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MetaCyc EC 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Parent Class: EC-Numbers1 -- Oxidoreductases1.2 -- Acting on the aldehyde or oxo group of donors

Instances:
1.2.1.2 -- formate dehydrogenase,
1.2.1.3 -- aldehyde dehydrogenase (NAD+),
1.2.1.4 -- aldehyde dehydrogenase (NADP+),
1.2.1.5 -- aldehyde dehydrogenase [NAD(P)+],
1.2.1.7 -- benzaldehyde dehydrogenase (NADP+),
1.2.1.8 -- betaine-aldehyde dehydrogenase,
1.2.1.9 -- glyceraldehyde-3-phosphate dehydrogenase (NADP+),
1.2.1.10 -- acetaldehyde dehydrogenase (acetylating),
1.2.1.11 -- aspartate-semialdehyde dehydrogenase,
1.2.1.12 -- glyceraldehyde-3-phosphate dehydrogenase (phosphorylating),
1.2.1.13 -- glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating),
1.2.1.15 -- malonate-semialdehyde dehydrogenase,
1.2.1.16 -- succinate-semialdehyde dehydrogenase [NAD(P)+],
1.2.1.17 -- glyoxylate dehydrogenase (acylating),
1.2.1.18 -- malonate-semialdehyde dehydrogenase (acetylating),
1.2.1.19 -- aminobutyraldehyde dehydrogenase,
1.2.1.20 -- glutarate-semialdehyde dehydrogenase,
1.2.1.21 -- glycolaldehyde dehydrogenase,
1.2.1.22 -- lactaldehyde dehydrogenase,
1.2.1.23 -- 2-oxoaldehyde dehydrogenase (NAD+),
1.2.1.24 -- succinate-semialdehyde dehydrogenase (NAD+),
1.2.1.25 -- 2-oxoisovalerate dehydrogenase (acylating),
1.2.1.26 -- 2,5-dioxovalerate dehydrogenase,
1.2.1.27 -- methylmalonate-semialdehyde dehydrogenase (CoA-acylating),
1.2.1.28 -- benzaldehyde dehydrogenase (NAD+),
1.2.1.29 -- aryl-aldehyde dehydrogenase,
1.2.1.30 -- aryl-aldehyde dehydrogenase (NADP+),
1.2.1.31 -- L-aminoadipate-semialdehyde dehydrogenase,
1.2.1.32 -- aminomuconate-semialdehyde dehydrogenase,
1.2.1.33 -- (R)-dehydropantoate dehydrogenase,
1.2.1.36 -- retinal dehydrogenase,
1.2.1.38 -- N-acetyl-γ-glutamyl-phosphate reductase,
1.2.1.39 -- phenylacetaldehyde dehydrogenase,
1.2.1.41 -- glutamate-5-semialdehyde dehydrogenase,
1.2.1.42 -- hexadecanal dehydrogenase (acylating),
1.2.1.43 -- formate dehydrogenase (NADP+),
1.2.1.44 -- cinnamoyl-CoA reductase,
1.2.1.46 -- formaldehyde dehydrogenase,
1.2.1.47 -- 4-trimethylammoniobutyraldehyde dehydrogenase,
1.2.1.48 -- long-chain-aldehyde dehydrogenase,
1.2.1.49 -- 2-oxoaldehyde dehydrogenase (NADP+),
1.2.1.50 -- long-chain-fatty-acyl-CoA reductase,
1.2.1.51 -- pyruvate dehydrogenase (NADP+),
1.2.1.52 -- oxoglutarate dehydrogenase (NADP+),
1.2.1.53 -- 4-hydroxyphenylacetaldehyde dehydrogenase,
1.2.1.54 -- γ-guanidinobutyraldehyde dehydrogenase,
1.2.1.57 -- butanal dehydrogenase,
1.2.1.58 -- phenylglyoxylate dehydrogenase (acylating),
1.2.1.59 -- glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating),
1.2.1.60 -- 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase,
1.2.1.61 -- 4-hydroxymuconic-semialdehyde dehydrogenase,
1.2.1.62 -- 4-formylbenzenesulfonate dehydrogenase,
1.2.1.63 -- 6-oxohexanoate dehydrogenase,
1.2.1.64 -- 4-hydroxybenzaldehyde dehydrogenase (NAD+),
1.2.1.65 -- salicylaldehyde dehydrogenase,
1.2.1.67 -- vanillin dehydrogenase,
1.2.1.68 -- coniferyl-aldehyde dehydrogenase,
1.2.1.69 -- fluoroacetaldehyde dehydrogenase,
1.2.1.70 -- glutamyl-tRNA reductase,
1.2.1.71 -- succinylglutamate-semialdehyde dehydrogenase,
1.2.1.72 -- erythrose-4-phosphate dehydrogenase,
1.2.1.73 -- sulfoacetaldehyde dehydrogenase,
1.2.1.74 -- abieta-7,13-dien-18-al dehydrogenase,
1.2.1.75 -- malonyl-CoA reductase (malonate semialdehyde-forming),
1.2.1.76 -- succinate-semialdehyde dehydrogenase (acylating),
1.2.1.77 -- 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+),
1.2.1.78 -- 2-formylbenzoate dehydrogenase,
1.2.1.79 -- succinate-semialdehyde dehydrogenase (NADP+),
1.2.1.80 -- long-chain acyl-[acyl-carrier-protein] reductase,
1.2.1.81 -- sulfoacetaldehyde dehydrogenase (acylating),
1.2.1.82 -- β-apo-4′-carotenal oxygenase,
1.2.1.83 -- 3-succinoylsemialdehyde-pyridine dehydrogenase,
1.2.1.84 -- alcohol-forming fatty acyl-CoA reductase,
1.2.1.85 -- 2-hydroxymuconate-6-semialdehyde dehydrogenase,
1.2.1.86 -- geranial dehydrogenase,
1.2.1.87 -- propanal dehydrogenase (CoA-propanoylating),
1.2.1.88 -- L-glutamate γ-semialdehyde dehydrogenase,
1.2.1.89 -- D-glyceraldehyde dehydrogenase (NADP+),
1.2.1.90 -- glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+],
1.2.1.91 -- 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase,
1.2.1.92 -- 3,6-anhydro-α-L-galactose dehydrogenase,
1.2.1.93 -- formate dehydrogenase (NAD+, ferredoxin),
1.2.1.94 -- farnesal dehydrogenase,
1.2.1.95 -- L-2-aminoadipate reductase,
1.2.1.96 -- 4-hydroxybenzaldehyde dehydrogenase (NADP+),
1.2.1.97 -- 3-sulfolactaldehyde dehydrogenase,
1.2.1.ad -- 2-hydroxy-2-methylpropanal dehydrogenase

Unofficial Reactions:
apo-4'-lycopenal + NAD(P)+ + H2O → apo-4'-lycopenoate + NADPH + H+,
2,5-dioxopentanoate + NAD(P)+ + H2O → 2-oxoglutarate + NAD(P)H + 2 H+,
3-oxo-24-ethyl-26-al-cholest-4-ene + NAD+ + H2O → 3-oxo-24-ethyl-cholest-4-en-26-oate + NADH + 2 H+,
a long-chain aldehyde + coenzyme A + NAD+ ← a long-chain acyl-CoA + NADH + H+,
bixin aldehyde + 2 NAD+ + 2 H2O → norbixin + 2 NADH + 4 H+,
arabidopaldehyde + NAD(P)+ + H2O → arabidopate + NAD(P)H + 2 H+,
(S)-lactaldehyde + NADP+ + H2O → (S)-lactate + NADPH + 2 H+,
4-guanidinobutyraldehyde + an oxidized unknown electron acceptor + H2O → 4-guanidinobutanoate + an reduced unknown electron acceptor + H+,
an ω-oxo fatty acid + NAD+ + H2O → an α,ω-dicarboxylate + NADH + 2 H+,
1-hexanal + coenzyme A + NAD(P)+ ← hexanoyl-CoA + NAD(P)H + H+,
3-aminopropanal + NAD+ + H2O = β-alanine + NADH + 2 H+,
a very long chain alcohol + coenzyme A + 2 NADP+ ← a very long chain fatty acyl-CoA + 2 NADPH + 2 H+,
4-hydroxybenzaldehyde + NAD(P)+ + H2O → 4-hydroxybenzoate + NAD(P)H + 2 H+,
L-4-hydroxyglutamate semialdehyde + NAD+ + H2O → erythro-4-hydroxy-L-glutamate + NADH + 2 H+,
indole-3-glycol aldehyde + an oxidized unknown electron acceptor + H2O → indole-3-glycolate + an reduced unknown electron acceptor + H+,
16-oxo-palmitate + NADP+ + H2O → hexadecanedioate + NADPH + 2 H+,
22-oxo-docosanoyl-CoA + NADP+ + H2O → 22-carboxy-docosanoyl-CoA + NADPH + 2 H+,
indole-3-glyoxal + an oxidized unknown electron acceptor + H2O → indole-3-glyoxylate + an reduced unknown electron acceptor + H+,
18-oxo-oleoyl-CoA + NADP+ + H2O = ω-carboxy-(9Z)-octadec-9-enoyl-CoA + NADPH + 2 H+,
gentisaldehyde + NADP+ + H2O → gentisate + NADPH + 2 H+,
3-aminopropanal + NAD(P)+ + H2O → β-alanine + NAD(P)H + 2 H+,
4-aminobutanal + NADP+ + H2O = 4-aminobutanoate + NADPH + 2 H+,
(8E,10E)-dodeca-8,10-dienoate + 2 NADPH + 3 H+ = (8E,10E)-dodeca-8,10-dienol + 2 NADP+ + H2O,
4-carboxybenzaldehyde + NAD+ + H2O ↔ terephthalate + NADH + 2 H+,
4-(6-hydroxy-pyridin-3-yl)-4-oxobutanal + NADP+ + H2O → 6-hydroxy-3-succinoyl-pyridine + NADPH + 2 H+,
glutarate semialdehyde + NADP+ + H2O → glutarate + NADPH + 2 H+,
3-hydroxy-3-methyl-butanal + NAD+ + H2O = 3-hydroxy-3-methylbutanoate + NADH + 2 H+,
iso-arabidopaldehyde + NAD(P)+ + H2O → iso-arabidopate + NAD(P)H + 2 H+,
18-oxo-oleate + NADP+ + H2O → α,ω-9Z-octadecenedioate + NADPH + 2 H+,
3-formyl-4-hydroxybenzoate + NAD+ + H2O → 4-hydroxyisophthalate + NADH + 2 H+,
(10E,12Z)-10,12-hexadecadienoate + 2 NADPH + 3 H+ → bombykol + 2 NADP+ + H2O,
phosphonoacetaldehyde + NAD+ + H2O → phosphonoacetate + NADH + 2 H+,
4-(γ-glutamylamino)butanal + NAD(P)+ + H2O → 4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+,
(-)-dehydrodiconiferyl aldehyde + NAD+ + H2O → (-)-dehydrodiconiferyl acid + NADH + 2 H+,
3-oxopropanoate + coenzyme A + NADP+ = acetyl-CoA + CO2 + NADPH,
phosphonoformaldehyde + NADP+ + H2O → phosphonoformate + NADPH + H+,
glycolaldehyde + an oxidized unknown electron acceptor → glycolate + an reduced unknown electron acceptor + H+,
(15Z)-tetracos-15-enal + coenzyme A + NAD+ ← (Z)-15-tetracosenoyl-CoA + NADH + H+,
sinapaldehyde + NADP+ + H2O → sinapate + NADPH + 2 H+,
a long-chain aldehyde + NADH + H+ → a long-chain alcohol + NAD+,
syringaldehyde + NAD+ + H2O = syringate + NADH + 2 H+,
a [LysW]-C-terminal-L-glutamyl-γ-L-2-aminoadipate 6-phosphate + NADPH + H+ → a [LysW]-C-terminal-L-glutamyl-γ-L-2-aminoadipate semialdehyde + NADP+ + phosphate,
3-oxopropanoate + coenzyme A + NAD+ → acetyl-CoA + CO2 + NADH,
a very-long-chain aldehyde + coenzyme A + NADP+ ← a very long chain fatty acyl-CoA + NADPH + H+,
3-hydroxypropionaldehyde + NAD+ + H2O → 3-hydroxypropanoate + NADH + 2 H+,
1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+,
2-hydroxy-2-methyl-butanal + NAD+ + H2O = 2-hydroxy-2-methylbutanoate + NADH + 2 H+,
4-methyl-2-oxopentanoate + coenzyme A + NAD+ → isovaleryl-CoA + CO2 + NADH,
pyruvate + coenzyme A + NAD+ → acetyl-CoA + CO2 + NADH,
(S)-3-methyl-2-oxopentanoate + coenzyme A + NAD+ ↔ 2-methylbutanoyl-CoA + CO2 + NADH

Enzymes and Genes:
pyruvate dehydrogenase: lpd, aceE, aceF ( Escherichia coli K-12 substr. MG1655 )
pyruvate dehydrogenase complex: pdhB, Synpcc7942_1944, pdhC, pdhD ( Synechococcus elongatus PCC 7942 )
pyruvate dehydrogenase complex: DLD, AF123459, DLAT, PDHA1, PDHB ( Ascaris suum )
pyruvate dehydrogenase complex: PDHA1, PDHB, DLAT, PDHX, DLD ( Homo sapiens )
pyruvate dehydrogenase complex ( Crithidia fasciculata )
pyruvate dehydrogenase complex ( Pisum sativum )
pyruvate dehydrogenase complex: pdhB, pdhA, pdhC, pdhD ( Mycoplasma pneumoniae M129 )
branched-chain α-keto acid dehydrogenase complex: BCKDHB, BCKDHA, DBT, DLD ( Homo sapiens )
branched-chain α-keto acid dehydrogenase complex: bfmBAB, bfmBAA, bfmBB, pdhD ( Bacillus subtilis )
malonate semialdehyde dehydrogenase (CoA-acylating): ALD6 ( Candida albicans SC5314 )
(methyl)malonate-semialdehyde dehydrogenase: mmsA ( Bacillus subtilis subtilis 168 )
malonate-semialdehyde dehydrogenase ( Enterobacter aerogenes )
malonate semialdehyde dehydrogenase ( Pseudomonas fluorescens )
malonate semialdehyde dehydrogenase ( Rattus norvegicus )
[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase: lysY ( Sulfolobus acidocaldarius )
[LysW]-L-2-aminoadipate 6-phosphate reductase: lysY ( Thermus thermophilus )
hydroxycinnamaldehyde dehydrogenase: REF1 ( Arabidopsis thaliana col )
glycolaldehyde oxidoreductase: SSO2637, SSO2636, SSO2639 ( Sulfolobus solfataricus P2 )
phosphonoformaldehyde dehydrogenase: phpJ ( Kitasatospora phosalacinea )
phosphonoformaldehyde dehydrogenase: phpJ ( Streptomyces viridochromogenes DSM 40736 )
malonate-semialdehyde dehydrogenase (acetylating): dddC ( Halomonas sp. HTNK1 )
aromatic aldehyde dehydrogenase: bzaA ( Sphingobium sp. SYK-6 )
γ-glutamyl-γ-aminobutyraldehyde dehydrogenase: puuC ( Escherichia coli K-12 substr. MG1655 )
phosphonoacetaldehyde dehydrogenase: phnY ( Sinorhizobium meliloti 1021 )
pheromone gland-specific fatty-acyl reductase: FAR ( Bombyx mori )
glutarate semialdehyde dehydrogenase: PA0265 ( Pseudomonas aeruginosa )
glutarate semialdehyde dehydrogenase: davD ( Pseudomonas putida )
4-carboxybenzaldehyde dehydrogenase / 4-sulfobenzaldehyde dehydrogenase: tsaD ( Comamonas testosteroni T-2 )
Δ1-pyrroline-5-carboxylate dehydrogenase, mitochondrial: ALDH4A1 ( Homo sapiens )
Δ1-pyrroline-5-carboxylate dehydrogenase ( Bos taurus )
alcohol-forming fatty acyl-CoA reductase: CER4 ( Arabidopsis thaliana col )
betaine aldehyde / aminoaldehyde dehydrogenase: ALDH10A9 ( Arabidopsis thaliana col )
3-aminopropionaldehyde dehydrogenase ( Setaria italica )
aminopropionaldehyde dehydrogenase ( Arthrobacter sp. TMP-1 )
aldehyde dehydrogenase: ALD2 ( Saccharomyces cerevisiae )
aldehyde dehydrogenase: ALD3 ( Saccharomyces cerevisiae )
aldehyde/alcohol dehydrogenase: adhE2 ( Clostridium acetobutylicum )
NAD(P)+ L-lactaldehyde dehydrogenase: LADH ( Scheffersomyces stipitis CBS 6054 )
bixin aldehyde dehydrogenase: BADH ( Bixa orellana )
acyl-CoA reductase (NADH): U80676 ( Botryococcus braunii BOT88-2 )
2-ketoglutarate semialdehyde dehydrogenase: PA2217 ( Pseudomonas aeruginosa PAO1 )
α-ketoglutaric semialdehyde dehydrogenase: araE ( Azospirillum brasilense )
apo-4'-lycopenal dehydrogenase: YLO-1 ( Neurospora crassa )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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