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MetaCyc Gene-Ontology-Terms Class: GO:0006508 - proteolysis

Synonyms: peptidolysis

Definition: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Summary:
This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.

Parent Classes:
GO:0019538 - protein metabolic process

Child Classes:
GO:0016485 - protein processing (7) ,
GO:0051603 - proteolysis involved in cellular protein catabolic process (8) ,
GO:0070646 - protein modification by small protein removal (1)

Term Members:
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA) ,
D-Ala-D-Ala dipeptidase (ddpX) ,
TolB ,
DD-carboxypeptidase, penicillin-binding protein 6b (dacD) ,
penicillin-binding protein 6 (dacC) ,
ArgE ,
N-succinyl-L-diaminopimelate desuccinylase subunit (dapE) ,
MrcB ,
MrcA ,
L,D-transpeptidase ErfK (ldtA) ,
L,D-transpeptidase YbiS (ldtB) ,
L,D-transpeptidase YcfS (ldtC) ,
murein tripeptide amidase A (mpaA) ,
leader peptidase (signal peptidase I) (lepB) ,
leader peptidase, integral membrane protein (gspO) ,
meso-diaminopimelic acid-D-alanyl endopeptidase / D-alanyl-D-alanine carboxypeptidase (dacB) ,
penicillin-binding protein 7 (pbpG) ,
DD-endopeptidase / DD-carboxypeptidase (ampH) ,
murein DD-endopeptidase MepM ,
murein DD-endopeptidase MepH ,
murein LD-carboxypeptidase / murein DD-endopeptidase (mepS) ,
aminopeptidase N (pepN) ,
peptidase D (pepD) ,
MepA ,
intramembrane serine protease GlpG ,
Xaa-Pro dipeptidase (pepQ) ,
tail-specific protease (prc) ,
protease IV (sppA) ,
aminopeptidase (ypdF) ,
Mlc titration factor (mtfA) ,
outer membrane protease VII (outer membrane protein 3b) (ompT) ,
alkaline phosphatase isozyme conversion protein (iap) ,
methionine aminopeptidase (map) ,
prolipoprotein signal peptidase II (lspA) ,
PepP ,
oligopeptidase A (prlC) ,
L,D-transpeptidase LdtD ,
L,D-transpeptidase LdtE ,
D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 (dacA) ,
deubiquitinase (elaD) ,
DegP ,
serine endoprotease, periplasmic (degQ) ,
broad-specificity exoaminopeptidase (ypdE) ,
oligopeptidase B (ptrB) ,
IadA ,
IaaA ,
ClpX ,
ClpA ,
ClpP ,
hydrogenase 3 maturation protease (hycI) ,
peptidase T ,
protease III (ptrA) ,
L,D-carboxypeptidase A (ldcA) ,
peptidase E, a dipeptidase where amino-terminal residue is aspartate (pepE) ,
dipeptidyl carboxypeptidase II (dcp) ,
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC ,
Lon ,
TesA ,
aminopeptidase B (pepB) ,
γ-glutamyltranspeptidase (ggt) ,
aminopeptidase A/I (pepA) ,
ATP-dependent zinc metalloprotease FtsH ,
outer membrane metallopeptidase (loiP) ,
penicillin binding protein 4B (yfeW) ,
Beta-Ala-His dipeptidase (CNDP1) ,
leukotriene A4 hydrolase (LTA4H) ,
cancer-related nucleoside-triphosphatase (NTPCR) ,
aminoacylase 1 monomer (ACY1) ,
Dipeptidase 1 (DPEP1) ,
Dipeptidase 2 (DPEP2)

Unification Links: GO:0006508


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Jul 1, 2015, biocyc13.