MetaCyc Gene-Ontology-Terms Class: GO:0005515 - protein binding

Synonyms: GO:0045308, protein amino acid binding

Definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

Parent Classes:
GO:0005488 - binding

Child Classes:
GO:0001948 - glycoprotein binding (1),
GO:0005102 - receptor binding (4),
GO:0005516 - calmodulin binding (1),
GO:0008013 - beta-catenin binding (1),
GO:0008134 - transcription factor binding (4),
GO:0019899 - enzyme binding (7),
GO:0030674 - protein binding, bridging (2),
GO:0031072 - heat shock protein binding (1),
GO:0032403 - protein complex binding (1),
GO:0032794 - GTPase activating protein binding (1),
GO:0042802 - identical protein binding (369),
GO:0044183 - protein binding involved in protein folding (2),
GO:0046983 - protein dimerization activity (181),
GO:0051082 - unfolded protein binding (10),
GO:0051087 - chaperone binding (3),
GO:0097351 - toxin-antitoxin pair type II binding (1)

Term Members:
apo-[acyl carrier protein] (acpP),
sulfur transfer protein (tusA),
biotin carboxyl carrier protein (accB),
thioredoxin 1 (trxA),
protein disulfide oxidoreductase - DsbBreduced,
50S ribosomal subunit protein L11 (rplK),
30S ribosomal subunit protein S5 (rpsE),
50S ribosomal subunit protein L22 (rplV),
50S ribosomal subunit protein L1 (rplA),
primosome factor N' (priA),
MazE antitoxin of the MazF-MazE toxin-antitoxin system (chpR),
putative protein secretion protein for export (gspH),
30S ribosomal subunit protein S18 (rpsR),
30S ribosomal subunit protein S2 (rpsB),
putative protein secretion protein for export (gspE),
50S ribosomal subunit protein L14 (rplN),
30S ribosomal subunit protein S12 (rpsL),
sulfite reductase, hemoprotein subunit (cysI),
50S ribosomal subunit protein L28 (rpmB),
30S ribosomal subunit protein S6 (rpsF),
50S ribosomal subunit protein L23 (rplW),
50S ribosomal subunit protein L2 (rplB),
frataxin CyaY,
50S ribosomal subunit protein L15 (rplO),
essential cell division protein FtsI; penicillin-binding protein 3,
50S ribosomal subunit protein L32 (rpmF),
TolB - periplasmic protein of the Tol-Pal system,
30S ribosomal subunit protein S10 (rpsJ),
30S ribosomal subunit protein S7 (rpsG),
50S ribosomal subunit protein L3 (rplC),
primosomal replication protein N'' (priC),
accessory protein for nickel incorporation into hydrogenase 3 (hypA),
30S ribosomal subunit protein S4 (rpsD),
periplasmic chaperone (skp),
chaperone protein DnaK,
50S ribosomal subunit protein L27 (rpmA),
GrpE monomer,
MqsA antitoxin of the MqsRA toxin-antitoxin system and DNA-binding transcriptional repressor,
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity (chpA),
50S ribosomal subunit protein L4 (rplD),
DinJ antitoxin of YafQ-DinJ toxin-antitoxin system and DNA-binding transcriptional repressor,
MalT transcriptional activator,
co-chaperone for [Fe-S] cluster biosynthesis (hscB),
serine/threonine kinase HipA,
HipB antitoxin and DNA-binding transcriptional repressor,
GroES cochaperonin (groS),
GroEL chaperonin,
iron-sulfur cluster scaffold protein (nfuA),
PurR transcriptional repressor,
aldehyde dehydrogenase: molybdenum cofactor-binding subunit (paoC),
aldehyde dehydrogenase, FAD-binding subunit (paoB),
aldehyde dehydrogenase, Fe-S subunit (paoA),
DNA polymerase III, ψ subunit (holD),
DNA polymerase III, χ subunit (holC),
DNA polymerase III, δ subunit (holA),
DNA polymerase III, δ prime subunit (holB),
DNA polymerase III, τ subunit (dnaX),
DNA polymerase III, θ subunit (holE),
iron-sulfur cluster assembly protein (iscA),
primosomal protein DnaT,
RelB Qin prophage; antitoxin of the RelE-RelB toxin-antitoxin system and DNA binding transcriptional repressor,
RNA polymerase, sigma 24 (sigma E) factor (rpoE),
RNA polymerase, sigma 28 (sigma F) factor (fliA),
RNA polymerase, sigma 32 (sigma H) factor (rpoH),
RNA polymerase, sigma 70 (sigma D) factor (rpoD),
reduced ferredoxin (fdx),
ThiS adenylyltransferase (thiF),
2-iminoacetate synthase (thiH),
1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase (thiG),
cobalamin-independent homocysteine transmethylase (metE),
4-hydroxy-2-ketovalerate aldolase (mhpE),
acetaldehyde dehydrogenase 2 (mhpF),
N6-L-threonylcarbamoyladenine synthase, TsaB subunit,
N6-L-threonylcarbamoyladenine synthase, TsaD subunit,
N6-L-threonylcarbamoyladenine synthase, TsaE subunit,
UDP-N-acetylmuramate-alanine ligase (murC),
biosynthetic peptidoglycan transglycosylase (mtgA),
peptidoglycan glycosyltransferase (pbpC),
essential cell division protein FtsN,
outer membrane lipoprotein - activator of MrcB activity (lpoB),
outer membrane lipoprotein - activator of MrcA activity (lpoA),
L,D-transpeptidase ErfK (ldtA),
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (ispG),
adenylate kinase (adk),
citrate synthase monomer (gltA),
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB),
succinyl-CoA synthetase, β subunit,
succinyl-CoA synthetase, α subunit (sucD),
succinate:quinone oxidoreductase, FAD binding protein (sdhA),
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein (sdhB),
sulfate adenylyltransferase, CysN subunit,
sulfate adenylyltransferase, CysD subunit,
diaminopimelate decarboxylase (lysA),
methionine adenosyltransferase (metK),
anaerobic glycerol-3-phosphate dehydrogenase subunit A (glpA),
glutamate decarboxylase A subunit (gadA),
carbon-phosphorus lyase core complex, PhnJ subunit,
carbon-phosphorus lyase core complex, PhnG subunit,
carbon-phosphorus lyase core complex, PhnI subunit,
carbamoyl phosphate synthetase, α chain (carA),
carbamoyl phosphate synthetase, β chain,
aspartate carbamoyltransferase, PyrI subunit,
aspartate carbamoyltransferase, PyrB subunit,
ribulose-5-phosphate 3-epimerase (rpe),
acetyl-CoA:acetoacetyl-CoA transferase, β subunit (atoA),
glycerol-3-phosphate acyltransferase (plsB),
biotin synthase monomer (bioB),
3-dehydroquinate synthase (aroB),
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase (ubiF),
octaprenyl diphosphate synthase (ispB),
dihydrofolate reductase,
ribonucleoside hydrolase 1 (pyrimidine-specific) (rihA),
3-phenylpropionate dioxygenase, predicted ferredoxin reductase subunit (hcaD),
ring 1,2-phenylacetyl-CoA epoxidase, structural subunit (paaC),
phosphoribosylglycinamide formyltransferase 2 (purT),
fructose bisphosphate aldolase monomer (fbaB),
triosephosphate isomerase monomer (tpiA),
5-formyltetrahydrofolate cyclo-ligase (fau),
fructose bisphosphate aldolase monomer (fbaA),
pyruvate kinase II monomer (pykA),
molybdenum cofactor cytidylyltransferase (mocA),
tagatose-1,6-bisphosphate aldolase 2 subunit GatY,
N-acetylmuramic acid 6-phosphate etherase (murQ),
fructoselysine 6-kinase (frlD),
3-deoxy-D-manno-octulosonate cytidylyltransferase (kdsB),
pantothenate synthetase monomer (panC),
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD),
UDP-glucose 4-epimerase monomer (galE),
mannose-6-phosphate isomerase (manA),
formate dehydrogenase N, γ subunit (fdnI),
formate dehydrogenase N, α subunit (fdnG),
formate dehydrogenase-O, α subunit (fdoG),
dimethyl sulfoxide reductase, chain A (dmsA),
fumarate reductase,
fumarate reductase iron-sulfur protein (frdB),
fumarate reductase flavoprotein (frdA),
hydrogenase 2, small subunit (hybO),
cytochrome bo terminal oxidase subunit III (cyoC),
cytochrome bo terminal oxidase subunit I (cyoB),
cytochrome bo terminal oxidase subunit IV (cyoD),
cytochrome bd-I terminal oxidase subunit II (cydB),
cytochrome bd-I terminal oxidase subunit I (cydA),
trimethylamine N-oxide reductase, catalytic subunit (torA),
trimethylamine N-oxide reductase, cytochrome c-type subunit (torC),
NADH:ubiquinone oxidoreductase, chain CD (nuoC),
NADH:ubiquinone oxidoreductase, chain E (nuoE),
NADH:ubiquinone oxidoreductase, chain G (nuoG),
NADH:ubiquinone oxidoreductase, membrane subunit K (nuoK),
glyoxalase I (gloA),
amino acid deglycase Hsp31 (hchA),
thioredoxin reductase monomer (trxB),
geranyl diphosphate synthase / farnesyl diphosphate synthase (ispA),
lipoyl synthase (lipA),
molybdopterin synthase large subunit (moaE),
molybdopterin synthase small subunit (moaD),
molybdopterin adenylyltransferase (mog),
molybdopterin molybdenumtransferase (moeA),
molybdopterin-synthase adenylyltransferase (moeB),
glutamate-1-semialdehyde aminotransferase (hemL),
pyridine nucleotide transhydrogenase, α subunit (pntA),
pyridine nucleotide transhydrogenase, β subunit (pntB),
guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase [multifunctional] (spoT),
threonyl-tRNA synthetase (thrS),
phenylalanyl-tRNA synthetase β-chain (pheT),
phenylalanyl-tRNA synthetase α-chain (pheS),
glycyl-tRNA synthetase, α subunit (glyQ),
glycyl-tRNA synthetase, β subunit (glyS),
methionyl-tRNA synthetase (metG),
7-cyano-7-deazaguanine synthase (queC),
carnitine-CoA ligase (caiC),
lysine decarboxylase 2 (ldcC),
L-serine deaminase I (sdaA),
tryptophanase (tnaA),
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY),
O-acetylserine sulfhydrylase A (cysK),
succinylglutamate desuccinylase (astE),
acetohydroxy acid synthase I, small subunit (ilvN),
acetohydroxy acid synthase I, large subunit (ilvB),
glutamate synthase, small subunit (gltD),
glutamate synthase, large subunit (gltB),
acetyl-CoA carboxyltransferase, α subunit (accA),
acetyl-CoA carboxyltransferase, β subunit (accD),
NADPH-dependent FMN reductase (ssuE),
GTP cyclohydrolase II (ribA),
peptidyl-lysine acetyltransferase (patZ),
excision nuclease subunit A (uvrA),
DNA repair; excision nuclease subunit B (uvrB),
L-tartrate dehydratase, α subunit (ttdA),
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system,
CP4-57 prophage; RNase LS, toxin of the RnlAB toxin-antitoxin system,
RNA polymerase, α subunit (rpoA),
RNA polymerase, β' subunit (rpoC),
RNA polymerase, β subunit (rpoB),
DNA gyrase, subunit B (gyrB),
DNA gyrase, subunit A,
diguanylate cyclase (dosC),
diguanylate cyclase (dgcM),
exonuclease VII, small subunit (xseB),
exonuclease VII, large subunit (xseA),
acetyl esterase (aes),
FKBP-type peptidyl prolyl cis-trans isomerase (slyD),
peptidyl-prolyl cis-trans isomerase B (rotamase B) (ppiB),
peptidyl-prolyl cis-trans isomerase C (rotamase C) (ppiC),
peptidyl-prolyl cis-trans isomerase (fkpB),
peptidyl-prolyl cis-trans isomerase (PPIase) (surA),
chaperone protein Tig; trigger factor,
tRNA threonylcarbamoyladenosine dehydratase (tcdA),
regulatory ATPase (ravA),
ribosome-binding ATPase, inhibitor of catalase activity (ychF),
Deg S monomer (degS),
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU),
sulfite reductase, flavoprotein subunit (cysJ),
endolytic murein transglycosylase (mltG),
RNase R (rnr),
protein involved in modification of U34 in tRNA (mnmG),
GTPase, involved in modification of U34 in tRNA (mnmE),
bacterioferritin monomer (bfr),
protein disulfide oxidoreductase - DsbAreduced,
DnaJ monomer,
hydrogenase 1, small subunit (hyaA),
hydrogenase 1, large subunit (hyaB),
hydrogenase 1, b-type cytochrome subunit (hyaC),
alkyl hydroperoxide reductase, AhpC component,
toxin of the YafQ-DinJ toxin-antitoxin system,
Qin prophage; toxin of the RelE-RelB toxin-antitoxin system and cofactor to enhance the repressor activity of RelB,
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis) (dinB),
DNA polymerase III, α subunit (dnaE),
DNA polymerase III, ε subunit (dnaQ),
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC,
SOS mutagenesis and repair (umuC),
nucleoside triphosphate pyrophosphohydrolase (mazG),
lipid hydroperoxide peroxidase (tpx),
scaffold protein for iron-sulfur cluster assembly (iscU),
methyltransferase for 50S ribosomal subunit protein L11 (prmA),
c-di-GMP phosphodiesterase, heme-regulated (dosP),
cyclic di-GMP phosphodiesterase (pdeR),
Ada DNA-binding transcriptional dual regulator,
hydrogenase maturation protein, carbamoyltransferase (hypF),
α-galactosidase monomer (melA),
cysteine sulfinate desulfinase (csdA),
E3 monomer (lpd),
subunit of E1p component of pyruvate dehydrogenase complex (aceE),
subunit of E1(0) component of 2-oxoglutarate dehydrogenase (sucA),
lipoyl(octanoyl) transferase (lipB),
DNA primase (dnaG),
Rep helicase,
ATP-dependent DNA helicase (recQ),
chaperone for [Fe-S] cluster biosynthesis (hscA),
PII uridylyltransferase / uridylyl removing enzyme (glnD),
ATP dependent, structure specific DNA nuclease - SbcD subunit,
ATP dependent, structure specific DNA nuclease - SbcC subunit,
23S rRNA pseudouridine synthase (rluD),
protein-lysine deacetylase and desuccinylase (cobB),
HflK-HflC complex; regulator of FtsH protease,
regulator of FtsH protease (hflK),
regulator of FtsH protease (hflC),
ADP-heptose:LPS heptosyltransferase I (waaC),
methionine-oxo-acid transaminase, PLP-dependent (ybdL),
branch migration of Holliday structures; repair helicase (ruvB),
Holliday junction nuclease; resolution of structures; repair (ruvC),
peptidase T,
predicted 5-keto 4-deoxyuronate isomerase monomer (kduI),
ssDNA and dsDNA binding, ATP binding (recF),
nitrate reductase A, β subunit (narH),
nitrate reductase A, α subunit (narG),
nitrate reductase Z, α subunit (narZ),
nitrate reductase Z, β subunit (narY),
isopentenyl-adenosine A37 tRNA methylthiolase (miaB),
GTPase that interacts with methylmalonyl-CoA mutase (argK),
ribosome small subunit-dependent GTPase A (rsgA),
accessory protein for nickel incorporation into hydrogenase isoenzymes (hypB),
NADPH nitroreductase (nfsA),
DNA-cytosine methyltransferase (dcm),
fused 23S rRNA m2G2445 methyltransferase and 23S rRNA m7G2069 methyltransferase (rlmL),
hydrogenase 3 and formate hydrogenlyase complex, HycG subunit,
hydrogenase 3, large subunit (hycE),
formate dehydrogenase H (fdhF),
ribosomal protein-arginine oxygenase (roxA),
oxidoreductase subunit (ynfF),
oxidoreductase subunit (ynfE),
meso-diaminopimelic acid-D-alanyl endopeptidase / D-alanyl-D-alanine carboxypeptidase (dacB),
murein DD-endopeptidase / murein LD-carboxypeptidase (mepS),
exonuclease I, 3' --> 5' specific; deoxyribophosphodiesterase (sbcB),
DNA nuclease / DNA damage response protein (yhbQ),
DNA damage response protein / protein implicated in 16S rRNA processing and ribosome maturation (yqgF),
23S rRNA m2A2503 methyltransferase and tRNA m2A37 methyltransferase (rlmN),
proofreading thioesterase in enterobactin biosynthesis (entH),
alkanesulfonate monooxygenase, FMNH2-dependent (ssuD),
peptidase component of the HslVU protease,
ATPase component of the HslVU protease (hslU),
EntB monomer,
serine hydroxymethyltransferase (glyA),
ribonuclease II (rnb),
NADH-dependent dihydropyrimidine dehydrogenase subunit (preA),
NADH-dependent dihydropyrimidine dehydrogenase subunit (preT),
16S rRNA pseudouridine 516 synthase (rsuA),
8-oxo-dGTP diphosphatase (mutT),
YhaV toxic ribonuclease,
23S rRNA pseudouridine 2605 synthase (rluB),
endonuclease III (nth),
uracil-DNA glycosylase (ung),
aminopeptidase (ypdF),
Mlc titration factor (mtfA),
lysophospholipase L2 (pldB),
crRNA endonuclease (casE),
Cascade subunit D (casD),
Cascade subunit C,
Cascade subunit B (casB),
Cascade subunit A (casA),
dihydroxyacetone kinase subunit L (dhaL),
dihydroxyacetone kinase subunit K (dhaK),
bis(molybdenum cofactor) synthase [multifunctional] (mobA),
membrane-bound lytic murein exotransglycosylase A (mltA),
membrane-bound lytic murein transglycosylase B (mltB),
soluble lytic murein transglycosylase (slt),
adenylate cyclase (cyaA),
lipid kinase (yegS),
polynucleotide phosphorylase monomer (pnp),
RNase E (rne),
glutathione S-transferase B (gstB),
peptide deformylase,
toxin of the YoeB-YefM toxin-antitoxin pair,
cysteine desulfurase monomer (iscS),
L-cysteine desulfurase (sufS),
dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC),
large subunit of periplasmic nitrate reductase, molybdoprotein (napA),
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaC subunit,
poly-β-1,6-N-acetyl-D-glucosamine synthase - PgaD subunit,
MalX PTS permease,
glucose PTS permease - PtsG subunit,
Enzyme IIAGlc; Crr,
2-O-α-mannosyl-D-glycerate PTS permease (mngA),
chitobiose PTS permease - ChbB subunit,
chitobiose PTS permease - ChbA subunit,
mannose PTS permease - ManX subunit,
ABC complex for formation and release of holoCcmE - membrane subunit CcmC,
membrane anchored periplasmic heme chaperone CcmE,
ABC complex for formation and release of holoCcmE - ATP binding subunit (ccmA),
ABC complex for formation and release of holoCcmE - membrane subunit CcmB,
ABC complex for formation and release of holoCcmE - membrane subunit CcmD,
galactose ABC transporter - periplasmic binding protein (mglB),
K+ transporting ATPase - KdpC subunit,
K+ transporting ATPase - ATP binding subunit (kdpB),
ribose ABC transporter - putative periplasmic binding protein (rbsB),
ribose ABC transporter - putative ATP binding subunit (rbsA),
glycine betaine / proline ABC transporter - periplasmic binding protein (proX),
glycine betaine / proline ABC transporter - membrane subunit (proW),
glycine betaine / proline ABC transporter - ATP binding subunit (proV),
ATP synthase F1 complex - epsilon subunit (atpC),
ATP synthase F1 complex - alpha subunit (atpA),
ATP synthase F1 complex - gamma subunit (atpG),
ATP synthase F1 complex - beta subunit (atpD),
maltose ABC transporter - periplasmic binding protein (malE),
maltose ABC transporter - membrane subunit (malG),
maltose ABC transporter - membrane subunit (malF),
maltose ABC transporter - ATP binding subunit (malK),
vitamin B12 ABC transporter - membrane subunit (btuC),
vitamin B12 ABC transporter - ATP binding subunit (btuD),
L-methionine / D-methionine ABC transporter - membrane subunit (metI),
L-methionine / D-methionine ABC transporter - ATP binding subunit (metN),
twin arginine protein translocation system - TatA protein,
twin arginine protein translocation system - TatC protein,
twin arginine protein translocation system - TatB protein,
TolC monomer,
branched chain amino acid transporter BrnQ,
lactose / melibiose:H+ symporter LacY,
melibiose:H+/Na+/Li+ symporter (melB),
copper / silver efflux system - membrane subunit (cusA),
copper / silver efflux system - periplasmic binding protein and metallochaperone (cusF),
copper / silver efflux system - membrane fusion protein (cusB),
copper / silver efflux system - outer membrane porin (cusC),
C4 dicarboxylate / orotate:H+ symporter (dctA),
ferric enterobactin / colicin B / colicin D outer membrane porin FepA,
TonB energy transducing system - TonB subunit,
TonB energy transducing system - ExbB subunit,
tonB energy transducing system - ExbD subunit,
AqpZ monomer,
OmpC monomer,
outer membrane lipopolysaccharide transport and assembly complex - LptD subunit,
outer membrane lipopolysaccharide transport and assembly complex - LptE subunit,
essential cell division protein FtsW; lipid II flippase,
hydrogenase maturation protein, carbamoyl dehydratase (hypE),
HPr (ptsH),
RelB-antitoxin and DNA-binding transcriptional repressor,
CSD sulfur transfer protein (csdE),
CP4-57 prophage; antitoxin of the RnlA-RnlB toxin-antitoxin system,
pyridoxal phosphate phosphatase (PHOSPHO2),
prostaglandin E synthase 3 (PTGES3),
GAP-like protein that activates GTPase activity of Der,
sulfur acceptor that activates SufS cysteine desulfurase,
Src proto-oncogene tyrosine-protein kinase,
pyruvate dehydrogenase protein E3 component, mitochondrial (PDHX),
pyruvate dehydrogenase E2 component (DLAT),
N-formyl-4-amino-5-aminomethyl-2- methylpyrimidine deformylase (thiQ),
retinoid isomerohydrolase (RPE65)

Unification Links: GO:0005515

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 20.0 (software by SRI International) on Thu May 5, 2016, BIOCYC13A.