Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Protein Class: a [lipoyl-carrier protein]

Summary:
Lipoate is an organosulfur compound that is used as an essential cofactor by many enzyme complexes. The functional group of lipoate is a ditholane ring, which is a cyclic disulfide.

The enzyme complexes that require lipoate have a dedicated lipoyl domain, and lipoate is actually produced on this domain. The precursor octanoate molecule is first attached to a specific L-lysine residue within the lipoyl domain (producing a [lipoyl-carrier protein] N6-octanoyl-L-lysine), and is then converted to lipoate by the enzyme lipoate synthase, resulting in a [lipoyl-carrier protein] N6-lipoyl-L-lysine.

Lipoate synthase not only catalyzes the reaction, but is also the source of the two sulfur atoms.

All protein classes related to lipoyl-containing proteins can be collected here.

Child Classes: 2-oxoglutarate dehydrogenase lipoyl carrier (0) , branched chain α-keto acid dehydrogenase lipoyl carrier (0) , Lipoamide (0) , pyruvate dehydrogenase lipoyl carrier (0)

Unification Links: KEGG:C16240


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc12.