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MetaCyc Gene-Ontology-Terms Class: GO:0003824 - catalytic activity

Synonyms: enzyme activity

Definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Parent Classes:
GO:0003674 - molecular_function

Child Classes:
GO:0000150 - recombinase activity (1),
GO:0004133 - glycogen debranching enzyme activity (3),
GO:0004803 - transposase activity (1),
GO:0008907 - integrase activity (1),
GO:0008987 - quinolinate synthetase A activity (2),
GO:0009975 - cyclase activity (2),
GO:0016491 - oxidoreductase activity (537),
GO:0016740 - transferase activity (746),
GO:0016787 - hydrolase activity (618),
GO:0016829 - lyase activity (235),
GO:0016853 - isomerase activity (128),
GO:0016874 - ligase activity (128),
GO:0019239 - deaminase activity (15),
GO:0032451 - demethylase activity (1),
GO:0043364 - catalysis of free radical formation (1),
GO:0070283 - radical SAM enzyme activity (4)

Term Members:
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA),
essential cell division protein FtsI; penicillin-binding protein 3,
endochitinase (chiA),
aldehyde dehydrogenase, FAD-binding subunit (paoB),
1-deoxyxylulose-5-phosphate synthase (dxs),
2-iminoacetate synthase (thiH),
1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase (thiG),
PdxJ,
homoserine O-succinyltransferase (metA),
S-ribosylhomocysteine lyase (luxS),
MhpD,
4-hydroxy-2-ketovalerate aldolase (mhpE),
glyoxylate carboligase (gcl),
malate synthase A (aceB),
malate synthase G (glcB),
UDP-N-acetylglucosamine enolpyruvoyl transferase (murA),
UDP-N-acetylenolpyruvoylglucosamine reductase (murB),
D-alanine-D-alanine ligase A (ddlA),
D-alanine-D-alanine ligase B (ddlB),
MrcB,
MrcA,
AspA,
coproporphyrinogen III dehydrogenase (hemN),
AnsA,
4-diphosphocytidyl-2C-methyl-D-erythritol synthetase monomer (ispD),
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ispG),
IlvA,
propionyl-CoA synthetase (prpE),
2-methylisocitrate lyase (prpB),
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT),
Kbl,
4-aminobutyrate aminotransferase (puuE),
ethanolamine ammonia-lyase, α subunit (eutB),
Amn,
xanthine dehydrogenase subunit, FAD-binding domain (xdhB),
AICAR transformylase / IMP cyclohydrolase (purH),
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase (cobC),
adenylosuccinate lyase (purB),
GuaB,
LysC,
ThrA,
MetL,
malate dehydrogenase (mdh),
isocitrate lyase monomer (aceA),
citrate synthase monomer (gltA),
fumarase C monomer (fumC),
succinyl-CoA synthetase, β subunit,
succinyl-CoA synthetase, α subunit (sucD),
CysH,
sulfate adenylyltransferase, CysD subunit,
diaminopimelate decarboxylase (lysA),
SerC,
4-hydroxy-tetrahydrodipicolinate synthase (dapA),
nicotinate-mononucleotide adenylyltransferase (nadD),
quinolinate phosphoribosyltransferase (decarboxylating) monomer (nadC),
GlpK,
glutamate decarboxylase A subunit (gadA),
glutamate decarboxylase B subunit (gadB),
phosphopentomutase (deoB),
deoxyribose-phosphate aldolase (deoC),
alanine racemase 1, PLP-binding, biosynthetic subunit (alr),
DadX,
glutamate-pyruvate aminotransferase (alaA),
glutamate-pyruvate aminotransferase (alaC),
carbamoyl phosphate synthetase, β chain,
PyrF,
dihydroorotate dehydrogenase, type 2 (pyrD),
UMP kinase (pyrH),
FadI monomer,
FadJ monomer,
uracil phosphoribosyltransferase subunit (upp),
Cdd,
malonyl-CoA-ACP transacylase (fabD),
FabH,
FabF,
thiamine phosphate synthase (thiE),
HisC,
HisB,
imidazole glycerol phosphate synthase, HisF subunit,
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (hisA),
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (hisI),
phosphoribosylamine-glycine ligase (purD),
transaldolase B (talB),
transketolase I (tktA),
transketolase II (tktB),
ribulose-5-phosphate 3-epimerase (rpe),
AtoB,
ornithine decarboxylase, biosynthetic (speC),
ornithine decarboxylase, degradative (speF),
glutamate-putrescine ligase (puuA),
SpeA,
Adi (adiA),
GlmU,
NadR DNA-binding transcriptional repressor and NMN adenylyltransferase,
D-mannonate oxidoreductase (uxuB),
GarL,
glucosamine-6-phosphate deaminase (nagB),
biotin synthase monomer (bioB),
adenosylmethionine-8-amino-7-oxononanoate aminotransferase monomer (bioA),
cardiolipin synthase 1 (clsA),
cardiolipin synthase 2 (clsB),
PssA,
cardiolipin synthase 3 (clsC),
AroG,
AroH,
AroF,
3-phosphoshikimate-1-carboxyvinyltransferase (aroA),
AroD,
argininosuccinate lyase (argH),
ArgI,
N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (argD),
4-aminobutyrate aminotransferase (gabT),
glutamine synthetase (glnA),
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC),
anthranilate synthase component II (trpD),
anthranilate synthase component I (trpE),
PheA,
TyrA,
o-succinylbenzoate-CoA ligase (menE),
o-succinylbenzoate synthase (menC),
MenD,
MenB,
GTP cyclohydrolase I monomer (folE),
pabC,
Udp,
thymidine kinase / deoxyuridine kinase (tdk),
3-phenylpropionate dioxygenase, β subunit (hcaF),
2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (mhpC),
β-ketoadipyl-CoA thiolase (paaJ),
phosphoribosylglycinamide formyltransferase 2 (purT),
3-hydroxy-2,4-pentadione 5-phosphate thiolase (lsrF),
fructose-1,6-bisphosphatase monomer (fbp),
fructose bisphosphate aldolase monomer (fbaB),
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmM),
phosphoenolpyruvate carboxykinase (ATP) (pck),
phosphoenolpyruvate synthetase (ppsA),
MaeB,
triosephosphate isomerase monomer (tpiA),
nicotinamidase / pyrazinamidase (pncA),
trehalose-6-phosphate synthase (otsA),
trehalose-6-phosphate phosphatase (otsB),
bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase (folC),
FolD,
fused UDP-L-Ara4N formyltransferase and UDP-GlcA dehydrogenase (arnA),
UDP-L-Ara4O C-4" transaminase (arnB),
fructose bisphosphate aldolase monomer (fbaA),
phosphogluconate dehydratase (edd),
pyruvate kinase II monomer (pykA),
pyruvate kinase I monomer (pykF),
6-phosphofructokinase-1 monomer (pfkA),
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase monomer (gpmA),
mannitol-1-phosphate 5-dehydrogenase (mtlD),
tagatose-1,6-bisphosphate aldolase 1 subunit KbaZ,
tagatose-1,6-bisphosphate aldolase 1 subunit KbaY,
tagatose-1,6-bisphosphate aldolase 2 subunit GatZ,
tagatose-1,6-bisphosphate aldolase 2 subunit GatY,
dTDP-4-dehydro-6-deoxy-D-glucose transaminase (wecE),
3-deoxy-D-manno-octulosonate 8-phosphate synthase (kdsA),
pantothenate synthetase monomer (panC),
3-methyl-2-oxobutanoate hydroxymethyltransferase monomer (panB),
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (rfaE),
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD),
Fcl,
UDP-N-acetylglucosamine 2-epimerase (wecB),
galactose-1-phosphate uridylyltransferase (galT),
galactose-1-epimerase (galM),
NADH:ubiquinone oxidoreductase, chain CD (nuoC),
D-lactate dehydrogenase (dld),
ScpA,
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4, inactive (tdcE),
PflB,
Ppc,
methylmalonyl-CoA decarboxylase (scpB),
propionyl-CoA:succinate CoA transferase (scpC),
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD),
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH),
glutathione synthetase monomer (gshB),
L-Ala-D/L-Glu epimerase (ycjG),
GlgP,
limit dextrin α-1,6-glucohydrolase (glgX),
lipoyl synthase (lipA),
pantetheine-phosphate adenylyltransferase monomer (coaD),
Dfp,
molybdopterin biosynthesis protein A (moaA),
porphobilinogen synthase (hemB),
glutamate-1-semialdehyde aminotransferase (hemL),
CaiB monomer,
crotonobetainyl-CoA hydratase (caiD),
carnitine-CoA ligase (caiC),
fused PutA transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase,
CadA,
lysine decarboxylase 2 (ldcC),
TdcB,
tryptophanase (tnaA),
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY),
O-acetylserine sulfhydrylase A (cysK),
MetC,
succinylornithine transaminase (astC),
IlvD,
acetohydroxy acid synthase I, large subunit (ilvB),
IlvI,
selenocysteine synthase (selA),
IlvE,
2-isopropylmalate synthase (leuA),
glutamate synthase, large subunit (gltB),
AccC,
periplasmic trehalase (treA),
cytoplasmic trehalase (treF),
trehalose-6-phosphate hydrolase (treC),
1,4-α-glucan branching enzyme (glgB),
GlgC,
SpeE,
adenosylmethionine decarboxylase, proenzyme (speD),
glycine decarboxylase (gcvP),
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA),
D-galactonate dehydratase (dgoD),
allulose-6-phosphate 3-epimerase (alsE),
α-mannosidase (mngB),
bifunctional riboflavin kinase / FMN adenylyltransferase (ribF),
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD),
acetyl-CoA synthetase (AMP-forming) (acs),
excision nuclease subunit A (uvrA),
fused tRNA nucleotidyltransferase / 2',3'-cyclic phosphodiesterase / 2' nucleotidase and phosphatase (cca),
lysine 2,3-aminomutase (epmB),
ribosomal protein S6 modification protein (rimK),
N-acetylneuraminate lyase (nanA),
N-ethylmaleimide reductase, FMN-linked (nemA),
valine-pyruvate aminotransferase (avtA),
RNA 3'-terminal phosphate cyclase (rtcA),
pyridoxal phosphatase / fructose 1,6-bisphosphatase (ybhA),
phosphoethanolamine transferase EptA,
L-rhamnonate dehydratase (yfaW),
sugar phosphatase (ybiV),
sugar phosphatase (yidA),
phosphosugar phosphatase (yigL),
MetB,
tryptophan synthase, α subunit (trpA),
D-glucarate dehydratase (gudD),
poly-β-1,6-N-acetyl-D-glucosamine N-deacetylase (pgaB),
RNase D (rnd),
oxalyl-CoA decarboxylase (oxc),
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU),
AspC,
host restriction; endonuclease R (hsdR),
AdhE,
2,4-dienoyl-CoA reductase (fadH),
DNA polymerase III, α subunit (dnaE),
xanthosine phosphorylase (xapA),
sulfoquinovose isomerase (yihS),
purine nucleoside phosphorylase (deoD),
FabB,
LtaE,
ribonucleoside diphosphate reductase 1, α subunit (nrdA),
NrdE,
Gss,
tRNA-specific adenosine deaminase (tadA),
α-amylase (amyA),
phosphoethanolamine transferase EptC,
O6-alkylguanine-DNA-alkyltransferase (ogt),
Ada DNA-binding transcriptional dual regulator,
pyruvate:flavodoxin oxidoreductase (ydbK),
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH),
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE),
β-galactosidase monomer (lacZ),
α-galactosidase monomer (melA),
8-amino-7-oxononanoate synthase monomer (bioF),
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase (aas),
3-ketoacyl-CoA thiolase (fadA),
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB),
cysteine sulfinate desulfinase (csdA),
Fsa (fsaA),
fructose 6-phosphate aldolase 2 (fsaB),
subunit of E1p component of pyruvate dehydrogenase complex (aceE),
lipoyl(octanoyl) transferase (lipB),
ATP-dependent DNA helicase (recQ),
TyrB,
PII uridylyltransferase / uridylyl removing enzyme (glnD),
formamidopyrimidine DNA glycosylase (mutM),
glycolate oxidase, predicted FAD-binding subunit (glcE),
glycolate oxidase, predicted FAD-linked subunit (glcD),
pyruvate oxidase monomer (poxB),
KpLE2 phage-like element; D-xylonate dehydratase (yjhG),
CP4-6 prophage; D-xylonate dehydratase (yagF),
phosphoglycerol transferase I (opgB),
methionine-oxo-acid transaminase, PLP-dependent (ybdL),
ribosomal protein S12 D88 methylthiotransferase (rimO),
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ),
protease III (ptrA),
peroxyureidoacrylate / ureidoacrylate amido hydrolase (rutB),
GuaC,
fused 5-methylaminomethyl-2-thiouridine-forming methyltransferase and FAD-dependent demodification enzyme (mnmC),
isopentenyl-adenosine A37 tRNA methylthiolase (miaB),
3-methyl-adenine DNA glycosylase I, constitutive (tag),
glycoside hydrolase (ygjK),
putrescine aminotransferase (patA),
aldose sugar dehydrogenase (yliI),
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase monomer (mtn),
maltodextrin phosphorylase monomer (malP),
23S rRNA m2A2503 methyltransferase and tRNA m2A37 methyltransferase (rlmN),
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF),
sulfoquinovosidase (yihQ),
monoacetylchitobiose-6-phosphate hydrolase (chbF),
pyridoxal phosphatase / HMP-PP hydrolase (cof),
purine nucleoside phosphoramidase monomer (hinT),
α-xylosidase (yicI),
peptidase component of the HslVU protease,
EntE,
apo-serine activating enzyme (entF),
EntB monomer,
serine hydroxymethyltransferase (glyA),
NrdG,
ribonucleoside-triphosphate reductase (nrdD),
chito-oligosaccharide mono-deacetylase (chbG),
DLP12 prophage; lysozyme (rrrD),
NADH-dependent dihydropyrimidine dehydrogenase subunit (preA),
D-cysteine desulfhydrase (dcyD),
tRNA-dihydrouridine synthase A (dusA),
tRNA-dihydrouridine synthase B (dusB),
tRNA-dihydrouridine synthase C (dusC),
hybrid-cluster protein (hcp),
FadD,
short chain acyl-CoA synthetase (fadK),
RNA/ssDNA exonuclease 5' → 3' specific (yciV),
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA),
fumarase A monomer,
α-amylase (malS),
3-methyl-adenine DNA glycosylase II, inducible (alkA),
endonuclease III (nth),
endo-1,4-D-glucanase (bcsZ),
acetyl-CoA:oxalate CoA-transferase (yfdE),
formyl-CoA transferase monomer (frc),
L-lactate dehydrogenase (lldD),
10-formyltetrahydrofolate:L-methionyl-tRNAfMet N-formyltransferase (fmt),
phosphoethanolamine transferase (opgE),
fumarase B monomer (fumB),
bis(molybdenum cofactor) synthase [multifunctional] (mobA),
Eda,
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB),
maltodextrin glucosidase (malZ),
arylsulfatase (aslA),
CDP-diacylglycerol pyrophosphatase (cdh),
Kdo2-lipid A phosphoethanolamine 7''-transferase (eptB),
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase (ybjI),
PhoA,
Ppk,
AppA monomer,
cysteine desulfurase monomer (iscS),
L-cysteine desulfurase (sufS),
citrate lyase, citryl-ACP lyase β subunit (citE),
siroheme synthase subunit (cysG),
α-methylacyl-CoA racemase (mcr),
isocaprenoyl-CoA:2-hydroxyisocaproate CoA-transferase (hadA),
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase (ycsE),
cholesterol 25-hydroxylase (CH25H),
sucrase-isomaltase propeptide (SI),
2-oxo-4-methylthiobutanoate-glutamine aminotransferase (mtnE),
fructose-2,6-bisphosphatase TIGAR,
Aldo-keto reductase family 1 member C1 (AKR1C1),
Arginase-1 (ARG1),
lysine-8-amino-7-oxononanoate aminotransferase (bioK),
Delta-aminolevulinic acid dehydratase (ALAD),
kanosamine-6-phosphate phosphatase (ntdB),
3-oxo-glucose-6-phosphate:glutamate aminotransferase (ntdA),
glucose-6-phosphate 3-dehydrogenase (ntdC),
phosphoenolpyruvate-protein phosphotransferase PtsP, enzyme INtr,
glucitol dehydrogenase monomer (gutB),
scyllo-inositol dehydrogenase (NADP+) (iolW),
2-deoxy-5-keto-D-gluconate 6-phosphate aldolase (iolJ),
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD),
inositol 2-dehydrogenase monomer (iolG),
scyllo-inositol 2-dehydrogenase (NAD+) (iolX),
CTP synthetase (pyrG),
cytidine/deoxycytidine deaminase monomer (cdd),
long-chain acyl-CoA synthetase ACSBG1,
long-chain acyl-CoA synthetase 8 ACSBG2,
phytanoyl-CoA dioxygenase, peroxisomal (PHYH),
sphingoliid fatty acid 2-hydroxylase (FA2H),
enoyl-acyl carrier protein reductase III (fabL),
mycophenolic acid acyl-glucuronide esterase (ABHD10),
arabinogalactan endo-1,4-β-galactosidase (ganB),
lipoate-protein ligase (lplJ),
lipoyl synthase (lipoic acid synthetase) (lipA),
GcvH:[lipoyl domain] amidotransferase (lipL),
thiamine monophosphate kinase (thiL),
thiamine phosphate synthase (thiE),
1-deoxyxylulose-5-phosphate synthase (dxs),
thiazole synthase (thiG),
cysteine desulfurase monomer (iscS),
[sulfur-carrier protein ThiS] adenylyltransferase (thiF),
thiazole tautomerase (tenI),
retinal dehydrogenase 2 (ALDH1A2),
gephyrin (GPHN),
glucuronoarabinoxylan endo-1,4-β-xylanase (xynC),
α-L-arabinofuranosidase 2 (xsa),
α-L-arabinofuranosidase 1 (abfA),
7-carboxy-7-deazaguanine synthase (queE),
CTP synthase 2 (CTPS2)

Unification Links: GO:0003824

Relationship Links: Wikipedia:RELATED-TO:Enzyme


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 20.0 (software by SRI International) on Thu May 5, 2016, BIOCYC13A.