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MetaCyc EC 6.2.1 -- Acid--thiol ligases

Parent Class: EC-Numbers6 -- Ligases6.2 -- Forming carbon-sulfur bonds

Instances:
6.2.1.1 -- acetate—CoA ligase,
6.2.1.2 -- butyrate—CoA ligase,
6.2.1.3 -- long-chain-fatty-acid—CoA ligase,
6.2.1.4 -- succinate—CoA ligase (GDP-forming),
6.2.1.5 -- succinate—CoA ligase (ADP-forming),
6.2.1.6 -- glutarate—CoA ligase,
6.2.1.7 -- cholate—CoA ligase,
6.2.1.8 -- oxalate—CoA ligase,
6.2.1.9 -- malate—CoA ligase,
6.2.1.10 -- carboxylic acid—CoA ligase (GDP-forming),
6.2.1.11 -- biotin—CoA ligase,
6.2.1.12 -- 4-coumarate—CoA ligase,
6.2.1.13 -- acetate—CoA ligase (ADP-forming),
6.2.1.14 -- 6-carboxyhexanoate—CoA ligase,
6.2.1.15 -- arachidonate—CoA ligase,
6.2.1.16 -- acetoacetate—CoA ligase,
6.2.1.17 -- propionate—CoA ligase,
6.2.1.18 -- citrate—CoA ligase,
6.2.1.19 -- long-chain-fatty-acid--protein ligase,
6.2.1.20 -- long-chain-fatty-acid—[acyl-carrier-protein] ligase,
6.2.1.22 -- [citrate (pro-3S)-lyase] ligase,
6.2.1.23 -- dicarboxylate—CoA ligase,
6.2.1.24 -- phytanate—CoA ligase,
6.2.1.25 -- benzoate—CoA ligase,
6.2.1.26 -- o-succinylbenzoate—CoA ligase,
6.2.1.27 -- 4-hydroxybenzoate—CoA ligase,
6.2.1.28 -- 3α,7α-dihydroxy-5β-cholestanate—CoA ligase,
6.2.1.30 -- phenylacetate—CoA ligase,
6.2.1.31 -- 2-furoate—CoA ligase,
6.2.1.32 -- anthranilate—CoA ligase,
6.2.1.33 -- 4-chlorobenzoate—CoA ligase,
6.2.1.34 -- trans-feruloyl-CoA synthase,
6.2.1.35 -- ACP-SH:acetate ligase,
6.2.1.36 -- 3-hydroxypropionyl-CoA synthase,
6.2.1.37 -- 3-hydroxybenzoate—CoA ligase,
6.2.1.38 -- (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase,
6.2.1.39 -- [butirosin acyl-carrier protein]—L-glutamate ligase,
6.2.1.40 -- 4-hydroxybutyrate—CoA ligase,
6.2.1.41 -- 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate—CoA ligase,
6.2.1.42 -- 3-oxocholest-4-en-26-oate—CoA ligase,
6.2.1.43 -- 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase,
6.2.1.44 -- 3-(methylthio)propionyl—CoA ligase,
6.2.1.45 -- E1 ubiquitin-activating enzyme,
6.2.1.46 -- L-allo-isoleucine:holo-[CmaA peptidyl-carrier protein] ligase,
6.2.1.l -- medium-chain-fatty-acid--[acyl-carrier-protein] ligase

Unofficial Reactions:
trans-cinnamate + ATP + coenzyme A → (E)-cinnamoyl-CoA + AMP + diphosphate,
3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-octanoate + ATP + coenzyme A → OPC8-CoA + AMP + diphosphate,
hexanoate + ATP + coenzyme A → hexanoyl-CoA + AMP + diphosphate,
cyclohexane-1-carboxylate + ATP + coenzyme A + H2O → cyclohexane-1-carbonyl-CoA + AMP + 2 phosphate + H+,
malonamate + ATP + coenzyme A → malonamoyl-CoA + AMP + diphosphate,
(3R)-β-phenylalanine + ATP + coenzyme A → (3R)-3-amino-3-phenylpropanoyl-CoA + AMP + diphosphate,
5-aminolevulinate + ATP + coenzyme A → 5-aminolevulinyl-CoA + AMP + diphosphate,
citronellate + ATP + coenzyme A → citronellyll-CoA + AMP + diphosphate,
sulfoacetate + ATP + coenzyme A → sulfoacetyl-CoA + AMP + diphosphate,
a (2R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acid + ATP + coenzyme A → a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA + AMP + diphosphate,
2,4-dichlorobenzoate + ATP + coenzyme A = 2,4-dichlorobenzoyl-CoA + AMP + diphosphate,
an ω-hydroxy long-chain fatty acid + ATP + coenzyme A → an ω-hydroxy long-chain fatty acyl-CoA + AMP + diphosphate,
3-sulfinopropionate + ATP + coenzyme A → 3-sulfinopropanoyl-CoA + ADP + phosphate,
3-oxo-24-ethyl-cholest-4-en-26-oate + ATP + coenzyme A → 3-oxo-24-ethyl-cholest-4-en-26-oyl-CoA + AMP + diphosphate,
N-methylanthranilate + ATP + coenzyme A → N-methylanthraniloyl-CoA + AMP + diphosphate,
malonate + ATP + coenzyme A → malonyl-CoA + AMP + diphosphate,
L-carnitine + ATP + coenzyme A → L-carnitinyl-CoA + AMP + diphosphate,
2-furoate + ATP + coenzyme A → 2-furoyl-CoA + ADP + phosphate,
2-naphthoate + ATP + coenzyme A → 2-naphthoyl-CoA + AMP + diphosphate,
4-aminobenzoate + ATP + coenzyme A → 4-aminobenzoyl-CoA + ADP + phosphate,
3,24-dioxo-cholest-4-en-26-oate + ATP + coenzyme A → 3,24-dioxocholest-4-en-26-oyl-CoA + AMP + diphosphate,
a holo-[seryl-carrier protein] + L-serine + ATP → an L-seryl-[seryl-carrier protein] + AMP + diphosphate,
a holo-[tryptophanyl-carrier protein] + L-tryptophan + ATP → an L-tryptophanyl-[tryptophanyl-carrier protein] + AMP + diphosphate,
a C52-α-meroacyl-[acp] + ATP + H2O → a C52-α-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate,
a fatty acid + a holo-[acyl-carrier protein] + ATP → a 2,3,4-saturated fatty acyl-[acp] + AMP + diphosphate,
a cis-methoxy-C59-meroacyl-[acp] + ATP + H2O → a cis-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate,
malonate + a holo-[acyl-carrier protein] + ATP → a malonyl-[acp] + AMP + diphosphate,
a trans-keto-C61-meroacyl-[acp] + ATP + H2O → a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate,
a cis-keto-C60-meroacyl-[acp] + ATP + H2O → a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate,
2-aminoisobutyrate + ATP + a holo-[acyl-carrier protein] → a 2-aminoisobutanoyl-[acp] + AMP + diphosphate,
L-proline + a holo-[PigG peptidyl-carrier protein] + ATP → L-prolyl-S-[PigG peptidyl-carrier protein] + AMP + diphosphate,
a trans-methoxy-C60-meroacyl-[acp] + ATP + H2O → a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate

Enzymes and Genes:
L-proline--[PigG acyl-carrier protein] ligase: pigI ( Serratia marcescens )
fumiquinazoline F-indoline-2'-2-aminobutyryl-3'-ol synthetase: TqaB ( Penicillium aethiopicum )
malonyl-ACP synthetase ( Pisum sativum )
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase: aas ( Escherichia coli K-12 substr. MG1655 )
acyl-CoA synthetase: fadD32 ( Mycobacterium tuberculosis H37Rv )
tryptophanyl-carrier-protein Ecm13: ecm13 ( Streptomyces lasaliensis )
tryptophanyl-carrier-protein Swb11: swb11 ( Streptomyces sp. SNA15896 )
L-serine--[seryl-carrier protein] ligase: zmaJ ( Bacillus cereus )
L-serine--[seryl-carrier protein] ligase: gdnB ( Streptomyces sp. K01-0509 )
4-aminobenzoate--CoA ligase: fscA ( Streptomyces sp. FR-008 )
2-naphthoate-CoA ligase: N47_B20660 ( delta proteobacterium N47 )
furoyl-CoA synthetase: hmfD ( Cupriavidus basilensis )
carnitine-CoA ligase: caiC ( Escherichia coli K-12 substr. MG1655 )
malonate-CoA synthetase ( Pisum sativum )
succinyl-CoA synthetase: sucD, sucC ( Advenella mimigardefordensis DPN7 )
fatty acyl-CoA synthetase: ACOS5 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 3: LACS3 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 8: LACS8 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 1: LACS1 ( Arabidopsis thaliana col )
long chain acyl-CoA synthetase 5: LACS5 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 4: LACS4 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 9: LACS9 ( Arabidopsis thaliana col )
long-chain-fatty-acid-CoA ligase 1: Acs1 ( Rattus norvegicus )
long-chain-fatty-acid—CoA ligase: FX056196 ( Botryococcus braunii BOT88-2 )
sulfoacetate-CoA ligase (AMP-forming): SauT ( Ralstonia eutropha H16 )
acyl-CoA ligase: ORF35 ( Streptomyces aizunenesis NRRL-B-11277 )
malonamate-CoA ligase: VrtB ( Penicillium aethiopicum )
cyclohexanecarboxylate-CoA ligase: aliA ( Rhodopseudomonas palustris )
hexanoyl-CoA synthetase: AAE1 ( Cannabis sativa )
long-chain acyl-CoA synthetase 6: LACS6 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 7: LACS7 ( Arabidopsis thaliana col )
long-chain-fatty-acid--CoA ligase 1: ACSL1 ( Homo sapiens )
very long-chain acyl-CoA synthetase: SLC27A2 ( Homo sapiens )
long-chain acyl-CoA synthetase 8 ACSBG2: ACSBG2 ( Homo sapiens )
long-chain acyl-CoA synthetase ACSBG1: ACSBG1 ( Homo sapiens )
long-chain acyl-CoA synthetase 4: ACSL4 ( Homo sapiens )
long-chain acyl-CoA synthetase 5: ACSL5 ( Homo sapiens )
long-chain acyl-CoA synthetase 6: ACSL6 ( Homo sapiens )
long-chain acyl-CoA synthetase 3: ACSL3 ( Homo sapiens )
medium-chain acyl-CoA synthetase: FAA2 ( Saccharomyces cerevisiae )
short chain acyl-CoA synthetase: fadK ( Escherichia coli K-12 substr. MG1655 )
fatty acyl-CoA synthetase: fadD ( Escherichia coli K-12 substr. MG1655 )
3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase: OPCL1 ( Arabidopsis thaliana col )
cinnamate:CoA ligase: CNL ( Hypericum calycinum )
cinnamate:CoA ligase: CNL ( Petunia x hybrida )
cinnamate:CoA ligase: encH ( Streptomyces maritimus )
cinnamate:CoA ligase ( Hypericum androsaemum )


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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