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discounted EARLY registration ends Dec 31, 2014
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discounted EARLY registration ends Dec 31, 2014
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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Gene-Ontology-Terms Class: GO:0016829 - lyase activity

Definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Summary:
Note that enzymes of class EC:4.99.-.- should also be annotated to this term.

Parent Classes:
GO:0003824 - catalytic activity

Child Classes:
GO:0004325 - ferrochelatase activity (3) ,
GO:0016830 - carbon-carbon lyase activity (89) ,
GO:0016835 - carbon-oxygen lyase activity (86) ,
GO:0016840 - carbon-nitrogen lyase activity (20) ,
GO:0016846 - carbon-sulfur lyase activity (21) ,
GO:0016848 - carbon-halide lyase activity (2) ,
GO:0016849 - phosphorus-oxygen lyase activity (2)

Term Members:
predicted ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) (paaG) ,
carbonic anhydrase 2 monomer (yadF) ,
IlvA ,
IlvD ,
FabA ,
threonine synthase (thrC) ,
GDP-mannose 4,6-dehydratase (gmd) ,
PanD proenzyme, π protein ,
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA) ,
D-galactonate dehydratase (dgoD) ,
LeuD ,
LeuC ,
LysA ,
4-hydroxy-tetrahydrodipicolinate synthase (dapA) ,
HisB ,
imidazole glycerol phosphate synthase, HisF subunit ,
PyrF ,
N-acetylmuramic acid 6-phosphate etherase (murQ) ,
chorismate lyase (ubiC) ,
3-octaprenyl-4-hydroxybenzoate carboxy-lyase monomer (ubiD) ,
3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG (ubiX) ,
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT) ,
phosphatidylserine decarboxylase, proenzyme (psd) ,
rhamnulose-1-phosphate aldolase monomer (rhaD) ,
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD) ,
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH) ,
phosphogluconate dehydratase (edd) ,
glyoxylate carboligase (gcl) ,
methylmalonyl-CoA decarboxylase (scpB) ,
carbon-phosphorous lyase (phnJ) ,
D-altronate dehydratase (uxaA) ,
o-succinylbenzoate synthase (menC) ,
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH) ,
MenB ,
Dfp ,
PheA ,
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC) ,
anthranilate synthase component II (trpD) ,
anthranilate synthase component I (trpE) ,
deoxyribose-phosphate aldolase (deoC) ,
FadJ monomer ,
D-mannonate dehydratase (uxuA) ,
KbaY ,
GatY ,
FucA ,
uroporphyrinogen III synthase (hemD) ,
porphobilinogen synthase (hemB) ,
ornithine decarboxylase, biosynthetic (speC) ,
ornithine decarboxylase, degradative (speF) ,
SpeA ,
Adi (adiA) ,
adenosylmethionine decarboxylase, proenzyme (speD) ,
CadA ,
LdcC ,
S-ribosylhomocysteine lyase (luxS) ,
AspA ,
uroporphyrinogen decarboxylase (hemE) ,
ferrochelatase (hemH) ,
6-carboxy-5,6,7,8-tetrahydropterin synthase (queD) ,
CysG ,
ethanolamine ammonia-lyase, β subunit (eutC) ,
ethanolamine ammonia-lyase, α subunit (eutB) ,
2-methylcitrate dehydratase (prpD) ,
2-methylisocitrate lyase (prpB) ,
adenylosuccinate lyase (purB) ,
HMP-P synthase (thiC) ,
tyrosine lyase (thiH) ,
isocitrate lyase monomer (aceA) ,
aconitate hydratase 1 (acnA) ,
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB) ,
fumarase C monomer (fumC) ,
MhpD ,
4-hydroxy-2-ketovalerate aldolase (mhpE) ,
ureidoglycolate lyase (allA) ,
dTDP-glucose 4,6-dehydratase (rfbB) ,
dTDP-glucose 4,6-dehydratase 2 (rffG) ,
fructose bisphosphate aldolase monomer (fbaB) ,
GarL ,
galactarate dehydratase (garD) ,
3-dehydroquinate synthase (aroB) ,
AroC ,
AroD ,
FabZ ,
argininosuccinate lyase (argH) ,
pabC ,
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase monomer (ispF) ,
phosphoenolpyruvate carboxykinase (ATP) (pck) ,
fructose bisphosphate aldolase monomer (fbaA) ,
glutamate decarboxylase A subunit (gadA) ,
glutamate decarboxylase B subunit (gadB) ,
Ppc ,
tryptophanase (tnaA) ,
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY) ,
O-acetylserine sulfhydrylase A (cysK) ,
MetC ,
L-serine deaminase III (tdcG) ,
L-serine deaminase I (sdaA) ,
TdcB ,
L-serine deaminase II (sdaB) ,
D-serine ammonia-lyase (dsdA) ,
carbonic anhydrase monomer (cynT) ,
cyanase monomer (cynS) ,
3,4-dihydroxy-2-butanone 4-phosphate synthase (ribB) ,
glyoxalase I (gloA) ,
glyoxalase III, Hsp31 molecular chaperone (hchA) ,
crotonobetainyl-CoA hydratase (caiD) ,
D-glucarate dehydratase (gudD) ,
N-acetylneuraminate lyase (nanA) ,
dihydroneopterin aldolase (folB) ,
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ) ,
KpLE2 phage-like element; D-xylonate dehydratase (yjhG) ,
CP4-6 prophage; D-xylonate dehydratase (yagF) ,
membrane-bound lytic murein transglycosylase B (mltB) ,
membrane-bound lytic murein transglycosylase A (mltA) ,
soluble lytic murein transglycosylase (slt) ,
membrane-bound lytic murein transglycosylase C (mltC) ,
membrane-bound lytic murein transglycosylase D (mltD) ,
lytic murein transglycosylase E (emtA) ,
membrane-bound lytic murein transglycosylase F (mltF) ,
Eda ,
cysteine sulfinate desulfinase (csdA) ,
Fsa (fsaA) ,
fructose 6-phosphate aldolase 2 (fsaB) ,
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH) ,
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE) ,
methylglyoxal synthase (mgsA) ,
fumarase B monomer (fumB) ,
formamidopyrimidine DNA glycosylase (mutM) ,
2,3-diaminopropionate ammonia-lyase (ygeX) ,
D-cysteine desulfhydrase (dcyD) ,
citrate lyase, citryl-ACP lyase β subunit (citE) ,
citrate lyase, citrate-ACP transferase α subunit (citF) ,
adenylate cyclase (cyaA) ,
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB) ,
fumarase A monomer ,
L-cysteine desulfurase (sufS) ,
endonuclease III; specific for apurinic and/or apyrimidinic sites (nth) ,
tryptophan synthase, β subunit (trpB) ,
tryptophan synthase, α subunit (trpA) ,
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU) ,
deoxyribodipyrimidine photolyase (photoreactivation) (phr) ,
Eno ,
L-tartrate dehydratase, β subunit (ttdB) ,
L-tartrate dehydratase, α subunit (ttdA) ,
LtaE ,
L-rhamnonate dehydratase (yfaW) ,
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF) ,
oxalyl-CoA decarboxylase (oxc) ,
Cysteine sulfinic acid decarboxylase (CSAD) ,
ATP-citrate synthase (ACLY) ,
Histidine decarboxylase (HDC) ,
arginine decarboxylase (ADC) ,
argininosuccinate lyase (ASL) ,
Glutamate decarboxylase 1 (GAD1) ,
glutamate decarboxylase 2 monomer (GAD2) ,
Serine dehydratase-like (SDSL) ,
L-serine dehydratase (SDS) ,
adenylosuccinate lyase (ADSL) ,
Uroporphyrinogen decarboxylase (UROD) ,
uroporphyrinogen-III synthase (UROS) ,
porphobilinogen deaminase (HMBS) ,
Delta-aminolevulinic acid dehydratase (ALAD) ,
phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) ,
Fructose-bisphosphate aldolase B (ALDOB) ,
Fructose-bisphosphate aldolase A (ALDOA) ,
fructose-bisphosphate aldolase C monomer (ALDOC) ,
Beta-enolase (ENO3) ,
gamma enolase monomer (ENO2) ,
phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PCK1) ,
2-deoxy-5-keto-D-gluconate 6-phosphate aldolase (iolJ) ,
scyllo-inosose dehydratase (iolE) ,
Alpha-enolase (ENO1) ,
long chain 3-hydroxyacyl-CoA dehydrogenase (HADHA) ,
mitochondrial enoyl-CoA hydratase (ECHS1) ,
peroxisomal bifunctional enzyme (EHHADH) ,
2-hydroxyacyl-CoA lyase 1 (HACL1) ,
S-adenosylmethionine decarboxylase proenzyme (AMD1) ,
phosphomethylpyrimidine synthase monomer (thiC) ,
thiazole synthase (thiG) ,
7-carboxy-7-deazaguanine synthase (queE) ,
6-carboxy-5,6,7,8-tetrahydropterin synthase (queD) ,
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) ,
sphingosine phosphate lyase 1 (Sgpl1)

Unification Links: GO:0016829


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.