Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Protein Class: an apo-[acp]

Synonyms: an apo-[acyl-carrier protein]

Superclasses: all acyl-carrier proteins

Summary:
This class includes all the acyl-carrier proteins, which consist of the acyl-carrier proteins (ACPs) of fatty acid synthases, ACPs of polyketide synthases (PKSs), and peptidyl carrier proteins (PCPs) and aryl carrier proteins of non-ribosomal peptide synthetases (NRPSs).

Acyl carrier proteins exist as either a distinct domain within a large multifunctional protein, or as discrete soluble single-domain proteins.

ACP proteins are synthesized in their "apo" inactive form, and are activated by attachment of a 4'-phosphopantetheine moiety, removed from coenzyme A, to a serine residue, in a reaction catalyzed by 4'-phosphopantetheinyl transferase [Byers07].

Child Classes: an apo aryl-carrier protein (1) , an apo- fatty acid synthase [acyl carrier protein] (1)

Instances:
apo-[acyl carrier protein] (Escherichia coli K-12 substr. MG1655)

Alternative forms of an apo-[acp]:
a holo-[acyl-carrier protein] (summary available)
a 2,3,4-saturated fatty acyl-[acp]
an acyl-[acyl-carrier protein] (summary available)
a (R)-3-hydroxybutanoyl-[acp]
an (R)-3-hydroxydecanoyl-[acp]
a (R)-3-hydroxydodecanoyl-[acp]
an (R)-3-hydroxyhexanoyl-[acp]
an (3R)-3-hydroxymyristoyl-[acp]
a (R)-3-hydroxyoctanoyl-[acp]
an acetoacetyl-[acp]
an (R)-3-hydroxypalmitoyl-[acp]
an arachidoyl-[acp]
an octanoyl-[acp]
an oleoyl-[acp]
a cis-enoyl-acyl-[acp]
a malonyl-[acp]
an acetyl-[acp]

Reactions known to consume the compound:

acyl carrier protein metabolism I , acyl carrier protein metabolism II (mammalian) :
an apo-[acp] + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein]

Reactions known to produce the compound:

acyl carrier protein metabolism I :
a holo-[acyl-carrier protein] + H2O → 4'-phosphopantetheine + an apo-[acp]

Enzymes inhibited by an apo-[acp], sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase [Rock81, Comment 1]

Inhibitor (Other types) of: acetyl-CoA carboxylase [Davis01]

Gene-Reaction Schematic: ?

Credits:
Revised 12-Sep-2008 by Caspi R , SRI International


References

Byers07: Byers DM, Gong H (2007). "Acyl carrier protein: structure-function relationships in a conserved multifunctional protein family." Biochem Cell Biol 85(6);649-62. PMID: 18059524

Davis01: Davis MS, Cronan, Jr. JE (2001). "Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein." J Bacteriol. 183(4):1499-503. PMID: 11157970

Rock81: Rock CO, Goelz SE, Cronan JE (1981). "Phospholipid synthesis in Escherichia coli. Characteristics of fatty acid transfer from acyl-acyl carrier protein to sn-glycerol 3-phosphate." J Biol Chem 1981;256(2);736-42. PMID: 7005223


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, biocyc13.