MetaCyc Gene-Ontology-Terms Class: GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system

Definition: The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Parent Classes:
GO:0008643 - carbohydrate transport

Term Members:
predicted PTS permease - SgcB subunit,
predicted PTS permease - FrwC subunit,
predicted PTS permease - FrvA subunit,
predicted PTS permease - SgcA subunit,
GlvB subunit of predicted PTS permease (pseudogene),
AgaX (yadI),
predicted PTS permease - FrvB subunit,
fructose PTS permease - FruA subunit,
predicted PTS permease - SgcC subunit,
predicted PTS permease - FrwB subunit,
fructose PTS permease - FruB subunit,
dihydroxyacetone kinase subunit M (dhaM),
MalX PTS permease,
2-O-α-mannosyl-D-glycerate PTS permease (mngA),
chitobiose PTS permease,
chitobiose PTS permease - ChbB subunit,
chitobiose PTS permease - ChbC subunit,
chitobiose PTS permease - ChbA subunit,
galactitol / sorbitol PTS permease,
galactitol PTS permease - GatA subunit,
galactitol PTS permease - GatB subunit,
galactitol PTS permease - GatC subunit,
L-ascorbate PTS permease,
L-ascorbate PTS permease - UlaA subunit,
L-ascorbate PTS permease - UlaB subunit,
L-ascorbate PTS permease (ulaC),
AscF monomer,
glucose PTS permease,
glucose PTS permease - PtsG subunit,
mannose PTS permease,
mannose PTS permease - ManX subunit,
mannose PTS permease - ManY subunit,
mannose PTS permease - ManZ subunit,
trehalose PTS permease - TreB subunit,
N-acetylmuramic acid PTS permease,
Enzyme IIAGlc; Crr,
N-acetylmuramic acid PTS permease / anhydro-N-acetylmuramic acid permease (murP),
predicted PTS permease CmtBA,
predicted PTS permease - CmtA subunit,
predicted PTS permease - CmtB subunit,
sorbitol PTS permease,
sorbitol PTS permease - SrlE subunit,
sorbitol PTS permease - SrlB subunit,
sorbitol PTS permease - SrlA subunit,
HPr (ptsH)

Unification Links: GO:0009401

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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