This class contains forms of the TCA cycle, a component of central metabolism, that operate under various conditions, including aerobic and anaerobic growth. It also contains the linker reactions between glycolysis and the TCA cycle that convert pyruvate to acetyl-CoA. Reactions of the TCA cycle yield three precursor metabolites, alpha-oxoglutarate, succinyl-CoA, and oxaloacetate. The variations of the cycle function to synthesize these precursor metabolites under diverse conditions, for example anaerobiosis, when the complete cycle cannot function.
Generation of Precursor Metabolites and Energy
Note: This class is a variant class, i.e. its purpose is to group together a set of variant pathways. Variant pathways are those that accomplish roughly the same biological function, such as degradation of a given starting material, or biosynthesis of an end product. The variant pathways may or may not share any common reactions.
superpathway of glyoxylate bypass and TCA ,
TCA cycle I (prokaryotic) ,
TCA cycle II (plants and fungi) ,
TCA cycle III (animals) ,
TCA cycle IV (2-oxoglutarate decarboxylase) ,
TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) ,
TCA cycle VI (obligate autotrophs) ,
TCA cycle VII (acetate-producers) ,
TCA cycle VIII (helicobacter)
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