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MetaCyc Gene-Ontology-Terms Class: GO:0006508 - proteolysis

Synonyms: peptidolysis

Definition: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.

Parent Classes:
GO:0019538 - protein metabolic process

Child Classes:
GO:0016485 - protein processing (9),
GO:0051603 - proteolysis involved in cellular protein catabolic process (8),
GO:0070646 - protein modification by small protein removal (1)

Term Members:
penicillin-binding protein 6 (dacC),
D-Ala-D-Ala dipeptidase (ddpX),
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA),
DD-carboxypeptidase, penicillin-binding protein 6b (dacD),
L,D-transpeptidase ErfK (ldtA),
L,D-transpeptidase YbiS (ldtB),
L,D-transpeptidase YcfS (ldtC),
murein tripeptide amidase A (mpaA),
N6-L-threonylcarbamoyladenine synthase, TsaB subunit,
N6-L-threonylcarbamoyladenine synthase, TsaD subunit,
N-succinyl-L-diaminopimelate desuccinylase subunit (dapE),
protease IV (sppA),
leader peptidase (signal peptidase I) (lepB),
aminopeptidase (ypdF),
Mlc titration factor (mtfA),
alkaline phosphatase isozyme conversion protein (iap),
peptidase T,
leader peptidase, integral membrane protein (gspO),
peptidase E, a dipeptidase where amino-terminal residue is aspartate (pepE),
L,D-transpeptidase LdtD,
L,D-transpeptidase LdtE,
dipeptidyl carboxypeptidase II (dcp),
Deg S monomer (degS),
serine endoprotease, periplasmic monomer (degQ),
outer membrane protease VII (outer membrane protein 3b) (ompT),
broad-specificity exoaminopeptidase (ypdE),
aminopeptidase A/I (pepA),
γ-glutamyltranspeptidase (ggt),
aminopeptidase B (pepB),
prolipoprotein signal peptidase II (lspA),
hydrogenase 3 maturation protease (hycI),
peptidase D (pepD),
oligopeptidase A (prlC),
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC,
L,D-carboxypeptidase A (ldcA),
Xaa-Pro dipeptidase (pepQ),
D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 (dacA),
tail-specific protease (prc),
oligopeptidase B (ptrB),
ATP-dependent zinc metalloprotease FtsH,
outer membrane metallopeptidase (loiP),
methionine aminopeptidase (map),
protease III (ptrA),
meso-diaminopimelic acid-D-alanyl endopeptidase / D-alanyl-D-alanine carboxypeptidase (dacB),
penicillin-binding protein 7 (pbpG),
DD-endopeptidase / DD-carboxypeptidase (ampH),
murein DD-endopeptidase MepM,
murein DD-endopeptidase MepH,
murein DD-endopeptidase / murein LD-carboxypeptidase (mepS),
aminopeptidase N (pepN),
deubiquitinase (elaD),
intramembrane serine protease GlpG,
peptidase component of the HslVU protease,
ATPase component of the HslVU protease (hslU),
penicillin binding protein 4B (yfeW),
Beta-Ala-His dipeptidase (CNDP1),
leukotriene A4 hydrolase (LTA4H),
cancer-related nucleoside-triphosphatase (NTPCR),
aminoacylase 1 monomer (ACY1),
Dipeptidase 1 (DPEP1),
Dipeptidase 2 (DPEP2)

Unification Links: GO:0006508

Relationship Links: Reactome:RELATED-TO:REACT_733, Reactome:RELATED-TO:REACT_84556, Reactome:RELATED-TO:REACT_92566, Reactome:RELATED-TO:REACT_95969, Reactome:RELATED-TO:REACT_98959, Reactome:RELATED-TO:REACT_105459, Reactome:RELATED-TO:REACT_106013, Reactome:RELATED-TO:REACT_106377, Reactome:RELATED-TO:REACT_107219, Reactome:RELATED-TO:REACT_110326, Wikipedia:RELATED-TO:Proteolysis

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon May 2, 2016, biocyc14.