Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
twitter

MetaCyc EC 6.2.1 -- Acid--thiol ligases

Parent Class: EC-Numbers 6 -- Ligases 6.2 -- Forming carbon-sulfur bonds

Instances:
6.2.1.1 -- acetate—CoA ligase ,
6.2.1.2 -- butyrate—CoA ligase ,
6.2.1.3 -- long-chain-fatty-acid—CoA ligase ,
6.2.1.4 -- succinate—CoA ligase (GDP-forming) ,
6.2.1.5 -- succinate—CoA ligase (ADP-forming) ,
6.2.1.6 -- glutarate—CoA ligase ,
6.2.1.7 -- cholate—CoA ligase ,
6.2.1.8 -- oxalate—CoA ligase ,
6.2.1.9 -- malate—CoA ligase ,
6.2.1.10 -- carboxylic acid—CoA ligase (GDP-forming) ,
6.2.1.11 -- biotin—CoA ligase ,
6.2.1.12 -- 4-coumarate—CoA ligase ,
6.2.1.13 -- acetate—CoA ligase (ADP-forming) ,
6.2.1.14 -- 6-carboxyhexanoate—CoA ligase ,
6.2.1.15 -- arachidonate—CoA ligase ,
6.2.1.16 -- acetoacetate—CoA ligase ,
6.2.1.17 -- propionate—CoA ligase ,
6.2.1.18 -- citrate—CoA ligase ,
6.2.1.19 -- long-chain-fatty-acid—luciferin-component ligase ,
6.2.1.20 -- long-chain-fatty-acid—[acyl-carrier-protein] ligase ,
6.2.1.22 -- [citrate (pro-3S)-lyase] ligase ,
6.2.1.23 -- dicarboxylate—CoA ligase ,
6.2.1.24 -- phytanate—CoA ligase ,
6.2.1.25 -- benzoate—CoA ligase ,
6.2.1.26 -- o-succinylbenzoate—CoA ligase ,
6.2.1.27 -- 4-hydroxybenzoate—CoA ligase ,
6.2.1.28 -- 3α,7α-dihydroxy-5β-cholestanate—CoA ligase ,
6.2.1.30 -- phenylacetate—CoA ligase ,
6.2.1.31 -- 2-furoate—CoA ligase ,
6.2.1.32 -- anthranilate—CoA ligase ,
6.2.1.33 -- 4-chlorobenzoate—CoA ligase ,
6.2.1.34 -- trans-feruloyl-CoA synthase ,
6.2.1.35 -- ACP-SH:acetate ligase ,
6.2.1.36 -- 3-hydroxypropionyl-CoA synthase ,
6.2.1.37 -- 3-hydroxybenzoate—CoA ligase ,
6.2.1.38 -- (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase ,
6.2.1.39 -- [butirosin acyl-carrier protein]—L-glutamate ligase ,
6.2.1.40 -- 4-hydroxybutyrate—CoA ligase ,
6.2.1.41 -- 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate—CoA ligase ,
6.2.1.42 -- 3-oxocholest-4-en-26-oate–CoA ligase ,
6.2.1.43 -- 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase ,
6.2.1.44 -- 3-(methylthio)propionyl--CoA ligase ,
6.2.1.i -- E1 ubiquitin-activating enzyme ,
6.2.1.k -- L-allo-isoleucine:holo-[CmaA peptidyl-carrier protein] ligase

Unofficial Reactions:
a (2R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acid + ATP + coenzyme A → a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA + AMP + diphosphate ,
an ω-hydroxy long-chain fatty acid + ATP + coenzyme A → an ω-hydroxy long-chain fatty acyl-CoA + AMP + diphosphate ,
N-methylanthranilate + ATP + coenzyme A → N-methylanthraniloyl-CoA + AMP + diphosphate ,
citronellate + ATP + coenzyme A → citronellyll-CoA + AMP + diphosphate ,
(3R)-β-phenylalanine + ATP + coenzyme A → (3R)-3-amino-3-phenylpropanoyl-CoA + AMP + diphosphate ,
malonamate + ATP + coenzyme A → malonamoyl-CoA + AMP + diphosphate ,
3-sulfinopropionate + ATP + coenzyme A → 3-sulfinopropanoyl-CoA + ADP + phosphate ,
3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-octanoate + ATP + coenzyme A → OPC8-CoA + AMP + diphosphate ,
trans-cinnamate + ATP + coenzyme A → (E)-cinnamoyl-CoA + AMP + diphosphate ,
3,24-dioxo-cholest-4-en-26-oate + ATP + coenzyme A → 3,24-dioxocholest-4-en-26-oyl-CoA + AMP + diphosphate ,
hexanoate + ATP + coenzyme A → hexanoyl-CoA + AMP + diphosphate ,
5-aminolevulinate + ATP + coenzyme A → 5-aminolevulinyl-CoA + AMP + diphosphate ,
4-aminobenzoate + ATP + coenzyme A → 4-aminobenzoyl-CoA + ADP + phosphate ,
2-furoate + ATP + coenzyme A → 2-furoyl-CoA + ADP + phosphate ,
cyclohexane-1-carboxylate + ATP + coenzyme A + H2O → cyclohexane-1-carbonyl-CoA + AMP + 2 phosphate + H+ ,
malonate + ATP + coenzyme A → malonyl-CoA + AMP + diphosphate ,
sulfoacetate + ATP + coenzyme A → sulfoacetyl-CoA + AMP + diphosphate ,
3-oxo-24-ethyl-cholest-4-en-26-oate + ATP + coenzyme A → 3-oxo-24-ethyl-cholest-4-en-26-oyl-CoA + AMP + diphosphate ,
L-carnitine + ATP + coenzyme A → L-carnitinyl-CoA + AMP + diphosphate ,
2-naphthoate + ATP + coenzyme A → 2-naphthoyl-CoA + AMP + diphosphate ,
malonate + a holo-[acyl-carrier protein] + ATP → a malonyl-[acp] + AMP + diphosphate ,
a trans-keto-C61-meroacyl-[acp] + ATP + H2O → a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate ,
a fatty acid + a holo-[acyl-carrier protein] + ATP → a 2,3,4-saturated fatty acyl-[acp] + AMP + diphosphate ,
a cis-methoxy-C59-meroacyl-[acp] + ATP + H2O → a cis-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate ,
a C52-α-meroacyl-[acp] + ATP + H2O → a C52-α-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate ,
L-proline + a holo-[PigG peptidyl-carrier protein] + ATP → L-prolyl-S-[PigG peptidyl-carrier protein] + AMP + diphosphate ,
a trans-methoxy-C60-meroacyl-[acp] + ATP + H2O → a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate ,
2-aminoisobutyrate + ATP + a holo-[acyl-carrier protein] → a 2-aminoisobutanoyl-[acp] + AMP + diphosphate ,
a cis-keto-C60-meroacyl-[acp] + ATP + H2O → a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein] + diphosphate

Enzymes and Genes:
fumiquinazoline F-indoline-2'-2-aminobutyryl-3'-ol synthetase : TqaB ( Penicillium aethiopicum )
L-proline--[PigG acyl-carrier protein] ligase : pigI ( Serratia marcescens )
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase : aas ( Escherichia coli K-12 substr. MG1655 )
acyl-CoA synthetase : fadD32 ( Mycobacterium tuberculosis H37Rv )
malonyl-ACP synthetase ( Pisum sativum )
2-naphthoate-CoA ligase : N47_B20660 ( delta proteobacterium N47 )
carnitine-CoA ligase : caiC ( Escherichia coli K-12 substr. MG1655 )
sulfoacetate-CoA ligase (AMP-forming) : SauT ( Ralstonia eutropha H16 )
malonate-CoA synthetase ( Pisum sativum )
cyclohexanecarboxylate-CoA ligase : aliA ( Rhodopseudomonas palustris )
furoyl-CoA synthetase : hmfD ( Cupriavidus basilensis )
4-aminobenzoate--CoA ligase : fscA ( Streptomyces sp. FR-008 )
acyl-CoA ligase : ORF35 ( Streptomyces aizunenesis NRRL-B-11277 )
hexanoyl-CoA synthetase : AAE1 ( Cannabis sativa )
cinnamate:CoA ligase : CNL ( Hypericum calycinum )
cinnamate:CoA ligase : CNL ( Petunia x hybrida )
cinnamate:CoA ligase : encH ( Streptomyces maritimus )
cinnamate:CoA ligase ( Hypericum androsaemum )
3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase : OPCL1 ( Arabidopsis thaliana col )
succinyl-CoA synthetase : sucD , sucC ( Advenella mimigardefordensis DPN7 )
malonamate-CoA ligase : VrtB ( Penicillium aethiopicum )
fatty acyl-CoA synthetase : ACOS5 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 3 : LACS3 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 8 : LACS8 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 1 : LACS1 ( Arabidopsis thaliana col )
long chain acyl-CoA synthetase 5 : LACS5 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 4 : LACS4 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 9 : LACS9 ( Arabidopsis thaliana col )
long-chain-fatty-acid-CoA ligase 1 : Acs1 ( Rattus norvegicus )
long-chain-fatty-acid—CoA ligase : FX056196 ( Botryococcus braunii BOT88-2 )
long-chain acyl-CoA synthetase 6 : LACS6 ( Arabidopsis thaliana col )
long-chain acyl-CoA synthetase 7 : LACS7 ( Arabidopsis thaliana col )
long-chain-fatty-acid--CoA ligase 1 : ACSL1 ( Homo sapiens )
very long-chain acyl-CoA synthetase : SLC27A2 ( Homo sapiens )
long-chain acyl-CoA synthetase 8 ACSBG2 : ACSBG2 ( Homo sapiens )
long-chain acyl-CoA synthetase ACSBG1 : ACSBG1 ( Homo sapiens )
long-chain acyl-CoA synthetase 4 : ACSL4 ( Homo sapiens )
long-chain acyl-CoA synthetase 5 : ACSL5 ( Homo sapiens )
long-chain acyl-CoA synthetase 6 : ACSL6 ( Homo sapiens )
long-chain acyl-CoA synthetase 3 : ACSL3 ( Homo sapiens )
medium-chain acyl-CoA synthetase : FAA2 ( Saccharomyces cerevisiae )
short chain acyl-CoA synthetase : fadK ( Escherichia coli K-12 substr. MG1655 )
fatty acyl-CoA synthetase : fadD ( Escherichia coli K-12 substr. MG1655 )


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Aug 30, 2015, biocyc11.