MetaCyc Gene-Ontology-Terms Class: GO:0005515 - protein binding

Synonyms: GO:0045308, protein amino acid binding

Definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

Parent Classes:
GO:0005488 - binding

Child Classes:
GO:0001948 - glycoprotein binding (1),
GO:0005102 - receptor binding (4),
GO:0005516 - calmodulin binding (1),
GO:0008013 - beta-catenin binding (1),
GO:0008134 - transcription factor binding (3),
GO:0019899 - enzyme binding (7),
GO:0030674 - protein binding, bridging (2),
GO:0031072 - heat shock protein binding (1),
GO:0032403 - protein complex binding (1),
GO:0032794 - GTPase activating protein binding (1),
GO:0042802 - identical protein binding (335),
GO:0044183 - protein binding involved in protein folding (2),
GO:0046983 - protein dimerization activity (164),
GO:0051082 - unfolded protein binding (8),
GO:0051087 - chaperone binding (4),
GO:0097351 - toxin-antitoxin pair type II binding (1)

Term Members:
thioredoxin 1 (trxA),
protein disulfide oxidoreductase - DsbBreduced,
biotin carboxyl carrier protein (accB),
50S ribosomal subunit protein L11 (rplK),
sulfur transfer protein (tusA),
periplasmic chaperone (skp),
50S ribosomal subunit protein L15 (rplO),
chaperone protein DnaK,
50S ribosomal subunit protein L32 (rpmF),
TolB - periplasmic protein of the Tol-Pal system,
30S ribosomal subunit protein S10 (rpsJ),
GrpE monomer,
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity (chpA),
30S ribosomal subunit protein S7 (rpsG),
50S ribosomal subunit protein L3 (rplC),
primosomal replication protein N'' (priC),
MazE antitoxin of the MazF-MazE toxin-antitoxin system (chpR),
30S ribosomal subunit protein S4 (rpsD),
frataxin CyaY,
putative protein secretion protein for export (gspH),
putative protein secretion protein for export (gspE),
hydrogenase maturation protein, carbamoyl dehydratase (hypE),
MqsA antitoxin of the MqsRA toxin-antitoxin system and DNA-binding transcriptional repressor,
50S ribosomal subunit protein L4 (rplD),
30S ribosomal subunit protein S5 (rpsE),
50S ribosomal subunit protein L22 (rplV),
50S ribosomal subunit protein L1 (rplA),
primosome factor N' (priA),
30S ribosomal subunit protein S18 (rpsR),
30S ribosomal subunit protein S2 (rpsB),
sulfite reductase, hemoprotein subunit (cysI),
50S ribosomal subunit protein L14 (rplN),
essential cell division protein FtsI; penicillin-binding protein 3,
DinJ antitoxin of YafQ-DinJ toxin-antitoxin system and DNA-binding transcriptional repressor,
DnaJ monomer,
30S ribosomal subunit protein S12 (rpsL),
50S ribosomal subunit protein L28 (rpmB),
accessory protein for nickel incorporation into hydrogenase 3 (hypA),
30S ribosomal subunit protein S6 (rpsF),
50S ribosomal subunit protein L23 (rplW),
50S ribosomal subunit protein L2 (rplB),
50S ribosomal subunit protein L27 (rpmA),
RNA polymerase, sigma 70 (sigma D) factor (rpoD),
RNA polymerase, sigma 24 (sigma E) factor (rpoE),
RNA polymerase, sigma 28 (sigma F) factor (fliA),
RNA polymerase, sigma 32 (sigma H) factor (rpoH),
MalT transcriptional activator,
co-chaperone for [Fe-S] cluster biosynthesis (hscB),
iron-sulfur cluster assembly protein (iscA),
primosomal protein DnaT,
RelB Qin prophage; antitoxin of the RelE-RelB toxin-antitoxin system and DNA binding transcriptional repressor,
serine/threonine kinase HipA,
iron-sulfur cluster scaffold protein (nfuA),
HipB antitoxin and DNA-binding transcriptional repressor,
DNA polymerase III, ψ subunit (holD),
DNA polymerase III, χ subunit (holC),
DNA polymerase III, δ subunit (holA),
DNA polymerase III, δ prime subunit (holB),
DNA polymerase III, τ subunit (dnaX),
DNA polymerase III, θ subunit (holE),
reduced ferredoxin (fdx),
apo-[acyl carrier protein] (acpP),
carbon-phosphorus lyase core complex, PhnJ subunit,
carbon-phosphorus lyase core complex, PhnG subunit,
carbon-phosphorus lyase core complex, PhnI subunit,
methionine adenosyltransferase (metK),
molybdenum cofactor cytidylyltransferase (mocA),
anaerobic glycerol-3-phosphate dehydrogenase subunit A (glpA),
formate dehydrogenase N, γ subunit (fdnI),
formate dehydrogenase N, α subunit (fdnG),
formate dehydrogenase-O, α subunit (fdoG),
NADPH-dependent FMN reductase (ssuE),
sulfate adenylyltransferase, CysN subunit,
sulfate adenylyltransferase, CysD subunit,
fructoselysine 6-kinase (frlD),
N-acetylmuramic acid 6-phosphate etherase (murQ),
guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase [multifunctional] (spoT),
α-galactosidase monomer (melA),
mannose-6-phosphate isomerase (manA),
acetaldehyde dehydrogenase 2 (mhpF),
biosynthetic peptidoglycan transglycosylase (mtgA),
outer membrane lipoprotein - activator of MrcB activity (lpoB),
outer membrane lipoprotein - activator of MrcA activity (lpoA),
L,D-transpeptidase ErfK (ldtA),
pyridine nucleotide transhydrogenase, α subunit (pntA),
pyridine nucleotide transhydrogenase, β subunit (pntB),
lysine decarboxylase 2 (ldcC),
cobalamin-independent homocysteine transmethylase (metE),
7-cyano-7-deazaguanine synthase (queC),
UDP-N-acetylmuramate-alanine ligase (murC),
4-hydroxy-2-ketovalerate aldolase (mhpE),
3-phenylpropionate dioxygenase, predicted ferredoxin reductase subunit (hcaD),
dihydroxyacetone kinase subunit L (dhaL),
dihydroxyacetone kinase subunit K (dhaK),
acetyl-CoA:acetoacetyl-CoA transferase, β subunit (atoA),
glyoxalase III, Hsp31 molecular chaperone (hchA),
glyoxalase I (gloA),
adenylate kinase (adk),
ThiS adenylyltransferase (thiF),
tyrosine lyase (thiH),
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ispG),
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase (ubiF),
octaprenyl diphosphate synthase (ispB),
3-dehydroquinate synthase (aroB),
dihydrofolate reductase,
ribonucleoside hydrolase 1 (pyrimidine-specific) (rihA),
pyruvate kinase II monomer (pykA),
triosephosphate isomerase monomer (tpiA),
fructose bisphosphate aldolase monomer (fbaB),
N6-L-threonylcarbamoyladenine synthase, TsaB subunit,
N6-L-threonylcarbamoyladenine synthase, TsaD subunit,
N6-L-threonylcarbamoyladenine synthase, TsaE subunit,
ribulose-5-phosphate 3-epimerase (rpe),
biotin synthase monomer (bioB),
carbamoyl phosphate synthetase, α chain (carA),
carbamoyl phosphate synthetase, β chain,
threonyl-tRNA synthetase (thrS),
phenylalanyl-tRNA synthetase β-chain (pheT),
phenylalanyl-tRNA synthetase α-chain (pheS),
glycyl-tRNA synthetase, α subunit (glyQ),
glycyl-tRNA synthetase, β subunit (glyS),
methionyl-tRNA synthetase (metG),
glutamate decarboxylase A subunit (gadA),
citrate synthase monomer (gltA),
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB),
succinyl-CoA synthetase, β subunit,
succinyl-CoA synthetase, α subunit (sucD),
succinate:quinone oxidoreductase, FAD binding protein (sdhA),
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein (sdhB),
ring 1,2-phenylacetyl-CoA epoxidase, structural subunit (paaC),
molybdopterin synthase large subunit (moaE),
molybdopterin synthase small subunit (moaD),
molybdopterin adenylyltransferase (mog),
molybdopterin molybdenumtransferase (moeA),
molybdopterin-synthase adenylyltransferase (moeB),
glutamate-1-semialdehyde aminotransferase (hemL),
lipoyl synthase (lipA),
acetohydroxy acid synthase I, small subunit (ilvN),
acetohydroxy acid synthase I, large subunit (ilvB),
aspartate carbamoyltransferase, PyrI subunit,
aspartate carbamoyltransferase, PyrB subunit,
phosphoribosylglycinamide formyltransferase 2 (purT),
UDP-glucose 4-epimerase monomer (galE),
3-deoxy-D-manno-octulosonate cytidylyltransferase (kdsB),
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD),
carnitine-CoA ligase (caiC),
fumarate reductase,
fumarate reductase iron-sulfur protein (frdB),
fumarate reductase flavoprotein (frdA),
5-formyltetrahydrofolate cyclo-ligase (fau),
glycerol-3-phosphate acyltransferase (plsB),
pantothenate synthetase monomer (panC),
cytochrome bo terminal oxidase subunit III (cyoC),
cytochrome bo terminal oxidase subunit I (cyoB),
cytochrome bo terminal oxidase subunit IV (cyoD),
cytochrome bd-I terminal oxidase subunit II (cydB),
cytochrome bd-I terminal oxidase subunit I (cydA),
trimethylamine N-oxide reductase, catalytic subunit (torA),
trimethylamine N-oxide reductase, cytochrome c-type subunit (torC),
acetyl-CoA carboxyltransferase, α subunit (accA),
acetyl-CoA carboxyltransferase, β subunit (accD),
dimethyl sulfoxide reductase, chain A (dmsA),
hydrogenase 2, small subunit (hybO),
NADH:ubiquinone oxidoreductase, chain CD (nuoC),
NADH:ubiquinone oxidoreductase, chain E (nuoE),
NADH:ubiquinone oxidoreductase, chain G (nuoG),
NADH:ubiquinone oxidoreductase, membrane subunit K (nuoK),
fructose bisphosphate aldolase monomer (fbaA),
thioredoxin reductase monomer (trxB),
GTP cyclohydrolase II (ribA),
L-serine deaminase I (sdaA),
tryptophanase (tnaA),
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY),
O-acetylserine sulfhydrylase A (cysK),
succinylglutamate desuccinylase (astE),
glutamate synthase, small subunit (gltD),
glutamate synthase, large subunit (gltB),
geranyl diphosphate synthase / farnesyl diphosphate synthase (ispA),
aminopeptidase (ypdF),
Mlc titration factor (mtfA),
sulfite reductase, flavoprotein subunit (cysJ),
crRNA endonuclease (casE),
Cascade subunit D (casD),
Cascade subunit C,
Cascade subunit B (casB),
Cascade subunit A (casA),
nitrate reductase A, β subunit (narH),
nitrate reductase A, α subunit (narG),
nitrate reductase Z, α subunit (narZ),
nitrate reductase Z, β subunit (narY),
hydrogenase 1, small subunit (hyaA),
hydrogenase 1, large subunit (hyaB),
hydrogenase 1, b-type cytochrome subunit (hyaC),
uracil-DNA glycosylase (ung),
branch migration of Holliday structures; repair helicase (ruvB),
Holliday junction nuclease; resolution of structures; repair (ruvC),
peptidase T,
lipid kinase (yegS),
fused 23S rRNA m2G2445 methyltransferase and 23S rRNA m7G2069 methyltransferase (rlmL),
protein-lysine deacetylase and desuccinylase (cobB),
peptide deformylase,
predicted 5-keto 4-deoxyuronate isomerase monomer (kduI),
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system,
CP4-57 prophage; RNase LS, toxin of the RnlAB toxin-antitoxin system,
RNA polymerase, α subunit (rpoA),
RNA polymerase, β' subunit (rpoC),
RNA polymerase, β subunit (rpoB),
excision nuclease subunit A (uvrA),
DNA repair; excision nuclease subunit B (uvrB),
exonuclease I, 3' --> 5' specific; deoxyribophosphodiesterase (sbcB),
diguanylate cyclase (dosC),
diguanylate cyclase (dgcM),
ribosomal protein-arginine oxygenase (roxA),
23S rRNA pseudouridine synthase (rluD),
proofreading thioesterase in enterobactin biosynthesis (entH),
Deg S monomer (degS),
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU),
aldehyde dehydrogenase: molybdenum cofactor-binding subunit (paoC),
aldehyde dehydrogenase, FAD-binding subunit (paoB),
aldehyde dehydrogenase, Fe-S subunit (paoA),
dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC),
toxin of the YoeB-YefM toxin-antitoxin pair,
large subunit of periplasmic nitrate reductase, molybdoprotein (napA),
protein disulfide oxidoreductase - DsbAreduced,
E3 monomer (lpd),
subunit of E1p component of pyruvate dehydrogenase complex (aceE),
subunit of E1(0) component of 2-oxoglutarate dehydrogenase (sucA),
lipoyl(octanoyl) transferase (lipB),
Ada DNA-binding transcriptional dual regulator,
lipid hydroperoxide peroxidase (tpx),
PII uridylyltransferase / uridylyl removing enzyme (glnD),
methyltransferase for 50S ribosomal subunit protein L11 (prmA),
chaperone for [Fe-S] cluster biosynthesis (hscA),
hydrogenase maturation protein, carbamoyltransferase (hypF),
scaffold protein for iron-sulfur cluster assembly (iscU),
bis(molybdenum cofactor) synthase [multifunctional] (mobA),
alkyl hydroperoxide reductase, AhpC component,
adenylate cyclase (cyaA),
toxin of the YafQ-DinJ toxin-antitoxin system,
Qin prophage; toxin of the RelE-RelB toxin-antitoxin system and cofactor to enhance the repressor activity of RelB,
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis) (dinB),
DNA polymerase III, α subunit (dnaE),
DNA polymerase III, ε subunit (dnaQ),
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC,
SOS mutagenesis and repair (umuC),
16S rRNA pseudouridine 516 synthase (rsuA),
protein involved in modification of U34 in tRNA (mnmG),
GTPase, involved in modification of U34 in tRNA (mnmE),
peptidyl-lysine acetyltransferase (patZ),
23S rRNA pseudouridine 2605 synthase (rluB),
exonuclease VII, small subunit (xseB),
exonuclease VII, large subunit (xseA),
c-di-GMP phosphodiesterase, heme-regulated (dosP),
cyclic di-GMP phosphodiesterase (pdeR),
DNA gyrase, subunit B (gyrB),
DNA gyrase, subunit A,
lysophospholipase L2 (pldB),
NADH-dependent dihydropyrimidine dehydrogenase subunit (preA),
NADH-dependent dihydropyrimidine dehydrogenase subunit (preT),
cysteine desulfurase monomer,
DNA primase (dnaG),
Rep helicase,
ATP-dependent DNA helicase (recQ),
acetyl esterase (aes),
YhaV toxic ribonuclease,
methionine-oxo-acid transaminase, PLP-dependent (ybdL),
23S rRNA m2A2503 methyltransferase and tRNA m2A37 methyltransferase (rlmN),
cysteine sulfinate desulfinase (csdA),
L-cysteine desulfurase (sufS),
HflK-HflC complex; regulator of FtsH protease,
regulator of FtsH protease (hflK),
regulator of FtsH protease (hflC),
ADP-heptose:LPS heptosyltransferase I (waaC),
8-oxo-dGTP diphosphatase (mutT),
regulatory ATPase (ravA),
ribosome-binding ATPase, inhibitor of catalase activity (ychF),
NADPH nitroreductase (nfsA),
tRNA threonylcarbamoyladenosine dehydratase (tcdA),
endonuclease III (nth),
hydrogenase 3 and formate hydrogenlyase complex, HycG subunit,
hydrogenase 3, large subunit (hycE),
isopentenyl-adenosine A37 tRNA methylthiolase (miaB),
L-tartrate dehydratase, α subunit (ttdA),
GTPase that interacts with methylmalonyl-CoA mutase (argK),
ribosome small subunit-dependent GTPase A (rsgA),
accessory protein for nickel incorporation into hydrogenase isoenzymes (hypB),
glutathione S-transferase B (gstB),
DNA-cytosine methyltransferase (dcm),
ssDNA and dsDNA binding, ATP binding (recF),
meso-diaminopimelic acid-D-alanyl endopeptidase / D-alanyl-D-alanine carboxypeptidase (dacB),
murein DD-endopeptidase / murein LD-carboxypeptidase (mepS),
nucleoside triphosphate pyrophosphohydrolase (mazG),
alkanesulfonate monooxygenase, FMNH2-dependent (ssuD),
polynucleotide phosphorylase monomer (pnp),
RNase E (rne),
RNase R (rnr),
oxidoreductase subunit (ynfF),
oxidoreductase subunit (ynfE),
peptidase component of the HslVU protease,
ATPase component of the HslVU protease (hslU),
EntB monomer,
serine hydroxymethyltransferase (glyA),
FKBP-type peptidyl prolyl cis-trans isomerase (slyD),
peptidyl-prolyl cis-trans isomerase B (rotamase B) (ppiB),
peptidyl-prolyl cis-trans isomerase C (rotamase C) (ppiC),
peptidyl-prolyl cis-trans isomerase (fkpB),
peptidyl-prolyl cis-trans isomerase (PPIase) (surA),
chaperone protein Tig; trigger factor,
ribonuclease II (rnb),
MalX PTS permease,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaC subunit,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaD subunit,
2-O-α-mannosyl-D-glycerate PTS permease (mngA),
chitobiose PTS permease - ChbB subunit,
chitobiose PTS permease - ChbA subunit,
glucose PTS permease - PtsG subunit,
mannose PTS permease - ManX subunit,
Enzyme IIAGlc; Crr,
ABC complex for formation and release of holoCcmE - membrane subunit CcmC,
membrane anchored periplasmic heme chaperone CcmE,
ABC complex for formation and release of holoCcmE - ATP binding subunit (ccmA),
ABC complex for formation and release of holoCcmE - membrane subunit CcmB,
ABC complex for formation and release of holoCcmE - membrane subunit CcmD,
ATP synthase F1 complex - epsilon subunit (atpC),
ATP synthase F1 complex - alpha subunit (atpA),
ATP synthase F1 complex - gamma subunit (atpG),
ATP synthase F1 complex - beta subunit (atpD),
K+ transporting ATPase - KdpC subunit,
K+ transporting ATPase - ATP binding subunit (kdpB),
glycine betaine / proline ABC transporter - periplasmic binding protein (proX),
glycine betaine / proline ABC transporter - membrane subunit (proW),
glycine betaine / proline ABC transporter - ATP binding subunit (proV),
maltose ABC transporter - periplasmic binding protein (malE),
maltose ABC transporter - membrane subunit (malG),
maltose ABC transporter - membrane subunit (malF),
maltose ABC transporter - ATP binding subunit (malK),
L-methionine / D-methionine ABC transporter - membrane subunit (metI),
L-methionine / D-methionine ABC transporter - ATP binding subunit (metN),
galactose ABC transporter - periplasmic binding protein (mglB),
ribose ABC transporter - putative periplasmic binding protein (rbsB),
ribose ABC transporter - putative ATP binding subunit (rbsA),
copper / silver efflux system - membrane subunit (cusA),
copper / silver efflux system - periplasmic binding protein and metallochaperone (cusF),
copper / silver efflux system - membrane fusion protein (cusB),
copper / silver efflux system - outer membrane porin (cusC),
branched chain amino acid transporter BrnQ,
lactose / melibiose:H+ symporter LacY,
twin arginine protein translocation system - TatA protein,
twin arginine protein translocation system - TatC protein,
twin arginine protein translocation system - TatB protein,
melibiose:H+/Na+/Li+ symporter (melB),
C4 dicarboxylate / orotate:H+ symporter (dctA),
vitamin B12 ABC transporter - ATP binding subunit (btuD),
vitamin B12 ABC transporter - membrane subunit (btuC),
ferric enterobactin / colicin B / colicin D outer membrane porin FepA,
tonB energy transducing system - ExbD subunit,
TonB energy transducing system - ExbB subunit,
TonB energy transducing system - TonB subunit,
OmpC monomer,
AqpZ monomer,
essential cell division protein FtsW; lipid II flippase,
outer membrane lipopolysaccharide transport and assembly complex - LptD subunit,
outer membrane lipopolysaccharide transport and assembly complex - LptE subunit,
HPr (ptsH),
RelB-antitoxin and DNA-binding transcriptional repressor,
CSD sulfur transfer protein (csdE),
CP4-57 prophage; antitoxin of the RnlA-RnlB toxin-antitoxin system,
pyridoxal phosphate phosphatase (PHOSPHO2),
prostaglandin E synthase 3 (PTGES3),
GAP-like protein that activates GTPase activity of Der,
sulfur acceptor that activates SufS cysteine desulfurase,
Src proto-oncogene tyrosine-protein kinase,
pyruvate dehydrogenase protein E3 component, mitochondrial (PDHX),
pyruvate dehydrogenase E2 component (DLAT),
N-formyl-4-amino-5-aminomethyl-2- methylpyrimidine deformylase (thiQ),
retinoid isomerohydrolase (RPE65)

Unification Links: GO:0005515

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC11A.