Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Protein Class: a [lipoyl-carrier protein]

Summary:
Lipoate is an organosulfur compound that is used as an essential cofactor by many enzyme complexes. The functional group of lipoate is a ditholane ring, which is a cyclic disulfide.

The enzyme complexes that require lipoate have a dedicated lipoyl domain, and lipoate is actually produced on this domain. The precursor octanoate molecule is first attached to a specific L-lysine residue within the lipoyl domain (producing a [lipoyl-carrier protein] N6-octanoyl-L-lysine), and is then converted to lipoate by the enzyme lipoate synthase, resulting in a [lipoyl-carrier protein] N6-lipoyl-L-lysine.

Lipoate synthase not only catalyzes the reaction, but is also the source of the two sulfur atoms.

All protein classes related to lipoyl-containing proteins can be collected here.

Child Classes: 2-oxoglutarate dehydrogenase lipoyl carrier (0) , branched chain α-keto acid dehydrogenase lipoyl carrier (0) , Lipoamide (0) , pyruvate dehydrogenase lipoyl carrier (0)

Unification Links: KEGG:C16240


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.