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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Gene-Ontology-Terms Class: GO:0003824 - catalytic activity

Synonyms: enzyme activity

Definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Parent Classes:
GO:0003674 - molecular_function

Child Classes:
GO:0000150 - recombinase activity (1) ,
GO:0004133 - glycogen debranching enzyme activity (3) ,
GO:0004803 - transposase activity (1) ,
GO:0008641 - small protein activating enzyme activity (1) ,
GO:0008907 - integrase activity (1) ,
GO:0008987 - quinolinate synthetase A activity (2) ,
GO:0009975 - cyclase activity (2) ,
GO:0016491 - oxidoreductase activity (511) ,
GO:0016740 - transferase activity (711) ,
GO:0016787 - hydrolase activity (584) ,
GO:0016829 - lyase activity (225) ,
GO:0016853 - isomerase activity (123) ,
GO:0016874 - ligase activity (123) ,
GO:0019239 - deaminase activity (14) ,
GO:0030366 - molybdopterin synthase activity (1) ,
GO:0032451 - demethylase activity (1) ,
GO:0043364 - catalysis of free radical formation (1) ,
GO:0070283 - radical SAM enzyme activity (4)

Term Members:
EntB monomer ,
predicted ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) (paaG) ,
hydrogenase maturation protein, carbamoyl dehydratase (hypE) ,
endochitinase (chiA) ,
aldehyde dehydrogenase, FAD-binding subunit (yagS) ,
IlvA ,
IlvD ,
acetohydroxy acid synthase I, large subunit (ilvB) ,
acetolactate synthase II, large subunit, C-ter fragment (pseudogene) (ilvG_2) ,
acetolactate synthase II, large subunit, N-ter fragment (pseudogene) (ilvG_1) ,
IlvI ,
UDP-glucose 4-epimerase monomer (galE) ,
GDP-mannose 4,6-dehydratase (gmd) ,
Fcl ,
malonyl-CoA-ACP transacylase (fabD) ,
FabH ,
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA) ,
D-galactonate dehydratase (dgoD) ,
2-isopropylmalate synthase (leuA) ,
LysA ,
4-hydroxy-tetrahydrodipicolinate synthase (dapA) ,
LysC ,
HisC ,
HisB ,
imidazole glycerol phosphate synthase, HisF subunit ,
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (hisA) ,
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (hisI) ,
glutamate synthase, large subunit (gltB) ,
carbamoyl phosphate synthetase, β chain ,
PyrF ,
dihydroorotate dehydrogenase, type 2 (pyrD) ,
UMP kinase (pyrH) ,
selenide, water dikinase (selD) ,
selenocysteine synthase (selA) ,
GlmU ,
3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG (ubiX) ,
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT) ,
cardiolipin synthase 1 (clsA) ,
cardiolipin synthase 2 (clsB) ,
PssA ,
cardiolipin synthase 3 (clsC) ,
periplasmic trehalase (treA) ,
cytoplasmic trehalase (treF) ,
trehalose-6-phosphate hydrolase (treC) ,
nicotinate-mononucleotide adenylyltransferase (nadD) ,
quinolinate phosphoribosyltransferase (decarboxylating) monomer (nadC) ,
NadR DNA-binding transcriptional repressor and NMN adenylyltransferase ,
nicotinamidase / pyrazinamidase (pncA) ,
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD) ,
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH) ,
3-deoxy-D-manno-octulosonate 8-phosphate synthase (kdsA) ,
AccC ,
ScpA ,
phosphogluconate dehydratase (edd) ,
glyoxylate carboligase (gcl) ,
glycolate oxidase, predicted FAD-binding subunit (glcE) ,
glycolate oxidase, predicted FAD-linked subunit (glcD) ,
malate synthase A (aceB) ,
malate synthase G (glcB) ,
methylmalonyl-CoA decarboxylase (scpB) ,
propionyl-CoA:succinate CoA transferase (scpC) ,
Cdd ,
Upp ,
Udp ,
MenE ,
o-succinylbenzoate synthase (menC) ,
MenD ,
MenB ,
thymidine kinase / deoxyuridine kinase (tdk) ,
pantetheine-phosphate adenylyltransferase monomer (coaD) ,
Dfp ,
molybdopterin-synthase adenylyltransferase (moeB) ,
molybdenum cofactor guanylyltransferase (mobA) ,
GlnA ,
IlvE ,
PheA ,
TyrA ,
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC) ,
anthranilate synthase component II (trpD) ,
anthranilate synthase component I (trpE) ,
allulose-6-phosphate 3-epimerase (alsE) ,
phosphopentomutase (deoB) ,
deoxyribose-phosphate aldolase (deoC) ,
FadD ,
short chain acyl-CoA synthetase (fadK) ,
FadI monomer ,
FadJ monomer ,
1,4-α-glucan branching enzyme (glgB) ,
GlgC ,
α-mannosidase (mngB) ,
D-mannonate oxidoreductase (uxuB) ,
KbaZ ,
KbaY ,
GatZ ,
GatY ,
mannitol-1-phosphate 5-dehydrogenase (mtlD) ,
porphobilinogen synthase (hemB) ,
glutamate-1-semialdehyde aminotransferase (hemL) ,
ArgD ,
ThrA ,
MetL ,
AtoB ,
ornithine decarboxylase, biosynthetic (speC) ,
ornithine decarboxylase, degradative (speF) ,
GlpK ,
SpeA ,
Adi (adiA) ,
adenosylmethionine decarboxylase, proenzyme (speD) ,
SpeE ,
CadA ,
LdcC ,
homoserine O-succinyltransferase (metA) ,
S-ribosylhomocysteine lyase (luxS) ,
AspA ,
lipoate synthase monomer (lipA) ,
coproporphyrinogen III dehydrogenase (hemN) ,
GTP cyclohydrolase I monomer (folE) ,
CysG ,
AnsA ,
Kbl ,
4-aminobutyrate aminotransferase monomer (gabT) ,
4-aminobutyrate aminotransferase (puuE) ,
ethanolamine ammonia-lyase, α subunit (eutB) ,
propionyl-CoA synthetase (prpE) ,
2-methylisocitrate lyase (prpB) ,
Amn ,
xanthine dehydrogenase subunit, FAD-binding domain (xdhB) ,
AICAR transformylase / IMP cyclohydrolase (purH) ,
GuaB ,
adenylosuccinate lyase (purB) ,
thiamin monophosphate kinase (thiL) ,
Dxs ,
ThiS adenylyltransferase (thiF) ,
tyrosine lyase (thiH) ,
ThiG ,
malate dehydrogenase (mdh) ,
isocitrate lyase monomer (aceA) ,
citrate synthase monomer (gltA) ,
fumarase C monomer (fumC) ,
succinyl-CoA synthetase, β subunit ,
succinyl-CoA synthetase, α subunit (sucD) ,
CysH ,
sulfate adenylyltransferase, CysD subunit ,
PdxJ ,
SerC ,
acetyl-CoA synthetase (AMP-forming) (acs) ,
MhpD ,
4-hydroxy-2-ketovalerate aldolase (mhpE) ,
alanine racemase 1, PLP-binding, biosynthetic (alr) ,
DadX ,
glutamate-pyruvate aminotransferase (alaA) ,
glutamate-pyruvate aminotransferase (alaC) ,
thiamine phosphate synthase (thiE) ,
phosphoribosylamine-glycine ligase (purD) ,
phosphoribosylformylglycinamide synthetase (purL) ,
PurM ,
phosphoribosylglycinamide formyltransferase 2 (purT) ,
isoleucyl-tRNA synthetase (ileS) ,
essential cell division protein FtsI; penicillin-binding protein 3 ,
peptidoglycan synthetase; penicillin-binding protein 1A (mrcA) ,
MrcB ,
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA) ,
UDP-N-acetylglucosamine enolpyruvoyl transferase (murA) ,
UDP-N-acetylenolpyruvoylglucosamine reductase (murB) ,
D-alanine-D-alanine ligase A (ddlA) ,
D-alanine-D-alanine ligase B (ddlB) ,
transaldolase B (talB) ,
transketolase I (tktA) ,
transketolase II (tktB) ,
ribulose-5-phosphate 3-epimerase (rpe) ,
glutamate-putrescine ligase (puuA) ,
dTDP-glucose 4,6-dehydratase (rfbB) ,
dTDP-glucose 4,6-dehydratase 2 (rffG) ,
pyruvate kinase II monomer (pykA) ,
pyruvate kinase I monomer (pykF) ,
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmM) ,
triose phosphate isomerase monomer (tpiA) ,
fructose bisphosphate aldolase monomer (fbaB) ,
phosphoenolpyruvate synthetase (ppsA) ,
fructose-1,6-bisphosphatase monomer (fbp) ,
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase monomer (gpmA) ,
GarL ,
glucosamine-6-phosphate deaminase (nagB) ,
L-lactate dehydrogenase (lldD) ,
dTDP-4-dehydro-6-deoxy-D-glucose transaminase (rffA) ,
AroG ,
AroH ,
AroF ,
3-phosphoshikimate-1-carboxyvinyltransferase (aroA) ,
AroD ,
biotin synthase monomer (bioB) ,
adenosylmethionine-8-amino-7-oxononanoate aminotransferase monomer (bioA) ,
argininosuccinate lyase (argH) ,
ArgI ,
pabC ,
β-ketoadipyl-CoA thiolase (paaJ) ,
3-phenylpropionate dioxygenase, β subunit (hcaF) ,
2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (mhpC) ,
FolD ,
bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase (folC) ,
pantothenate synthetase monomer (panC) ,
3-methyl-2-oxobutanoate hydroxymethyltransferase monomer (panB) ,
4-diphosphocytidyl-2C-methyl-D-erythritol synthetase monomer (ispD) ,
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ispG) ,
phosphoenolpyruvate carboxykinase (ATP) (pck) ,
MaeB ,
trehalose-6-phosphate synthase (otsA) ,
trehalose-6-phosphate phosphatase (otsB) ,
6-phosphofructokinase-1 monomer (pfkA) ,
fructose bisphosphate aldolase monomer (fbaA) ,
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase (cobC) ,
glutamate decarboxylase A subunit (gadA) ,
glutamate decarboxylase B subunit (gadB) ,
fused UDP-L-Ara4N formyltransferase and UDP-GlcA C-4''-decarboxylase (arnA) ,
UDP-L-Ara4O C-4" transaminase (arnB) ,
glycine decarboxylase (gcvP) ,
subunit of E1p component of pyruvate dehydrogenase complex (aceE) ,
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (rfaE) ,
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD) ,
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4, inactive (tdcE) ,
PflB ,
Ppc ,
glutathione synthetase monomer (gshB) ,
galactose-1-phosphate uridylyltransferase (galT) ,
galactose-1-epimerase (galM) ,
NADH:ubiquinone oxidoreductase, chain CD (nuoC) ,
D-lactate dehydrogenase (dld) ,
succinylornithine transaminase (astC) ,
tryptophanase (tnaA) ,
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY) ,
O-acetylserine sulfhydrylase A (cysK) ,
MetC ,
fused PutA transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase ,
TdcB ,
bifunctional riboflavin kinase / FMN adenylyltransferase (ribF) ,
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD) ,
L-Ala-D/L-Glu epimerase (ycjG) ,
CaiB monomer ,
crotonobetainyl-CoA hydratase (caiD) ,
carnitine-CoA ligase (caiC) ,
FabF ,
GlgP ,
glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase (glgX) ,
DegP ,
serine endoprotease, periplasmic (degQ) ,
ATP-dependent DNA helicase (recQ) ,
RNase D (rnd) ,
D-glucarate dehydratase (gudD) ,
hybrid-cluster protein (hcp) ,
α-amylase (amyA) ,
TyrB ,
host restriction; endonuclease R (hsdR) ,
protein with low undecaprenyl pyrophosphate phosphatase activity (lpxT) ,
N-acetylneuraminate lyase (nanA) ,
CDP-diacylglycerol pyrophosphatase (cdh) ,
2,4-dienoyl-CoA reductase (fadH) ,
2'-5' RNA ligase (ligT) ,
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ) ,
protease III (ptrA) ,
AdhE ,
tRNA threonylcarbamoyladenosine dehydratase (tcdA) ,
KpLE2 phage-like element; D-xylonate dehydratase (yjhG) ,
CP4-6 prophage; D-xylonate dehydratase (yagF) ,
phosphoethanolamine transferase EptA ,
sulfoquinovose isomerase (yihS) ,
tRNA-specific adenosine deaminase monomer (tadA) ,
purine nucleoside phosphoramidase monomer (hinT) ,
DNA polymerase III, α subunit (dnaE) ,
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA) ,
N-ethylmaleimide reductase, FMN-linked (nemA) ,
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase monomer (mtn) ,
Eda ,
cysteine sulfinate desulfinase (csdA) ,
Fsa (fsaA) ,
fructose 6-phosphate aldolase 2 (fsaB) ,
β-galactosidase monomer (lacZ) ,
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH) ,
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE) ,
ribosomal protein S6 modification protein (rimK) ,
phosphoglycerol transferase I (opgB) ,
xanthosine phosphorylase (xapA) ,
fumarase B monomer (fumB) ,
pyruvate oxidase monomer (poxB) ,
methionine-oxo-acid transaminase, PLP-dependent (ybdL) ,
formamidopyrimidine DNA glycosylase (mutM) ,
8-amino-7-oxononanoate synthase monomer (bioF) ,
D-cysteine desulfhydrase (dcyD) ,
putrescine aminotransferase (patA) ,
arylsulfatase (aslA) ,
purine nucleoside phosphorylase (deoD) ,
citrate lyase, citryl-ACP lyase β subunit (citE) ,
phosphoethanolamine transferase EptB ,
3-methyl-adenine DNA glycosylase I, constitutive (tag) ,
glycoside hydrolase (ygjK) ,
phosphoethanolamine transferase EptC ,
ribosomal protein S12 D88 methylthiotransferase (rimO) ,
3-ketoacyl-CoA thiolase (fadA) ,
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB) ,
aldose sugar dehydrogenase (yliI) ,
phosphoethanolamine transferase (opgE) ,
Autoinducer 2-degrading protein (lsrG) ,
fumarase A monomer ,
fused 5-methylaminomethyl-2-thiouridine-forming methyltransferase and FAD-dependent demodification enzyme (mnmC) ,
tRNA-dihydrouridine synthase A (dusA) ,
tRNA-dihydrouridine synthase B (dusB) ,
tRNA-dihydrouridine synthase C (dusC) ,
L-cysteine desulfurase (sufS) ,
chito-oligosaccharide mono-deacetylase (chbG) ,
fused tRNA nucleotidyltransferase / 2',3'-cyclic phosphodiesterase / 2' nucleotidase and phosphatase (cca) ,
Gss ,
DLP12 prophage; lysozyme (rrrD) ,
pyruvate:flavodoxin oxidoreductase (ydbK) ,
RNA 3'-terminal phosphate cyclase (rtcA) ,
cysteine desulfurase monomer (iscS) ,
serine hydroxymethyltransferase (glyA) ,
formyl-CoA transferase monomer (frc) ,
sugar phosphatase (ybiV) ,
sugar phosphatase (yidA) ,
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase (aas) ,
α-amylase (malS) ,
3-methyl-adenine DNA glycosylase II, inducible (alkA) ,
poly-β-1,6-N-acetyl-D-glucosamine N-deacetylase (pgaB) ,
FabB ,
maltodextrin glucosidase (malZ) ,
endonuclease III; specific for apurinic and/or apyrimidinic sites (nth) ,
10-formyltetrahydrofolate:L-methionyl-tRNAfMet N-formyltransferase (fmt) ,
endo-1,4-D-glucanase (bcsZ) ,
NrdG ,
ribonucleoside-triphosphate reductase (nrdD) ,
lipoyl(octanoyl) transferase (lipB) ,
tryptophan synthase, α subunit (trpA) ,
O6-alkylguanine-DNA-alkyltransferase (ogt) ,
Ada DNA-binding transcriptional dual regulator ,
AspC ,
peroxyureidoacrylate / ureidoacrylate amido hydrolase (rutB) ,
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU) ,
maltodextrin phosphorylase monomer (malP) ,
ribonucleoside diphosphate reductase 1, α subunit (nrdA) ,
NrdE ,
[protein-PII] uridylyltransferase (glnD) ,
excision nuclease subunit A (uvrA) ,
phosphatidylglycerophosphatase [multifunctional] (pgpB) ,
isopentenyl-adenosine A37 tRNA methylthiolase (miaB) ,
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase (ybjI) ,
GuaC ,
Ppk ,
LtaE ,
acetyl-CoA:oxalate CoA-transferase (yfdE) ,
23S rRNA m2A2503 methyltransferase and tRNA m2A37 methyltransferase (rlmN) ,
lysine 2,3-aminomutase (epmB) ,
AppA ,
EntE ,
apo-serine activating enzyme (entF) ,
NADH-dependent dihydropyrimidine dehydrogenase subunit (preA) ,
α-xylosidase (yicI) ,
valine-pyruvate aminotransferase (avtA) ,
pyridoxal phosphatase / fructose 1,6-bisphosphatase (ybhA) ,
phosphosugar phosphatase (yigL) ,
pyridoxal phosphatase / HMP-PP hydrolase (cof) ,
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB) ,
PhoA ,
L-rhamnonate dehydratase (yfaW) ,
MetB ,
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF) ,
oxalyl-CoA decarboxylase (oxc) ,
2-oxo-4-methylthiobutanoate-glutamine aminotransferase (mtnE) ,
fructose-2,6-bisphosphatase TIGAR ,
Aldo-keto reductase family 1 member C1 (AKR1C1) ,
Arginase-1 (ARG1) ,
lysine-8-amino-7-oxononanoate aminotransferase (bioK) ,
Delta-aminolevulinic acid dehydratase (ALAD) ,
kanosamine-6-phosphate phosphatase (ntdB) ,
3-oxo-glucose-6-phosphate:glutamate aminotransferase (ntdA) ,
glucose-6-phosphate 3-dehydrogenase (ntdC) ,
phosphoenolpyruvate-protein phosphotransferase PtsP, enzyme INtr ,
glucitol dehydrogenase monomer (gutB) ,
scyllo-inositol dehydrogenase (NADP+) (iolW) ,
2-deoxy-5-keto-D-gluconate 6-phosphate aldolase (iolJ) ,
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD) ,
inositol 2-dehydrogenase monomer (iolG) ,
scyllo-inositol 2-dehydrogenase (NAD+) (iolX) ,
CTP synthetase (pyrG) ,
cytidine/deoxycytidine deaminase monomer (cdd) ,
Long-chain-fatty-acid--CoA ligase ACSBG1 ,
Long-chain-fatty-acid--CoA ligase ACSBG2 ,
phytanoyl-CoA dioxygenase, peroxisomal (PHYH) ,
fatty acid 2-hydroxylase (FA2H) ,
enoyl-acyl carrier protein reductase III (fabL) ,
mycophenolic acid acyl-glucuronide esterase (ABHD10) ,
protoporphyrinogen oxidase (hemY) ,
arabinogalactan endo-1,4-β-galactosidase (ganB) ,
lipoate-protein ligase (lplJ) ,
lipoyl synthase (lipoic acid synthetase) (lipA) ,
GcvH:[lipoyl domain] amidotransferase (lipL) ,
thiamine monophosphate kinase (thiL) ,
thiamin phosphate synthase (thiE) ,
1-deoxyxylulose-5-phosphate synthase (dxs) ,
thiazole synthase (thiG) ,
cysteine desulfurase monomer (iscS) ,
[sulfur-carrier protein ThiS] adenylyltransferase (thiF) ,
thiazole tautomerase (tenI) ,
retinal dehydrogenase 2 (ALDH1A2) ,
gephyrin (GPHN) ,
glucuronoarabinoxylan endo-1,4-β-xylanase (xynC) ,
α-L-arabinofuranosidase 2 (xsa) ,
α-L-arabinofuranosidase 1 (abfA) ,
7-carboxy-7-deazaguanine synthase (queE) ,
CTP synthase 2 (CTPS2)

Unification Links: GO:0003824


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13A.