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MetaCyc Gene-Ontology-Terms Class: GO:0003824 - catalytic activity

Synonyms: enzyme activity

Definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Parent Classes:
GO:0003674 - molecular_function

Child Classes:
GO:0000150 - recombinase activity (1),
GO:0004133 - glycogen debranching enzyme activity (3),
GO:0004803 - transposase activity (1),
GO:0008907 - integrase activity (1),
GO:0008987 - quinolinate synthetase A activity (2),
GO:0009975 - cyclase activity (2),
GO:0016491 - oxidoreductase activity (528),
GO:0016740 - transferase activity (733),
GO:0016787 - hydrolase activity (602),
GO:0016829 - lyase activity (229),
GO:0016853 - isomerase activity (125),
GO:0016874 - ligase activity (128),
GO:0019239 - deaminase activity (15),
GO:0032451 - demethylase activity (1),
GO:0043364 - catalysis of free radical formation (1),
GO:0070283 - radical SAM enzyme activity (4)

Term Members:
endochitinase (chiA),
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA),
essential cell division protein FtsI; penicillin-binding protein 3,
L-lactate dehydrogenase (lldD),
GTP cyclohydrolase I monomer (folE),
GlmU,
nicotinate-mononucleotide adenylyltransferase (nadD),
quinolinate phosphoribosyltransferase (decarboxylating) monomer (nadC),
NadR DNA-binding transcriptional repressor and NMN adenylyltransferase,
nicotinamidase / pyrazinamidase (pncA),
periplasmic trehalase (treA),
cytoplasmic trehalase (treF),
trehalose-6-phosphate hydrolase (treC),
phosphogluconate dehydratase (edd),
sulfate adenylyltransferase, CysD subunit,
GarL,
mannitol-1-phosphate 5-dehydrogenase (mtlD),
KbaZ,
KbaY,
GatZ,
GatY,
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT),
glucosamine-6-phosphate deaminase (nagB),
D-mannonate oxidoreductase (uxuB),
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA),
D-galactonate dehydratase (dgoD),
propionyl-CoA synthetase (prpE),
2-methylisocitrate lyase (prpB),
glutamine synthetase (glnA),
glutamate-putrescine ligase (puuA),
PheA,
TyrA,
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC),
anthranilate synthase component II (trpD),
anthranilate synthase component I (trpE),
glyoxylate carboligase (gcl),
glycolate oxidase, predicted FAD-binding subunit (glcE),
glycolate oxidase, predicted FAD-linked subunit (glcD),
malate synthase A (aceB),
malate synthase G (glcB),
allulose-6-phosphate 3-epimerase (alsE),
phosphopentomutase (deoB),
deoxyribose-phosphate aldolase (deoC),
α-mannosidase (mngB),
ScpA,
MrcB,
MrcA,
1,4-α-glucan branching enzyme (glgB),
GlgC,
LysC,
ThrA,
MetL,
ornithine decarboxylase, biosynthetic (speC),
ornithine decarboxylase, degradative (speF),
SpeA,
Adi (adiA),
adenosylmethionine decarboxylase, proenzyme (speD),
SpeE,
CadA,
lysine decarboxylase 2 (ldcC),
homoserine O-succinyltransferase (metA),
S-ribosylhomocysteine lyase (luxS),
AspA,
UDP-N-acetylglucosamine enolpyruvoyl transferase (murA),
UDP-N-acetylenolpyruvoylglucosamine reductase (murB),
D-alanine-D-alanine ligase A (ddlA),
D-alanine-D-alanine ligase B (ddlB),
Udp,
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase (cobC),
coproporphyrinogen III dehydrogenase (hemN),
CysG,
AnsA,
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD),
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH),
Kbl,
IlvA,
MhpD,
4-hydroxy-2-ketovalerate aldolase (mhpE),
3-phenylpropionate dioxygenase, β subunit (hcaF),
2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (mhpC),
3-hydroxy-2,4-pentadione 5-phosphate thiolase (lsrF),
4-aminobutyrate aminotransferase (gabT),
4-aminobutyrate aminotransferase (puuE),
Cdd,
Amn,
xanthine dehydrogenase subunit, FAD-binding domain (xdhB),
L-Ala-D/L-Glu epimerase (ycjG),
ethanolamine ammonia-lyase, α subunit (eutB),
AtoB,
D-lactate dehydrogenase (dld),
AICAR transformylase / IMP cyclohydrolase (purH),
GuaB,
adenylosuccinate lyase (purB),
3-phosphoshikimate-1-carboxyvinyltransferase (aroA),
AroD,
1-deoxyxylulose-5-phosphate synthase (dxs),
tyrosine lyase (thiH),
ThiG,
GlpK,
PssA,
4-diphosphocytidyl-2C-methyl-D-erythritol synthetase monomer (ispD),
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ispG),
cardiolipin synthase 3 (clsC),
cardiolipin synthase 1 (clsA),
cardiolipin synthase 2 (clsB),
Upp,
AroG,
AroH,
AroF,
MenE,
o-succinylbenzoate synthase (menC),
MenD,
MenB,
pabC,
CysH,
thymidine kinase / deoxyuridine kinase (tdk),
alanine racemase 1, PLP-binding, biosynthetic subunit (alr),
DadX,
glutamate-pyruvate aminotransferase (alaA),
glutamate-pyruvate aminotransferase (alaC),
UMP kinase (pyrH),
pyruvate kinase II monomer (pykA),
pyruvate kinase I monomer (pykF),
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmM),
triosephosphate isomerase monomer (tpiA),
fructose bisphosphate aldolase monomer (fbaB),
phosphoenolpyruvate synthetase (ppsA),
fructose-1,6-bisphosphatase monomer (fbp),
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase monomer (gpmA),
transaldolase B (talB),
transketolase I (tktA),
transketolase II (tktB),
ribulose-5-phosphate 3-epimerase (rpe),
biotin synthase monomer (bioB),
adenosylmethionine-8-amino-7-oxononanoate aminotransferase monomer (bioA),
argininosuccinate lyase (argH),
ArgI,
carbamoyl phosphate synthetase, β chain,
glutamate decarboxylase A subunit (gadA),
glutamate decarboxylase B subunit (gadB),
malate dehydrogenase (mdh),
isocitrate lyase monomer (aceA),
citrate synthase monomer (gltA),
fumarase C monomer (fumC),
succinyl-CoA synthetase, β subunit,
succinyl-CoA synthetase, α subunit (sucD),
β-ketoadipyl-CoA thiolase (paaJ),
molybdopterin biosynthesis protein A (moaA),
porphobilinogen synthase (hemB),
glutamate-1-semialdehyde aminotransferase (hemL),
LysA,
N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (argD),
4-hydroxy-tetrahydrodipicolinate synthase (dapA),
lipoyl synthase (lipA),
thiamine phosphate synthase (thiE),
pantetheine-phosphate adenylyltransferase monomer (coaD),
Dfp,
IlvE,
2-isopropylmalate synthase (leuA),
IlvD,
acetohydroxy acid synthase I, large subunit (ilvB),
IlvI,
phosphoenolpyruvate carboxykinase (ATP) (pck),
MaeB,
trehalose-6-phosphate synthase (otsA),
trehalose-6-phosphate phosphatase (otsB),
fused UDP-L-Ara4N formyltransferase and UDP-GlcA C-4''-decarboxylase (arnA),
UDP-L-Ara4O C-4" transaminase (arnB),
malonyl-CoA-ACP transacylase (fabD),
FabH,
FabF,
PyrF,
dihydroorotate dehydrogenase, type 2 (pyrD),
HisC,
HisB,
imidazole glycerol phosphate synthase, HisF subunit,
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (hisA),
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (hisI),
phosphoribosylamine-glycine ligase (purD),
phosphoribosylglycinamide formyltransferase 2 (purT),
dTDP-4-dehydro-6-deoxy-D-glucose transaminase (rffA),
UDP-N-acetylglucosamine 2-epimerase (wecB),
PdxJ,
SerC,
3-deoxy-D-manno-octulosonate 8-phosphate synthase (kdsA),
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (rfaE),
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD),
methylmalonyl-CoA decarboxylase (scpB),
propionyl-CoA:succinate CoA transferase (scpC),
CaiB monomer,
crotonobetainyl-CoA hydratase (caiD),
carnitine-CoA ligase (caiC),
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4, inactive (tdcE),
PflB,
Ppc,
glycine decarboxylase (gcvP),
FolD,
bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase (folC),
pantothenate synthetase monomer (panC),
3-methyl-2-oxobutanoate hydroxymethyltransferase monomer (panB),
AccC,
NADH:ubiquinone oxidoreductase, chain CD (nuoC),
6-phosphofructokinase-1 monomer (pfkA),
fructose bisphosphate aldolase monomer (fbaA),
FadD,
short chain acyl-CoA synthetase (fadK),
FadI monomer,
FadJ monomer,
glutathione synthetase monomer (gshB),
bifunctional riboflavin kinase / FMN adenylyltransferase (ribF),
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD),
Fcl,
galactose-1-phosphate uridylyltransferase (galT),
galactose-1-epimerase (galM),
fused PutA transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase,
TdcB,
tryptophanase (tnaA),
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY),
O-acetylserine sulfhydrylase A (cysK),
MetC,
succinylornithine transaminase (astC),
selenocysteine synthase (selA),
glutamate synthase, large subunit (gltB),
GlgP,
limit dextrin α-1,6-glucohydrolase (glgX),
xanthosine phosphorylase (xapA),
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH),
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE),
α-amylase (malS),
α-amylase (amyA),
oxalyl-CoA decarboxylase (oxc),
tRNA-dihydrouridine synthase A (dusA),
tRNA-dihydrouridine synthase B (dusB),
tRNA-dihydrouridine synthase C (dusC),
tryptophan synthase, α subunit (trpA),
formamidopyrimidine DNA glycosylase (mutM),
8-amino-7-oxononanoate synthase monomer (bioF),
fumarase B monomer (fumB),
formyl-CoA transferase monomer (frc),
GuaC,
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase (ybjI),
AdhE,
lysine 2,3-aminomutase (epmB),
sulfoquinovose isomerase (yihS),
chito-oligosaccharide mono-deacetylase (chbG),
excision nuclease subunit A (uvrA),
N-ethylmaleimide reductase, FMN-linked (nemA),
valine-pyruvate aminotransferase (avtA),
phosphoethanolamine transferase EptA,
RNA/ssDNA exonuclease 5' → 3' specific (yciV),
AspC,
DLP12 prophage; lysozyme (rrrD),
hybrid-cluster protein (hcp),
D-glucarate dehydratase (gudD),
poly-β-1,6-N-acetyl-D-glucosamine N-deacetylase (pgaB),
Eda,
phosphoethanolamine transferase (opgE),
3-methyl-adenine DNA glycosylase II, inducible (alkA),
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU),
phosphoglycerol transferase I (opgB),
aldehyde dehydrogenase, FAD-binding subunit (paoB),
citrate lyase, citryl-ACP lyase β subunit (citE),
subunit of E1p component of pyruvate dehydrogenase complex (aceE),
lipoyl(octanoyl) transferase (lipB),
O6-alkylguanine-DNA-alkyltransferase (ogt),
Ada DNA-binding transcriptional dual regulator,
pyruvate:flavodoxin oxidoreductase (ydbK),
PII uridylyltransferase / uridylyl removing enzyme (glnD),
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase (aas),
FabB,
ribonucleoside diphosphate reductase 1, α subunit (nrdA),
NrdE,
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF),
bis(molybdenum cofactor) synthase [multifunctional] (mobA),
endo-1,4-D-glucanase (bcsZ),
acetyl-CoA:oxalate CoA-transferase (yfdE),
KpLE2 phage-like element; D-xylonate dehydratase (yjhG),
CP4-6 prophage; D-xylonate dehydratase (yagF),
arylsulfatase (aslA),
N-acetylneuraminate lyase (nanA),
purine nucleoside phosphorylase (deoD),
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase monomer (mtn),
2,4-dienoyl-CoA reductase (fadH),
DNA polymerase III, α subunit (dnaE),
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA),
phosphoethanolamine transferase EptC,
ribosomal protein S6 modification protein (rimK),
TyrB,
acetyl-CoA synthetase (AMP-forming) (acs),
pyridoxal phosphatase / fructose 1,6-bisphosphatase (ybhA),
fused 5-methylaminomethyl-2-thiouridine-forming methyltransferase and FAD-dependent demodification enzyme (mnmC),
3-ketoacyl-CoA thiolase (fadA),
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB),
β-galactosidase monomer (lacZ),
fumarase A monomer,
NADH-dependent dihydropyrimidine dehydrogenase subunit (preA),
tRNA-specific adenosine deaminase monomer (tadA),
Fsa (fsaA),
fructose 6-phosphate aldolase 2 (fsaB),
RNase D (rnd),
cysteine desulfurase monomer,
ATP-dependent DNA helicase (recQ),
10-formyltetrahydrofolate:L-methionyl-tRNAfMet N-formyltransferase (fmt),
Kdo2-lipid A phosphoethanolamine 7''-transferase (eptB),
D-cysteine desulfhydrase (dcyD),
methionine-oxo-acid transaminase, PLP-dependent (ybdL),
23S rRNA m2A2503 methyltransferase and tRNA m2A37 methyltransferase (rlmN),
sugar phosphatase (ybiV),
sugar phosphatase (yidA),
phosphosugar phosphatase (yigL),
cysteine sulfinate desulfinase (csdA),
L-cysteine desulfurase (sufS),
host restriction; endonuclease R (hsdR),
peroxyureidoacrylate / ureidoacrylate amido hydrolase (rutB),
maltodextrin glucosidase (malZ),
ribosomal protein S12 D88 methylthiotransferase (rimO),
pyruvate oxidase monomer (poxB),
endonuclease III (nth),
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ),
protease III (ptrA),
isopentenyl-adenosine A37 tRNA methylthiolase (miaB),
3-methyl-adenine DNA glycosylase I, constitutive (tag),
maltodextrin phosphorylase monomer (malP),
glycoside hydrolase (ygjK),
AppA,
aldose sugar dehydrogenase (yliI),
CDP-diacylglycerol pyrophosphatase (cdh),
putrescine aminotransferase (patA),
LtaE,
Ppk,
RNA 3'-terminal phosphate cyclase (rtcA),
NrdG,
ribonucleoside-triphosphate reductase (nrdD),
pyridoxal phosphatase / HMP-PP hydrolase (cof),
Gss,
fused tRNA nucleotidyltransferase / 2',3'-cyclic phosphodiesterase / 2' nucleotidase and phosphatase (cca),
purine nucleoside phosphoramidase monomer (hinT),
α-xylosidase (yicI),
peptidase component of the HslVU protease,
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB),
L-rhamnonate dehydratase (yfaW),
EntE,
apo-serine activating enzyme (entF),
EntB monomer,
serine hydroxymethyltransferase (glyA),
MetB,
PhoA,
sucrase-isomaltase propeptide (SI),
2-oxo-4-methylthiobutanoate-glutamine aminotransferase (mtnE),
fructose-2,6-bisphosphatase TIGAR,
Aldo-keto reductase family 1 member C1 (AKR1C1),
Arginase-1 (ARG1),
lysine-8-amino-7-oxononanoate aminotransferase (bioK),
Delta-aminolevulinic acid dehydratase (ALAD),
kanosamine-6-phosphate phosphatase (ntdB),
3-oxo-glucose-6-phosphate:glutamate aminotransferase (ntdA),
glucose-6-phosphate 3-dehydrogenase (ntdC),
phosphoenolpyruvate-protein phosphotransferase PtsP, enzyme INtr,
glucitol dehydrogenase monomer (gutB),
scyllo-inositol dehydrogenase (NADP+) (iolW),
2-deoxy-5-keto-D-gluconate 6-phosphate aldolase (iolJ),
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD),
inositol 2-dehydrogenase monomer (iolG),
scyllo-inositol 2-dehydrogenase (NAD+) (iolX),
CTP synthetase (pyrG),
cytidine/deoxycytidine deaminase monomer (cdd),
long-chain acyl-CoA synthetase ACSBG1,
long-chain acyl-CoA synthetase 8 ACSBG2,
phytanoyl-CoA dioxygenase, peroxisomal (PHYH),
sphingoliid fatty acid 2-hydroxylase (FA2H),
enoyl-acyl carrier protein reductase III (fabL),
mycophenolic acid acyl-glucuronide esterase (ABHD10),
protoporphyrinogen oxidase (hemY),
arabinogalactan endo-1,4-β-galactosidase (ganB),
lipoate-protein ligase (lplJ),
lipoyl synthase (lipoic acid synthetase) (lipA),
GcvH:[lipoyl domain] amidotransferase (lipL),
thiamine monophosphate kinase (thiL),
thiamine phosphate synthase (thiE),
1-deoxyxylulose-5-phosphate synthase (dxs),
thiazole synthase (thiG),
cysteine desulfurase monomer (iscS),
[sulfur-carrier protein ThiS] adenylyltransferase (thiF),
thiazole tautomerase (tenI),
retinal dehydrogenase 2 (ALDH1A2),
gephyrin (GPHN),
glucuronoarabinoxylan endo-1,4-β-xylanase (xynC),
α-L-arabinofuranosidase 2 (xsa),
α-L-arabinofuranosidase 1 (abfA),
7-carboxy-7-deazaguanine synthase (queE),
CTP synthase 2 (CTPS2)

Unification Links: GO:0003824

Relationship Links: Wikipedia:RELATED-TO:Enzyme


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Tue Feb 9, 2016, BIOCYC11A.