MetaCyc Compound Class: a poly-β-hydroxybutyrate

Synonyms: poly-3-hydroxybutyrate, PHB, polyhydroxybutyrate, 2-methyl-3-ketobutyrate, poly-hydroxybutyrate

Superclasses: a secondary metabolite
an ester a poly[(R)-3-hydroxyalkanoate]

During enzymatic polymerization the ester bond in this polymer is derived from the hydroxyl group of the (R)-3-hydroxybutanoyl moiety of (R)-3-hydroxybutanoyl-CoA [Jia01].

a poly-β-hydroxybutyrate compound structure


Unification Links: KEGG:C06143 , Wikipedia:Polyhydroxybutyrate

Reactions known to consume the compound:

polyhydroxybutyrate biosynthesis :
(R)-3-hydroxybutanoyl-CoA + [(R)-3-hydroxybutanoate]n[(R)-3-hydroxybutanoate](n+1) + coenzyme A

Not in pathways:
[(R)-3-hydroxybutanoate]n + H2O → [(R)-3-hydroxybutanoate](n-1) + (R)-3-hydroxybutanoate

This compound has been characterized as an alternative substrate of the following enzymes: acetoacetate decarboxylase

Revised 16-Apr-2014 by Fulcher CA , SRI International


Jia01: Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J (2001). "Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism." Biochemistry 40(4);1011-9. PMID: 11170423

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed May 27, 2015, BIOCYC13B.