Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
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MetaCyc Compound: acetyl phosphate

Synonyms: acetyl-P

Chemical Formula: C2H3O5P

Molecular Weight: 138.02 Daltons

Monoisotopic Molecular Weight: 139.987459781 Daltons

SMILES: CC(OP([O-])(=O)[O-])=O

InChI: InChI=1S/C2H5O5P/c1-2(3)7-8(4,5)6/h1H3,(H2,4,5,6)/p-2

InChIKey: InChIKey=LIPOUNRJVLNBCD-UHFFFAOYSA-L

Unification Links: CAS:19926-71-7 , ChEBI:22191 , ChemSpider:3394205 , HMDB:HMDB01494 , IAF1260:34318 , KEGG:C00227 , PubChem:4183249 , UMBBD-Compounds:c0049

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -273.5149 Inferred by computational analysis [Latendresse13]

Reactions known to produce the compound:

Bifidobacterium shunt :
β-D-fructofuranose 6-phosphate + phosphate → D-erythrose 4-phosphate + acetyl phosphate + H2O
D-xylulose 5-phosphate + phosphate → D-glyceraldehyde 3-phosphate + acetyl phosphate + H2O

heterolactic fermentation :
D-xylulose 5-phosphate + phosphate → D-glyceraldehyde 3-phosphate + acetyl phosphate + H2O

purine nucleobases degradation I (anaerobic) :
acetyl phosphate + ammonium + an oxidized thioredoxin + H2O ← glycine + a reduced thioredoxin + phosphate + H+

sulfoacetaldehyde degradation I , sulfolactate degradation II :
acetyl phosphate + sulfite + H+ ← sulfoacetaldehyde + phosphate

Not in pathways:
pyruvate + phosphate + H+ + oxygen → acetyl phosphate + CO2 + hydrogen peroxide

Reactions known to both consume and produce the compound:

acetate formation from acetyl-CoA I :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

acetylene degradation :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

Bifidobacterium shunt , purine nucleobases degradation I (anaerobic) :
ATP + acetate ↔ ADP + acetyl phosphate

gallate degradation III (anaerobic) :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

heterolactic fermentation , sulfoacetaldehyde degradation I , sulfolactate degradation II :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A

lysine fermentation to acetate and butyrate :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

methanogenesis from acetate :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

mixed acid fermentation :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

purine nucleobases degradation II (anaerobic) :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

pyruvate fermentation to acetate II :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

pyruvate fermentation to acetate IV :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

superpathway of fermentation (Chlamydomonas reinhardtii) :
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A
ATP + acetate ↔ ADP + acetyl phosphate

In Reactions of unknown directionality:

Not in pathways:
acetate + diphosphate = acetyl phosphate + phosphate
sarcosine + phosphate + 3 H+ = methylamine + acetyl phosphate + H2O
L-lysine + acetyl phosphate = N6-acetyl-L-lysine + phosphate + H+
acetyl phosphate + trimethylamine + an oxidized thioredoxin + H2O = glycine betaine + a reduced thioredoxin + phosphate + H+
acetyl phosphate + methylamine + an oxidized thioredoxin + H2O = sarcosine + a reduced thioredoxin + phosphate + H+
L-ascorbate + acetyl phosphate = 2-phospho-L-ascorbate + acetate + H+

Enzymes activated by acetyl phosphate, sorted by the type of activation, are:

Activator (Mechanism unknown) of: malate dehydrogenase [Bologna07]

Enzymes inhibited by acetyl phosphate, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: thiamine phosphate synthase [Kayama73, Kawasaki79, Comment 1]


References

Bologna07: Bologna FP, Andreo CS, Drincovich MF (2007). "Escherichia coli malic enzymes: two isoforms with substantial differences in kinetic properties, metabolic regulation, and structure." J Bacteriol 189(16);5937-46. PMID: 17557829

Kawasaki79: Kawasaki T (1979). "Thiamine phosphate pyrophosphorylase." Methods Enzymol 1979;62;69-73. PMID: 374983

Kayama73: Kayama Y, Kawasaki T (1973). "Purification and properties of thiaminephosphate pyrophosphorylase of Escherichia coli." Arch Biochem Biophys 1973;158(1);242-8. PMID: 4580841

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 26, 2014, BIOCYC13A.