Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Compound: Ag+

Synonyms: silver

Superclasses: an ion a cation

Component of: silver nitrate

Chemical Formula: Ag

Molecular Weight: 107.87 Daltons

Monoisotopic Molecular Weight: 107.9129180321 Daltons

SMILES: [Ag+]

InChI: InChI=1S/Ag/q+1

InChIKey: InChIKey=FOIXSVOLVBLSDH-UHFFFAOYSA-N

Unification Links: CAS:14701-21-4 , ChEBI:49468 , ChemSpider:94565 , HMDB:HMDB02659 , IAF1260:48910 , PubChem:104755

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -0.3120594 Inferred by computational analysis [Latendresse13]

In Transport reactions:
Ag+[cytosol] + ATP + H2O ↔ Ag+[extracellular space] + ADP + phosphate + H+ ,
Ag+[cytosol] + H+[periplasmic space]Ag+[extracellular space] + H+[cytosol]

Enzymes inhibited by Ag+, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: NADPH-dependent curcumin reductase [Hassaninasab11] , glutaminase [Hartman68] , fumarase A [Xu12] , cellobiose 2-epimerase [Taguchi08] , luteolin glucuronide β-glucuronidase [Schulz87] , luteolin triglucuronide β-glucuronidase [Schulz87] , synephrine dehydratase [Manne86] , superoxide dismutase [Takenaka11] , 1,2,4-trihydroxybenzene 1,2-dioxygenase [Takenaka03] , 2-hydroxybiphenyl-3-monooxygenase [Suske97] , pesudooxynicotine oxidase [Qiu12] , nicotine dehydrogenase [Tang09a] , pseudoroxynicotine dehydrogenase [Tang09a] , N-cyclohexylformamide hydratase [Goda01] , N-benzylformamide deformylase [Fukatsu04] , 7-methylxanthine demethylase [Gluck88] , cholate 12α-hydroxy dehydrogenase [Braun91] , 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [Condemine84] , β-alanine amide amidase [Komeda04] , L-proline amide hydrolase [Komeda04a] , hydroxyproline 2-epimerase [Adams64] , Δ1-pyrroline-4-hydroxy-2-carboxylate deaminase [Singh65] , glycerol dehydratase [Schneider70] , NAD-dependent formate dehydrogenase [Asano88] , 1-sucrose:sucrose fructosyltransferase [Koops96] , rubredoxin NAD+ reductase [Petitdemange79] , streptomycin 6-kinase [Sugiyama83] , 4-oxalocrotonate decarboxylase [Takenaka00] , 2-aminomuconic 6-semialdehyde dehydrogenase [Takenaka00] , 2-aminophenol 1,6-dioxygenase [Takenaka97] , N-acetylneuraminate synthase [Komaki97] , porphobilinogen deaminase [Jones94] , L-carnitine dehydrogenase [Mori88] , (S)-tetrahydroprotoberberine oxidase [Amann88] , kynurenine formamidase [Brown86] , choline dehydrogenase [Nagasawa76] , kynurenine formamidase [Brown86] , sarcosine oxidase [Nishiya93] , N-carbamoylsarcosine amidohydrolase [Kim86] , arginine deiminase [Monstadt91] , D-carnitine dehydrogenase [Setyahadi97] , nicotinate dehydrogenase [Hurh94] , putrescine N-methyltransferase [Mizusaki71] , α-D-galactosyl-(1-3)-1D-myo-inositol:raffinose galactosyltransferase [Gaudreault81]

Inhibitor (Other types) of: xylan 1,3-β-xylosidase [Umemoto08] , trans-permethrin hydrolase [Wu06a] , chitin disaccharide deacetylase [Ohishi97] , 3-hydroxyisobutyrate dehydrogenase [Chowdhury96] , nitrilase [Nagasawa90] , L-allo-threonine aldolase [Kataoka97] , raffinose synthase [Lehle73]


References

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Amann88: Amann M, Nagakura N, Zenk MH "Purification and properties of (S)-tetrahydroprotoberberine oxidase from suspension-cultured cells of Berberis wilsoniae." Eur. J. Biochem., 1988, 175:17-25.

Asano88: Asano Y, Sekigawa T, Inukai H, Nakazawa A (1988). "Purification and properties of formate dehydrogenase from Moraxella sp. strain C-1." J Bacteriol 170(7);3189-93. PMID: 3384805

Braun91: Braun M, Lunsdorf H, Buckmann AF (1991). "12 alpha-hydroxysteroid dehydrogenase from Clostridium group P, strain C 48-50. Production, purification and characterization." Eur J Biochem 196(2);439-50. PMID: 2007406

Brown86: Brown D, Hitchcock MJ, Katz E (1986). "Purification and characterization of kynurenine formamidase activities from Streptomyces parvulus." Can J Microbiol 32(6);465-72. PMID: 2425918

Chowdhury96: Chowdhury EK, Nagata S, Misono H (1996). "3-Hydroxyisobutyrate dehydrogenase from Pseudomonas putida E23: purification and characterization." Biosci Biotechnol Biochem 60(12);2043-7. PMID: 8988636

Condemine84: Condemine G, Hugouvieux-Cotte-Pattat N, Robert-Baudouy J (1984). "An enzyme in the pectinolytic pathway of Erwinia chrysanthemi: 2-keto-3-deoxygluconate oxidoreductase." Journal of General Microbiology 130, 2839-2844.

Fukatsu04: Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M (2004). "Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning." Proc Natl Acad Sci U S A 101(38);13726-31. PMID: 15358859

Gaudreault81: Gaudreault, P.R., Webb, J.A. (1981). "Stachyose synthesis in leaves of Cucurbita pepo." Phytochemistry 20:2629-2633.

Gluck88: Gluck M, Lingens F (1988). "Heteroxanthinedemethylase, a new enzyme in the degradation of caffeine by Pseudomonas putida." Appl. Microbiol. Biotechnol. 28:59-62.

Goda01: Goda M, Hashimoto Y, Shimizu S, Kobayashi M (2001). "Discovery of a novel enzyme, isonitrile hydratase, involved in nitrogen-carbon triple bond cleavage." J Biol Chem 276(26);23480-5. PMID: 11306561

Hartman68: Hartman SC (1968). "Glutaminase of Escherichia coli. I. Purification and general catalytic properties." J Biol Chem 1968;243(5);853-63. PMID: 4966660

Hassaninasab11: Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M (2011). "Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism." Proc Natl Acad Sci U S A 108(16);6615-20. PMID: 21467222

Hurh94: Hurh B, Yamane T, Nagasawa T (1994). "Purification and characterization of nicotinic acid dehydrogenase from Pseudomonas fluorescens TN5." J. Ferment. Bioeng. 78, No. 1, 19-26.

Jones94: Jones RM, Jordan PM (1994). "Purification and properties of porphobilinogen deaminase from Arabidopsis thaliana." Biochem J 299 ( Pt 3);895-902. PMID: 8192681

Kataoka97: Kataoka M, Wada M, Nishi K, Yamada H, Shimizu S (1997). "Purification and characterization of L-allo-threonine aldolase from Aeromonas jandaei DK-39." FEMS Microbiol Lett 151(2);245-8. PMID: 9228760

Kim86: Kim JM, Shimizu S, Yamada H (1986). "Purification and characterization of a novel enzyme, N-carbamoylsarcosine amidohydrolase, from Pseudomonas putida 77." J Biol Chem 261(25);11832-9. PMID: 3745168

Komaki97: Komaki E, Ohta Y, Tsukada Y (1997). "Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12." Biosci Biotechnol Biochem 61(12);2046-50. PMID: 9438985

Komeda04: Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y (2004). "A novel R-stereoselective amidase from Pseudomonas sp. MCI3434 acting on piperazine-2-tert-butylcarboxamide." Eur J Biochem 271(8);1580-90. PMID: 15066183

Komeda04a: Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y (2004). "S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase." Eur J Biochem 271(8);1465-75. PMID: 15066172

Koops96: Koops AJ, Jonker HH (1996). "Purification and Characterization of the Enzymes of Fructan Biosynthesis in Tubers of Helianthus tuberosus Colombia (II. Purification of Sucrose:Sucrose 1-Fructosyltransferase and Reconstitution of Fructan Synthesis in Vitro with Purified Sucrose:Sucrose 1-Fructosyltransferase and Fructan:Fructan 1-Fructosyltransferase)." Plant Physiol 1996;110(4);1167-1175. PMID: 12226250

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lehle73: Lehle L, Tanner W (1973). "The function of myo-inositol in the biosynthesis of raffinose. Purification and characterization of galactinol:sucrose 6-galactosyltransferase from Vicia faba seeds." Eur J Biochem 38(1);103-10. PMID: 4774118

Manne86: Manne V, Kutty KR, Pillarisetti SR (1986). "Purification and properties of synephrinase from Arthrobacter synephrinum." Arch Biochem Biophys 248(1);324-34. PMID: 3729420

Mizusaki71: Mizusaki, Shigenobu, Tanabe, Yoko, Noguchi, Masao, Tamaki, Einosuke (1971). "Phytochemical studies on tobacco alkaloids XIV. The occurrence and properties of putrescine N-methyltransferase in tobacco roots." Plant and Cell Physiology, 12:633-640.

Monstadt91: Monstadt GM, Holldorf AW (1991). "Arginine deiminase from Halobacterium salinarium. Purification and properties." Biochem J 1991;273 ( Pt 3);739-45. PMID: 1847623

Mori88: Mori, N., Kasugai, T., Kitamato, Y., Ichikawa, Y. (1988). "Purification and some properties of carnitine dehydrogenase from Xanthomonas translucens." Agric. Biol. Chem. 52, 249-250.

Nagasawa76: Nagasawa, T., Mori, N., Tani, Y., Ogata, K. (1976). "Characterization of choline dehydrogenase from Pseudomonas aeruginosa A-16." Agr. Biol. Chem. 40(10):2077-2084.

Nagasawa90: Nagasawa T, Mauger J, Yamada H (1990). "A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3. Purification and characterization." Eur J Biochem 194(3);765-72. PMID: 2269298

Nishiya93: Nishiya, Y., Imanaka, T. (1993). "Cloning and sequencing of the sarcosine oxidase gene from Arthrobacter sp. TE1826." J. Ferment. bioeng. 75 (4):239-244.

Ohishi97: Ohishi, K., Yamagishi, M., Ohta, T., Motosugi, M., Izumida,H., Sano, H., Adachi, K., Miwa, T. (1997). "Purification and properties of two deacetylases produced by Vibrio alginolyticus H-8." Bioscience, biotechnology, and biochemistry 61(7):1113-1117.

Petitdemange79: Petitdemange H, Marczak R, Blusson H, Gay R (1979). "Isolation and properties of reduced nicotinamide adenine dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum." Biochem Biophys Res Commun 1979;91(4);1258-65. PMID: 526302

Qiu12: Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W (2012). "Functional Identification of Two Novel Genes from Pseudomonas sp. Strain HZN6 Involved in the Catabolism of Nicotine." Appl Environ Microbiol. PMID: 22267672

Schneider70: Schneider Z, Larsen EG, Jacobson G, Johnson BC, Pawelkiewicz J (1970). "Purification and properties of glycerol dehydrase." J Biol Chem 245(13);3388-96. PMID: 4989992

Schulz87: Schulz M, Weissenbock G (1987). "Partial purification and characterization of a luteolin-triglucuronide-specific β-glucuronidase from rye primary leaves (Secale cereale)." Phytochemistry 26(4):933-937.

Setyahadi97: Setyahadi S, Ueyama T, Arimoto T, Mori N, Kitamoto Y (1997). "Purification and properties of a new enzyme, D-carnitine dehydrogenase, from Agrobacterium sp. 525a." Biosci Biotechnol Biochem 61(6);1055-8. PMID: 9214773

Singh65: Singh RM, Adams E (1965). "Enzymatic deamination of delta-1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde)." J Biol Chem 240(11);4344-51. PMID: 5845838

Sugiyama83: Sugiyama M, Sakamoto M, Mochizuki H, Nimi O, Nomi R (1983). "Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin-producing micro-organism." J Gen Microbiol 129(6);1683-7. PMID: 6313852

Suske97: Suske WA, Held M, Schmid A, Fleischmann T, Wubbolts MG, Kohler HP (1997). "Purification and characterization of 2-hydroxybiphenyl 3-monooxygenase, a novel NADH-dependent, FAD-containing aromatic hydroxylase from Pseudomonas azelaica HBP1." J Biol Chem 272(39);24257-65. PMID: 9305879

Taguchi08: Taguchi H, Hamada S, Kawauchi S, Ito H, Senoura T, Watanabe J, Nishimukai M, Ito S, Matsui H (2008). "Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme." Appl Microbiol Biotechnol 79(3);433-41. PMID: 18392616

Takenaka00: Takenaka S, Murakami S, Kim YJ, Aoki K (2000). "Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3." Arch Microbiol 174(4);265-72. PMID: 11081795

Takenaka03: Takenaka S, Okugawa S, Kadowaki M, Murakami S, Aoki K (2003). "The metabolic pathway of 4-aminophenol in Burkholderia sp. strain AK-5 differs from that of aniline and aniline with C-4 substituents." Appl Environ Microbiol 69(9);5410-3. PMID: 12957929

Takenaka11: Takenaka S, Koshiya J, Okugawa S, Takata A, Murakami S, Aoki K (2011). "Fe-superoxide dismutase and 2-hydroxy-1,4-benzoquinone reductase preclude the auto-oxidation step in 4-aminophenol metabolism by Burkholderia sp. strain AK-5." Biodegradation 22(1);1-11. PMID: 20480210

Takenaka97: Takenaka S, Murakami S, Shinke R, Hatakeyama K, Yukawa H, Aoki K (1997). "Novel genes encoding 2-aminophenol 1,6-dioxygenase from Pseudomonas species AP-3 growing on 2-aminophenol and catalytic properties of the purified enzyme." J Biol Chem 272(23);14727-32. PMID: 9169437

Tang09a: Tang H, Wang L, Meng X, Ma L, Wang S, He X, Wu G, Xu P (2009). "Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation by Pseudomonas putida strain S16." Appl Environ Microbiol 75(3);772-8. PMID: 19060159

Umemoto08: Umemoto Y, Onishi R, Araki T (2008). "Cloning of a novel gene encoding beta-1,3-xylosidase from a marine bacterium, Vibrio sp. strain XY-214, and characterization of the gene product." Appl Environ Microbiol 74(1);305-8. PMID: 17993567

Wu06a: Wu PC, Liu YH, Wang ZY, Zhang XY, Li H, Liang WQ, Luo N, Hu JM, Lu JQ, Luan TG, Cao LX (2006). "Molecular cloning, purification, and biochemical characterization of a novel pyrethroid-hydrolyzing esterase from Klebsiella sp. strain ZD112." J Agric Food Chem 54(3);836-42. PMID: 16448191

Xu12: Xu FF, Imlay JA (2012). "Silver(I), mercury(II), cadmium(II), and zinc(II) target exposed enzymic iron-sulfur clusters when they toxify Escherichia coli." Appl Environ Microbiol 78(10);3614-21. PMID: 22344668


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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