-oxidase: CYP716A12 ( Medicago truncatula )
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase: ubiF ( Escherichia coli K-12 substr. MG1655 )
glucosinolate S-oxygenase: GS-OX3 ( Arabidopsis thaliana col )
glucosinolate S-oxygenase: GS-OX1 ( Arabidopsis thaliana col )
gibberellin 16α, 17-epoxidase: CYP714D1 ( Oryza sativa Japonica Group )


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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