Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

MetaCyc Gene-Ontology-Terms Class: GO:0016787 - hydrolase activity

Definition: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

Parent Classes:
GO:0003824 - catalytic activity

Child Classes:
GO:0008233 - peptidase activity (78),
GO:0016788 - hydrolase activity, acting on ester bonds (191),
GO:0016798 - hydrolase activity, acting on glycosyl bonds (55),
GO:0016801 - hydrolase activity, acting on ether bonds (5),
GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (82),
GO:0016817 - hydrolase activity, acting on acid anhydrides (198),
GO:0016822 - hydrolase activity, acting on acid carbon-carbon bonds (4),
GO:0017171 - serine hydrolase activity (30),
GO:0019213 - deacetylase activity (7),
GO:0051747 - cytosine C-5 DNA demethylase activity (1)

Term Members:
endochitinase (chiA),
N-acetylmuramyl-L-alanine amidase C (amiC),
30S ribosomal subunit protein S16 (rpsP),
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity (chpA),
N-acetylmuramoyl-L-alanine amidase A (amiA),
penicillin-binding protein 6 (dacC),
primosome factor N' (priA),
EnvC divisome associated factor, activator of peptidoglycan hydrolases,
N-acetylmuramoyl-L-alanine amidase B (amiB),
D-Ala-D-Ala dipeptidase (ddpX),
DD-carboxypeptidase, penicillin-binding protein 6b (dacD),
RhlB,
RPnTP hydrolase (phnM),
5-phospho-α-D-ribosyl 1,2-cyclic phosphate phosphodiesterase (phnP),
acyl carrier protein phosphodiesterase (acpH),
GTP cyclohydrolase I monomer (folE),
NMN aminohydrolase (pncC),
nicotinamidase / pyrazinamidase (pncA),
periplasmic trehalase (treA),
cytoplasmic trehalase (treF),
trehalose-6-phosphate hydrolase (treC),
β-D-glucuronidase (uidA),
glucosamine-6-phosphate deaminase (nagB),
N-acetylglucosamine-6-phosphate deacetylase (nagA),
glutaminase (yneH),
glutaminase (ybaS),
fructoselysine 6-phosphate deglycase monomer (frlB),
N-acetyl-anhydromuramyl-L-alanine amidase (ampD),
anhydro-N-acetylmuramoyl-L-alanine amidase,
γ-glutamyl-γ-aminobutyrate hydrolase (puuD),
Gpp,
guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase [multifunctional] (spoT),
α-galactosidase monomer (melA),
α-D-glucose-1-phosphatase (yihX),
α-mannosidase (mngB),
MrcB,
MrcA,
L,D-transpeptidase ErfK (ldtA),
L,D-transpeptidase YbiS (ldtB),
L,D-transpeptidase YcfS (ldtC),
Dut,
Dcd,
ArgE,
SpeB,
allantoinase monomer (allB),
allantoate amidohydrolase monomer (allC),
S-ureidoglycine aminohydrolase (allE),
predicted adenosylcobalamin phosphatase/α-ribazole phosphatase (cobC),
asparaginase II (ansB),
AnsA,
L-ascorbate 6-phosphate lactonase (ulaG),
2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (mhpC),
Cdd,
GlpQ,
Amn,
guanine deaminase (guaD),
adenosine deaminase (add),
glyoxalase III, Hsp31 molecular chaperone (hchA),
AICAR transformylase / IMP cyclohydrolase (purH),
glyoxalase II (gloB),
glyoxalase II (gloC),
isopentenyl diphosphate isomerase (idi),
phosphatidylglycerophosphatase A (pgpA),
phosphatidylglycerophosphatase C (pgpC),
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH),
1,4-dihydroxy-2-naphthoyl-CoA thioesterase (menI),
phosphoserine phosphatase (serB),
ribonucleoside hydrolase 1 (pyrimidine-specific) (rihA),
RNase P protein component; processes tRNA, 4.5S RNA (rnpA),
fructose-1,6-bisphosphatase monomer (fbp),
fructose 1,6-bisphosphatase II (glpX),
fructose-1,6-bisphosphatase (yggF),
6-phosphogluconolactonase (pgl),
N-succinyl-L-diaminopimelate desuccinylase subunit (dapE),
trehalose-6-phosphate phosphatase (otsB),
PyrC,
HisB,
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase (hisI),
D,D-heptose 1,7-bisphosphate phosphatase (gmhB),
FolD,
UDP-2,3-diacylglucosamine hydrolase (lpxH),
UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC),
thioesterase III (fadM),
S-formylglutathione hydrolase (frmB),
YeiG,
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD),
GTP cyclohydrolase II (ribA),
AstB,
succinylglutamate desuccinylase (astE),
limit dextrin α-1,6-glucohydrolase (glgX),
undecaprenyl pyrophosphate phosphatase (bacA),
undecaprenyl pyrophosphate phosphatase (ybjG),
glucose-1-phosphatase (agp),
oligoribonuclease monomer (orn),
β-D-glucoside glucohydrolase, periplasmic (bglX),
Rnt,
Lon,
exonuclease VIII, ds DNA exonuclease, 5' --> 3' specific (recE),
α-amylase (malS),
α-amylase (amyA),
Gmm,
protease IV (sppA),
endonuclease IV (nfo),
formamidopyrimidine DNA glycosylase (mutM),
leader peptidase (signal peptidase I) (lepB),
aminopeptidase (ypdF),
crRNA endonuclease (casE),
pimeloyl-[acp] methyl ester esterase (bioH),
uracil-DNA glycosylase (ung),
alkaline phosphatase isozyme conversion protein (iap),
branch migration of Holliday structures; repair (ruvA),
branch migration of Holliday structures; repair helicase (ruvB),
Holliday junction nuclease; resolution of structures; repair (ruvC),
peptidase T,
leader peptidase, integral membrane protein (gspO),
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase (yigB),
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase (ybjI),
ribonucleoside hydrolase 2 (pyrimidine-specific) (rihB),
protein-lysine deacetylase and desuccinylase (cobB),
RecB,
RecC,
RecD,
phosphoglycolate phosphatase (gph),
RNase III (rnc),
peptidase E, a dipeptidase where amino-terminal residue is aspartate (pepE),
peptide deformylase,
L,D-transpeptidase LdtD,
L,D-transpeptidase LdtE,
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system,
CP4-57 prophage; RNase LS, toxin of the RnlAB toxin-antitoxin system,
antitoxin of the GhoTS toxin-antitoxin system (ghoS),
chito-oligosaccharide mono-deacetylase (chbG),
DNA repair; excision nuclease subunit B (uvrB),
exonuclease I, 3' --> 5' specific; deoxyribophosphodiesterase (sbcB),
ssDNA/RNA exonuclease, 3' → 5' specific (tatD),
Ppa,
inorganic triphosphatase (ygiF),
dipeptidyl carboxypeptidase II (dcp),
adenosine-3'(2'),5'-bisphosphate nucleotidase (cysQ),
ADP-sugar pyrophosphatase (nudF),
ADP-sugar pyrophosphorylase (nudE),
β-phosphoglucomutase (ycjU),
ribonuclease G (RNAse G) monomer (rng),
RNA/ssDNA exonuclease 5' → 3' specific (yciV),
DLP12 prophage; lysozyme (rrrD),
DegP,
cAMP phosphodiesterase (cpdA),
GDP-mannose hydrolase (nudK),
monoacetylchitobiose-6-phosphate hydrolase (chbF),
poly-β-1,6-N-acetyl-D-glucosamine N-deacetylase (pgaB),
RNase I, cleaves phosphodiester bond between any two nucleotides,
proofreading thioesterase in enterobactin biosynthesis (entH),
exopolyphosphatase (ppx),
phenylhydantoinase (hyuA),
TesA,
Deg S monomer (degS),
serine endoprotease, periplasmic monomer (degQ),
DNA-specific endonuclease I (endA),
3-methyl-adenine DNA glycosylase II, inducible (alkA),
outer membrane protease VII (outer membrane protein 3b) (ompT),
broad-specificity exoaminopeptidase (ypdE),
D-Tyr-tRNATyr deacylase (dtd),
toxin of the YoeB-YefM toxin-antitoxin pair,
RNA 2',3'-cyclic phosphodiesterase (thpR),
aminopeptidase A/I (pepA),
PII uridylyltransferase / uridylyl removing enzyme (glnD),
protein-tyrosine phosphatase (wzb),
phosphotyrosine-protein phosphatase (etp),
CheB,
γ-glutamyltranspeptidase (ggt),
AceK,
aminopeptidase B (pepB),
phosphoprotein phosphatase 1 (pphA),
phosphoprotein phosphatase 2 (pphB),
IadA,
IaaA,
endonuclease V (nfi),
prolipoprotein signal peptidase II (lspA),
fructose-1-phosphatase (yqaB),
6-phospho-β-glucosidase B; cryptic (bglB),
endo-1,4-D-glucanase (bcsZ),
O-acetyl-ADP-ribose deacetylase, regulator of RNase III activity (ymdB),
restriction of DNA at 5-methylcytosine residues (mcrA),
hydrogenase 3 maturation protease (hycI),
peptidase D (pepD),
oligopeptidase A (prlC),
phenylacetyl-CoA thioesterase (paaI),
peptidyl-tRNA hydrolase (pth),
peptidyl-tRNA hydrolase, ribosome rescue factor (arfB),
arylsulfatase (aslA),
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system,
translation-dependent mRNA interferase, toxin of the HigB-HigA toxin-antitoxin system,
toxin of the YafQ-DinJ toxin-antitoxin system,
Qin prophage; toxin of the RelE-RelB toxin-antitoxin system and cofactor to enhance the repressor activity of RelB,
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase monomer (mtn),
5-hydroxy-CTP diphosphatase (nudG),
DNA polymerase III, ε subunit (dnaQ),
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC,
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA),
phosphatidylglycerophosphatase [multifunctional] (pgpB),
L,D-carboxypeptidase A (ldcA),
Xaa-Pro dipeptidase (pepQ),
diadenosine tetraphosphatase (apaH),
acyl-CoA thioesterase (yciA),
β-lactamase; penicillin resistance (ampC),
D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 (dacA),
predicted NUDIX hydrolase with low 3-phosphohydroxypyruvate phosphatase activity (nudL),
GTPase, involved in modification of U34 in tRNA (mnmE),
MutH,
exonuclease VII, small subunit (xseB),
exonuclease VII, large subunit (xseA),
pyridoxal phosphatase / fructose 1,6-bisphosphatase (ybhA),
phosphodiesterase, c-di-GMP-specific (pdeL),
c-di-GMP phosphodiesterase, heme-regulated (dosP),
cyclic di-GMP phosphodiesterase (pdeR),
c-di-GMP phosphodiesterase (pdeH),
cyclic di-GMP phosphodiesterase (pdeF),
tail-specific protease (prc),
pyrimidine deoxynucleoside triphosphate pyrophosphohydrolase (nudI),
TesB,
acylphosphatase (yccX),
β-galactosidase monomer (lacZ),
Rbn,
lysophospholipase L2 (pldB),
deoxyguanosine triphosphate triphosphohydrolase (dgt),
Rac prophage; DNA endonuclease toxin of the RalRA toxin-antitoxin system, restriction alleviation and modification enhancement,
tRNA-specific adenosine deaminase monomer (tadA),
RNase D (rnd),
β-N-acetylhexosaminidase (nagZ),
DnaB,
Rep helicase,
ATP-dependent DNA helicase (recQ),
oligopeptidase B (ptrB),
p-aminobenzoyl-glutamate hydrolase subunit A (abgA),
p-aminobenzoyl-glutamate hydrolase subunit B (abgB),
acetyl esterase (aes),
cryptic adenine deaminase monomer (adeD),
YhaV toxic ribonuclease,
stationary phase mismatch/uracil DNA glycosylase (mug),
sugar phosphatase (ybiV),
sugar phosphatase (yfbT),
sugar phosphatase (yidA),
phosphosugar phosphatase (yigL),
inositol monophosphatase (suhB),
ATP-dependent zinc metalloprotease FtsH,
outer membrane metallopeptidase (loiP),
host restriction; endonuclease R (hsdR),
dihydroneopterin triphosphate pyrophosphohydrolase (nudB),
methionine aminopeptidase (map),
ClpP,
peroxyureidoacrylate / ureidoacrylate amido hydrolase (rutB),
8-oxo-dGTP diphosphatase (mutT),
6-phosphogluconate phosphatase (yieH),
maltodextrin glucosidase (malZ),
6-phospho-β-glucosidase; cryptic (ascB),
regulatory ATPase (ravA),
alkyl sulfatase (yjcS),
CodA,
endonuclease III (nth),
MrcB subunit of 5-methylcytosine restriction system (mcrB),
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ),
PepP,
NADH pyrophosphatase (nudC),
protease III (ptrA),
ribonucleoside hydrolase 3 (rihC),
UDP-sugar hydrolase / 5'-ribonucleotidase / 5'-deoxyribonucleotidase (ushA),
pyrimidine nucleotidase (yjjG),
UMP phosphatase (umpH),
3-methyl-adenine DNA glycosylase I, constitutive (tag),
dCMP phosphohydrolase (yfbR),
glycoside hydrolase (ygjK),
GTPase that interacts with methylmalonyl-CoA mutase (argK),
ribosome small subunit-dependent GTPase A (rsgA),
accessory protein for nickel incorporation into hydrogenase isoenzymes (hypB),
AppA,
CDP-diacylglycerol pyrophosphatase (cdh),
purine nucleotidase (yrfG),
ATP-dependent RNA helicase, specific for 23S rRNA (dbpA),
formyltetrahydrofolate deformylase (purU),
broad specificity 5'(3')-nucleotidase and polyphosphatase (umpG),
meso-diaminopimelic acid-D-alanyl endopeptidase / D-alanyl-D-alanine carboxypeptidase (dacB),
penicillin-binding protein 7 (pbpG),
DD-endopeptidase / DD-carboxypeptidase (ampH),
murein DD-endopeptidase MepM,
murein DD-endopeptidase MepH,
murein DD-endopeptidase / murein LD-carboxypeptidase (mepS),
RNase HI, degrades RNA of DNA-RNA hybrids, participates in DNA replication (rnhA),
RNAse HII, degrades RNA of DNA-RNA hybrids (rnhB),
nucleoside triphosphate pyrophosphohydrolase (mazG),
ITPase/XTPase (yjjX),
glycerophosphodiester phosphodiesterase, cytosolic (ugpQ),
aminopeptidase N (pepN),
MepA,
AphA monomer,
RNA pyrophosphohydrolase (rppH),
RNase E (rne),
PldA,
6-phospho-β-glucosidase A (bglA),
RNase R (rnr),
RdgB,
exonuclease III (xthA),
nucleoside di- and triphosphate hydrolase [multifunctional] (nudJ),
pyridoxal phosphatase / HMP-PP hydrolase (cof),
Gss,
fused tRNA nucleotidyltransferase / 2',3'-cyclic phosphodiesterase / 2' nucleotidase and phosphatase (cca),
2-deoxyglucose-6-phosphatase (yniC),
purine nucleoside phosphoramidase monomer (hinT),
deubiquitinase (elaD),
α-xylosidase (yicI),
intramembrane serine protease GlpG,
peptidase component of the HslVU protease,
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB),
EntB monomer,
ChpB toxin of the ChpB-ChpS toxin-antitoxin system,
ribonuclease II (rnb),
PhoA,
xylose ABC transporter - ATP binding subunit (xylG),
taurine ABC transporter - ATP binding subunit (tauB),
ABC complex for formation and release of holoCcmE - ATP binding subunit (ccmA),
arabinose ABC transporter - ATP binding subunit (araG),
glutathione ABC transporter - ATP binding subunit (gsiA),
phosphate ABC transporter - ATP binding subunit (pstB),
D-allose ABC transporter - ATP binding subunit (alsA),
Zn2+ ABC transporter - ATP binding subunit (znuC),
glycine betaine ABC transporter - putative ATP binding subunit (yehX),
ATP synthase F1 complex - alpha subunit (atpA),
ATP synthase F1 complex - beta subunit (atpD),
Cu+ efflux ATPase (copA),
molybdate ABC transporter - ATP binding subunit (modC),
L-arginine ABC transporter - ATP binding subunit (artP),
AI-2 ABC transporter - ATP binding subunit (lsrA),
K+ transporting ATPase - ATP binding subunit (kdpB),
phosphonate ABC transporter - ATP binding subunit (phnC),
maltose ABC transporter - ATP binding subunit (malK),
aliphatic sulfonate ABC transporter - ATP binding subunit (ssuB),
glycerol-3-phosphate ABC transporter - ATP binding subunit (ugpC),
zinc, cadmium and lead efflux system (zntA),
L-methionine / D-methionine ABC transporter - ATP binding subunit (metN),
L-cystine ABC transporter - predicted ATP binding subunit (tcyN),
galactose ABC transporter - ATP binding subunit (mglA),
nickel ABC transporter - ATP binding subunit (nikE),
nickel ABC transporter - ATP binding subunit (nikD),
sulfate / thiosulfate ABC transporter - ATP binding subunit (cysA),
putrescine / spermidine ABC transporter - ATP binding subunit (potA),
ATP-binding lipopolysaccharide transport protein (msbA),
ribose ABC transporter - putative ATP binding subunit (rbsA),
vitamin B12 ABC transporter - ATP binding subunit (btuD),
iron (III) hydroxamate ABC transporter - ATP binding subunit (fhuC),
LptB,
2-oxoglutaramte:glutamine aminotransferase (mtnU),
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (mtnX),
Dihydropyrimidinase (DPYS),
glycosylasparaginase beta chain (AGA),
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2),
Fructose-2,6-bisphosphatase (PFKFB4),
Fructose-2,6-bisphosphatase (PFKFB3),
Beta-Ala-His dipeptidase (CNDP1),
Fumarylacetoacetase (FAH),
6-phosphogluconolactonase (PGLS),
agmatinase,
Arginase-1 (ARG1),
Arginase-2, mitochondrial (ARG2),
bifunctional purine biosynthesis protein purh (ATIC),
kanosamine-6-phosphate phosphatase (ntdB),
V-type proton ATPase subunit S1 (ATP6AP1),
H+-translocating V-ATPase subunit G3 (ATP6V1G3),
H+-translocating V-ATPase subunit G2 (ATP6V1G2),
H+-translocating V-ATPase subunit B1 (ATP6V1B1),
H+-translocating V-ATPase subunit H (ATP6V1H),
H+-translocating V-ATPase subunit G1 (ATP6V1G1),
H+-translocating V-ATPase subunit F (ATP6V1F),
H+-translocating V-ATPase subunit E1 (ATP6V1E1),
H+-translocating V-ATPase subunit D (ATP6V1D),
H+-translocating V-ATPase subunit C1 (ATP6V1C1),
H+-translocating V-ATPase subunit B2 (ATP6V1B2),
H+-translocating V-ATPase subunit A (ATP6V1A),
H+-translocating V-ATPase subunit e1 (ATP6V0E1),
H+-translocating V-ATPase subunit c'' (ATP6V0B),
H+-translocating V-ATPase subunit d1 (ATP6V0D1),
glucose-6-phosphatase (G6PC),
fructose-1,6-bisphosphatase 2 (FBP2),
fructose-1,6-bisphosphatase 1 (FBP1),
phosphoglycerate mutase 2 (PGAM2),
Bisphosphoglycerate mutase (BPGM),
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD),
phosphoglycerate mutase 1 (PGAM1),
nucleoside triphosphate phosphohydrolase (ytkD),
cytidine/deoxycytidine deaminase monomer (cdd),
deoxycytidylate deaminase monomer (DCTD),
mitochondrial deoxyuridine 5'-triphosphate nucleotidohydrolase monomer (DUT),
cytidine deaminase monomer (CDA),
ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2),
ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4),
ectonucleoside triphosphate diphosphohydrolase 1 monomer (ENTPD1),
aminoacylase 2 monomer (ASPA),
aminoacylase 1 monomer (ACY1),
RNAse L (RNASEL),
arabinogalactan endo-1,4-β-galactosidase (ganB),
8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase (MTH1),
mitochondrial glutaminase precursor (kidney isoform) (GLS),
N-formyl-4-amino-5-aminomethyl-2- methylpyrimidine deformylase (thiQ),
thiaminase II (tenA),
pancreatic triacylglycerol lipase (PNLIP),
liver carboxylesterase 1 monomer (CES1),
carboxylesterase 3 (CES3),
Dipeptidase 1 (DPEP1),
glucuronoarabinoxylan endo-1,4-β-xylanase (xynC),
α-L-arabinofuranosidase 2 (xsa),
α-L-arabinofuranosidase 1 (abfA),
arabinan-endo 1,5-α-L-arabinanase (abnA),
GTP cyclohydrolase I (folEA),
CAD protein,
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (bphD),
sphingomyelin phosphodiesterase 4 (Smpd4),
N-acylsphingosine amidohydrolase 1 (Asah1),
sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1),
sphingomyelin phosphodiesterase 3, neutral (Smpd3),
sphingomyelin phosphodiesterase 2, neutral (Smpd2),
sphingosine-1-phosphate phosphatase 1 (Sgpp1),
acyl-CoA thioesterase 2 (mitochondrial) (ACOT2)

Unification Links: GO:0016787

Relationship Links: ENZYME:RELATED-TO:3, Reactome:RELATED-TO:REACT_15331, Reactome:RELATED-TO:REACT_83734, Reactome:RELATED-TO:REACT_84047, Reactome:RELATED-TO:REACT_87959, Reactome:RELATED-TO:REACT_88159, Reactome:RELATED-TO:REACT_90118, Reactome:RELATED-TO:REACT_91045, Reactome:RELATED-TO:REACT_98572, Reactome:RELATED-TO:REACT_110436, Reactome:RELATED-TO:REACT_111159


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue May 3, 2016, biocyc14.