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MetaCyc Gene-Ontology-Terms Class: GO:0000166 - nucleotide binding

Definition: Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Parent Classes:
GO:0036094 - small molecule binding,
GO:1901265 - nucleoside phosphate binding

Child Classes:
GO:0008327 - methyl-CpG binding (1),
GO:0017076 - purine nucleotide binding (367),
GO:0030551 - cyclic nucleotide binding (2),
GO:0032553 - ribonucleotide binding (389),
GO:0050660 - flavin adenine dinucleotide binding (58),
GO:0050661 - NADP binding (28),
GO:0051287 - NAD binding (46)

Term Members:
ThiS protein,
glycerate kinase II (glxK),
chaperone protein DnaK,
putative protein secretion protein for export (gspE),
primosome factor N' (priA),
50S ribosomal subunit protein L23 (rplW),
MalT transcriptional activator,
GlnK,
RhlB,
serine/threonine kinase HipA,
DNA polymerase III, τ subunit (dnaX),
predicted carbon-phosphorus lyase subunit (phnK),
PhnL subunit of methylphosphonate degradation complex,
methionine adenosyltransferase (metK),
molybdenum cofactor cytidylyltransferase (mocA),
triphosphoribosyl-dephospho-CoA synthase (citG),
GTP cyclohydrolase I monomer (folE),
nicotinate-mononucleotide adenylyltransferase (nadD),
NadE,
NadR DNA-binding transcriptional repressor and NMN adenylyltransferase,
glucokinase (glk),
L-rhamnulose kinase (rhaB),
L-ribulokinase monomer (araB),
sulfate adenylyltransferase, CysN subunit,
sulfate adenylyltransferase, CysD subunit,
CysC,
glycerate kinase I (garK),
2-keto-3-deoxygluconokinase (kdgK),
6-deoxy-6-sulfofructose kinase (yihV),
AsnA,
AsnB,
D-gluconate kinase, thermosensitive (idnK),
D-gluconate kinase, thermostable (gntK),
2-dehydro-3-deoxygalactonate kinase (dgoK),
propionyl-CoA synthetase (prpE),
fructoselysine 6-kinase (frlD),
anhydro-N-acetylmuramic acid kinase (anmK),
UDP-N-acetylmuramate:L-alanyl-γ-D-glutamyl-meso-diaminoheptanedioate-D-alanine ligase [multifunctional] (mpl),
glutamine synthetase (glnA),
glutamate-putrescine ligase (puuA),
ribose 1,5-bisphosphokinase (phnN),
ribose-phosphate diphosphokinase (prs),
GDP pyrophosphokinase / GTP pyrophosphokinase (relA),
N-acetylmannosamine kinase (nanK),
L-fuculokinase (fucK),
D-allose kinase (alsK),
ribokinase (rbsK),
1-phosphofructokinase monomer (fruK),
NAD kinase monomer (nadK),
pyridine nucleotide transhydrogenase, α subunit (pntA),
GlgC,
ThiD,
dTMP kinase (tmk),
acetylglutamate kinase monomer (argB),
LysC,
ThrA,
MetL,
7-cyano-7-deazaguanine synthase (queC),
D-alanyl-D-alanine-adding enzyme (murF),
UDP-N-acetylmuramate-alanine ligase (murC),
UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (murD),
UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase (murE),
D-alanine-D-alanine ligase A (ddlA),
D-alanine-D-alanine ligase B (ddlB),
L-xylulose kinase (lyxK),
propionate kinase (tdcD),
hypoxanthine-guanine phosphoribosyltransferase (hpt),
Gsk,
dihydroxyacetone kinase subunit L (dhaL),
dihydroxyacetone kinase subunit M (dhaM),
PurC,
N5-carboxyaminoimidazole ribonucleotide synthetase monomer (purK),
PurA,
adenylate kinase (adk),
shikimate kinase II (aroL),
shikimate dehydrogenase (aroE),
ThiS adenylyltransferase (thiF),
GlpK,
thiamine monophosphate kinase (thiL),
IspE,
acetate kinase (ackA),
Upp,
uridine kinase / cytidine kinase (udk),
cytidylate kinase (cmk),
MenE,
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (folK),
thymidine kinase / deoxyuridine kinase (tdk),
UMP kinase (pyrH),
PyrG,
pyruvate kinase II monomer (pykA),
pyruvate kinase I monomer (pykF),
phosphoglycerate kinase (pgk),
glyceraldehyde 3-phosphate dehydrogenase-A monomer (gapA),
6-phosphofructokinase-2 monomer (pfkB),
phosphoenolpyruvate synthetase (ppsA),
fructose-1,6-bisphosphatase monomer (fbp),
N6-L-threonylcarbamoyladenine synthase, TsaE subunit,
threonylcarbamoyl-AMP synthase (tsaC),
dethiobiotin synthetase monomer (bioD),
carbamoyl phosphate synthetase, α chain (carA),
carbamoyl phosphate synthetase, β chain,
arginyl-tRNA synthetase (argS),
cysteinyl-tRNA synthetase (cysS),
glutaminyl-tRNA synthetase (glnS),
glutamyl-tRNA synthetase (gltX),
isoleucyl-tRNA synthetase (ileS),
leucyl-tRNA synthetase (leuS),
valyl-tRNA synthetase (valS),
alanyl-tRNA synthetase (alaS),
asparaginyl-tRNA synthetase (asnS),
aspartyl-tRNA synthetase (aspS),
tyrosyl-tRNA synthetase (tyrS),
tryptophanyl-tRNA synthetase (trpS),
threonyl-tRNA synthetase (thrS),
prolyl-tRNA synthetase (proS),
phenylalanyl-tRNA synthetase β-chain (pheT),
phenylalanyl-tRNA synthetase α-chain (pheS),
lysyl tRNA synthetase (LysRSs), constitutive (lysS),
histidyl-tRNA synthetase (hisS),
glycyl-tRNA synthetase, α subunit (glyQ),
glycyl-tRNA synthetase, β subunit (glyS),
methionyl-tRNA synthetase (metG),
succinyl-CoA synthetase, β subunit,
succinyl-CoA synthetase, α subunit (sucD),
molybdopterin biosynthesis protein A (moaA),
molybdopterin synthase small subunit (moaD),
molybdopterin adenylyltransferase (mog),
molybdopterin-synthase adenylyltransferase (moeB),
hydroxyethylthiazole kinase (thiM),
pantetheine-phosphate adenylyltransferase monomer (coaD),
dephospho-CoA kinase (coaE),
phosphoenolpyruvate carboxykinase (ATP) (pck),
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (hisI),
HisG,
phosphoribosylamine-glycine ligase (purD),
phosphoribosylformylglycinamide synthetase (purL),
PurM,
phosphoribosylglycinamide formyltransferase 2 (purT),
PdxK,
pyridoxal kinase 2 (pdxY),
D-arabinose 5-phosphate isomerase (gutQ),
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (rfaE),
5-formyltetrahydrofolate cyclo-ligase (fau),
bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase (folC),
pantothenate synthetase monomer (panC),
pantothenate kinase monomer (coaA),
bifunctional biotin-[acetyl-CoA-carboxylase] ligase and transcriptional repressor (birA),
AccC,
acetyl-CoA carboxyltransferase, α subunit (accA),
acetyl-CoA carboxyltransferase, β subunit (accD),
lipopolysaccharide core heptose (I) kinase (waaP),
lipopolysaccharide core heptose (II) kinase (waaY),
tetraacyldisaccharide 4'-kinase (lpxK),
6-phosphofructokinase-1 monomer (pfkA),
FadD,
short chain acyl-CoA synthetase (fadK),
γ-glutamate-cysteine ligase (gshA),
glutathione synthetase monomer (gshB),
bifunctional riboflavin kinase / FMN adenylyltransferase (ribF),
GTP cyclohydrolase II (ribA),
mannose-1-phosphate guanylyltransferase (cpsB),
galactokinase (galK),
TdcB,
selenide, water dikinase (selD),
seryl-tRNA synthetase (serS),
ProB,
Lon,
tRNAMet cytidine acetyltransferase (tmcA),
Ndk,
oxalyl-CoA decarboxylase (oxc),
DgkA,
branch migration of Holliday structures; repair (ruvA),
branch migration of Holliday structures; repair helicase (ruvB),
lipid kinase (yegS),
RecB,
RecC,
RecD,
RNase III (rnc),
deoxyribodipyrimidine photolyase (photoreactivation) (phr),
excision nuclease subunit A (uvrA),
DNA repair; excision nuclease subunit B (uvrB),
diguanylate cyclase (dgcP),
diguanylate cyclase (dosC),
diguanylate cyclase (dgcT),
diguanylate cyclase (dgcZ),
diguanylate cyclase (dgcM),
diguanylate cyclase (dgcC),
RNA/ssDNA exonuclease 5' → 3' specific (yciV),
EF-P-lysine lysyltransferase (epmA),
cAMP phosphodiesterase (cpdA),
NAD(P)H:quinone oxidoreductase (wrbA),
autophosphorylating protein tyrosine kinase (etk),
protein-tyrosine kinase (wzc),
xylulokinase (xylB),
lipoate-protein ligase A (lplA),
PII,
glutamine synthetase adenylyltransferase / glutamine synthetase deadenylase (glnE),
chaperone for [Fe-S] cluster biosynthesis (hscA),
AceK,
serine/threonine protein kinase (rdoA),
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase (aas),
ribonucleoside diphosphate reductase 1, α subunit (nrdA),
NrdE,
guanylate kinase (gmk),
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF),
bis(molybdenum cofactor) synthase [multifunctional] (mobA),
tRNA-specific 2-thiouridylase (mnmA),
GMP synthetase (guaA),
adenylate cyclase (cyaA),
DNA polymerase II (polB),
N-acetyl-D-glucosamine kinase (nagK),
ribosomal protein S6 modification protein (rimK),
GTPase, involved in modification of U34 in tRNA (mnmE),
acetyl-CoA synthetase (AMP-forming) (acs),
MutS,
MutL,
c-di-GMP phosphodiesterase (pdeH),
cyclic di-GMP phosphodiesterase (pdeF),
DNA gyrase, subunit B (gyrB),
DNA gyrase, subunit A,
YdiB,
thiamin kinase (thiK),
RNase D (rnd),
ThiI,
tRNA C32 thiolase (ttcA),
DnaB,
Rep helicase,
ATP-dependent DNA helicase (recQ),
glutamyl-Q tRNAAsp synthetase (gluQ),
tRNA(i6A37) synthase (miaA),
ATP-dependent zinc metalloprotease FtsH,
host restriction; endonuclease R (hsdR),
ClpX,
ClpA,
regulatory ATPase (ravA),
ribosome-binding ATPase, inhibitor of catalase activity (ychF),
tRNAIle-lysidine synthetase (tilS),
tRNA threonylcarbamoyladenosine dehydratase (tcdA),
MrcB subunit of 5-methylcytosine restriction system (mcrB),
UDP-sugar hydrolase / 5'-ribonucleotidase / 5'-deoxyribonucleotidase (ushA),
pyrimidine nucleotidase (yjjG),
dCMP phosphohydrolase (yfbR),
GTPase that interacts with methylmalonyl-CoA mutase (argK),
ribosome small subunit-dependent GTPase A (rsgA),
GTPase associated with the 50S subunit of the ribosome (hflX),
50S ribosomal subunit stability factor (der),
selenocysteyl-tRNA-specific translation elongation factor (selB),
accessory protein for nickel incorporation into hydrogenase isoenzymes (hypB),
P-loop guanosine triphosphatase (yjiA),
ATP-dependent RNA helicase, specific for 23S rRNA (dbpA),
ssDNA and dsDNA binding, ATP binding (recF),
broad specificity 5'(3')-nucleotidase and polyphosphatase (umpG),
nucleoside triphosphate pyrophosphohydrolase (mazG),
ITPase/XTPase (yjjX),
Ppk,
poly(A) polymerase I (pcnB),
RNA 3'-terminal phosphate cyclase (rtcA),
ribonucleoside-triphosphate reductase (nrdD),
manno(fructo)kinase (mak),
RdgB,
Gss,
fused tRNA nucleotidyltransferase / 2',3'-cyclic phosphodiesterase / 2' nucleotidase and phosphatase (cca),
purine nucleoside phosphoramidase monomer (hinT),
ATPase component of the HslVU protease (hslU),
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB),
lysyl-tRNA synthetase (lysU),
EntE,
apo-serine activating enzyme (entF),
ThrB,
xylose ABC transporter - ATP binding subunit (xylG),
taurine ABC transporter - ATP binding subunit (tauB),
ABC complex for formation and release of holoCcmE - ATP binding subunit (ccmA),
dipeptide ABC transporter - putative ATP binding subunit (dppF),
dipeptide ABC transporter - putative ATP binding subunit (dppD),
glutamate / aspartate ABC transporter - ATP binding subunit (gltL),
arabinose ABC transporter - ATP binding subunit (araG),
glutathione ABC transporter - ATP binding subunit (gsiA),
phosphate ABC transporter - ATP binding subunit (pstB),
D-allose ABC transporter - ATP binding subunit (alsA),
glutamine ABC transporter - ATP binding subunit (glnQ),
Zn2+ ABC transporter - ATP binding subunit (znuC),
glycine betaine ABC transporter - putative ATP binding subunit (yehX),
branched chain amino acid transporter - ATP binding subunit (livG),
branched chain amino acid ABC transporter - ATP binding subunit (livF),
ATP synthase F1 complex - alpha subunit (atpA),
ATP synthase F1 complex - beta subunit (atpD),
Cu+ efflux ATPase (copA),
molybdate ABC transporter - ATP binding subunit (modC),
L-arginine ABC transporter - ATP binding subunit (artP),
AI-2 ABC transporter - ATP binding subunit (lsrA),
K+ transporting ATPase - KdpC subunit,
K+ transporting ATPase - ATP binding subunit (kdpB),
glycine betaine / proline ABC transporter - ATP binding subunit (proV),
phosphonate ABC transporter - ATP binding subunit (phnC),
maltose ABC transporter - ATP binding subunit (malK),
aliphatic sulfonate ABC transporter - ATP binding subunit (ssuB),
glycerol-3-phosphate ABC transporter - ATP binding subunit (ugpC),
zinc, cadmium and lead efflux system (zntA),
L-methionine / D-methionine ABC transporter - ATP binding subunit (metN),
L-cystine ABC transporter - predicted ATP binding subunit (tcyN),
galactose ABC transporter - ATP binding subunit (mglA),
murein tripeptide ABC transporter / peptide ABC transporter - putative ATP binding subunit (oppF),
murein tripeptide ABC transporter / peptide ABC transporter - putative ATP binding subunit (oppD),
nickel ABC transporter - ATP binding subunit (nikE),
nickel ABC transporter - ATP binding subunit (nikD),
sulfate / thiosulfate ABC transporter - ATP binding subunit (cysA),
putrescine ABC transporter - ATP binding subunit (potG),
putrescine / spermidine ABC transporter - ATP binding subunit (potA),
glutathione / L-cysteine efflux transporter - CydC subunit,
glutathione / L-cysteine efflux transporter - CydD subunit,
galactofuranose / galactopyranose ABC transporter - putative ATP binding subunit (ytfR),
ATP-binding lipopolysaccharide transport protein (msbA),
ribose ABC transporter - putative ATP binding subunit (rbsA),
KefC,
vitamin B12 ABC transporter - ATP binding subunit (btuD),
ferric dicitrate ABC transporter - ATP binding subunit (fecE),
ferric enterobactin ABC transporter - ATP binding subunit (fepC),
iron (III) hydroxamate ABC transporter - ATP binding subunit (fhuC),
Fe2+ transporter FeoB,
LptB,
bifunctional coenzyme A synthase (COASY),
5-dehydro-2-deoxy-D-gluconate kinase (iolC),
CTP synthetase (pyrG),
deoxyadenosine/deoxycytidine kinase monomer (dck),
cancer-related nucleoside-triphosphatase (NTPCR),
lipoate-protein ligase (lplJ),
4-amino-2-methyl-5-phosphomethylpyrimidine kinase (thiD),
thiamine monophosphate kinase (thiL),
ThiI,
ThiS sulfur carrier protein,
[sulfur-carrier protein ThiS] adenylyltransferase (thiF),
thiamine pyrophosphokinase (thiN),
hydroxyethylthiazole kinase monomer (thiM),
retinol dehydrogenase 3 (DHRS3),
GTP cyclohydrolase I (folEA),
7-cyano-7-deazaguanine synthase (queC)

Unification Links: GO:0000166


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue May 3, 2016, biocyc14.