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MetaCyc Protein Class: an apo-[acyl-carrier protein]

Abbrev Name: an acyl-carrier protein

Synonyms: an apo-[acp]

Superclasses: a polypeptide all acyl-carrier proteins
a protein all acyl-carrier proteins

Summary:
This class includes all the acyl-carrier proteins, which consist of the acyl-carrier proteins (ACPs) of fatty acid synthases, ACPs of polyketide synthases (PKSs), and peptidyl carrier proteins (PCPs) and aryl carrier proteins of non-ribosomal peptide synthetases (NRPSs).

Acyl carrier proteins exist as either a distinct domain within a large multifunctional protein, or as discrete soluble single-domain proteins.

ACP proteins are synthesized in their "apo" inactive form, and are activated by attachment of a 4'-phosphopantetheine moiety, removed from coenzyme A, to a serine residue, in a reaction catalyzed by 4'-phosphopantetheinyl transferase [Byers07].

an apo-[acyl-carrier protein] compound structure

Child Classes: 3O,4-dimethyl,5-hydroxy L-tyrosinyl-[SfmC peptidyl-carrier-protein] (0) , a glycyl-[SfmB peptidyl-carrier-protein] (0) , a holo-[SfmA peptidyl-carrier-protein] (0) , a holo-[SfmB peptidyl-carrier-protein] (0) , a holo-[SfmC peptidyl-carrier-protein] (0) , an acyl-L-alanyl-glycyl-[SfmB peptidyl-carrier-protein] (0) , an acyl-[SfmA peptidyl-carrier-protein] (0) , an apo-[aryl-carrier protein] (2) , an apo-[CmaA peptidyl-carrier-protein] (0) , an apo-[CmaD peptidyl-carrier-protein] (0) , an apo-[fatty acid synthase acyl-carrier protein] (1) , an apo-[LYS2 peptidyl-carrier-protein] (0) , an apo-[PigJ acyl-carrier protein] (0) , an apo-[SfmA peptidyl-carrier-protein] (0) , an apo-[SfmB peptidyl-carrier-protein] (0) , an apo-[SfmC peptidyl-carrier-protein] (0) , L-2-aminoadipyl-S-[LYS2 peptidyl-carrier-protein] (0) , L-alanyl-[SfmA peptidyl-carrier-protein] (0)

Instances:
apo-[acyl carrier protein] (Escherichia coli K-12 substr. MG1655)

Alternative forms of an apo-[acyl-carrier protein]:
a holo-[acyl-carrier protein] (extended summary available)
a 2,3,4-saturated fatty acyl-[acp]
an acyl-[acyl-carrier protein] (summary available)
a (3R)-3-hydroxybutanoyl-[acp]
a (3R)-3-hydroxydodecanoyl-[acp]
a (3R)-3-hydroxyhexanoyl-[acp]
a (3R)-3-hydroxymyristoyl-[acp]
a (3R)-3-hydroxyoctanoyl-[acp]
an acetoacetyl-[acp]
a (3R)-3-hydroxypalmitoyl-[acp]
an arachidoyl-[acp]
an octanoyl-[acp]
a malonyl-[acp]
an acetyl-[acp]

SMILES: C(O)C(N[an apo-[acyl-carrier protein]])C(=O)[an apo-[acyl-carrier protein]]

Reactions known to consume the compound:

acyl carrier protein metabolism I , acyl carrier protein metabolism II (mammalian) :
an acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein] + H+

Reactions known to produce the compound:

acyl carrier protein metabolism I :
a holo-[acyl-carrier protein] + H2O → 4'-phosphopantetheine + an acyl-carrier protein + H+

Enzymes inhibited by an apo-[acyl-carrier protein], sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase [Rock81, Comment 1]

Inhibitor (Other types) of: acetyl-CoA carboxylase [Davis01]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [an acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[acyl-carrier protein] + H+] (2.7.8.7):
i1: [EntB aryl-carrier protein] + coenzyme A → a holo-[EntB isochorismatase/aryl-carrier protein] + adenosine 3',5'-bisphosphate + H+ (2.7.8.7)

i2: AsbD acyl-carrier protein + coenzyme A → adenosine 3',5'-bisphosphate + a holo-[AsbD acyl-carrier protein] + H+ (no EC#)

Credits:
Revised 12-Sep-2008 by Caspi R , SRI International


References

Byers07: Byers DM, Gong H (2007). "Acyl carrier protein: structure-function relationships in a conserved multifunctional protein family." Biochem Cell Biol 85(6);649-62. PMID: 18059524

Davis01: Davis MS, Cronan, Jr. JE (2001). "Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein." J Bacteriol. 183(4):1499-503. PMID: 11157970

Rock81: Rock CO, Goelz SE, Cronan JE (1981). "Phospholipid synthesis in Escherichia coli. Characteristics of fatty acid transfer from acyl-acyl carrier protein to sn-glycerol 3-phosphate." J Biol Chem 1981;256(2);736-42. PMID: 7005223


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Jul 30, 2015, biocyc14.