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MetaCyc EC 3.5.1 -- In linear amides

Parent Class: EC-Numbers3 -- Hydrolases3.5 -- Acting on carbon-nitrogen bonds, other than peptide bonds

Instances:
3.5.1.1 -- asparaginase,
3.5.1.2 -- glutaminase,
3.5.1.3 -- ω-amidase,
3.5.1.4 -- amidase,
3.5.1.5 -- urease,
3.5.1.6 -- β-ureidopropionase,
3.5.1.7 -- ureidosuccinase,
3.5.1.8 -- formylaspartate deformylase,
3.5.1.9 -- arylformamidase,
3.5.1.10 -- formyltetrahydrofolate deformylase,
3.5.1.11 -- penicillin amidase,
3.5.1.12 -- biotinidase,
3.5.1.13 -- aryl-acylamidase,
3.5.1.14 -- N-acyl-aliphatic-L-amino acid amidohydrolase,
3.5.1.15 -- aspartoacylase,
3.5.1.16 -- acetylornithine deacetylase,
3.5.1.17 -- acyl-lysine deacylase,
3.5.1.18 -- succinyl-diaminopimelate desuccinylase,
3.5.1.19 -- nicotinamidase,
3.5.1.20 -- citrullinase,
3.5.1.21 -- N-acetyl-β-alanine deacetylase,
3.5.1.22 -- pantothenase,
3.5.1.23 -- ceramidase,
3.5.1.24 -- choloylglycine hydrolase,
3.5.1.25 -- N-acetylglucosamine-6-phosphate deacetylase,
3.5.1.26 -- N4-(β-N-acetylglucosaminyl)-L-asparaginase,
3.5.1.28 -- N-acetylmuramoyl-L-alanine amidase,
3.5.1.29 -- 2-(acetamidomethylene)succinate hydrolase,
3.5.1.30 -- 5-aminopentanamidase,
3.5.1.31 -- formylmethionine deformylase,
3.5.1.32 -- hippurate hydrolase,
3.5.1.33 -- N-acetylglucosamine deacetylase,
3.5.1.35 -- D-glutaminase,
3.5.1.36 -- N-methyl-2-oxoglutaramate hydrolase,
3.5.1.38 -- glutamin-(asparagin-)ase,
3.5.1.39 -- alkylamidase,
3.5.1.40 -- acylagmatine amidase,
3.5.1.41 -- chitin deacetylase,
3.5.1.42 -- nicotinamide-nucleotide amidase,
3.5.1.43 -- peptidyl-glutaminase,
3.5.1.44 -- protein-glutamine glutaminase,
3.5.1.46 -- 6-aminohexanoate-oligomer exohydrolase ,
3.5.1.47 -- N-acetyldiaminopimelate deacetylase,
3.5.1.48 -- acetylspermidine deacetylase,
3.5.1.49 -- formamidase,
3.5.1.50 -- pentanamidase,
3.5.1.51 -- 4-acetamidobutyryl-CoA deacetylase,
3.5.1.52 -- peptide-N4-(N-acetyl-β-glucosaminyl)asparagine amidase,
3.5.1.53 -- N-carbamoylputrescine amidase,
3.5.1.54 -- allophanate hydrolase,
3.5.1.55 -- long-chain-fatty-acyl-glutamate deacylase,
3.5.1.56 -- N,N-dimethylformamidase,
3.5.1.57 -- tryptophanamidase,
3.5.1.58 -- N-benzyloxycarbonylglycine hydrolase,
3.5.1.59 -- N-carbamoylsarcosine amidase,
3.5.1.60 -- N-(long-chain-acyl)ethanolamine deacylase,
3.5.1.61 -- mimosinase,
3.5.1.62 -- acetylputrescine deacetylase,
3.5.1.63 -- 4-acetamidobutyrate deacetylase,
3.5.1.64 -- Nα-benzyloxycarbonylleucine hydrolase,
3.5.1.65 -- theanine hydrolase,
3.5.1.66 -- 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase,
3.5.1.67 -- 4-methyleneglutaminase,
3.5.1.68 -- N-formylglutamate deformylase,
3.5.1.69 -- glycosphingolipid deacylase,
3.5.1.70 -- aculeacin-A deacylase,
3.5.1.71 -- N-feruloylglycine deacylase,
3.5.1.72 -- D-benzoylarginine-4-nitroanilide amidase,
3.5.1.73 -- carnitinamidase,
3.5.1.74 -- chenodeoxycholoyltaurine hydrolase,
3.5.1.75 -- urethanase,
3.5.1.76 -- arylalkyl acylamidase,
3.5.1.77 -- N-carbamoyl-D-amino-acid hydrolase,
3.5.1.78 -- glutathionylspermidine amidase,
3.5.1.79 -- phthalyl amidase,
3.5.1.81 -- N-acyl-D-amino-acid deacylase,
3.5.1.82 -- N-acyl-D-glutamate deacylase,
3.5.1.83 -- N-acyl-D-aspartate deacylase,
3.5.1.84 -- biuret amidohydrolase,
3.5.1.85 -- (S)-N-acetyl-1-phenylethylamine hydrolase,
3.5.1.86 -- mandelamide amidase,
3.5.1.87 -- N-carbamoyl-L-amino-acid hydrolase,
3.5.1.88 -- peptide deformylase,
3.5.1.89 -- N-acetylglucosaminylphosphatidylinositol deacetylase,
3.5.1.90 -- adenosylcobinamide hydrolase,
3.5.1.91 -- N-substituted formamide deformylase,
3.5.1.92 -- pantetheine hydrolase,
3.5.1.93 -- glutaryl-7-aminocephalosporanic-acid acylase,
3.5.1.94 -- γ-glutamyl-γ-aminobutyrate hydrolase,
3.5.1.95 -- N-malonylurea hydrolase,
3.5.1.96 -- succinylglutamate desuccinylase,
3.5.1.97 -- acyl-homoserine-lactone acylase,
3.5.1.98 -- histone deacetylase,
3.5.1.99 -- fatty acid amide hydrolase,
3.5.1.100 -- (R)-amidase,
3.5.1.101 -- L-proline amide hydrolase,
3.5.1.102 -- 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5′-monophosphate deformylase,
3.5.1.103 -- N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase,
3.5.1.104 -- peptidoglycan-N-acetylglucosamine deacetylase,
3.5.1.105 -- chitin disaccharide deacetylase,
3.5.1.106 -- N-formylmaleamate deformylase,
3.5.1.107 -- maleamate amidohydrolase,
3.5.1.108 -- UDP-3-O-acyl-N-acetylglucosamine deacetylase,
3.5.1.109 -- sphingomyelin deacylase,
3.5.1.110 -- peroxyureidoacrylate/ureidoacrylate amidohydrolase,
3.5.1.111 -- 2-oxoglutaramate amidase,
3.5.1.112 -- 2′-N-acetylparomamine deacetylase,
3.5.1.113 -- 2′′′-acetyl-6′′′-hydroxyneomycin C deacetylase,
3.5.1.114 -- N-acyl-aromatic-L-amino acid amidohydrolase,
3.5.1.115 -- mycothiol S-conjugate amidase,
3.5.1.116 -- ureidoglycolate amidohydrolase,
3.5.1.117 -- 6-aminohexanoate-oligomer endohydrolase ,
3.5.1.118 -- γ-glutamyl hercynylcysteine S-oxide hydrolase,
3.5.1.x -- Pup deamidase

Unofficial Reactions:
N5-phenyl-L-glutamine + H2O → L-glutamate + aniline + H+,
3-methylglutaconyl-CoA + N5-hydroxy-L-ornithine → methylglutaconyl hydroxy ornithine + coenzyme A,
oxamate + H2O = oxalate + ammonium,
N-acetyl-β-D-glucosaminyl-(1→4)-D-glucosamine + H2O = chitobiose + acetate,
N,N'-diacetylchitobiose + H2O → 2-acetamido-4-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-2-deoxy-D-glucose + acetate,
N-(3-hydroxybutan-2-yl)acetamide + H2O → 3-amino-2-butanol + acetate,
pyrazinamide + H2O = ammonium + pyrazine-2-carboxylate,
4-ureido-5-imidazole carboxylate + H2O + 2 H+ → 4-amino-5-imidazole carboxylate + CO2 + ammonium,
γ-glutamylanilide diol + H2O → 1-aminocyclohexa-3,5-diene-1,2-diol + L-glutamate,
N-formyldemecolcine + H2O → demecolcine + formate,
echinocandin B + H2O → echinocandin B nucleus + linoleate,
indole-3-acetyl-glutamate-N-beta-D-glucose + H2O → indole-3-acetyl-N-beta-D-glucose + L-glutamate,
2'''-acetyl-6'''-hydroxyparomomycin + H2O → 6'''-hydroxyparomomycin + acetate,
5-acetamidovalerate + H2O → 5-aminopentanoate + acetate,
an [L-2-aminoadipate carrier protein]-L-ornithine + H2O → L-ornithine + a [LysW protein]-L-glutamate,
indole-3-acetyl-leucine + H2O → indole-3-acetate + L-leucine,
4-hydroxy-2-nonenal-N-acetyl-L-cysteine + H2O = 4-hydroxy-2-nonenal-[L-Cys] conjugate + acetate,
linuron + H2O → N,O-dimethylhydroxylamine + CO2 + 3,4-dichloroaniline,
a [LysW]-C-terminal-L-glutamyl-γ-L-lysine + H2O ↔ L-lysine + a [LysW protein]-L-glutamate,
indole-3-acetyl-aspartate-N-beta-D-glucose + H2O → indole-3-acetyl-N-beta-D-glucose + L-aspartate,
chitotriose + H2O = N,N''-diacetylchitotriose + acetate,
(Z)-N,N'-(but-2-ene-2,3-diyl)diacetamide + H2O → N-(3-oxobutan-2-yl)acetamide + acetamide,
formylaminopyrimidine + H2O → aminomethylpyrimidine + formate,
p-aminobenzoyl glutamate + H2O → 4-aminobenzoate + L-glutamate,
2-formylaminobenzaldehyde + H2O → O-aminobenzaldehyde + formate + H+,
2-oxosuccinamate + H2O → oxaloacetate + ammonium,
indole-3-acetyl-alanine + H2O → indole-3-acetate + L-alanine,
myristoylated pyoverdine intermediate + H2O = pyoverdine biosynthetic intermediate + myristate + H+,
a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O → a [lipoyl-carrier protein]-L-lysine + (R)-lipoate

Enzymes and Genes:
lipoamidase: lpa ( Enterococcus faecalis )
lipoamidase ( Listeria monocytogenes )
pyoverdine intermediate deacylase: pvdQ ( Pseudomonas aeruginosa )
indole-3-acetyl-ala hydrolase: ill2 ( Arabidopsis thaliana col )
indole-3-acetyl-ala hydrolase: iar3 ( Arabidopsis thaliana col )
2-oxosuccinamate deamidase ( Pisum sativum )
p-aminobenzoyl-glutamate hydrolase: abgB, abgA ( Escherichia coli K-12 substr. MG1655 )
p-aminobenzoylglutamate hydrolase ( Arabidopsis thaliana )
N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase: ylmB ( Bacillus halodurans )
(Z)-N,N'-(but-2-ene-2,3-diyl)diacetamide hydrolase: tpdC ( Rhodococcus sp. TMP1 )
chitin oligosaccharide deacetylase: cod ( Vibrio cholerae O1 biovar El Tor str. N16961 )
[L-2-aminoadipate carrier protein]-L-lysine lysine-hydrolase: lysK ( Thermus thermophilus )
phenylurea hydrolase A: puhA ( Arthrobacter globiformis D47 )
phenylurea hydrolase B: puhB ( Mycobacterium brisbanense JK1 )
linuron hydrolase: libA ( Variovorax sp. SRS16 )
linuron hydrolase: hylA ( Variovorax sp. WDL1 )
aminoacylase 3: ACY3 ( Homo sapiens )
indole-3-acetyl-leu hydrolase: AT3G02875 ( Arabidopsis thaliana col )
L-2-aminoadipate carrier protein]-lysine/ornithine hydrolase: lysK ( Sulfolobus acidocaldarius )
2'''-acetyl-6'''-hydroxyparomomycin deacetylase: livD ( Streptomyces lividus )
echinocandin B deacylase ( Actinoplanes utahensis )
N-formyldemecolcine deformylase [multifunctional] ( Colchicum autumnale )
4-ureido-5-imidazolecarboxylate amidohydrolase ( Clostridium cylindrosporum )
nicotinamidase / pyrazinamidase: pncA ( Escherichia coli K-12 substr. MG1655 )
chitin deacetylase: cda ( Colletotrichum lindemuthianum )
diacetylchitobiose deacetylase: dac ( Thermococcus kodakarensis KOD1 )
N-hydroxyornithine acylase: Fer5 ( Ustilago maydis )
N-glutamylanilide hydrolase / N-glutamylanilide diol hydrolase: atdA2 ( Acinetobacter sp. YAA )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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