MetaCyc Gene-Ontology-Terms Class: GO:0030976 - thiamine pyrophosphate binding

Synonyms: aneurine pyrophosphate binding, cocarboxylase binding, diphosphothiamin binding, thiamin pyrophosphate binding, TPP binding

Definition: Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

Parent Classes:
GO:0019842 - vitamin binding,
GO:0043169 - cation binding,
GO:1901681 - sulfur compound binding,
GO:0050662 - coenzyme binding,
GO:0043168 - anion binding,
GO:1901363 - heterocyclic compound binding,
GO:0097159 - organic cyclic compound binding

Term Members:
1-deoxyxylulose-5-phosphate synthase (dxs),
glyoxylate carboligase (gcl),
transketolase I (tktA),
acetohydroxy acid synthase I, large subunit (ilvB),
oxalyl-CoA decarboxylase (oxc),
pyruvate:flavodoxin oxidoreductase (ydbK),
subunit of E1(0) component of 2-oxoglutarate dehydrogenase (sucA),
pyruvate oxidase monomer (poxB),
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD)

Unification Links: GO:0030976

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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