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MetaCyc Gene-Ontology-Terms Class: GO:0004519 - endonuclease activity

Definition: Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

Parent Classes:
GO:0004518 - nuclease activity

Child Classes:
GO:0004520 - endodeoxyribonuclease activity (15),
GO:0004521 - endoribonuclease activity (19),
GO:0016893 - endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters (11),
GO:0016894 - endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters (4),
GO:0043765 - T/G mismatch-specific endonuclease activity (1)

Term Members:
30S ribosomal subunit protein S16 (rpsP),
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity (chpA),
RNase P protein component; processes tRNA, 4.5S RNA (rnpA),
endonuclease IV (nfo),
formamidopyrimidine DNA glycosylase (mutM),
crRNA endonuclease (casE),
RecBCD,
RecB,
RecC,
RecD,
RNase III (rnc),
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system,
CP4-57 prophage; RNase LS, toxin of the RnlAB toxin-antitoxin system,
antitoxin of the GhoTS toxin-antitoxin system (ghoS),
ribonuclease G (RNAse G) monomer (rng),
RNase I, cleaves phosphodiester bond between any two nucleotides,
DNA-specific endonuclease I (endA),
toxin of the YoeB-YefM toxin-antitoxin pair,
endonuclease V (nfi),
restriction of DNA at 5-methylcytosine residues (mcrA),
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system,
translation-dependent mRNA interferase, toxin of the HigB-HigA toxin-antitoxin system,
toxin of the YafQ-DinJ toxin-antitoxin system,
Qin prophage; toxin of the RelE-RelB toxin-antitoxin system and cofactor to enhance the repressor activity of RelB,
MutH,
Rbn,
Rac prophage; DNA endonuclease toxin of the RalRA toxin-antitoxin system, restriction alleviation and modification enhancement,
YhaV toxic ribonuclease,
host restriction; endonuclease R (hsdR),
MrcB subunit of 5-methylcytosine restriction system (mcrB),
RNase HI, degrades RNA of DNA-RNA hybrids, participates in DNA replication (rnhA),
RNAse HII, degrades RNA of DNA-RNA hybrids (rnhB),
RNase E (rne),
exonuclease III (xthA),
ChpB toxin of the ChpB-ChpS toxin-antitoxin system

Unification Links: GO:0004519

Relationship Links: Reactome:RELATED-TO:REACT_1124, Reactome:RELATED-TO:REACT_1914, Reactome:RELATED-TO:REACT_6746, Reactome:RELATED-TO:REACT_6774, Reactome:RELATED-TO:REACT_34610, Reactome:RELATED-TO:REACT_77706, Reactome:RELATED-TO:REACT_78624, Reactome:RELATED-TO:REACT_79198, Reactome:RELATED-TO:REACT_80387, Reactome:RELATED-TO:REACT_80628, Reactome:RELATED-TO:REACT_80681, Reactome:RELATED-TO:REACT_80797, Reactome:RELATED-TO:REACT_81714, Reactome:RELATED-TO:REACT_87541, Reactome:RELATED-TO:REACT_89800, Reactome:RELATED-TO:REACT_90034, Reactome:RELATED-TO:REACT_90935, Reactome:RELATED-TO:REACT_92894, Reactome:RELATED-TO:REACT_100654, Reactome:RELATED-TO:REACT_101397, Reactome:RELATED-TO:REACT_103600, Reactome:RELATED-TO:REACT_106502, Reactome:RELATED-TO:REACT_108614, Reactome:RELATED-TO:REACT_110731, Reactome:RELATED-TO:REACT_112366, Reactome:RELATED-TO:REACT_112509, Reactome:RELATED-TO:REACT_112615, Reactome:RELATED-TO:REACT_112782, Reactome:RELATED-TO:REACT_113127, Reactome:RELATED-TO:REACT_113480, Reactome:RELATED-TO:REACT_113819, Reactome:RELATED-TO:REACT_114931, Reactome:RELATED-TO:REACT_115221, Reactome:RELATED-TO:REACT_115226, Reactome:RELATED-TO:REACT_115382, Reactome:RELATED-TO:REACT_115937, Reactome:RELATED-TO:REACT_116011


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Wed Feb 10, 2016, BIOCYC11A.