MetaCyc Gene-Ontology-Terms Class: GO:0004519 - endonuclease activity

Definition: Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

Parent Classes:
GO:0004518 - nuclease activity

Child Classes:
GO:0004520 - endodeoxyribonuclease activity (15) ,
GO:0004521 - endoribonuclease activity (18) ,
GO:0016893 - endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters (11) ,
GO:0016894 - endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters (3) ,
GO:0043765 - T/G mismatch-specific endonuclease activity (1)

Term Members:
30S ribosomal subunit protein S16 (rpsP) ,
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity (chpA) ,
RNase P protein component; processes tRNA, 4.5S RNA (rnpA) ,
DNA-specific endonuclease I (endA) ,
endonuclease V (deoxyinosine 3'-endonuclease) (nfi) ,
ChpB toxin of the ChpB-ChpS toxin-antitoxin system ,
crRNA endonuclease (casE) ,
host restriction; endonuclease R (hsdR) ,
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system ,
CP4-57 prophage; RNase LS, toxin of the RnlAB toxin-antitoxin system ,
antitoxin of the GhoTS toxin-antitoxin system (ghoS) ,
ribonuclease G (RNAse G) monomer (rng) ,
toxin of the YoeB-YefM toxin-antitoxin pair ,
endonuclease IV (nfo) ,
formamidopyrimidine DNA glycosylase (mutM) ,
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system ,
translation-dependent mRNA interferase, toxin of the HigB-HigA toxin-antitoxin system ,
toxin of the YafQ-DinJ toxin-antitoxin system ,
Qin prophage; toxin of the RelE-RelB toxin-antitoxin system and cofactor to enhance the repressor activity of RelB ,
RNase III (rnc) ,
RNase E (rne) ,
RNase I, cleaves phosphodiester bond between any two nucleotides ,
RNase HI, degrades RNA of DNA-RNA hybrids, participates in DNA replication (rnhA) ,
RNAse HII, degrades RNA of DNA-RNA hybrids (rnhB) ,
exonuclease III (xthA) ,
restriction of DNA at 5-methylcytosine residues (mcrA) ,
MrcB subunit of 5-methylcytosine restriction system (mcrB) ,
Rac prophage; DNA endonuclease toxin of the RalRA toxin-antitoxin system, restriction alleviation and modification enhancement ,
Rbn ,
RecBCD ,
RecB ,
RecC ,
RecD ,
MutH ,
YhaV toxic ribonuclease

Unification Links: GO:0004519

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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