Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
twitter

MetaCyc Gene-Ontology-Terms Class: GO:0016829 - lyase activity

Definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Summary:
Note that enzymes of class EC:4.99.-.- should also be annotated to this term.

Parent Classes:
GO:0003824 - catalytic activity

Child Classes:
GO:0004325 - ferrochelatase activity (3) ,
GO:0016830 - carbon-carbon lyase activity (91) ,
GO:0016835 - carbon-oxygen lyase activity (86) ,
GO:0016840 - carbon-nitrogen lyase activity (19) ,
GO:0016846 - carbon-sulfur lyase activity (21) ,
GO:0016848 - carbon-halide lyase activity (2) ,
GO:0016849 - phosphorus-oxygen lyase activity (2)

Term Members:
3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG (ubiX) ,
carbonic anhydrase 2 monomer (yadF) ,
FabA ,
deoxyribose-phosphate aldolase (deoC) ,
Dfp ,
PanD proenzyme, π protein ,
3-dehydroquinate synthase (aroB) ,
dTDP-glucose 4,6-dehydratase (rfbB) ,
dTDP-glucose 4,6-dehydratase 2 (rffG) ,
SpeA ,
Adi (adiA) ,
glutamate decarboxylase A subunit (gadA) ,
glutamate decarboxylase B subunit (gadB) ,
carbonic anhydrase monomer (cynT) ,
cyanase monomer (cynS) ,
6-carboxy-5,6,7,8-tetrahydropterin synthase (queD) ,
3-hydroxy-2,4-pentadione 5-phosphate thiolase (lsrF) ,
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD) ,
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH) ,
S-ribosylhomocysteine lyase (luxS) ,
glyoxalase I (gloA) ,
glyoxalase III, Hsp31 molecular chaperone (hchA) ,
ornithine decarboxylase, biosynthetic (speC) ,
ornithine decarboxylase, degradative (speF) ,
argininosuccinate lyase (argH) ,
PyrF ,
FadJ monomer ,
AspA ,
CadA ,
LdcC ,
adenosylmethionine decarboxylase, proenzyme (speD) ,
phosphogluconate dehydratase (edd) ,
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase monomer (ispF) ,
3,4-dihydroxy-2-butanone 4-phosphate synthase (ribB) ,
L-serine deaminase III (tdcG) ,
L-serine deaminase I (sdaA) ,
L-serine deaminase II (sdaB) ,
methylmalonyl-CoA decarboxylase (scpB) ,
MhpD ,
4-hydroxy-2-ketovalerate aldolase (mhpE) ,
KbaY ,
GatY ,
2-methylcitrate dehydratase (prpD) ,
2-methylisocitrate lyase (prpB) ,
threonine synthase (thrC) ,
LysA ,
4-hydroxy-tetrahydrodipicolinate synthase (dapA) ,
LeuD ,
LeuC ,
IlvD ,
TdcB ,
IlvA ,
AroC ,
AroD ,
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC) ,
anthranilate synthase component II (trpD) ,
anthranilate synthase component I (trpE) ,
PheA ,
carbon-phosphorous lyase (phnJ) ,
D-serine ammonia-lyase (dsdA) ,
FucA ,
fructose bisphosphate aldolase monomer (fbaB) ,
chorismate lyase (ubiC) ,
3-octaprenyl-4-hydroxybenzoate carboxy-lyase monomer (ubiD) ,
GarL ,
galactarate dehydratase (garD) ,
rhamnulose-1-phosphate aldolase monomer (rhaD) ,
HisB ,
imidazole glycerol phosphate synthase, HisF subunit ,
adenylosuccinate lyase (purB) ,
D-altronate dehydratase (uxaA) ,
D-mannonate dehydratase (uxuA) ,
o-succinylbenzoate synthase (menC) ,
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH) ,
MenB ,
pabC ,
GDP-mannose 4,6-dehydratase (gmd) ,
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA) ,
D-galactonate dehydratase (dgoD) ,
uroporphyrinogen III synthase (hemD) ,
porphobilinogen synthase (hemB) ,
HMP-P synthase (thiC) ,
tyrosine lyase (thiH) ,
molybdopterin biosynthesis protein A (moaA) ,
N-acetylmuramic acid 6-phosphate etherase (murQ) ,
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT) ,
glyoxylate carboligase (gcl) ,
tryptophanase (tnaA) ,
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY) ,
O-acetylserine sulfhydrylase A (cysK) ,
MetC ,
fumarase C monomer (fumC) ,
aconitate hydratase 1 (acnA) ,
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB) ,
isocitrate lyase monomer (aceA) ,
ureidoglycolate lyase (allA) ,
phosphatidylserine decarboxylase, proenzyme (psd) ,
uroporphyrinogen decarboxylase (hemE) ,
ferrochelatase (hemH) ,
FabZ ,
Ppc ,
fructose bisphosphate aldolase monomer (fbaA) ,
crotonobetainyl-CoA hydratase (caiD) ,
CysG ,
ethanolamine ammonia-lyase, β subunit (eutC) ,
ethanolamine ammonia-lyase, α subunit (eutB) ,
phosphoenolpyruvate carboxykinase (ATP) (pck) ,
2,3-diaminopropionate ammonia-lyase (ygeX) ,
methylglyoxal synthase (mgsA) ,
fumarase B monomer (fumB) ,
dihydroneopterin aldolase (folB) ,
tryptophan synthase, β subunit (trpB) ,
tryptophan synthase, α subunit (trpA) ,
fumarase A monomer ,
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ) ,
adenylate cyclase (cyaA) ,
L-tartrate dehydratase, β subunit (ttdB) ,
L-tartrate dehydratase, α subunit (ttdA) ,
D-glucarate dehydratase (gudD) ,
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU) ,
L-rhamnonate dehydratase (yfaW) ,
KpLE2 phage-like element; D-xylonate dehydratase (yjhG) ,
CP4-6 prophage; D-xylonate dehydratase (yagF) ,
Eda ,
formamidopyrimidine DNA glycosylase (mutM) ,
N-acetylneuraminate lyase (nanA) ,
oxalyl-CoA decarboxylase (oxc) ,
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF) ,
membrane-bound lytic murein transglycosylase B (mltB) ,
membrane-bound lytic murein transglycosylase A (mltA) ,
soluble lytic murein transglycosylase (slt) ,
membrane-bound lytic murein transglycosylase C (mltC) ,
membrane-bound lytic murein transglycosylase D (mltD) ,
lytic murein transglycosylase E (emtA) ,
membrane-bound lytic murein transglycosylase F (mltF) ,
LtaE ,
Eno ,
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB) ,
deoxyribodipyrimidine photolyase (photoreactivation) (phr) ,
endonuclease III (nth) ,
Fsa (fsaA) ,
fructose 6-phosphate aldolase 2 (fsaB) ,
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH) ,
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE) ,
D-cysteine desulfhydrase (dcyD) ,
cysteine sulfinate desulfinase (csdA) ,
citrate lyase, citryl-ACP lyase β subunit (citE) ,
citrate lyase, citrate-ACP transferase α subunit (citF) ,
L-cysteine desulfurase (sufS) ,
Cysteine sulfinic acid decarboxylase (CSAD) ,
ATP-citrate synthase (ACLY) ,
Histidine decarboxylase (HDC) ,
arginine decarboxylase (ADC) ,
argininosuccinate lyase (ASL) ,
Glutamate decarboxylase 1 (GAD1) ,
glutamate decarboxylase 2 monomer (GAD2) ,
Serine dehydratase-like (SDSL) ,
L-serine dehydratase (SDS) ,
adenylosuccinate lyase (ADSL) ,
Uroporphyrinogen decarboxylase (UROD) ,
uroporphyrinogen-III synthase (UROS) ,
porphobilinogen deaminase (HMBS) ,
Delta-aminolevulinic acid dehydratase (ALAD) ,
phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) ,
Fructose-bisphosphate aldolase B (ALDOB) ,
Fructose-bisphosphate aldolase A (ALDOA) ,
fructose-bisphosphate aldolase C monomer (ALDOC) ,
Beta-enolase (ENO3) ,
gamma enolase monomer (ENO2) ,
phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PCK1) ,
2-deoxy-5-keto-D-gluconate 6-phosphate aldolase (iolJ) ,
scyllo-inosose dehydratase (iolE) ,
Alpha-enolase (ENO1) ,
long chain 3-hydroxyacyl-CoA dehydrogenase (HADHA) ,
mitochondrial enoyl-CoA hydratase (ECHS1) ,
peroxisomal bifunctional enzyme (EHHADH) ,
2-hydroxyacyl-CoA lyase 1 (HACL1) ,
S-adenosylmethionine decarboxylase proenzyme (AMD1) ,
phosphomethylpyrimidine synthase monomer (thiC) ,
thiazole synthase (thiG) ,
7-carboxy-7-deazaguanine synthase (queE) ,
6-carboxy-5,6,7,8-tetrahydropterin synthase (queD) ,
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) ,
sphingosine phosphate lyase 1 (Sgpl1)

Unification Links: GO:0016829


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Sep 4, 2015, BIOCYC14A.