Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Protein Class: a pimeloyl-[acp] methyl ester

Synonyms: a pimelyl-[acp] methyl ester, a pimeloyl-[acyl-carrier protein] methyl ester

Superclasses: a modified protein an acyl-protein thioester an acyl-[acyl-carrier protein] a saturated acyl-[acp]
a modified protein an acyl-[acyl-carrier protein] a saturated acyl-[acp]

SMILES: COC(=O)CCCCCC(=O)[a holo-[acyl-carrier protein]]

Reactions known to consume the compound:

8-amino-7-oxononanoate biosynthesis I :
a pimeloyl-[acp] methyl ester + H2O → a pimeloyl-[acp] + methanol + H+

acyl-ACP thioesterase pathway :
an acyl-[acyl-carrier protein] + H2O → a fatty acid + a holo-[acyl-carrier protein] + H+

autoinducer AI-1 biosynthesis :
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine → a holo-[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone + H+

CDP-diacylglycerol biosynthesis II :
a 1-acyl-sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein] → a 1,2-diacyl-sn-glycerol 3-phosphate + a holo-[acyl-carrier protein]
an acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate → a 1-acyl-sn-glycerol 3-phosphate + a holo-[acyl-carrier protein]

CDP-diacylglycerol biosynthesis III :
a 1-acyl-sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein] → a 1,2-diacyl-sn-glycerol 3-phosphate + a holo-[acyl-carrier protein]
an acyl-[acyl-carrier protein] + phosphate → an acyl phosphate + a holo-[acyl-carrier protein]

ornithine lipid biosynthesis :
a lyso-ornithine lipid + an acyl-[acyl-carrier protein] → an ornithine lipid + a holo-[acyl-carrier protein]

Reactions known to produce the compound:

8-amino-7-oxononanoate biosynthesis I :
a pimeloyl-[acp] methyl ester + NAD+ ← an enoylpimeloyl-[acp] methyl ester + NADH + H+

Not in pathways:
an acyl-[acyl-carrier protein] + NAD+ ← a trans-2-enoyl-[acyl-carrier protein] + NADH + H+


an acyl-protein synthetase + a carboxylate + ATP → an acyl-protein thioester + AMP + diphosphate

Reactions known to both consume and produce the compound:

Not in pathways:
an acyl-[acyl-carrier protein] + a 1-lyso-2-acyl-sn-glycero-3-phosphoethanolamine ↔ a holo-[acyl-carrier protein] + an L-1-phosphatidyl-ethanolamine

In Reactions of unknown directionality:

Not in pathways:
an sn-3-D-galactosyl-sn-2-acylglycerol + an acyl-[acyl-carrier protein] = a holo-[acyl-carrier protein] + a 1,2-diacyl-3-β-D-galactosyl-sn-glycerol
an acyl-[acyl-carrier protein] + a malonyl-[acp] + H+ = a 3-oxoacyl-[acp] + CO2 + a holo-[acyl-carrier protein]

Enzymes inhibited by a pimeloyl-[acp] methyl ester, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: β-ketoacyl-ACP synthase [Comment 1]

Inhibitor (Mechanism unknown) of: acetyl-CoA carboxyltransferase [Davis01] , 2,3,4-saturated fatty acyl-[acp]:NAD+ oxidoreductase [Heath95, Comment 2]

Inhibitor (Other types) of: β-ketoacyl-ACP synthase [Heath96a, Comment 3]


References

Davis01: Davis MS, Cronan, Jr. JE (2001). "Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein." J Bacteriol. 183(4):1499-503. PMID: 11157970

Heath95: Heath RJ, Rock CO (1995). "Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli." J Biol Chem 270(44);26538-42. PMID: 7592873

Heath96a: Heath RJ, Rock CO (1996). "Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli." J Biol Chem 1996;271(18);10996-1000. PMID: 8631920

Heath96b: Heath RJ, Rock CO (1996). "Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli." J Biol Chem 1996;271(4);1833-6. PMID: 8567624


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC13B.