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MetaCyc Gene-Ontology-Terms Class: GO:0003824 - catalytic activity

Synonyms: enzyme activity

Definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Parent Classes:
GO:0003674 - molecular_function

Child Classes:
GO:0000150 - recombinase activity (1) ,
GO:0004133 - glycogen debranching enzyme activity (3) ,
GO:0004803 - transposase activity (1) ,
GO:0008907 - integrase activity (1) ,
GO:0008987 - quinolinate synthetase A activity (2) ,
GO:0009975 - cyclase activity (2) ,
GO:0016491 - oxidoreductase activity (521) ,
GO:0016740 - transferase activity (715) ,
GO:0016787 - hydrolase activity (583) ,
GO:0016829 - lyase activity (224) ,
GO:0016853 - isomerase activity (123) ,
GO:0016874 - ligase activity (125) ,
GO:0019239 - deaminase activity (14) ,
GO:0030366 - molybdopterin synthase activity (1) ,
GO:0032451 - demethylase activity (1) ,
GO:0043364 - catalysis of free radical formation (1) ,
GO:0070283 - radical SAM enzyme activity (4)

Term Members:
GlnA ,
homoserine O-succinyltransferase (metA) ,
LysC ,
ThrA ,
MetL ,
NadR DNA-binding transcriptional repressor and NMN adenylyltransferase ,
GarL ,
L-lactate dehydrogenase (lldD) ,
CysH ,
sulfate adenylyltransferase, CysD subunit ,
HisC ,
HisB ,
imidazole glycerol phosphate synthase, HisF subunit ,
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (hisA) ,
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (hisI) ,
phosphoribosylamine-glycine ligase (purD) ,
phosphoribosylformylglycinamide synthetase (purL) ,
PurM ,
AICAR transformylase / IMP cyclohydrolase (purH) ,
GuaB ,
adenylosuccinate lyase (purB) ,
carbamoyl phosphate synthetase, β chain ,
PyrF ,
dihydroorotate dehydrogenase, type 2 (pyrD) ,
UMP kinase (pyrH) ,
Upp ,
GlpK ,
Dxs ,
PdxJ ,
thiamin monophosphate kinase (thiL) ,
essential cell division protein FtsI; penicillin-binding protein 3 ,
peptidoglycan synthetase; penicillin-binding protein 1A (mrcA) ,
MrcB ,
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA) ,
UDP-N-acetylglucosamine enolpyruvoyl transferase (murA) ,
UDP-N-acetylenolpyruvoylglucosamine reductase (murB) ,
D-alanine-D-alanine ligase A (ddlA) ,
D-alanine-D-alanine ligase B (ddlB) ,
glutathione synthetase monomer (gshB) ,
Kbl ,
IlvA ,
coproporphyrinogen III dehydrogenase (hemN) ,
dTDP-glucose 4,6-dehydratase (rfbB) ,
dTDP-glucose 4,6-dehydratase 2 (rffG) ,
GlmU ,
D-mannonate oxidoreductase (uxuB) ,
Cdd ,
Udp ,
thymidine kinase / deoxyuridine kinase (tdk) ,
MenE ,
o-succinylbenzoate synthase (menC) ,
MenD ,
MenB ,
lipoyl synthase (lipA) ,
pantetheine-phosphate adenylyltransferase monomer (coaD) ,
Dfp ,
pantothenate synthetase monomer (panC) ,
3-methyl-2-oxobutanoate hydroxymethyltransferase monomer (panB) ,
CysG ,
glutamate-putrescine ligase (puuA) ,
SpeA ,
Adi (adiA) ,
4-aminobutyrate aminotransferase (puuE) ,
S-ribosylhomocysteine lyase (luxS) ,
ornithine decarboxylase, biosynthetic (speC) ,
ornithine decarboxylase, degradative (speF) ,
molybdopterin-synthase adenylyltransferase (moeB) ,
porphobilinogen synthase (hemB) ,
glutamate-1-semialdehyde aminotransferase (hemL) ,
3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG (ubiX) ,
AroG ,
AroH ,
AroF ,
3-phosphoshikimate-1-carboxyvinyltransferase (aroA) ,
AroD ,
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC) ,
anthranilate synthase component II (trpD) ,
anthranilate synthase component I (trpE) ,
PheA ,
TyrA ,
GTP cyclohydrolase I monomer (folE) ,
pabC ,
malate dehydrogenase (mdh) ,
malate synthase A (aceB) ,
malate synthase G (glcB) ,
isocitrate lyase monomer (aceA) ,
citrate synthase monomer (gltA) ,
fumarase C monomer (fumC) ,
succinyl-CoA synthetase, β subunit ,
succinyl-CoA synthetase, α subunit (sucD) ,
alanine racemase 1, PLP-binding, biosynthetic (alr) ,
DadX ,
glutamate-pyruvate aminotransferase (alaA) ,
glutamate-pyruvate aminotransferase (alaC) ,
FolD ,
bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase (folC) ,
adenosylmethionine decarboxylase, proenzyme (speD) ,
GDP-mannose 4,6-dehydratase (gmd) ,
Fcl ,
4-aminobutyrate aminotransferase (gabT) ,
D-lactate dehydrogenase (dld) ,
fused UDP-L-Ara4N formyltransferase and UDP-GlcA C-4''-decarboxylase (arnA) ,
UDP-L-Ara4O C-4" transaminase (arnB) ,
cardiolipin synthase 1 (clsA) ,
cardiolipin synthase 2 (clsB) ,
PssA ,
cardiolipin synthase 3 (clsC) ,
nicotinate-mononucleotide adenylyltransferase (nadD) ,
quinolinate phosphoribosyltransferase (decarboxylating) monomer (nadC) ,
malonyl-CoA-ACP transacylase (fabD) ,
FabH ,
nicotinamidase / pyrazinamidase (pncA) ,
FabF ,
thiamine phosphate synthase (thiE) ,
ThiS adenylyltransferase (thiF) ,
tyrosine lyase (thiH) ,
ThiG ,
pyruvate kinase II monomer (pykA) ,
pyruvate kinase I monomer (pykF) ,
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmM) ,
triosephosphate isomerase monomer (tpiA) ,
fructose bisphosphate aldolase monomer (fbaB) ,
phosphoenolpyruvate synthetase (ppsA) ,
fructose-1,6-bisphosphatase monomer (fbp) ,
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase monomer (gpmA) ,
GlgP ,
glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase (glgX) ,
3-phenylpropionate dioxygenase, β subunit (hcaF) ,
2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (mhpC) ,
β-ketoadipyl-CoA thiolase (paaJ) ,
dTDP-4-dehydro-6-deoxy-D-glucose transaminase (rffA) ,
IlvD ,
acetohydroxy acid synthase I, large subunit (ilvB) ,
acetolactate synthase II, large subunit, C-ter fragment (pseudogene) (ilvG_2) ,
acetolactate synthase II, large subunit, N-ter fragment (pseudogene) (ilvG_1) ,
IlvI ,
UDP-glucose 4-epimerase monomer (galE) ,
AccC ,
3-deoxy-D-manno-octulosonate 8-phosphate synthase (kdsA) ,
LysA ,
N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (argD) ,
SerC ,
4-hydroxy-tetrahydrodipicolinate synthase (dapA) ,
AspA ,
AnsA ,
IlvE ,
2-isopropylmalate synthase (leuA) ,
fused PutA transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase ,
SpeE ,
CadA ,
LdcC ,
argininosuccinate lyase (argH) ,
ArgI ,
galactose-1-phosphate uridylyltransferase (galT) ,
galactose-1-epimerase (galM) ,
NADH:ubiquinone oxidoreductase, chain CD (nuoC) ,
molybdenum cofactor guanylyltransferase (mobA) ,
isoleucyl-tRNA synthetase (ileS) ,
6-phosphofructokinase-1 monomer (pfkA) ,
fructose bisphosphate aldolase monomer (fbaA) ,
phosphogluconate dehydratase (edd) ,
FadD ,
short chain acyl-CoA synthetase (fadK) ,
FadI monomer ,
FadJ monomer ,
glutamate decarboxylase A subunit (gadA) ,
glutamate decarboxylase B subunit (gadB) ,
bifunctional riboflavin kinase / FMN adenylyltransferase (ribF) ,
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD) ,
phosphopentomutase (deoB) ,
deoxyribose-phosphate aldolase (deoC) ,
transaldolase B (talB) ,
transketolase I (tktA) ,
transketolase II (tktB) ,
ribulose-5-phosphate 3-epimerase (rpe) ,
CaiB monomer ,
crotonobetainyl-CoA hydratase (caiD) ,
carnitine-CoA ligase (caiC) ,
glucosamine-6-phosphate deaminase (nagB) ,
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT) ,
glutamate synthase, large subunit (gltB) ,
4-diphosphocytidyl-2C-methyl-D-erythritol synthetase monomer (ispD) ,
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ispG) ,
biotin synthase monomer (bioB) ,
adenosylmethionine-8-amino-7-oxononanoate aminotransferase monomer (bioA) ,
periplasmic trehalase (treA) ,
cytoplasmic trehalase (treF) ,
trehalose-6-phosphate hydrolase (treC) ,
propionyl-CoA synthetase (prpE) ,
2-methylisocitrate lyase (prpB) ,
ScpA ,
1,4-α-glucan branching enzyme (glgB) ,
GlgC ,
trehalose-6-phosphate synthase (otsA) ,
trehalose-6-phosphate phosphatase (otsB) ,
phosphoenolpyruvate carboxykinase (ATP) (pck) ,
MaeB ,
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY) ,
O-acetylserine sulfhydrylase A (cysK) ,
MetC ,
succinylornithine transaminase (astC) ,
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase (cobC) ,
glyoxylate carboligase (gcl) ,
glycolate oxidase, predicted FAD-binding subunit (glcE) ,
glycolate oxidase, predicted FAD-linked subunit (glcD) ,
ethanolamine ammonia-lyase, α subunit (eutB) ,
TdcB ,
methylmalonyl-CoA decarboxylase (scpB) ,
propionyl-CoA:succinate CoA transferase (scpC) ,
selenide, water dikinase (selD) ,
selenocysteine synthase (selA) ,
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA) ,
D-galactonate dehydratase (dgoD) ,
acetyl-CoA synthetase (AMP-forming) (acs) ,
phosphoribosylglycinamide formyltransferase 2 (purT) ,
MhpD ,
4-hydroxy-2-ketovalerate aldolase (mhpE) ,
3-hydroxy-2,4-pentadione 5-phosphate thiolase (lsrF) ,
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (rfaE) ,
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD) ,
mannitol-1-phosphate 5-dehydrogenase (mtlD) ,
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD) ,
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH) ,
KbaZ ,
KbaY ,
GatZ ,
GatY ,
allulose-6-phosphate 3-epimerase (alsE) ,
glycine decarboxylase (gcvP) ,
AtoB ,
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4, inactive (tdcE) ,
PflB ,
Ppc ,
α-mannosidase (mngB) ,
tryptophanase (tnaA) ,
L-Ala-D/L-Glu epimerase (ycjG) ,
Amn ,
xanthine dehydrogenase subunit, FAD-binding domain (xdhB) ,
tRNA-dihydrouridine synthase A (dusA) ,
tRNA-dihydrouridine synthase B (dusB) ,
tRNA-dihydrouridine synthase C (dusC) ,
2,4-dienoyl-CoA reductase (fadH) ,
α-amylase (malS) ,
GuaC ,
poly-β-1,6-N-acetyl-D-glucosamine N-deacetylase (pgaB) ,
phosphoethanolamine transferase EptA ,
AdhE ,
CDP-diacylglycerol pyrophosphatase (cdh) ,
formyl-CoA transferase monomer (frc) ,
KpLE2 phage-like element; D-xylonate dehydratase (yjhG) ,
CP4-6 prophage; D-xylonate dehydratase (yagF) ,
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU) ,
phosphoethanolamine transferase (opgE) ,
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase (ybjI) ,
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH) ,
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE) ,
L-rhamnonate dehydratase (yfaW) ,
MetB ,
endo-1,4-D-glucanase (bcsZ) ,
acetyl-CoA:oxalate CoA-transferase (yfdE) ,
excision nuclease subunit A (uvrA) ,
lysine 2,3-aminomutase (epmB) ,
formamidopyrimidine DNA glycosylase (mutM) ,
hybrid-cluster protein (hcp) ,
8-amino-7-oxononanoate synthase monomer (bioF) ,
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase monomer (mtn) ,
oxalyl-CoA decarboxylase (oxc) ,
fumarase B monomer (fumB) ,
DNA polymerase III, α subunit (dnaE) ,
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA) ,
N-ethylmaleimide reductase, FMN-linked (nemA) ,
valine-pyruvate aminotransferase (avtA) ,
D-cysteine desulfhydrase (dcyD) ,
N-acetylneuraminate lyase (nanA) ,
ribosomal protein S6 modification protein (rimK) ,
putrescine aminotransferase (patA) ,
D-glucarate dehydratase (gudD) ,
phosphoethanolamine transferase EptC ,
LtaE ,
DegP ,
serine endoprotease, periplasmic (degQ) ,
phosphatidylglycerophosphatase [multifunctional] (pgpB) ,
3-ketoacyl-CoA thiolase (fadA) ,
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB) ,
sulfoquinovose isomerase (yihS) ,
Kdo2-lipid A phosphotransferase (lpxT) ,
arylsulfatase (aslA) ,
tRNA threonylcarbamoyladenosine dehydratase (tcdA) ,
DLP12 prophage; lysozyme (rrrD) ,
ribosomal protein S12 D88 methylthiotransferase (rimO) ,
fused tRNA nucleotidyltransferase / 2',3'-cyclic phosphodiesterase / 2' nucleotidase and phosphatase (cca) ,
Kdo2-lipid A phosphoethanolamine 7''-transferase (eptB) ,
3-methyl-adenine DNA glycosylase II, inducible (alkA) ,
endonuclease III; specific for apurinic and/or apyrimidinic sites (nth) ,
AppA ,
aldose sugar dehydrogenase (yliI) ,
methionine-oxo-acid transaminase, PLP-dependent (ybdL) ,
AspC ,
peroxyureidoacrylate / ureidoacrylate amido hydrolase (rutB) ,
RNA 3'-terminal phosphate cyclase (rtcA) ,
phosphoglycerol transferase I (opgB) ,
tRNA-specific adenosine deaminase monomer (tadA) ,
sugar phosphatase (ybiV) ,
sugar phosphatase (yidA) ,
tryptophan synthase, α subunit (trpA) ,
β-galactosidase monomer (lacZ) ,
xanthosine phosphorylase (xapA) ,
cysteine sulfinate desulfinase (csdA) ,
Fsa (fsaA) ,
fructose 6-phosphate aldolase 2 (fsaB) ,
23S rRNA m2A2503 methyltransferase and tRNA m2A37 methyltransferase (rlmN) ,
ATP-dependent DNA helicase (recQ) ,
aldehyde dehydrogenase, FAD-binding subunit (paoB) ,
O6-alkylguanine-DNA-alkyltransferase (ogt) ,
Ada DNA-binding transcriptional dual regulator ,
purine nucleoside phosphorylase (deoD) ,
pyruvate oxidase monomer (poxB) ,
chito-oligosaccharide mono-deacetylase (chbG) ,
pyridoxal phosphatase / fructose 1,6-bisphosphatase (ybhA) ,
phosphosugar phosphatase (yigL) ,
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB) ,
Ppk ,
NADH-dependent dihydropyrimidine dehydrogenase subunit (preA) ,
isopentenyl-adenosine A37 tRNA methylthiolase (miaB) ,
3-methyl-adenine DNA glycosylase I, constitutive (tag) ,
RNase D (rnd) ,
Gss ,
glycoside hydrolase (ygjK) ,
maltodextrin glucosidase (malZ) ,
fumarase A monomer ,
citrate lyase, citryl-ACP lyase β subunit (citE) ,
[protein-PII] uridylyltransferase (glnD) ,
L-cysteine desulfurase (sufS) ,
FabB ,
ribonucleoside diphosphate reductase 1, α subunit (nrdA) ,
NrdE ,
pyruvate:flavodoxin oxidoreductase (ydbK) ,
NrdG ,
ribonucleoside-triphosphate reductase (nrdD) ,
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase (aas) ,
subunit of E1p component of pyruvate dehydrogenase complex (aceE) ,
lipoyl(octanoyl) transferase (lipB) ,
TyrB ,
host restriction; endonuclease R (hsdR) ,
Eda ,
maltodextrin phosphorylase monomer (malP) ,
10-formyltetrahydrofolate:L-methionyl-tRNAfMet N-formyltransferase (fmt) ,
α-amylase (amyA) ,
cysteine desulfurase monomer (iscS) ,
fused 5-methylaminomethyl-2-thiouridine-forming methyltransferase and FAD-dependent demodification enzyme (mnmC) ,
pyridoxal phosphatase / HMP-PP hydrolase (cof) ,
purine nucleoside phosphoramidase monomer (hinT) ,
α-xylosidase (yicI) ,
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ) ,
EntE ,
apo-serine activating enzyme (entF) ,
EntB monomer ,
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF) ,
serine hydroxymethyltransferase (glyA) ,
PhoA ,
protease III (ptrA) ,
hydrogenase maturation protein, carbamoyl dehydratase (hypE) ,
endochitinase (chiA) ,
2-oxo-4-methylthiobutanoate-glutamine aminotransferase (mtnE) ,
fructose-2,6-bisphosphatase TIGAR ,
Aldo-keto reductase family 1 member C1 (AKR1C1) ,
Arginase-1 (ARG1) ,
lysine-8-amino-7-oxononanoate aminotransferase (bioK) ,
Delta-aminolevulinic acid dehydratase (ALAD) ,
kanosamine-6-phosphate phosphatase (ntdB) ,
3-oxo-glucose-6-phosphate:glutamate aminotransferase (ntdA) ,
glucose-6-phosphate 3-dehydrogenase (ntdC) ,
phosphoenolpyruvate-protein phosphotransferase PtsP, enzyme INtr ,
glucitol dehydrogenase monomer (gutB) ,
scyllo-inositol dehydrogenase (NADP+) (iolW) ,
2-deoxy-5-keto-D-gluconate 6-phosphate aldolase (iolJ) ,
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD) ,
inositol 2-dehydrogenase monomer (iolG) ,
scyllo-inositol 2-dehydrogenase (NAD+) (iolX) ,
CTP synthetase (pyrG) ,
cytidine/deoxycytidine deaminase monomer (cdd) ,
Long-chain-fatty-acid--CoA ligase ACSBG1 ,
Long-chain-fatty-acid--CoA ligase ACSBG2 ,
phytanoyl-CoA dioxygenase, peroxisomal (PHYH) ,
fatty acid 2-hydroxylase (FA2H) ,
enoyl-acyl carrier protein reductase III (fabL) ,
mycophenolic acid acyl-glucuronide esterase (ABHD10) ,
protoporphyrinogen oxidase (hemY) ,
arabinogalactan endo-1,4-β-galactosidase (ganB) ,
lipoate-protein ligase (lplJ) ,
lipoyl synthase (lipoic acid synthetase) (lipA) ,
GcvH:[lipoyl domain] amidotransferase (lipL) ,
thiamine monophosphate kinase (thiL) ,
thiamin phosphate synthase (thiE) ,
1-deoxyxylulose-5-phosphate synthase (dxs) ,
thiazole synthase (thiG) ,
cysteine desulfurase monomer (iscS) ,
[sulfur-carrier protein ThiS] adenylyltransferase (thiF) ,
thiazole tautomerase (tenI) ,
retinal dehydrogenase 2 (ALDH1A2) ,
gephyrin (GPHN) ,
glucuronoarabinoxylan endo-1,4-β-xylanase (xynC) ,
α-L-arabinofuranosidase 2 (xsa) ,
α-L-arabinofuranosidase 1 (abfA) ,
7-carboxy-7-deazaguanine synthase (queE) ,
CTP synthase 2 (CTPS2)

Unification Links: GO:0003824


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri May 29, 2015, biocyc14.