MetaCyc Compound: ammonia

Synonyms: NH3

Chemical Formula: H3N

Molecular Weight: 17.03 Daltons

Monoisotopic Molecular Weight: 17.0265491015 Daltons

ammonia compound structure


InChI: InChI=1S/H3N/h1H3


Unification Links: CAS:7664-41-7, ChEBI:16134, ChemSpider:217, HMDB:HMDB00051, KEGG:C00014, KNApSAcK:C00007267, MetaboLights:MTBLC16134, PubChem:222

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 11.853362Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

ammonia oxidation I (aerobic) , ammonia oxidation III , ammonia oxidation IV (autotrophic ammonia oxidizers) :
ammonia[in] + an reduced unknown electron acceptor[in] + oxygen[in] → hydroxylamine[in] + an oxidized unknown electron acceptor[in] + H2O[in]

Reactions known to produce the compound:

gliotoxin biosynthesis :
3-benzyl-3,6 -bis(cysteinyl)- 6-(hydroxymethyl)-diketopiperazine + 2 H2O → 3-benzyl-3,6 -dithio-6-(hydroxymethyl)-diketopiperazine + 2 ammonia + 2 pyruvate + 2 H+

tryptoquialanine biosynthesis :
15,15-dimethyl-2-epi-fumiquinazoline A + NADPH + H+ + oxygen → (2R)-3-[(9S, 9aR)-9-hydroxy-2,2-dimethyl-3-oxo-1H, 2H, 3H, 9H, 9aH-imidazolidino[1,2-a] indol-9-yl]-2-(2-acetyl-4-oxo-3,4-dihydroquinazolin-3-yl) propanoate + ammonia + NADP+

Reactions known to both consume and produce the compound:

Not in pathways:
ammonia + H+ ↔ ammonium

In Reactions of unknown directionality:

Not in pathways:
5'-deoxyadenosine + H2O = 5'-deoxyinosine + ammonia
L-phenylalanine + oxygen + H2O = 2-oxo-3-phenylpropanoate + ammonia + hydrogen peroxide + H+

In Transport reactions:

In Redox half-reactions:
ammonia[in] + oxygen[in] + 2 H+[in] + 2 e-[membrane] → hydroxylamine[in] + H2O[in]

Enzymes inhibited by ammonia, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: asparagine synthetase [Cedar69a] Inhibitor (Mechanism unknown) of: porphobilinogen deaminase [Jones94], asparaginase [Sodek80], glutamate dehydrogenase [Kimura77]

This compound has been characterized as an alternative substrate of the following enzymes: hydrogenobyrinate a,c-diamide synthase, cobyrinate a,c-diamide synthase, cobyrinate A,C-diamide synthase, adenosyl-cobyric acid synthase, amidophosphoribosyl transferase, archaeosine synthase, anthranilate synthase, CTP synthase


Cedar69a: Cedar H, Schwartz JH (1969). "The asparagine synthetase of Escherichia coli. II. Studies on mechanism." J Biol Chem 1969;244(15);4122-7. PMID: 4895362

Jones94: Jones RM, Jordan PM (1994). "Purification and properties of porphobilinogen deaminase from Arabidopsis thaliana." Biochem J 299 ( Pt 3);895-902. PMID: 8192681

Kimura77: Kimura K, Miyakawa A, Imai T, Sasakawa T (1977). "Glutamate dehydrogenase from Bacillus subtilis PCI 219. I. Purification and properties." J Biochem (Tokyo) 81(2);467-76. PMID: 14949

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sodek80: Sodek, Ladaslav, Lea, Peter, Miflin, Benjamin "Distribution and properties of a potassium-dependdent asparaginase isolated from developing seeds of Pisum sativa and other plants." Plant Physiology, 1980, 65:22-26.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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