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MetaCyc Gene-Ontology-Terms Class: GO:0000166 - nucleotide binding

Definition: Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Parent Classes:
GO:0036094 - small molecule binding ,
GO:1901265 - nucleoside phosphate binding

Child Classes:
GO:0008327 - methyl-CpG binding (1) ,
GO:0017076 - purine nucleotide binding (359) ,
GO:0030551 - cyclic nucleotide binding (2) ,
GO:0032553 - ribonucleotide binding (380) ,
GO:0050660 - flavin adenine dinucleotide binding (60) ,
GO:0050661 - NADP binding (27) ,
GO:0051287 - NAD binding (46)

Term Members:
ThiS protein ,
primosome factor N' (priA) ,
50S ribosomal subunit protein L23 (rplW) ,
putative protein secretion protein for export (gspE) ,
RhlB ,
serine/threonine kinase HipA ,
MalT transcriptional activator ,
GlnK ,
chaperone protein DnaK ,
DNA polymerase III, τ subunit (dnaX) ,
predicted carbon-phosphorous lyase subunit (phnK) ,
phosphoribosylamine-glycine ligase (purD) ,
phosphoribosylformylglycinamide synthetase (purL) ,
PurM ,
bifunctional biotin-[acetyl-CoA-carboxylase] ligase and transcriptional repressor (birA) ,
AccC ,
acetyl-CoA carboxyltransferase, α subunit (accA) ,
acetyl-CoA carboxyltransferase, β subunit (accD) ,
lipopolysaccharide core heptose (I) kinase (waaP) ,
lipopolysaccharide core heptose (II) kinase (waaY) ,
tetraacyldisaccharide 4'-kinase (lpxK) ,
D-arabinose 5-phosphate isomerase (gutQ) ,
pantothenate synthetase monomer (panC) ,
pantothenate kinase monomer (coaA) ,
pantetheine-phosphate adenylyltransferase monomer (coaD) ,
dephospho-CoA kinase (coaE) ,
acetylglutamate kinase monomer (argB) ,
LysC ,
ThrA ,
MetL ,
pyridoxal kinase 2 (pdxY) ,
D-alanyl-D-alanine-adding enzyme (murF) ,
UDP-N-acetylmuramate-alanine ligase (murC) ,
UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (murD) ,
UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase (murE) ,
D-alanine-D-alanine ligase A (ddlA) ,
D-alanine-D-alanine ligase B (ddlB) ,
GTP cyclohydrolase I monomer (folE) ,
7-cyano-7-deazaguanine synthase (queC) ,
glutamate-putrescine ligase (puuA) ,
carbamoyl phosphate synthetase, α chain (carA) ,
carbamoyl phosphate synthetase, β chain ,
sulfate adenylyltransferase, CysN subunit ,
sulfate adenylyltransferase, CysD subunit ,
CysC ,
dTMP kinase (tmk) ,
UMP kinase (pyrH) ,
PyrG ,
AsnA ,
AsnB ,
Upp ,
uridine kinase / cytidine kinase (udk) ,
thymidine kinase / deoxyuridine kinase (tdk) ,
FadD ,
short chain acyl-CoA synthetase (fadK) ,
IspE ,
phosphoribosylglycinamide formyltransferase 2 (purT) ,
D-gluconate kinase, thermosensitive (idnK) ,
GntK ,
bifunctional riboflavin kinase / FMN adenylyltransferase (ribF) ,
GTP cyclohydrolase II (ribA) ,
γ-glutamate-cysteine ligase (gshA) ,
glutathione synthetase monomer (gshB) ,
selenide, water dikinase (selD) ,
acetyl-CoA synthetase (AMP-forming) (acs) ,
propionyl-CoA synthetase (prpE) ,
TdcB ,
shikimate kinase II (aroL) ,
shikimate dehydrogenase (aroE) ,
PhnL subunit of methylphosphonate degradation complex ,
L-xylulose kinase (lyxK) ,
N-acetylmannosamine kinase (nanK) ,
L-fuculokinase (fucK) ,
D-allose kinase (alsK) ,
nicotinate-mononucleotide adenylyltransferase (nadD) ,
NadE ,
NadR DNA-binding transcriptional repressor and NMN adenylyltransferase ,
ribokinase (rbsK) ,
NAD kinase monomer (nadK) ,
pyridine nucleotide transhydrogenase, α subunit (pntA) ,
1-phosphofructokinase monomer (fruK) ,
glycerate kinase I (garK) ,
pyruvate kinase II monomer (pykA) ,
pyruvate kinase I monomer (pykF) ,
phosphoglycerate kinase (pgk) ,
6-phosphofructokinase-2 monomer (pfkB) ,
phosphoenolpyruvate synthetase (ppsA) ,
fructose-1,6-bisphosphatase monomer (fbp) ,
methionine adenosyltransferase (metK) ,
L-rhamnulose kinase (rhaB) ,
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (hisI) ,
HisG ,
PurC ,
N5-carboxyaminoimidazole ribonucleotide synthetase monomer (purK) ,
GuaB ,
PurA ,
adenylate kinase (adk) ,
ribose-phosphate diphosphokinase (prs) ,
ribose 1,5-bisphosphokinase (phnN) ,
L-ribulokinase monomer (araB) ,
2-keto-3-deoxygluconokinase (kdgK) ,
MenE ,
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (folK) ,
mannose-1-phosphate guanylyltransferase (cpsB) ,
2-dehydro-3-deoxygalactonate kinase (dgoK) ,
glutamyl-tRNA synthetase (gltX) ,
PdxK ,
ThiD ,
hydroxyethylthiazole kinase (thiM) ,
thiamin monophosphate kinase (thiL) ,
ThiS adenylyltransferase (thiF) ,
molybdopterin biosynthesis protein A (moaA) ,
molybdopterin synthase small subunit (moaD) ,
molybdopterin adenylyltransferase (mog) ,
molybdopterin-synthase adenylyltransferase (moeB) ,
anhydro-N-acetylmuramic acid kinase (anmK) ,
UDP-N-acetylmuramate:L-alanyl-γ-D-glutamyl-meso-diaminoheptanedioate-D-alanine ligase [multifunctional] (mpl) ,
fructoselysine 6-kinase (frlD) ,
GlnA ,
6-deoxy-6-sulfofructose kinase (yihV) ,
glycerate kinase II (glxK) ,
molybdenum cofactor cytidylyltransferase (mocA) ,
triphosphoribosyl-dephospho-CoA synthase (citG) ,
GlpK ,
succinyl-CoA synthetase, β subunit ,
succinyl-CoA synthetase, α subunit (sucD) ,
dihydroxyacetone kinase subunit L (dhaL) ,
dihydroxyacetone kinase subunit M (dhaM) ,
GlgC ,
propionate kinase (tdcD) ,
acetate kinase (ackA) ,
glucokinase (glk) ,
GDP pyrophosphokinase / GTP pyrophosphokinase (relA) ,
5-formyltetrahydrofolate cyclo-ligase (fau) ,
bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase (folC) ,
arginyl-tRNA synthetase (argS) ,
cysteinyl-tRNA synthetase (cysS) ,
glutaminyl-tRNA synthetase (glnS) ,
isoleucyl-tRNA synthetase (ileS) ,
leucyl-tRNA synthetase (leuS) ,
valyl-tRNA synthetase (valS) ,
alanyl-tRNA synthetase (alaS) ,
asparaginyl-tRNA synthetase (asnS) ,
aspartyl-tRNA synthetase (aspS) ,
tyrosyl-tRNA synthetase (tyrS) ,
tryptophanyl-tRNA synthetase (trpS) ,
threonyl-tRNA synthetase (thrS) ,
seryl-tRNA synthetase (serS) ,
prolyl-tRNA synthetase (proS) ,
phenylalanyl-tRNA synthetase β-chain (pheT) ,
phenylalanyl-tRNA synthetase α-chain (pheS) ,
lysyl tRNA synthetase (LysRSs), constitutive (lysS) ,
histidyl-tRNA synthetase (hisS) ,
glycyl-tRNA synthetase, α subunit (glyQ) ,
glycyl-tRNA synthetase, β subunit (glyS) ,
methionyl-tRNA synthetase (metG) ,
dethiobiotin synthetase monomer (bioD) ,
6-phosphofructokinase-1 monomer (pfkA) ,
cytidylate kinase (cmk) ,
hypoxanthine-guanine phosphoribosyltransferase (hpt) ,
Gsk ,
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (rfaE) ,
galactokinase (galK) ,
phosphoenolpyruvate carboxykinase (ATP) (pck) ,
NAD(P)H:quinone oxidoreductase (wrbA) ,
tRNA threonylcarbamoyladenosine dehydratase (tcdA) ,
GTPase that interacts with methylmalonyl-CoA mutase (argK) ,
ribosome small subunit-dependent GTPase A (rsgA) ,
GTPase associated with the 50S subunit of the ribosome (hflX) ,
50S ribosomal subunit stability factor (der) ,
selenocysteyl-tRNA-specific translation elongation factor (selB) ,
accessory protein for nickel incorporation into hydrogenase isoenzymes (hypB) ,
P-loop guanosine triphosphatase (yjiA) ,
fused tRNA nucleotidyltransferase / 2',3'-cyclic phosphodiesterase / 2' nucleotidase and phosphatase (cca) ,
autophosphorylating protein tyrosine kinase (etk) ,
protein-tyrosine kinase (wzc) ,
guanylate kinase (gmk) ,
ProB ,
thiamin kinase (thiK) ,
manno(fructo)kinase (mak) ,
purine nucleoside phosphoramidase monomer (hinT) ,
GMP synthetase (guaA) ,
ThrB ,
ATP-dependent RNA helicase, specific for 23S rRNA (dbpA) ,
tRNAMet cytidine acetyltransferase (tmcA) ,
N-acetyl-D-glucosamine kinase (nagK) ,
RNase D (rnd) ,
DgkA ,
host restriction; endonuclease R (hsdR) ,
lipid kinase (yegS) ,
ITPase/XTPase (yjjX) ,
adenylate cyclase (cyaA) ,
RdgB ,
diguanylate cyclase (yeaP) ,
diguanylate cyclase (ycdT) ,
diguanylate cyclase (dgcZ) ,
diguanylate cyclase (ydaM) ,
EF-P-lysine lysyltransferase (epmA) ,
cAMP phosphodiesterase (cpdA) ,
DNA gyrase, subunit B (gyrB) ,
DNA gyrase, subunit A ,
poly(A) polymerase I (pcnB) ,
RNA 3'-terminal phosphate cyclase (rtcA) ,
xylulokinase (xylB) ,
Gss ,
ClpX ,
ClpA ,
Ndk ,
oxalyl-CoA decarboxylase (oxc) ,
regulatory ATPase (ravA) ,
tRNA-specific 2-thiouridylase (mnmA) ,
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF) ,
broad specificity 5'(3')-nucleotidase and polyphosphatase (umpG) ,
pyrimidine nucleotidase (yjjG) ,
RNase III (rnc) ,
nucleoside triphosphate pyrophosphohydrolase (mazG) ,
ribosomal protein S6 modification protein (rimK) ,
YdiB ,
GTPase, involved in modification of U34 in tRNA (mnmE) ,
ThiI ,
tRNA C32 thiolase (ttcA) ,
diguanylate cyclase (dosC) ,
c-di-GMP phosphodiesterase (yhjH) ,
cyclic di-GMP phosphodiesterase (yfgF) ,
Ppk ,
lysyl-tRNA synthetase (lysU) ,
branch migration of Holliday structures; repair (ruvA) ,
branch migration of Holliday structures; repair helicase (ruvB) ,
DNA polymerase II (polB) ,
deoxyribodipyrimidine photolyase (photoreactivation) (phr) ,
MrcB subunit of 5-methylcytosine restriction system (mcrB) ,
RecB ,
RecC ,
RecD ,
ssDNA and dsDNA binding, ATP binding (recF) ,
excision nuclease subunit A (uvrA) ,
DNA repair; excision nuclease subunit B (uvrB) ,
MutS ,
MutL ,
EntE ,
apo-serine activating enzyme (entF) ,
dCMP phosphohydrolase (yfbR) ,
UDP-sugar hydrolase / 5'-ribonucleotidase / 5'-deoxyribonucleotidase (ushA) ,
DnaB ,
rep ,
ATP-dependent DNA helicase (recQ) ,
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB) ,
Lon ,
glutamyl-Q tRNAAsp synthetase (gluQ) ,
tRNA(i6A37) synthase (miaA) ,
bis(molybdenum cofactor) synthase [multifunctional] (mobA) ,
tRNAIle-lysidine synthetase (tilS) ,
lipoate-protein ligase A (lplA) ,
glutamine synthetase adenylyltransferase / glutamine synthetase deadenylase (glnE) ,
chaperone for [Fe-S] cluster biosynthesis (hscA) ,
ribonucleoside-triphosphate reductase (nrdD) ,
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase (aas) ,
AceK ,
ATP-dependent zinc metalloprotease FtsH ,
ribonucleoside diphosphate reductase 1, α subunit (nrdA) ,
NrdE ,
Zn2+ ABC transporter - ATP binding subunit (znuC) ,
phosphate ABC transporter - ATP binding subunit (pstB) ,
ATP synthase F1 complex - alpha subunit (atpA) ,
ATP synthase F1 complex - beta subunit (atpD) ,
ABC complex for formation and release of holoCcmE - ATP binding subunit (ccmA) ,
glutamine ABC transporter - ATP binding subunit (glnQ) ,
molybdate ABC transporter - ATP binding subunit (modC) ,
L-arginine ABC transporter - ATP binding subunit (artP) ,
K+ transporting ATPase - KdpC subunit ,
K+ transporting ATPase - ATP binding subunit (kdpB) ,
K+ transporting ATPase - K+ channel forming subunit (kdpA) ,
aliphatic sulfonate ABC transporter - ATP binding subunit (ssuB) ,
phosphonate ABC transporter - ATP binding subunit (phnC) ,
glycine betaine / proline ABC transporter - ATP binding subunit (proV) ,
zinc, cadmium and lead efflux system (zntA) ,
Cu+ efflux ATPase (copA) ,
glycerol-3-phosphate ABC transporter - ATP binding subunit (ugpC) ,
AI-2 ABC transporter - ATP binding subunit (lsrA) ,
galactose ABC transporter - ATP binding subunit (mglA) ,
glutathione / L-cysteine efflux transporter - CydC subunit ,
glutathione / L-cysteine efflux transporter - CydD subunit ,
nickel ABC transporter - ATP binding subunit (nikE) ,
nickel ABC transporter - ATP binding subunit (nikD) ,
putrescine ABC transporter - ATP binding subunit (potG) ,
putrescine / spermidine ABC transporter - ATP binding subunit (potA) ,
taurine ABC transporter - ATP binding subunit (tauB) ,
ATP-binding lipopolysaccharide transport protein (msbA) ,
ribose ABC transporter - putative ATP binding subunit (rbsA) ,
dipeptide ABC transporter - putative ABC binding subunit (dppF) ,
dipeptide ABC transporter - putative ATP binding subunit (dppD) ,
L-methionine / D-methionine ABC transporter - ATP binding subunit (metN) ,
L-cystine ABC transporter - predicted ATP binding subunit (yecC) ,
glutamate / aspartate ABC transporter - ATP binding subunit (gltL) ,
xylose ABC transporter - ATP binding subunit (xylG) ,
murein tripeptide ABC transporter / peptide ABC transporter - putative ATP binding subunit (oppF) ,
murein tripeptide ABC transporter / peptide ABC transporter - putative ATP binding subunit (oppD) ,
maltose ABC transporter - ATP binding subunit (malK) ,
branched chain amino acid transporter - ATP binding subunit (livG) ,
branched chain amino acid ABC transporter - ATP binding subunit (livF) ,
glutathione ABC transporter - ATP binding subunit (gsiA) ,
sulfate / thiosulfate ABC transporter - ATP binding subunit (cysA) ,
arabinose ABC transporter - ATP binding subunit (araG) ,
D-allose ABC transporter - ATP binding subunit (alsA) ,
galactofuranose / galactopyranose ABC transporter - putative ATP binding subunit (ytfR) ,
KefC ,
vitamin B12 ABC transporter - ATP binding subunit (btuD) ,
ferric dicitrate ABC transporter - ATP binding subunit (fecE) ,
ferric enterobactin ABC transporter - ATP binding subunit (fepC) ,
iron (III) hydroxamate ABC transporter - ATP binding subunit (fhuC) ,
Fe2+ transporter FeoB ,
LptB ,
bifunctional coenzyme A synthase (COASY) ,
5-dehydro-2-deoxy-D-gluconate kinase (iolC) ,
CTP synthetase (pyrG) ,
deoxyadenosine/deoxycytidine kinase monomer (dck) ,
cancer-related nucleoside-triphosphatase (NTPCR) ,
lipoate-protein ligase (lplJ) ,
4-amino-2-methyl-5-phosphomethylpyrimidine kinase (thiD) ,
thiamine monophosphate kinase (thiL) ,
ThiI ,
ThiS sulfur carrier protein ,
[sulfur-carrier protein ThiS] adenylyltransferase (thiF) ,
thiamin pyrophosphokinase (thiN) ,
hydroxyethylthiazole kinase monomer (thiM) ,
retinol dehydrogenase 3 (DHRS3) ,
GTP cyclohydrolase I (folEA) ,
7-cyano-7-deazaguanine synthase (queC)

Unification Links: GO:0000166


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Aug 28, 2015, BIOCYC14A.