Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc EC 1.14 -- Acting on paired donors, with incorporation or reduction of molecular oxygen

Parent Class: EC-Numbers 1 -- Oxidoreductases

Child Classes:
1.14.3 -- With reduced pteridine as one donor (deleted sub-subclass) (1) ,
1.14.11 -- With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (137) ,
1.14.12 -- With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor (48) ,
1.14.13 -- With NADH or NADPH as one donor, and incorporation of one atom of oxygen (564) ,
1.14.14 -- With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (42) ,
1.14.15 -- With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (27) ,
1.14.16 -- With reduced pteridine as one donor, and incorporation of one atom of oxygen (9) ,
1.14.17 -- With reduced ascorbate as one donor, and incorporation of one atom of oxygen (4) ,
1.14.18 -- With another compound as one donor, and incorporation of one atom of oxygen (6) ,
1.14.19 -- With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (80) ,
1.14.20 -- With 2-oxoglutarate as one donor, and the other dehydrogenated (3) ,
1.14.21 -- With NADH or NADPH as one donor, and the other dehydrogenated (19) ,
1.14.99 -- Miscellaneous (requires further characterization) (79)

Unofficial Reactions:
fluorene + NADH + oxygen + H+ → 9-fluorenol + NAD+ + H2O ,
6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen → 3-demethylubiquinol-8 + an oxidized electron acceptor + H2O ,
adamantanone + NADH + H+ + oxygen → 5-hydroxyadamantan-2-one + NAD+ + H2O ,
4-oxahomoadamantan-5-one + NADH + H+ + oxygen → 1-hydroxy-4-oxahomoadamantan-5-one + NAD+ + H2O ,
2-methylthio-N6-dimethylallyladenosine37 in tRNA + a reduced electron acceptor + oxygen → 2-methylthio-6-dimethylallyl-(cis-hydroxy)-adenosine37 in tRNA + an oxidized electron acceptor + H2O ,
tricoumaroyl spermidine + 3 a reduced electron acceptor + 3 oxygen → tricaffeoyl spermidine + 3 an oxidized electron acceptor + 3 H2O ,
triferuloyl spermidine + 3 a reduced electron acceptor + 3 oxygen → trihydroxyferuloyl spermidine + 3 an oxidized electron acceptor + 3 H2O ,
gibberellin A4 + NAD(P)H + oxygen + H+ → 16α,17-epoxy gibberellin A4 + NAD(P)+ + H2O ,
gibberellin A12 + NAD(P)H + oxygen + H+ → 16α, 17-epoxy gibberellin A12 + NAD(P)+ + H2O ,
gibberellin A9 + NAD(P)H + oxygen + H+ → 16α, 17-epoxy gibberellin A9 + NAD(P)+ + H2O ,
solavetivone + a reduced electron acceptor + oxygen → 15-hydroxysolavetivone + an oxidized electron acceptor + H2O ,
11α,30-dihydroxy-β-amyrin + NADPH + oxygen + H+ → 30-hydroxy-11-oxo-β-amyrin + NADP+ + 2 H2O ,
betulin + NADPH + H+ + oxygen → betulinic aldehyde + NADP+ + 2 H2O ,
uvaol + NADPH + oxygen + H+ → ursolic aldehyde + NADP+ + 2 H2O ,
fluorene + 2 NADH + oxygen → (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene + 2 NAD+ ,
6-deoxotyphasterol + oxygen → typhasterol + H2O ,
lubimin + a reduced electron acceptor + oxygen → 3-hydroxylubimin + an oxidized electron acceptor + H2O ,
campestanol + a reduced electron acceptor + oxygen → (6α)-hydroxycampestanol + an oxidized electron acceptor + H2O ,
cathasterone + a reduced electron acceptor + oxygen → teasterone + an oxidized electron acceptor + H2O ,
typhasterol + a reduced electron acceptor + oxygen → castasterone + an oxidized electron acceptor + H2O ,
gibberellin A14 + NADPH + oxygen → gibberellin A4 + CO2 + NADP+ + 4 H+ ,
gibberellin A12 + NADPH + oxygen → gibberellin A9 + CO2 + NADP+ + 4 H+ ,
6-deoxocathasterone + a reduced electron acceptor + oxygen → 6-deoxoteasterone + an oxidized electron acceptor + H2O ,
6-deoxotyphasterol + a reduced electron acceptor + oxygen → 6-deoxocastasterone + an oxidized electron acceptor + H2O ,
6-deoxocastasterone + a reduced electron acceptor + oxygen → 6α-hydroxy-castasterone + an oxidized electron acceptor + H2O ,
deoxypodophyllotoxin + NADPH + H+ + oxygen → podophyllotoxin + NADP+ + H2O ,
demecolcine + NADPH + oxygen + H+ → deacetylcolchicine + formaldehyde + NADP+ + H2O ,
6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen → 3-demethylubiquinol-10 + an oxidized electron acceptor + H2O ,
6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen → 3-demethylubiquinol-9 + an oxidized electron acceptor + H2O ,
6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + a reduced electron acceptor + oxygen → 3-demethylubiquinol-6 + an oxidized electron acceptor + H2O

Enzymes and Genes:
5-demethoxyubiquinol hydroxylase : COQ7 ( Saccharomyces cerevisiae )
5-demethoxyubiquinol hydroxylase : PA0655 ( Pseudomonas aeruginosa )
5-demethoxyubiquinol hydroxylase : clk-1 ( Caenorhabditis elegans )
ubiquinone biosynthesis protein COQ7 homolog : COQ7 ( Homo sapiens )
gibberellin 20-oxidase : P450-2 ( Fusarium fujikuroi )
6-deoxotyphasterol C-23 hydroxylase [multifunctional] : CYP90D1 ( Arabidopsis thaliana col )
3-epi-6-deoxocathasterone C-23 hydroxylase [multifunctional] : CYP90C1 ( Arabidopsis thaliana col )
23α hydroxylase : CYP90A1 ( Arabidopsis thaliana col )
brassinolide synthase : CYP85A2 ( Arabidopsis thaliana col )
brassinosteroid-6-oxidase : CYP85A1 ( Arabidopsis thaliana col )
α/β-amyrin 28-monooxygenase : CYP716AL1 ( Catharanthus roseus )
ursolic aldehyde 28-monooxygenase [multifunctional] : CYP716A15 ( Vitis vinifera )
β-amyrin 28-oxidase : CYP716A12 ( Medicago truncatula )
11-oxo-β-amyrin 30-oxidase : CYP72A154 ( Glycyrrhiza uralensis )
gibberellin 16α, 17-epoxidase : CYP714D1 ( Oryza sativa Japonica Group )
CYP98A8 : At1G74540 ( Arabidopsis thaliana col )
cytochrome P-450cam : camC ( Pseudomonas putida ATCC 17453 )
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase : ubiF ( Escherichia coli K-12 substr. MG1655 )
naphthalene 1,2-dioxygenase multicomponent enzyme : nahAd , nahAc , nahAb , nahAa ( Pseudomonas sp. NCIB9816-4 )


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13B.