Abbrev Name: an acyl-carrier protein
Synonyms: an apo-[acp]
|Superclasses:||a polypeptide → all acyl-carrier proteins|
|a protein → all acyl-carrier proteins|
This class includes all the acyl-carrier proteins, which consist of the acyl-carrier proteins (ACPs) of fatty acid synthases, ACPs of polyketide synthases (PKSs), and peptidyl carrier proteins (PCPs) and aryl carrier proteins of non-ribosomal peptide synthetases (NRPSs).
Acyl carrier proteins exist as either a distinct domain within a large multifunctional protein, or as discrete soluble single-domain proteins.
ACP proteins are synthesized in their "apo" inactive form, and are activated by attachment of a 4'-phosphopantetheine moiety, removed from coenzyme A, to a serine residue, in a reaction catalyzed by 4'-phosphopantetheinyl transferase [Byers07].
Child Classes: an apo aryl-carrier protein (2) , an apo [CmaA peptidyl-carrier-protein] (0) , an apo [CmaD peptidyl-carrier-protein] (0) , an apo [PigJ acyl-carrier protein] (0) , an apo- fatty acid synthase [acyl carrier protein] (1)
apo-[acyl carrier protein] (Escherichia coli K-12 substr. MG1655)
Alternative forms of an apo-[acyl-carrier protein]:
a holo-[acyl-carrier protein] (extended summary available)
a 2,3,4-saturated fatty acyl-[acp]
an acyl-[acyl-carrier protein] (summary available)
an oleoyl-[acp] (summary available)
SMILES: C(O)C(N[an apo-[acyl-carrier protein]])C(=O)[an apo-[acyl-carrier protein]]
Reactions known to consume the compound:
Reactions known to produce the compound:
Enzymes inhibited by an apo-[acyl-carrier protein], sorted by the type of inhibition, are:
Inhibitor (Mechanism unknown) of: acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase [Rock81, Comment 1]
Instance reactions of [an acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein] + H+] (18.104.22.168):
i1: [EntB aryl-carrier protein] + coenzyme A → a holo EntB isochorismatase/aryl-carrier protein + adenosine 3',5'-bisphosphate + H+ (22.214.171.124)
i2: AsbD acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-AsbD acyl-carrier protein + H+ (no EC#)
Rock81: Rock CO, Goelz SE, Cronan JE (1981). "Phospholipid synthesis in Escherichia coli. Characteristics of fatty acid transfer from acyl-acyl carrier protein to sn-glycerol 3-phosphate." J Biol Chem 1981;256(2);736-42. PMID: 7005223
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