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MetaCyc Compound: ammonia

Synonyms: NH3

Chemical Formula: H3N

Molecular Weight: 17.03 Daltons

Monoisotopic Molecular Weight: 17.0265491015 Daltons

ammonia compound structure

SMILES: [NH3]

InChI: InChI=1S/H3N/h1H3

InChIKey: InChIKey=QGZKDVFQNNGYKY-UHFFFAOYSA-N

Unification Links: CAS:7664-41-7 , ChEBI:16134 , ChemSpider:217 , HMDB:HMDB00051 , KEGG:C00014 , KNApSAcK:C00007267 , MetaboLights:MTBLC16134 , PubChem:222

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 11.853362 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

ammonia oxidation I (aerobic) , ammonia oxidation III , ammonia oxidation IV (autotrophic ammonia oxidizers) :
ammonia[in] + an reduced unknown electron acceptor[in] + oxygen[in] → hydroxylamine[in] + an oxidized unknown electron acceptor[in] + H2O[in]

Reactions known to produce the compound:

gliotoxin biosynthesis :
3-benzyl-3,6 -bis(cysteinyl)- 6-(hydroxymethyl)-diketopiperazine + 2 H2O → 3-benzyl-3,6 -dithio-6-(hydroxymethyl)-diketopiperazine + 2 ammonia + 2 pyruvate + 2 H+

tryptoquialanine biosynthesis :
15,15-dimethyl-2-epi-fumiquinazoline A + NADPH + H+ + oxygen → (2R)-3-[(9S, 9aR)-9-hydroxy-2,2-dimethyl-3-oxo-1H, 2H, 3H, 9H, 9aH-imidazolidino[1,2-a] indol-9-yl]-2-(2-acetyl-4-oxo-3,4-dihydroquinazolin-3-yl) propanoate + ammonia + NADP+

Not in pathways:
ammonia + 6 an oxidized cytochrome c552 + 2 H2O ← nitrite + 6 a reduced cytochrome c552 + 7 H+

Reactions known to both consume and produce the compound:

Not in pathways:
ammonia + H+ ↔ ammonium

In Reactions of unknown directionality:

Not in pathways:
5'-deoxyadenosine + H2O = 5'-deoxyinosine + ammonia

In Transport reactions:
ammonia[periplasmic space]ammonia[cytosol]

In Redox half-reactions:
ammonia[in] + oxygen[in] + 2 H+[in] + 2 e-[membrane] → hydroxylamine[in] + H2O[in]

Enzymes inhibited by ammonia, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: asparagine synthetase [Cedar69a]

Inhibitor (Mechanism unknown) of: porphobilinogen deaminase [Jones94a] , asparaginase [Sodek80] , glutamate dehydrogenase [Kimura77]

This compound has been characterized as an alternative substrate of the following enzymes: cobyrinate A,C-diamide synthase , cobyrinate a,c-diamide synthase , hydrogenobyrinate a,c-diamide synthase , CTP synthase , adenosyl-cobyric acid synthase , amidophosphoribosyl transferase , archaeosine synthase , anthranilate synthase


References

Cedar69a: Cedar H, Schwartz JH (1969). "The asparagine synthetase of Escherichia coli. II. Studies on mechanism." J Biol Chem 1969;244(15);4122-7. PMID: 4895362

Jones94a: Jones RM, Jordan PM (1994). "Purification and properties of porphobilinogen deaminase from Arabidopsis thaliana." Biochem J 299 ( Pt 3);895-902. PMID: 8192681

Kimura77: Kimura K, Miyakawa A, Imai T, Sasakawa T (1977). "Glutamate dehydrogenase from Bacillus subtilis PCI 219. I. Purification and properties." J Biochem (Tokyo) 81(2);467-76. PMID: 14949

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sodek80: Sodek, Ladaslav, Lea, Peter, Miflin, Benjamin "Distribution and properties of a potassium-dependdent asparaginase isolated from developing seeds of Pisum sativa and other plants." Plant Physiology, 1980, 65:22-26.


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Sep 4, 2015, biocyc14.