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MetaCyc Gene-Ontology-Terms Class: GO:0003824 - catalytic activity

Synonyms: enzyme activity

Definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Parent Classes:
GO:0003674 - molecular_function

Child Classes:
GO:0000150 - recombinase activity (1) ,
GO:0004133 - glycogen debranching enzyme activity (3) ,
GO:0004803 - transposase activity (1) ,
GO:0008907 - integrase activity (1) ,
GO:0008987 - quinolinate synthetase A activity (2) ,
GO:0009975 - cyclase activity (2) ,
GO:0016491 - oxidoreductase activity (525) ,
GO:0016740 - transferase activity (720) ,
GO:0016787 - hydrolase activity (586) ,
GO:0016829 - lyase activity (226) ,
GO:0016853 - isomerase activity (124) ,
GO:0016874 - ligase activity (127) ,
GO:0019239 - deaminase activity (14) ,
GO:0030366 - molybdopterin synthase activity (1) ,
GO:0032451 - demethylase activity (1) ,
GO:0043364 - catalysis of free radical formation (1) ,
GO:0070283 - radical SAM enzyme activity (4)

Term Members:
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA) ,
essential cell division protein FtsI; penicillin-binding protein 3 ,
endochitinase (chiA) ,
3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG (ubiX) ,
hydrogenase maturation protein, carbamoyl dehydratase (hypE) ,
phosphoribosylamine-glycine ligase (purD) ,
phosphoribosylformylglycinamide synthetase (purL) ,
PurM ,
malonyl-CoA-ACP transacylase (fabD) ,
FabH ,
Amn ,
xanthine dehydrogenase subunit, FAD-binding domain (xdhB) ,
FabF ,
alanine racemase 1, PLP-binding, biosynthetic (alr) ,
DadX ,
glutamate-pyruvate aminotransferase (alaA) ,
glutamate-pyruvate aminotransferase (alaC) ,
phosphopentomutase (deoB) ,
deoxyribose-phosphate aldolase (deoC) ,
AccC ,
3-deoxy-D-manno-octulosonate 8-phosphate synthase (kdsA) ,
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase (cobC) ,
pantothenate synthetase monomer (panC) ,
3-methyl-2-oxobutanoate hydroxymethyltransferase monomer (panB) ,
pantetheine-phosphate adenylyltransferase monomer (coaD) ,
Dfp ,
AroG ,
AroH ,
AroF ,
LysC ,
ThrA ,
MetL ,
UDP-N-acetylglucosamine enolpyruvoyl transferase (murA) ,
UDP-N-acetylenolpyruvoylglucosamine reductase (murB) ,
D-alanine-D-alanine ligase A (ddlA) ,
D-alanine-D-alanine ligase B (ddlB) ,
1-deoxyxylulose-5-phosphate synthase (dxs) ,
PdxJ ,
dTDP-4-dehydro-6-deoxy-D-glucose transaminase (rffA) ,
dTDP-glucose 4,6-dehydratase (rfbB) ,
dTDP-glucose 4,6-dehydratase 2 (rffG) ,
SpeA ,
Adi (adiA) ,
glutamate decarboxylase A subunit (gadA) ,
glutamate decarboxylase B subunit (gadB) ,
GTP cyclohydrolase I monomer (folE) ,
3-hydroxy-2,4-pentadione 5-phosphate thiolase (lsrF) ,
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD) ,
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH) ,
S-ribosylhomocysteine lyase (luxS) ,
L-lactate dehydrogenase (lldD) ,
D-lactate dehydrogenase (dld) ,
glutamate-putrescine ligase (puuA) ,
4-aminobutyrate aminotransferase (gabT) ,
4-aminobutyrate aminotransferase (puuE) ,
succinylornithine transaminase (astC) ,
ornithine decarboxylase, biosynthetic (speC) ,
ornithine decarboxylase, degradative (speF) ,
argininosuccinate lyase (argH) ,
ArgI ,
carbamoyl phosphate synthetase, β chain ,
sulfate adenylyltransferase, CysD subunit ,
AnsA ,
PyrF ,
dihydroorotate dehydrogenase, type 2 (pyrD) ,
UMP kinase (pyrH) ,
Upp ,
Cdd ,
Udp ,
thymidine kinase / deoxyuridine kinase (tdk) ,
FadD ,
short chain acyl-CoA synthetase (fadK) ,
FadI monomer ,
FadJ monomer ,
AspA ,
CadA ,
LdcC ,
SpeE ,
adenosylmethionine decarboxylase, proenzyme (speD) ,
phosphogluconate dehydratase (edd) ,
4-diphosphocytidyl-2C-methyl-D-erythritol synthetase monomer (ispD) ,
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ispG) ,
phosphoribosylglycinamide formyltransferase 2 (purT) ,
bifunctional riboflavin kinase / FMN adenylyltransferase (ribF) ,
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD) ,
glutathione synthetase monomer (gshB) ,
ScpA ,
methylmalonyl-CoA decarboxylase (scpB) ,
propionyl-CoA:succinate CoA transferase (scpC) ,
MhpD ,
4-hydroxy-2-ketovalerate aldolase (mhpE) ,
mannitol-1-phosphate 5-dehydrogenase (mtlD) ,
KbaZ ,
KbaY ,
GatZ ,
GatY ,
homoserine O-succinyltransferase (metA) ,
selenide, water dikinase (selD) ,
selenocysteine synthase (selA) ,
acetyl-CoA synthetase (AMP-forming) (acs) ,
propionyl-CoA synthetase (prpE) ,
2-methylisocitrate lyase (prpB) ,
LysA ,
N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (argD) ,
SerC ,
4-hydroxy-tetrahydrodipicolinate synthase (dapA) ,
2-isopropylmalate synthase (leuA) ,
IlvD ,
IlvI ,
acetohydroxy acid synthase I, large subunit (ilvB) ,
acetolactate synthase II, large subunit, C-ter fragment (pseudogene) (ilvG_2) ,
acetolactate synthase II, large subunit, N-ter fragment (pseudogene) (ilvG_1) ,
TdcB ,
IlvA ,
3-phosphoshikimate-1-carboxyvinyltransferase (aroA) ,
AroD ,
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC) ,
anthranilate synthase component II (trpD) ,
anthranilate synthase component I (trpE) ,
IlvE ,
PheA ,
TyrA ,
allulose-6-phosphate 3-epimerase (alsE) ,
nicotinate-mononucleotide adenylyltransferase (nadD) ,
quinolinate phosphoribosyltransferase (decarboxylating) monomer (nadC) ,
NadR DNA-binding transcriptional repressor and NMN adenylyltransferase ,
nicotinamidase / pyrazinamidase (pncA) ,
α-mannosidase (mngB) ,
pyruvate kinase II monomer (pykA) ,
pyruvate kinase I monomer (pykF) ,
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmM) ,
triosephosphate isomerase monomer (tpiA) ,
fructose bisphosphate aldolase monomer (fbaB) ,
phosphoenolpyruvate synthetase (ppsA) ,
fructose-1,6-bisphosphatase monomer (fbp) ,
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase monomer (gpmA) ,
CysH ,
GarL ,
HisC ,
HisB ,
imidazole glycerol phosphate synthase, HisF subunit ,
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (hisA) ,
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (hisI) ,
AICAR transformylase / IMP cyclohydrolase (purH) ,
GuaB ,
adenylosuccinate lyase (purB) ,
GlmU ,
D-mannonate oxidoreductase (uxuB) ,
MenE ,
o-succinylbenzoate synthase (menC) ,
MenD ,
MenB ,
pabC ,
UDP-glucose 4-epimerase monomer (galE) ,
GDP-mannose 4,6-dehydratase (gmd) ,
Fcl ,
3-phenylpropionate dioxygenase, β subunit (hcaF) ,
2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (mhpC) ,
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA) ,
D-galactonate dehydratase (dgoD) ,
porphobilinogen synthase (hemB) ,
glutamate-1-semialdehyde aminotransferase (hemL) ,
thiamin monophosphate kinase (thiL) ,
thiamine phosphate synthase (thiE) ,
tyrosine lyase (thiH) ,
ThiG ,
glutamate synthase, large subunit (gltB) ,
molybdopterin biosynthesis protein A (moaA) ,
GlnA ,
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT) ,
glyoxylate carboligase (gcl) ,
glycolate oxidase, predicted FAD-binding subunit (glcE) ,
glycolate oxidase, predicted FAD-linked subunit (glcD) ,
malate synthase A (aceB) ,
malate synthase G (glcB) ,
tryptophanase (tnaA) ,
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY) ,
O-acetylserine sulfhydrylase A (cysK) ,
MetC ,
GlpK ,
malate dehydrogenase (mdh) ,
fumarase C monomer (fumC) ,
succinyl-CoA synthetase, β subunit ,
succinyl-CoA synthetase, α subunit (sucD) ,
citrate synthase monomer (gltA) ,
fused PutA transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase ,
isocitrate lyase monomer (aceA) ,
1,4-α-glucan branching enzyme (glgB) ,
GlgC ,
Kbl ,
periplasmic trehalase (treA) ,
cytoplasmic trehalase (treF) ,
trehalose-6-phosphate hydrolase (treC) ,
trehalose-6-phosphate synthase (otsA) ,
trehalose-6-phosphate phosphatase (otsB) ,
β-ketoadipyl-CoA thiolase (paaJ) ,
PssA ,
cardiolipin synthase 3 (clsC) ,
cardiolipin synthase 1 (clsA) ,
cardiolipin synthase 2 (clsB) ,
glycine decarboxylase (gcvP) ,
FolD ,
bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase (folC) ,
transaldolase B (talB) ,
transketolase I (tktA) ,
transketolase II (tktB) ,
ribulose-5-phosphate 3-epimerase (rpe) ,
glucosamine-6-phosphate deaminase (nagB) ,
isoleucyl-tRNA synthetase (ileS) ,
MrcB ,
MrcA ,
coproporphyrinogen III dehydrogenase (hemN) ,
biotin synthase monomer (bioB) ,
adenosylmethionine-8-amino-7-oxononanoate aminotransferase monomer (bioA) ,
AtoB ,
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4, inactive (tdcE) ,
PflB ,
Ppc ,
lipoyl synthase (lipA) ,
6-phosphofructokinase-1 monomer (pfkA) ,
fructose bisphosphate aldolase monomer (fbaA) ,
L-Ala-D/L-Glu epimerase (ycjG) ,
CaiB monomer ,
crotonobetainyl-CoA hydratase (caiD) ,
carnitine-CoA ligase (caiC) ,
fused UDP-L-Ara4N formyltransferase and UDP-GlcA C-4''-decarboxylase (arnA) ,
UDP-L-Ara4O C-4" transaminase (arnB) ,
CysG ,
ethanolamine ammonia-lyase, α subunit (eutB) ,
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (rfaE) ,
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD) ,
galactose-1-phosphate uridylyltransferase (galT) ,
galactose-1-epimerase (galM) ,
phosphoenolpyruvate carboxykinase (ATP) (pck) ,
MaeB ,
GlgP ,
glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase (glgX) ,
NADH:ubiquinone oxidoreductase, chain CD (nuoC) ,
3-methyl-adenine DNA glycosylase II, inducible (alkA) ,
hybrid-cluster protein (hcp) ,
8-amino-7-oxononanoate synthase monomer (bioF) ,
ribosomal protein S12 D88 methylthiotransferase (rimO) ,
fumarase B monomer (fumB) ,
pyruvate oxidase monomer (poxB) ,
AspC ,
isopentenyl-adenosine A37 tRNA methylthiolase (miaB) ,
glycoside hydrolase (ygjK) ,
aldose sugar dehydrogenase (yliI) ,
AdhE ,
methionine-oxo-acid transaminase, PLP-dependent (ybdL) ,
fused tRNA nucleotidyltransferase / 2',3'-cyclic phosphodiesterase / 2' nucleotidase and phosphatase (cca) ,
phosphoethanolamine transferase EptC ,
putrescine aminotransferase (patA) ,
aldehyde dehydrogenase, FAD-binding subunit (paoB) ,
purine nucleoside phosphoramidase monomer (hinT) ,
purine nucleoside phosphorylase (deoD) ,
xanthosine phosphorylase (xapA) ,
tryptophan synthase, α subunit (trpA) ,
α-amylase (malS) ,
pyridoxal phosphatase / fructose 1,6-bisphosphatase (ybhA) ,
pyridoxal phosphatase / HMP-PP hydrolase (cof) ,
tRNA-dihydrouridine synthase A (dusA) ,
tRNA-dihydrouridine synthase B (dusB) ,
tRNA-dihydrouridine synthase C (dusC) ,
sugar phosphatase (ybiV) ,
sugar phosphatase (yidA) ,
phosphosugar phosphatase (yigL) ,
RNase D (rnd) ,
fumarase A monomer ,
formyl-CoA transferase monomer (frc) ,
TyrB ,
host restriction; endonuclease R (hsdR) ,
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase (ybjI) ,
10-formyltetrahydrofolate:L-methionyl-tRNAfMet N-formyltransferase (fmt) ,
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ) ,
lysine 2,3-aminomutase (epmB) ,
arylsulfatase (aslA) ,
N-ethylmaleimide reductase, FMN-linked (nemA) ,
valine-pyruvate aminotransferase (avtA) ,
phosphoethanolamine transferase (opgE) ,
D-glucarate dehydratase (gudD) ,
poly-β-1,6-N-acetyl-D-glucosamine N-deacetylase (pgaB) ,
RNA 3'-terminal phosphate cyclase (rtcA) ,
chito-oligosaccharide mono-deacetylase (chbG) ,
Gss ,
Kdo2-lipid A phosphotransferase (lpxT) ,
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU) ,
L-rhamnonate dehydratase (yfaW) ,
MetB ,
endo-1,4-D-glucanase (bcsZ) ,
KpLE2 phage-like element; D-xylonate dehydratase (yjhG) ,
CP4-6 prophage; D-xylonate dehydratase (yagF) ,
Eda ,
formamidopyrimidine DNA glycosylase (mutM) ,
maltodextrin phosphorylase monomer (malP) ,
N-acetylneuraminate lyase (nanA) ,
oxalyl-CoA decarboxylase (oxc) ,
acetyl-CoA:oxalate CoA-transferase (yfdE) ,
Kdo2-lipid A phosphoethanolamine 7''-transferase (eptB) ,
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF) ,
protease III (ptrA) ,
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase monomer (mtn) ,
RNA/ssDNA exonuclease 5' → 3' specific (yciV) ,
phosphoglycerol transferase I (opgB) ,
CDP-diacylglycerol pyrophosphatase (cdh) ,
GuaC ,
phosphoethanolamine transferase EptA ,
LtaE ,
ribosomal protein S6 modification protein (rimK) ,
2,4-dienoyl-CoA reductase (fadH) ,
AppA ,
α-xylosidase (yicI) ,
Ppk ,
fused 5-methylaminomethyl-2-thiouridine-forming methyltransferase and FAD-dependent demodification enzyme (mnmC) ,
serine hydroxymethyltransferase (glyA) ,
β-galactosidase monomer (lacZ) ,
3-ketoacyl-CoA thiolase (fadA) ,
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB) ,
DNA polymerase III, α subunit (dnaE) ,
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA) ,
3-methyl-adenine DNA glycosylase I, constitutive (tag) ,
sulfoquinovose isomerase (yihS) ,
O6-alkylguanine-DNA-alkyltransferase (ogt) ,
Ada DNA-binding transcriptional dual regulator ,
endonuclease III (nth) ,
NADH-dependent dihydropyrimidine dehydrogenase subunit (preA) ,
excision nuclease subunit A (uvrA) ,
tRNA-specific adenosine deaminase monomer (tadA) ,
EntE ,
apo-serine activating enzyme (entF) ,
EntB monomer ,
Fsa (fsaA) ,
fructose 6-phosphate aldolase 2 (fsaB) ,
ATP-dependent DNA helicase (recQ) ,
DLP12 prophage; lysozyme (rrrD) ,
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB) ,
maltodextrin glucosidase (malZ) ,
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH) ,
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE) ,
PhoA ,
peroxyureidoacrylate / ureidoacrylate amido hydrolase (rutB) ,
α-amylase (amyA) ,
bis(molybdenum cofactor) synthase [multifunctional] (mobA) ,
23S rRNA m2A2503 methyltransferase and tRNA m2A37 methyltransferase (rlmN) ,
D-cysteine desulfhydrase (dcyD) ,
cysteine sulfinate desulfinase (csdA) ,
citrate lyase, citryl-ACP lyase β subunit (citE) ,
cysteine desulfurase monomer (iscS) ,
L-cysteine desulfurase (sufS) ,
pyruvate:flavodoxin oxidoreductase (ydbK) ,
NrdG ,
ribonucleoside-triphosphate reductase (nrdD) ,
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase (aas) ,
lipoyl(octanoyl) transferase (lipB) ,
PII uridylyltransferase / uridylyl removing enzyme (glnD) ,
FabB ,
ribonucleoside diphosphate reductase 1, α subunit (nrdA) ,
NrdE ,
phosphatidylglycerophosphatase [multifunctional] (pgpB) ,
subunit of E1p component of pyruvate dehydrogenase complex (aceE) ,
2-oxo-4-methylthiobutanoate-glutamine aminotransferase (mtnE) ,
fructose-2,6-bisphosphatase TIGAR ,
Aldo-keto reductase family 1 member C1 (AKR1C1) ,
Arginase-1 (ARG1) ,
lysine-8-amino-7-oxononanoate aminotransferase (bioK) ,
Delta-aminolevulinic acid dehydratase (ALAD) ,
kanosamine-6-phosphate phosphatase (ntdB) ,
3-oxo-glucose-6-phosphate:glutamate aminotransferase (ntdA) ,
glucose-6-phosphate 3-dehydrogenase (ntdC) ,
phosphoenolpyruvate-protein phosphotransferase PtsP, enzyme INtr ,
glucitol dehydrogenase monomer (gutB) ,
scyllo-inositol dehydrogenase (NADP+) (iolW) ,
2-deoxy-5-keto-D-gluconate 6-phosphate aldolase (iolJ) ,
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD) ,
inositol 2-dehydrogenase monomer (iolG) ,
scyllo-inositol 2-dehydrogenase (NAD+) (iolX) ,
CTP synthetase (pyrG) ,
cytidine/deoxycytidine deaminase monomer (cdd) ,
long-chain acyl-CoA synthetase ACSBG1 ,
long-chain acyl-CoA synthetase 8 ACSBG2 ,
phytanoyl-CoA dioxygenase, peroxisomal (PHYH) ,
sphingoliid fatty acid 2-hydroxylase (FA2H) ,
enoyl-acyl carrier protein reductase III (fabL) ,
mycophenolic acid acyl-glucuronide esterase (ABHD10) ,
protoporphyrinogen oxidase (hemY) ,
arabinogalactan endo-1,4-β-galactosidase (ganB) ,
lipoate-protein ligase (lplJ) ,
lipoyl synthase (lipoic acid synthetase) (lipA) ,
GcvH:[lipoyl domain] amidotransferase (lipL) ,
thiamine monophosphate kinase (thiL) ,
thiamin phosphate synthase (thiE) ,
1-deoxyxylulose-5-phosphate synthase (dxs) ,
thiazole synthase (thiG) ,
cysteine desulfurase monomer (iscS) ,
[sulfur-carrier protein ThiS] adenylyltransferase (thiF) ,
thiazole tautomerase (tenI) ,
retinal dehydrogenase 2 (ALDH1A2) ,
gephyrin (GPHN) ,
glucuronoarabinoxylan endo-1,4-β-xylanase (xynC) ,
α-L-arabinofuranosidase 2 (xsa) ,
α-L-arabinofuranosidase 1 (abfA) ,
7-carboxy-7-deazaguanine synthase (queE) ,
CTP synthase 2 (CTPS2)

Unification Links: GO:0003824


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Jul 4, 2015, biocyc12.