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discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Gene-Ontology-Terms Class: GO:0005515 - protein binding

Synonyms: GO:0045308, protein amino acid binding

Definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

Parent Classes:
GO:0005488 - binding

Child Classes:
GO:0005102 - receptor binding (4) ,
GO:0005516 - calmodulin binding (1) ,
GO:0008013 - beta-catenin binding (1) ,
GO:0008134 - transcription factor binding (2) ,
GO:0019899 - enzyme binding (5) ,
GO:0030674 - protein binding, bridging (2) ,
GO:0031072 - heat shock protein binding (2) ,
GO:0032403 - protein complex binding (1) ,
GO:0032794 - GTPase activating protein binding (1) ,
GO:0042802 - identical protein binding (285) ,
GO:0044183 - protein binding involved in protein folding (2) ,
GO:0046983 - protein dimerization activity (133) ,
GO:0051082 - unfolded protein binding (8) ,
GO:0051087 - chaperone binding (3)

Term Members:
RelB-antitoxin and DNA-binding transcriptional repressor ,
PII (glnB) ,
biotin carboxyl carrier protein (accB) ,
thioredoxin 1 (trxA) ,
GlnK ,
reduced ferredoxin (fdx) ,
apo-[acyl carrier protein] (acpP) ,
RelB Qin prophage; antitoxin of the RelE-RelB toxin-antitoxin system and DNA binding transcriptional repressor ,
primosome factor N' (priA) ,
primosomal protein DnaT ,
aldehyde dehydrogenase, Fe-S subunit (yagT) ,
putative protein secretion protein for export (gspH) ,
EntB monomer ,
DNA polymerase III, χ subunit (holC) ,
putative protein secretion protein for export (gspE) ,
MalT transcriptional activator ,
iron-sulfur cluster scaffold protein (nfuA) ,
ATP synthase F1 complex - epsilon subunit (atpC) ,
PurR ,
predicted ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) (paaG) ,
RNA polymerase, sigma 70 (sigma D) factor (rpoD) ,
PriB ,
DNA polymerase III, τ subunit (dnaX) ,
protein disulfide oxidoreductase - DsbBreduced ,
DNA polymerase III, θ subunit (holE) ,
CSD sulfur transfer protein (csdE) ,
serine/threonine kinase HipA ,
DnaN ,
aldehyde dehydrogenase: molybdenum cofactor-binding subunit (yagR) ,
DNA polymerase III, ψ subunit (holD) ,
ATP synthase F1 complex - gamma subunit (atpG) ,
co-chaperone for [Fe-S] cluster biosynthesis (hscB) ,
ATP synthase F1 complex - beta subunit (atpD) ,
DinJ antitoxin of YafQ-DinJ toxin-antitoxin system and DNA-binding transcriptional repressor ,
MqsA antitoxin of the MqsRA toxin-antitoxin system and DNA-binding transcriptional repressor ,
predicted 5-keto 4-deoxyuronate isomerase monomer (kduI) ,
scaffold protein for iron-sulfur cluster assembly (iscU) ,
RNA polymerase, sigma 24 (sigma E) factor (rpoE) ,
primosomal replication protein N'' (priC) ,
aldehyde dehydrogenase, FAD-binding subunit (yagS) ,
DNA polymerase III, δ prime subunit (holB) ,
iron-sulfur cluster assembly protein (iscA) ,
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity (chpA) ,
CP4-57 prophage; antitoxin of the RnlA-RnlB toxin-antitoxin system ,
accessory protein for nickel incorporation into hydrogenase 3 (hypA) ,
RNA polymerase, sigma 32 (sigma H) factor (rpoH) ,
50S ribosomal subunit protein L4 (rplD) ,
RhlB ,
RNA polymerase, sigma 28 (sigma F) factor (fliA) ,
acetohydroxy acid synthase I, small subunit (ilvN) ,
acetohydroxy acid synthase I, large subunit (ilvB) ,
UDP-glucose 4-epimerase monomer (galE) ,
mannose-6-phosphate isomerase (manA) ,
Ugd ,
LeuD ,
LeuC ,
LysA ,
HisB ,
geranyl diphosphate synthase / farnesyl diphosphate synthase (ispA) ,
octaprenyl diphosphate synthase (ispB) ,
glutamate synthase, small subunit (gltD) ,
glutamate synthase, large subunit (gltB) ,
carbamoyl phosphate synthetase, α chain (carA) ,
carbamoyl phosphate synthetase, β chain ,
aspartate carbamoyltransferase, PyrI subunit ,
aspartate carbamoyltransferase, PyrB subunit ,
PyrF ,
N-acetylmuramic acid 6-phosphate etherase (murQ) ,
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase (ubiF) ,
UbiG ,
fructoselysine 6-kinase (frlD) ,
GlmS ,
glycerol-3-phosphate acyltransferase (plsB) ,
LpxB ,
3-deoxy-D-manno-octulosonate cytidylyltransferase (kdsB) ,
AccC ,
acetyl-CoA carboxyltransferase, α subunit (accA) ,
acetyl-CoA carboxyltransferase, β subunit (accD) ,
ScpA ,
PhnG subunit of methylphosphonate degradation complex ,
acetaldehyde dehydrogenase 2 (mhpF) ,
dihydroxyacetone kinase subunit L (dhaL) ,
dihydroxyacetone kinase subunit K (dhaK) ,
anaerobic glycerol-3-phosphate dehydrogenase subunit A (glpA) ,
MenB ,
ribonucleoside hydrolase 1 (pyrimidine-specific) (rihA) ,
molybdopterin synthase large subunit (moaE) ,
molybdopterin synthase small subunit (moaD) ,
molybdopterin molybdenumtransferase (moeA) ,
molybdenum cofactor guanylyltransferase (mobA) ,
methionine adenosyltransferase (metK) ,
molybdenum cofactor cytidylyltransferase (mocA) ,
guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase [multifunctional] (spoT) ,
α-galactosidase monomer (melA) ,
pyridine nucleotide transhydrogenase, α subunit (pntA) ,
pyridine nucleotide transhydrogenase, β subunit (pntB) ,
glutamate-1-semialdehyde aminotransferase (hemL) ,
HemA ,
acetyl-CoA:acetoacetyl-CoA transferase, β subunit (atoA) ,
GlpK ,
CadA ,
LdcC ,
cobalamin-independent homocysteine transmethylase (metE) ,
AspA ,
7-cyano-7-deazaguanine synthase (queC) ,
Gsk ,
PurA ,
adenylate kinase (adk) ,
ThiS adenylyltransferase (thiF) ,
tyrosine lyase (thiH) ,
ThiG ,
citrate synthase monomer (gltA) ,
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB) ,
succinyl-CoA synthetase, β subunit ,
succinyl-CoA synthetase, α subunit (sucD) ,
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein (sdhB) ,
succinate:quinone oxidoreductase, FAD binding protein (sdhA) ,
sulfate adenylyltransferase, CysN subunit ,
sulfate adenylyltransferase, CysD subunit ,
Pta ,
4-hydroxy-2-ketovalerate aldolase (mhpE) ,
phosphoribosylglycinamide formyltransferase 2 (purT) ,
threonyl-tRNA synthetase (thrS) ,
phenylalanyl-tRNA synthetase β-chain (pheT) ,
phenylalanyl-tRNA synthetase α-chain (pheS) ,
methionyl-tRNA synthetase (metG) ,
glycyl-tRNA synthetase, α subunit (glyQ) ,
glycyl-tRNA synthetase, β subunit (glyS) ,
biosynthetic peptidoglycan transglycosylase (mtgA) ,
essential cell division protein FtsI; penicillin-binding protein 3 ,
peptidoglycan synthetase; penicillin-binding protein 1A (mrcA) ,
MrcB ,
UDP-N-acetylmuramate-alanine ligase (murC) ,
ribulose-5-phosphate 3-epimerase (rpe) ,
pyruvate kinase II monomer (pykA) ,
triose phosphate isomerase monomer (tpiA) ,
3-dehydroquinate synthase (aroB) ,
AroH ,
biotin synthase monomer (bioB) ,
dihydrofolate reductase ,
ring 1,2-phenylacetyl-CoA epoxidase, structural subunit (paaC) ,
3-phenylpropionate dioxygenase, predicted ferredoxin reductase subunit (hcaD) ,
NAD(P)H-dependent FMN reductase (ssuE) ,
5-formyltetrahydrofolate cyclo-ligase (fau) ,
pantothenate synthetase monomer (panC) ,
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ispG) ,
fructose bisphosphate aldolase monomer (fbaA) ,
glutamate decarboxylase A subunit (gadA) ,
E3 monomer (lpd) ,
SucB ,
subunit of E1(0) component of 2-oxoglutarate dehydrogenase (sucA) ,
AceF ,
subunit of E1p component of pyruvate dehydrogenase complex (aceE) ,
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD) ,
PflB ,
fumarate reductase ,
fumarate reductase iron-sulfur protein (frdB) ,
fumarate reductase flavoprotein (frdA) ,
thioredoxin reductase monomer (trxB) ,
cytochrome bo terminal oxidase subunit III (cyoC) ,
cytochrome bo terminal oxidase subunit I (cyoB) ,
cytochrome bo terminal oxidase subunit IV (cyoD) ,
formate dehydrogenase N, α subunit (fdnG) ,
formate dehydrogenase-O, α subunit (fdoG) ,
trimethylamine N-oxide reductase, catalytic subunit (torA) ,
TorC trimethylamine N-oxide reductase, cytochrome c-type subunit ,
dimethyl sulfoxide reductase, chain A (dmsA) ,
NADH:ubiquinone oxidoreductase, chain CD (nuoC) ,
NADH:ubiquinone oxidoreductase, chain E (nuoE) ,
NADH:ubiquinone oxidoreductase, chain G (nuoG) ,
NADH:ubiquinone oxidoreductase, membrane subunit K (nuoK) ,
cytochrome bd-I terminal oxidase subunit II (cydB) ,
cytochrome bd-I terminal oxidase subunit I (cydA) ,
succinylglutamate desuccinylase (astE) ,
tryptophanase (tnaA) ,
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY) ,
O-acetylserine sulfhydrylase A (cysK) ,
L-serine deaminase I (sdaA) ,
GTP cyclohydrolase II (ribA) ,
glyoxalase I (gloA) ,
glyoxalase III, Hsp31 molecular chaperone (hchA) ,
carnitine-CoA ligase (caiC) ,
FabF ,
DegP ,
rep ,
ATP-dependent DNA helicase (recQ) ,
acetyl esterase (aes) ,
aminopeptidase (ypdF) ,
Mlc titration factor (mtfA) ,
ClpA ,
regulatory ATPase (ravA) ,
sulfite reductase, flavoprotein subunit (cysJ) ,
NADPH nitroreductase (nfsA) ,
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis) (dinB) ,
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC ,
SOS mutagenesis and repair (umuC) ,
PepP ,
tRNA threonylcarbamoyladenosine dehydratase (tcdA) ,
MutH ,
MutL ,
meso-diaminopimelic acid-D-alanyl endopeptidase / D-alanyl-D-alanine carboxypeptidase (dacB) ,
nucleoside triphosphate pyrophosphohydrolase (mazG) ,
AidB ,
DNA polymerase III, ε subunit (dnaQ) ,
DNA polymerase III, α subunit (dnaE) ,
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system ,
CP4-57 prophage; RNase LS, toxin of the RnlAB toxin-antitoxin system ,
DNA gyrase, subunit B (gyrB) ,
DNA gyrase, subunit A ,
toxin of the YafQ-DinJ toxin-antitoxin system ,
Qin prophage; toxin of the RelE-RelB toxin-antitoxin system and cofactor to enhance the repressor activity of RelB ,
protein involved in modification of U34 in tRNA (mnmG) ,
GTPase, involved in modification of U34 in tRNA (mnmE) ,
cysteine sulfinate desulfinase (csdA) ,
23S rRNA pseudouridine synthase (rluD) ,
Lon ,
nitrate reductase A, β subunit (narH) ,
nitrate reductase A, α subunit (narG) ,
nitrate reductase Z, α subunit (narZ) ,
nitrate reductase Z, β subunit (narY) ,
methionine-oxo-acid transaminase, PLP-dependent (ybdL) ,
HflK-HflC complex; regulator of FtsH protease ,
regulator of FtsH protease (hflK) ,
regulator of FtsH protease (hflC) ,
ssDNA and dsDNA binding, ATP binding (recF) ,
DNA-cytosine methyltransferase (dcm) ,
branch migration of Holliday structures; repair helicase (ruvB) ,
Holliday junction nuclease; resolution of structures; repair (ruvC) ,
peptidase T ,
crRNA endonuclease (casE) ,
Cascade subunit D (casD) ,
Cascade subunit C ,
Cascade subunit B (casB) ,
Cascade subunit A (casA) ,
hydrogenase 2, small subunit (hybO) ,
hydrogenase 1, large subunit (hyaB) ,
dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC) ,
toxin of the YoeB-YefM toxin-antitoxin pair ,
oxidoreductase subunit (ynfF) ,
oxidoreductase subunit (ynfE) ,
large subunit of periplasmic nitrate reductase, molybdoprotein (napA) ,
peptide deformylase ,
adenylate cyclase (cyaA) ,
protein-lysine deacetylase and desuccinylase (cobB) ,
chaperone for [Fe-S] cluster biosynthesis (hscA) ,
16S rRNA pseudouridine 516 synthase (rsuA) ,
glutathione S-transferase B (gstB) ,
RNase R (rnr) ,
L-cysteine desulfurase (sufS) ,
DNA primase (dnaG) ,
DnaB ,
23S rRNA pseudouridine 2605 synthase (rluB) ,
protein disulfide oxidoreductase - DsbAreduced ,
Gss ,
cysteine desulfurase monomer (iscS) ,
serine hydroxymethyltransferase (glyA) ,
ribosomal protein-arginine oxygenase (roxA) ,
uracil-DNA glycosylase (ung) ,
endonuclease III; specific for apurinic and/or apyrimidinic sites (nth) ,
lipid hydroperoxide peroxidase (tpx) ,
ribonuclease II (rnb) ,
proofreading thioesterase in enterobactin biosynthesis (entH) ,
RecB ,
RecC ,
Ada DNA-binding transcriptional dual regulator ,
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU) ,
methyltransferase for 50S ribosomal subunit protein L11 (prmA) ,
NrdF ,
[protein-PII] uridylyltransferase (glnD) ,
excision nuclease subunit A (uvrA) ,
DNA repair; excision nuclease subunit B (uvrB) ,
alkyl hydroperoxide reductase, AhpC component ,
RNA polymerase, α subunit (rpoA) ,
RNA polymerase, β' subunit (rpoC) ,
RNA polymerase, β subunit (rpoB) ,
isopentenyl-adenosine A37 tRNA methylthiolase (miaB) ,
hydrogenase 3 and formate hydrogenlyase complex, HycG subunit ,
hydrogenase 3, large subunit (hycE) ,
lipid kinase (yegS) ,
GuaC ,
Eno ,
polynucleotide phosphorylase monomer (pnp) ,
RNase E (rne) ,
Ppk ,
L-tartrate dehydratase, α subunit (ttdA) ,
fused 23S rRNA m2G2445 methyltransferase and 23S rRNA m7G2069 methyltransferase (rlmL) ,
23S rRNA m2A2503 methyltransferase and tRNA m2A37 methyltransferase (rlmN) ,
8-oxo-dGTP diphosphatase (mutT) ,
alkanesulfonate monooxygenase, FMNH2-dependent (ssuD) ,
GTPase that interacts with methylmalonyl-CoA mutase (argK) ,
ribosome small subunit-dependent GTPase A (rsgA) ,
accessory protein for nickel incorporation into hydrogenase isoenzymes (hypB) ,
FKBP-type peptidyl prolyl cis-trans isomerase (slyD) ,
peptidyl-prolyl cis-trans isomerase B (rotamase B) (ppiB) ,
peptidyl-prolyl cis-trans isomerase C (rotamase C) (ppiC) ,
peptidyl-prolyl cis-trans isomerase (fkpB) ,
peptidyl-prolyl cis-trans isomerase (PPIase) (surA) ,
chaperone protein Tig; trigger factor ,
NADH-dependent dihydropyrimidine dehydrogenase subunit (preA) ,
NADH-dependent dihydropyrimidine dehydrogenase subunit (preT) ,
Ppa ,
cyclic di-GMP phosphodiesterase (gmr) ,
exonuclease VII, small subunit (xseB) ,
exonuclease VII, large subunit (xseA) ,
diguanylate cyclase (dosC) ,
c-di-GMP phosphodiesterase, heme-regulated (dosP) ,
diguanylate cyclase (ydaM) ,
PhoA ,
Ndk ,
MalX PTS permease ,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaC subunit ,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaD subunit ,
essential cell division protein FtsW; lipid II flippase ,
LptA ,
LptC ,
outer membrane lipopolysaccharide transport and assembly complex - LptD subunit ,
outer membrane lipopolysaccharide transport and assembly complex - LptE subunit ,
chitobiose PTS permease - ChbB subunit ,
chitobiose PTS permease - ChbA subunit ,
mannose PTS permease - ManX subunit ,
K+ transporting ATPase - KdpC subunit ,
K+ transporting ATPase - ATP binding subunit (kdpB) ,
glycine betaine / proline ABC transporter - periplasmic binding protein (proX) ,
glycine betaine / proline ABC transporter - membrane subunit (proW) ,
glycine betaine / proline ABC transporter - ATP binding subunit (proV) ,
protoheme IX ABC transporter - ATP binding subunit (ccmA) ,
protoheme IX ABC transporter - membrane subunit CcmB ,
protoheme IX ABC transporter - membrane subunit CcmD ,
membrane anchored periplasmic heme chaperone CcmE ,
protoheme IX ABC transporter - membrane subunit CcmC ,
ribose ABC transporter - putative periplasmic binding protein (rbsB) ,
ribose ABC transporter - putative ATP binding subunit (rbsA) ,
galactose ABC transporter - periplasmic binding protein (mglB) ,
maltose ABC transporter - periplasmic binding protein (malE) ,
maltose ABC transporter - membrane subunit (malF) ,
L-methionine / D-methionine ABC transporter - membrane subunit (metI) ,
L-methionine / D-methionine ABC transporter - ATP binding subunit (metN) ,
KefC ,
TatC ,
TatB ,
copper / silver efflux system - membrane subunit (cusA) ,
copper / silver efflux system - periplasmic binding protein and metallochaperone (cusF) ,
copper / silver efflux system - membrane fusion protein (cusB) ,
copper / silver efflux system - outer membrane porin (cusC) ,
branched chain amino acid transporter BrnQ ,
vitamin B12 ABC transporter - ATP binding subunit (btuD) ,
vitamin B12 ABC transporter - membrane subunit (btuC) ,
ferric enterobactin / colicin B / colicin D outer membrane porin FepA ,
tonB energy transducing system - ExbD subunit ,
TonB energy transducing system - ExbB subunit ,
TonB energy transducing system - TonB subunit ,
OmpC ,
LamB ,
AqpZ ,
50S ribosomal subunit protein L11 (rplK) ,
50S ribosomal subunit protein L14 (rplN) ,
30S ribosomal subunit protein S5 (rpsE) ,
50S ribosomal subunit protein L22 (rplV) ,
50S ribosomal subunit protein L1 (rplA) ,
periplasmic chaperone (skp) ,
chaperone protein DnaK ,
30S ribosomal subunit protein S18 (rpsR) ,
30S ribosomal subunit protein S2 (rpsB) ,
50S ribosomal subunit protein L15 (rplO) ,
30S ribosomal subunit protein S12 (rpsL) ,
MazE antitoxin of the MazF-MazE toxin-antitoxin system (chpR) ,
30S ribosomal subunit protein S6 (rpsF) ,
50S ribosomal subunit protein L23 (rplW) ,
50S ribosomal subunit protein L2 (rplB) ,
50S ribosomal subunit protein L27 (rpmA) ,
DNA polymerase III, δ subunit (holA) ,
30S ribosomal subunit protein S10 (rpsJ) ,
30S ribosomal subunit protein S7 (rpsG) ,
30S ribosomal subunit protein S4 (rpsD) ,
chaperone protein DnaJ ,
sulfite reductase, hemoprotein subunit (cysI) ,
TolB ,
ATP synthase F1 complex - alpha subunit (atpA) ,
pyridoxal phosphate phosphatase (PHOSPHO2) ,
prostaglandin E synthase 3 (PTGES3) ,
GAP-like protein that activates GTPase activity of Der ,
sulfur acceptor that activates SufS cysteine desulfurase ,
Src proto-oncogene tyrosine-protein kinase ,
pyruvate dehydrogenase protein E3 component, mitochondrial (PDHX) ,
pyruvate dehydrogenase E2 component (DLAT) ,
N-formyl-4-amino-5-aminomethyl-2- methylpyrimidine deformylase (thiQ) ,
retinoid isomerohydrolase (RPE65) ,
50S ribosomal subunit protein L3 (rplC) ,
50S ribosomal subunit protein L28 (rpmB) ,
50S ribosomal subunit protein L32 (rpmF)

Unification Links: GO:0005515


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14A.