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MetaCyc EC 2.5.1 -- Transferring alkyl or aryl groups, other than methyl groups

Parent Class: EC-Numbers2 -- Transferases2.5 -- Transferring alkyl or aryl groups, other than methyl groups

Instances:
2.5.1.1 -- dimethylallyltranstransferase,
2.5.1.2 -- thiamine pyridinylase,
2.5.1.3 -- thiamine phosphate synthase,
2.5.1.4 -- adenosylmethionine cyclotransferase,
2.5.1.5 -- galactose-6-sulfurylase,
2.5.1.6 -- methionine adenosyltransferase,
2.5.1.7 -- UDP-N-acetylglucosamine 1-carboxyvinyltransferase,
2.5.1.9 -- riboflavin synthase,
2.5.1.10 -- (2E,6E)-farnesyl diphosphate synthase,
2.5.1.15 -- dihydropteroate synthase,
2.5.1.16 -- spermidine synthase,
2.5.1.17 -- cob(I)yrinic acid a,c-diamide adenosyltransferase,
2.5.1.18 -- glutathione transferase,
2.5.1.19 -- 3-phosphoshikimate 1-carboxyvinyltransferase,
2.5.1.20 -- rubber cis-polyprenylcistransferase,
2.5.1.21 -- squalene synthase,
2.5.1.22 -- spermine synthase,
2.5.1.23 -- sym-norspermidine synthase,
2.5.1.24 -- discadenine synthase,
2.5.1.25 -- tRNA-uridine aminocarboxypropyltransferase,
2.5.1.26 -- alkylglycerone-phosphate synthase,
2.5.1.27 -- adenylate dimethylallyltransferase,
2.5.1.28 -- dimethylallylcistransferase,
2.5.1.29 -- geranylgeranyl diphosphate synthase,
2.5.1.30 -- heptaprenyl diphosphate synthase,
2.5.1.31 -- ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific],
2.5.1.32 -- 15-cis-phytoene synthase,
2.5.1.34 -- 4-dimethylallyltryptophan synthase,
2.5.1.35 -- aspulvinone dimethylallyltransferase,
2.5.1.36 -- trihydroxypterocarpan dimethylallyltransferase,
2.5.1.38 -- isonocardicin synthase,
2.5.1.39 -- 4-hydroxybenzoate polyprenyltransferase,
2.5.1.41 -- phosphoglycerol geranylgeranyltransferase,
2.5.1.42 -- geranylgeranylglycerol-phosphate geranylgeranyltransferase,
2.5.1.43 -- nicotianamine synthase,
2.5.1.44 -- homospermidine synthase,
2.5.1.45 -- homospermidine synthase (spermidine-specific),
2.5.1.46 -- deoxyhypusine synthase,
2.5.1.47 -- cysteine synthase,
2.5.1.48 -- cystathionine γ-synthase,
2.5.1.49 -- O-acetylhomoserine aminocarboxypropyltransferase,
2.5.1.50 -- zeatin 9-aminocarboxyethyltransferase,
2.5.1.51 -- β-pyrazolylalanine synthase,
2.5.1.52 -- L-mimosine synthase,
2.5.1.53 -- uracilylalanine synthase,
2.5.1.54 -- 3-deoxy-7-phosphoheptulonate synthase,
2.5.1.55 -- 3-deoxy-8-phosphooctulonate synthase,
2.5.1.56 -- N-acetylneuraminate synthase,
2.5.1.57 -- N-acylneuraminate-9-phosphate synthase,
2.5.1.58 -- protein farnesyltransferase,
2.5.1.59 -- protein geranylgeranyltransferase type I,
2.5.1.60 -- protein geranylgeranyltransferase type II,
2.5.1.61 -- hydroxymethylbilane synthase,
2.5.1.62 -- chlorophyll synthase,
2.5.1.63 -- adenosyl-fluoride synthase,
2.5.1.65 -- O-phosphoserine sulfhydrylase,
2.5.1.66 -- N2-(2-carboxyethyl)arginine synthase,
2.5.1.67 -- chrysanthemyl diphosphate synthase,
2.5.1.68 -- (2Z,6E)-farnesyl diphosphate synthase,
2.5.1.69 -- lavandulyl diphosphate synthase,
2.5.1.70 -- naringenin 8-dimethylallyltransferase,
2.5.1.71 -- leachianone-G 2′′-dimethylallyltransferase,
2.5.1.72 -- quinolinate synthase,
2.5.1.73 -- O-phospho-L-seryl-tRNA:Cys-tRNA synthase,
2.5.1.74 -- 1,4-dihydroxy-2-naphthoate polyprenyltransferase,
2.5.1.75 -- tRNA dimethylallyltransferase,
2.5.1.76 -- cysteate synthase,
2.5.1.77 -- 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase,
2.5.1.78 -- 6,7-dimethyl-8-ribityllumazine synthase,
2.5.1.79 -- thermospermine synthase,
2.5.1.80 -- 7-dimethylallyltryptophan synthase,
2.5.1.81 -- geranylfarnesyl diphosphate synthase,
2.5.1.82 -- hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific],
2.5.1.83 -- hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific],
2.5.1.84 -- all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific],
2.5.1.85 -- all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific],
2.5.1.86 -- trans,polycis-decaprenyl diphosphate synthase,
2.5.1.87 -- ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific],
2.5.1.88 -- trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific],
2.5.1.89 -- tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific],
2.5.1.90 -- all-trans-octaprenyl-diphosphate synthase,
2.5.1.91 -- all-trans-decaprenyl-diphosphate synthase,
2.5.1.92 -- (2Z,6Z)-farnesyl diphosphate synthase,
2.5.1.93 -- 4-hydroxybenzoate geranyltransferase,
2.5.1.94 -- adenosyl-chloride synthase,
2.5.1.95 -- xanthan ketal pyruvate transferase,
2.5.1.96 -- 4,4′-diapophytoene synthase,
2.5.1.97 -- pseudaminic acid synthase,
2.5.1.98 -- Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase,
2.5.1.99 -- all-trans-phytoene synthase,
2.5.1.100 -- fumigaclavine A dimethylallyltransferase,
2.5.1.101 -- N,N′-diacetyllegionaminate synthase,
2.5.1.102 -- geranyl-pyrophosphate—olivetolic acid geranyltransferase,
2.5.1.103 -- presqualene diphosphate synthase,
2.5.1.104 -- N1-aminopropylagmatine synthase,
2.5.1.105 -- 7,8-dihydropterin-6-yl-methyl-4-(β-D-ribofuranosyl)aminobenzene 5′-phosphate synthase,
2.5.1.106 -- tryprostatin B synthase,
2.5.1.107 -- verruculogen prenyltransferase,
2.5.1.108 -- 2-(3-amino-3-carboxypropyl)histidine synthase,
2.5.1.109 -- brevianamide F prenyltransferase (deoxybrevianamide E-forming),
2.5.1.110 -- 12α,13α-dihydroxyfumitremorgin C prenyltransferase,
2.5.1.111 -- 4-hydroxyphenylpyruvate 3-dimethylallyltransferase,
2.5.1.112 -- adenylate dimethylallyltransferase (ADP/ATP-dependent),
2.5.1.113 -- [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase,
2.5.1.114 -- tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase,
2.5.1.115 -- homogentisate phytyltransferase,
2.5.1.116 -- homogentisate geranylgeranyltransferase,
2.5.1.117 -- homogentisate solanesyltransferase,
2.5.1.118 -- β-(isoxazolin-5-on-2-yl)-L-alanine synthase,
2.5.1.119 -- β-(isoxazolin-5-on-4-yl)-L-alanine synthase,
2.5.1.120 -- aminodeoxyfutalosine synthase,
2.5.1.121 -- 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase ,
2.5.1.122 -- 4-O-dimethylallyl-L-tyrosine synthase,
2.5.1.123 -- flaviolin linalyltransferase,
2.5.1.124 -- 6-linalyl-2-O,3-dimethylflaviolin synthase,
2.5.1.125 -- 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase,
2.5.1.126 -- norspermine synthase,
2.5.1.127 -- caldopentamine synthase,
2.5.1.128 -- N4-bis(aminopropyl)spermidine synthase,
2.5.1.bh -- flavin prenyltransferase,
2.5.1.bi -- 1,4-dioxo-2-naphthoate phytyltransferase,
2.5.1.bj -- (4-{4-[2-(γ-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase,
2.5.1.M1 -- all-trans-undecaprenyl diphosphate synthase

Unofficial Reactions:
fosfomycin + bacillithiol = bacillithiol-fosfomycin,
5-hydroxyanthrotainin + geranyl diphosphate → previridicatumtoxin + diphosphate,
histidyltryptophanyldiketopiperazine + dimethylallyl diphosphate → roquefortine D + diphosphate,
all-trans-hexaprenyl diphosphate + 4-aminobenzoate → 3-hexaprenyl-4-aminobenzoate + diphosphate,
2,4,6-trihydroxybenzophenone + dimethylallyl diphosphate → hyperxanthone E + diphosphate,
2 (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate → (1R,6R)-1,2,5,5a,6,7-hexahydrophenazine-1,6-dicarboxylate + 2 H2O + 2 H+,
2'-hydroxygenistein + dimethylallyl diphosphate → phaseoluteone + diphosphate,
ω, mono-trans, poly-cis-pentaprenyl diphosphate + isopentenyl diphosphate = ω, mono-trans, poly-cis-hexaprenyl diphosphate + diphosphate,
all-trans-3,4-didehydrolycopene → torulene,
ν-carrageenan → ι-carrageenose + 2 sulfate,
all-trans-hexaprenyl diphosphate + 1,4-dihydroxy-6-naphthoate + H+ → demethylmenaquinol-6 + CO2 + diphosphate,
5,7-dihydroxy-4,6-dimethylphthalide + (2E,6E)-farnesyl diphosphate → farnesyl-5,7-dihydroxy-4,6-dimethylphthalide + diphosphate,
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + diphosphate,
didemethylasterriquinone D + dimethylallyl diphosphate → asterriquinone C1 + diphosphate,
chlorophyllide b + geranylgeranyl diphosphate + H+ = geranylgeranyl-chlorophyll b + diphosphate,
D-Man-β-(1→4)-GlcA-β-(1→2)-D-Man-α-(1→3)-D-Glc-β-(1→4)-D-Glc-α-1-diphospho-ditrans,octacis-undecaprenol + phosphoenolpyruvate = 4,6-CH3(COO-)C-D-Man-β-(1→4)-GlcA-β-(1→2)-D-Man-α-(1→3)-D-Glc-β-(1→4)-D-Glc-α-1-diphospho-ditrans,octacis-undecaprenol + phosphate,
genistein + dimethylallyl diphosphate → lupiwighteone + diphosphate,
ω, mono-trans, poly-cis-heptaprenyl diphosphate + isopentenyl diphosphate = ω, mono-trans, poly-cis-octaprenyl diphosphate + diphosphate,
4-amino-3-methoxybenzoate + all-trans-hexaprenyl diphosphate → 3-hexaprenyl-4-amino-5-methoxybenzoate + diphosphate,
D-mannopyranose 6-phosphate + phosphoenolpyruvate + 5 H+ → 2-keto-3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + phosphate,
genistein + dimethylallyl diphosphate → wighteone + diphosphate,
olivetolate + neryl diphosphate = cannabinerolate + diphosphate,
terpendole I + dimethylallyl diphosphate → terpendole J + diphosphate,
2'-hydroxygenistein + dimethylallyl diphosphate → 2,3-dehydrokievitone + diphosphate,
1-deoxy-1-imino-D-erythrose 4-phosphate + phosphoenolpyruvate + H2O → 3,4-dideoxy-4-amino-D-arabino-heptulosonate 7-phosphate + phosphate,
phlorisovalerophenone + dimethylallyl diphosphate → 4-prenylphlorisovalerophenone + diphosphate + H+,
lolitriol + dimethylallyl diphosphate → lolitrem E + diphosphate,
di-trans-poly-cispolyisoprenyln-PP + isopentenyl diphosphate = di-trans-poly-cispolyisoprenyln+1-PP + diphosphate,
(2Z,6Z,10E)-tetraprenyl diphosphate + isopentenyl diphosphate = ω, mono-trans, poly-cis-pentaprenyl diphosphate + diphosphate,
2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate → desmethylxanthohumol + diphosphate + H+,
paxilline + 2 dimethylallyl diphosphate → 21,22-diprenylpaxilline + 2 diphosphate,
2,4-diacetamido-2,4,6-trideoxy-β-L-gulopyranose + phosphoenolpyruvate + H2O → 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonate + phosphate,
genistein + dimethylallyl diphosphate → isowighteone + diphosphate,
ω, mono-trans, poly-cis-hexaprenyl diphosphate + isopentenyl diphosphate = ω, mono-trans, poly-cis-heptaprenyl diphosphate + diphosphate,
vanillate + all-trans-hexaprenyl diphosphate → 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + diphosphate,
all-trans-octaprenyl diphosphate + 1,4-dihydroxy-6-naphthoate + H+ → CO2 + demethylmenaquinol-8 + diphosphate,
2'-hydroxygenistein + dimethylallyl diphosphate → luteone + diphosphate,
umbelliferone + dimethylallyl diphosphate → demethylsuberosin + diphosphate,
ardeemin FQ + dimethylallyl diphosphate → ardeemin + diphosphate,
L-selenocysteine + O-phospho-L-homoserine → L-selenocystathionine + phosphate,
3 dimethylallyl diphosphate + 2 isopentenyl diphosphate = geranylfarnesyl diphosphate + 4 diphosphate,
L-cysteine + O-phospho-L-homoserine → L-cystathionine + phosphate,
4-prenylphlorisovalerophenone + dimethylallyl diphosphate → diprenylphlorisovalerophenone + diphosphate,
4,6,8-trihydroxydibenzodiazepinone + (2E,6E)-farnesyl diphosphate = diazepinomicin + diphosphate,
hydrodidemethylasterriquinone D + dimethylallyl diphosphate + an oxidized unknown electron acceptor + 2 H+ → ochrindole D + an reduced unknown electron acceptor + diphosphate + H2O,
4-prenylphlorisobutyrophenone + dimethylallyl diphosphate → diprenylphlorisobutyrophenone + diphosphate,
terpendole C + 2 dimethylallyl diphosphate → 20,21-diprenylterpendole C + 2 diphosphate,
(2E,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = all-trans-dodecaprenyl diphosphate + 9 diphosphate,
fusicoccin P + dimethylallyl diphosphate → fusicoccin J + diphosphate,
dehydrohistidyltryptophanyldiketopiperazine + dimethylallyl diphosphate → roquefortine C + diphosphate,
apo-4'-lycopenoate → neurosporaxanthin,
cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate → β-cyclopiazonate + diphosphate,
(-)-indolactam V + geranyl diphosphate → lyngbyatoxin A + diphosphate,
6-hydroxymethyl-7,8-dihydropterin + 4-aminobenzoate = 7,8-dihydropteroate + H2O,
(R)-benzodiazepinedione + dimethylallyl diphosphate → aszonalenin + diphosphate,
protocatechuate + all-trans-hexaprenyl diphosphate → 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + diphosphate,
paspalinine + dimethylallyl diphosphate → aflatrem + diphosphate,
chlorophyllide b + phytyl diphosphate + H+ → chlorophyll b + diphosphate,
4-O-acetyl-N-acetylmannosamine + phosphoenolpyruvate + H2O → N-acetyl-7-O-acetylneuraminate + phosphate,
geranylgeranyl diphosphate + 3 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 3 diphosphate,
heme b + (2E,6E)-farnesyl diphosphate + H2O ↔ heme o + diphosphate,
terpendole I + 2 dimethylallyl diphosphate → 20,21-diprenylterpendole I + 2 diphosphate,
(2E,6E)-farnesyl diphosphate + 2-methyl-4-hydroxyquinoline → aurachin D + diphosphate,
1,4-dihydroxy-2-naphthoate + dimethylallyl diphosphate → alizarin,
cadaverine + S-adenosyl 3-(methylthio)propylamine → aminopropylcadaverine + S-methyl-5'-thioadenosine + H+,
(2E,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = all-trans-tridecaprenyl diphosphate + 10 diphosphate,
terpendole J + 2 dimethylallyl diphosphate → 20,21-diprenylterpendole J + 2 diphosphate,
chlorophyllide a + geranylgeranyl diphosphate + H+ → geranylgeranyl-chlorophyll a + diphosphate,
ochrindole D + dimethylallyl diphosphate → terrequinone A + diphosphate,
phlorisobutyrophenone + dimethylallyl diphosphate → 4-prenylphlorisobutyrophenone + diphosphate + H+,
6-hydroxy-deoxybrevianamide E + dimethylallyl diphosphate → notoamide S + diphosphate,
2,3-dihydroxybenzoyl adenylate + a holo-[EntB isochorismatase/aryl-carrier protein] → a 2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H+

Enzymes and Genes:
2,3-dihydroxybenzoate-AMP ligase: entE ( Escherichia coli K-12 substr. MG1655 )
enterobactin synthase: entB, entD, entF, entE ( Escherichia coli K-12 substr. MG1655 )
6-hydroxy-deoxybrevianamide E prenyltransferase: notC ( Aspergillus sp. MF297-2 )
phlorisobutyrophenone dimethylallyltransferase ( Hypericum calycinum )
phlorisobutyrophenone dimethylallyltransferase ( Humulus lupulus )
spermidine synthase: speE ( Escherichia coli K-12 substr. MG1655 )
2-methyl-4-hydroxyquinoline farnesyltransferase: auaA ( Stigmatella aurantiaca Sg a15 )
2-methyl-4-hydroxy-quinoline farnesyltransferase: rauB ( Rhodococcus erythropolis JCM 6824 )
heme O synthase: cyoE ( Escherichia coli K-12 substr. MG1655 )
heptaprenyl diphosphate synthase: hepS, hepT ( Bacillus subtilis )
7-O-acetyl-N-acetylneuraminate synthase: neuB1 ( Aliivibrio salmonicida LFI1238 )
dimethylallyl-diphosphate:paspalinine dimethylallyltransferase, AtmD: atmD ( Aspergillus flavus )
benzodiazepinedione prenyltransferase: AnaPT ( Neosartorya fischeri )
indolactam V geranyltransferase: ltxC ( Moorea producens )
cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase: CpaD ( Aspergillus oryzae )
diterpene glucoside O-glucose prenyltransferase: PAPT ( Diaporthe amygdali )
multifunctional diprenyltransferase: LtmE ( Epichloe festucae )
prenyltransferase ( Humulus lupulus )
ABBA prenyltransferase DzmP: dzmP ( Micromonospora sp. RV115 )
prenyltransferase ( Humulus lupulus )
cystathionine γ-synthase / selenocystathione synthase: CGS1 ( Arabidopsis thaliana col )
ardeemin FQ prenyltransferase: ardB ( Neosartorya fischeri )
dimethylallyl diphosphate:umbelliferone dimethylallyltransferase ( Ammi majus )
diacetamido-8-epilegionaminic acid synthase: orf4 ( Escherichia coli O108 )
paxilline prenyltransferase: paxD ( Penicillium paxilli ATCC 26601 )
prenyltransferase ( Humulus lupulus )
3,4-dideosy-4-amino-D-arabino-heptulosonate 7-phosphate synthase: rifH ( Amycolatopsis mediterranei )
multifunctional aromatic O-prenyltransferase: LtmF ( Epichloe festucae )
NPP:olivetolate neryltransferase / GPP:olivetolate geranyltransferase ( Cannabis sativa )
DMAPP:isoflavone dimethylallyl transferase ( Lupinus albus )
2-keto-3-deoxy-D-glycero-D-galacto-nononate-9-phosphate synthase ( Oncorhynchus mykiss )
2-keto-3-deoxy-D-glycero-D-galacto-nononate-9-phosphate synthase: BT1714 ( Bacteroides thetaiotaomicron VPI-5482 )
xanthan ketal pyruvate transferase: gumL ( Xanthomonas campestris )
chlorophyll synthetase: G4 ( Arabidopsis thaliana col )
bisindolylquinone prenyltransferase: tdiB ( Aspergillus nidulans )
rubber transferase ( Hevea brasiliensis )
farnesyl-5,7-dihydroxy-4,6-dimethylphthalide synthase: andD ( Aspergillus stellatus )
D-galactose-2,6-sulfurylase II ( Chondrus crispus )
D-galactose-2,6-sulfurylase I ( Chondrus crispus )
apo-4'-lycopenoate cyclase / 3,4-didehydrolycopene cyclase: al-2 ( Neurospora crassa )
PhzA/B: phzA/B ( Burkholderia lata )
hexaprenyl-diphosphate hexaprenyltransferase: COQ2 ( Saccharomyces cerevisiae )
roquefortine synthase: roqD ( Penicillium chrysogenum )
5-hydroxyanthrotainin geranyltransferase: VrtC ( Penicillium aethiopicum )
bacillithiol-S-transferase: fosB ( Staphylococcus aureus aureus N315 )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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