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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc EC 6.2.1 -- Acid--thiol ligases

Parent Class: EC-Numbers 6 -- Ligases 6.2 -- Forming carbon-sulfur bonds

Instances:
6.2.1.1 -- acetate—CoA ligase ,
6.2.1.2 -- butyrate—CoA ligase ,
6.2.1.3 -- long-chain-fatty-acid—CoA ligase ,
6.2.1.4 -- succinate—CoA ligase (GDP-forming) ,
6.2.1.5 -- succinate—CoA ligase (ADP-forming) ,
6.2.1.6 -- glutarate—CoA ligase ,
6.2.1.7 -- cholate—CoA ligase ,
6.2.1.8 -- oxalate—CoA ligase ,
6.2.1.9 -- malate—CoA ligase ,
6.2.1.10 -- carboxylic acid—CoA ligase (GDP-forming) ,
6.2.1.11 -- biotin—CoA ligase ,
6.2.1.12 -- 4-coumarate—CoA ligase ,
6.2.1.13 -- acetate—CoA ligase (ADP-forming) ,
6.2.1.14 -- 6-carboxyhexanoate—CoA ligase ,
6.2.1.15 -- arachidonate—CoA ligase ,
6.2.1.16 -- acetoacetate—CoA ligase ,
6.2.1.17 -- propionate—CoA ligase ,
6.2.1.18 -- citrate—CoA ligase ,
6.2.1.19 -- long-chain-fatty-acid—luciferin-component ligase ,
6.2.1.20 -- long-chain-fatty-acid—[acyl-carrier-protein] ligase ,
6.2.1.22 -- [citrate (pro-3S)-lyase] ligase ,
6.2.1.23 -- dicarboxylate—CoA ligase ,
6.2.1.24 -- phytanate—CoA ligase ,
6.2.1.25 -- benzoate—CoA ligase ,
6.2.1.26 -- o-succinylbenzoate—CoA ligase ,
6.2.1.27 -- 4-hydroxybenzoate—CoA ligase ,
6.2.1.28 -- 3α,7α-dihydroxy-5β-cholestanate—CoA ligase ,
6.2.1.30 -- phenylacetate—CoA ligase ,
6.2.1.31 -- 2-furoate—CoA ligase ,
6.2.1.32 -- anthranilate—CoA ligase ,
6.2.1.33 -- 4-chlorobenzoate—CoA ligase ,
6.2.1.34 -- trans-feruloyl-CoA synthase ,
6.2.1.35 -- ACP-SH:acetate ligase ,
6.2.1.36 -- 3-hydroxypropionyl-CoA synthase ,
6.2.1.37 -- 3-hydroxybenzoate—CoA ligase ,
6.2.1.38 -- (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase ,
6.2.1.39 -- [butirosin acyl-carrier protein]—L-glutamate ligase ,
6.2.1.40 -- 4-hydroxybutyrate—CoA ligase ,
6.2.1.41 -- 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate—CoA ligase ,
6.2.1.43 -- 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase ,
6.2.1.f -- 3-oxocholest-4-en-26-oate–CoA ligase ,
6.2.1.i -- ubiquitin-activating enzyme E1

Unofficial Reactions:
L-carnitine + ATP + coenzyme A → L-carnitinyl-CoA + AMP + diphosphate ,
cyclohexane-1-carboxylate + ATP + coenzyme A + H2O → cyclohexane-1-carbonyl-CoA + AMP + 2 phosphate + H+ ,
3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-octanoate + ATP + coenzyme A → OPC8-CoA + AMP + diphosphate ,
sulfoacetate + ATP + coenzyme A → sulfoacetyl-CoA + AMP + diphosphate ,
citronellate + ATP + coenzyme A → citronellyll-CoA + AMP + diphosphate ,
an in-chain hydroxy fatty acid + ATP + coenzyme A → a hydroxyacyl-CoA + AMP + diphosphate ,
an ω-hydroxy fatty acid + ATP + coenzyme A → a hydroxyacyl-CoA + AMP + diphosphate ,
malonate + ATP + coenzyme A → malonyl-CoA + AMP + diphosphate ,
3,24-dioxo-cholest-4-en-26-oate + ATP + coenzyme A → 3,24-dioxocholest-4-en-26-oyl-CoA + AMP + diphosphate ,
3-oxo-24-ethyl-cholest-4-en-26-oate + ATP + coenzyme A → 3-oxo-24-ethyl-cholest-4-en-26-oyl-CoA + AMP + diphosphate ,
2-furoate + ATP + coenzyme A → 2-furoyl-CoA + ADP + phosphate ,
L-β-phenylalanine + ATP + coenzyme A → (3R)-3-amino-3-phenylpropanoyl-CoA + AMP + diphosphate ,
hexanoate + ATP + coenzyme A → hexanoyl-CoA + AMP + diphosphate ,
2-naphthoate + ATP + coenzyme A → 2-naphthoyl-CoA + AMP + diphosphate ,
3-sulfinopropionate + ATP + coenzyme A → 3-sulfinopropanoyl-CoA + ADP + phosphate ,
5-aminolevulinate + ATP + coenzyme A → 5-aminolevulinyl-CoA + AMP + diphosphate ,
trans-cinnamate + ATP + coenzyme A → (E)-cinnamoyl-CoA + AMP + diphosphate ,
N-methylanthranilate + ATP + coenzyme A → N-methylanthraniloyl-CoA + AMP + diphosphate ,
a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acid + ATP + coenzyme A → a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA + AMP + diphosphate ,
malonate + a holo-[acyl-carrier protein] + ATP → a malonyl-[acp] + AMP + diphosphate ,
an HmqF protein + decanoate + ATP → a decanoyl-HmqF protein + AMP + diphosphate ,
L-proline + [PigG peptidyl-carrier protein] + ATP → L-prolyl-S-[PigG peptidyl-carrier protein] + AMP + diphosphate ,
a C52-α-meroacyl-[acp] + ATP + H2O → a C52-α-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate ,
a cis-methoxy-C59-meroacyl-[acp] + ATP + H2O → a cis-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate ,
a trans-methoxy-C60-meroacyl-[acp] + ATP + H2O → a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate ,
a cis-keto-C60-meroacyl-[acp] + ATP + H2O → a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate ,
a trans-keto-C61-meroacyl-[acp] + ATP + H2O → a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate

Enzymes and Genes:
acyl-CoA synthetase : fadD32 ( Mycobacterium tuberculosis H37Rv )
L-proline--[PigG acyl-carrier protein] ligase : pigI ( Serratia marcescens )
decanoyl-[acp] 2-dehydrogenase : hmqF ( Burkholderia thailandensis E264 )
malonyl-ACP synthetase ( Pisum sativum )
cinnamate:CoA ligase : CNL ( Hypericum calycinum )
cinnamate:CoA ligase : CNL ( Petunia x hybrida )
cinnamate:CoA ligase : encH ( Streptomyces maritimus )
cinnamate:CoA ligase ( Hypericum androsaemum )
acyl-CoA ligase : ORF35 ( Streptomyces aizunenesis NRRL-B-11277 )
succinyl-CoA synthetase : sucD , sucC ( Advenella mimigardefordensis DPN7 )
hexanoyl-CoA synthetase : AAE1 ( Cannabis sativa )
acyl-CoA synthetase : alkK ( Pseudomonas oleovorans )
acyl-CoA synthetase : LACS6 ( Arabidopsis thaliana col )
acyl-CoA synthetase : LACS7 ( Arabidopsis thaliana col )
long-chain-fatty-acid--CoA ligase 1 : ACSL1 ( Homo sapiens )
very long-chain acyl-CoA synthetase : SLC27A2 ( Homo sapiens )
Long-chain-fatty-acid--CoA ligase ACSBG2 : ACSBG2 ( Homo sapiens )
Long-chain-fatty-acid--CoA ligase ACSBG1 : ACSBG1 ( Homo sapiens )
fatty-acid-Coenzyme A ligase, long-chain 6 : FACL6 ( Homo sapiens )
Long-chain-fatty-acid--CoA ligase 4 : ACSL4 ( Homo sapiens )
Long-chain-fatty-acid--CoA ligase 5 : ACSL5 ( Homo sapiens )
Long-chain-fatty-acid--CoA ligase 6 : ACSL6 ( Homo sapiens )
Long-chain-fatty-acid--CoA ligase 3 : ACSL3 ( Homo sapiens )
acyl-CoA synthetase : FAA2 ( Saccharomyces cerevisiae )
short chain acyl-CoA synthetase : fadK ( Escherichia coli K-12 substr. MG1655 )
fatty acyl-CoA synthetase : fadD ( Escherichia coli K-12 substr. MG1655 )
furoyl-CoA synthetase : hmfD ( Cupriavidus basilensis )
malonate-CoA synthetase ( Pisum sativum )
fatty acyl-CoA synthetase : ACOS5 ( Arabidopsis thaliana col )
sulfoacetate-CoA ligase (AMP-forming) : SauT ( Ralstonia eutropha H16 )
3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase : OPCL1 ( Arabidopsis thaliana col )
cyclohexanecarboxylate-CoA ligase : aliA ( Rhodopseudomonas palustris )
carnitine-CoA ligase : caiC ( Escherichia coli K-12 substr. MG1655 )


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc14.