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MetaCyc Compound: borohydride

Component of: sodium tetrahydridoborate

Chemical Formula: H4B

Molecular Weight: 14.844 Daltons

Monoisotopic Molecular Weight: 15.0406056284 Daltons

borohydride compound structure


InChI: InChI=1S/BH4/h1H4/q-1


Unification Links: ChEBI:30157, ChemSpider:10608156, PubChem:28123

Standard Gibbs Free Energy of Formation (ΔfG in kcal/mol): 40.772427Inferred by computational analysis [Latendresse13]

Enzymes inhibited by borohydride, sorted by the type of inhibition, are:

Inhibitor (Irreversible) of: fructose bisphosphate aldolase [Baldwin78] Inhibitor (Mechanism unknown) of: adenosylmethionine decarboxylase [Markham82], phosphatidylserine decarboxylase [Comment 1], selenocysteine synthase [Forchhammer91], acetoacetate decarboxylase [OLeary68, Warren66, Autor70, Boyer72], tryptophan decarboxylase [Buki85] Inhibitor (Other types) of: urocanase [Phillips71]


Autor70: Autor AP, Fridovich I (1970). "The interactions of acetoacetate decarboxylase with carbonyl compounds, hydrogen cyanide, and an organic mercurial." J Biol Chem 1970;245(20);5214-22. PMID: 5469163

Baldwin78: Baldwin SA, Perham RN (1978). "Novel kinetic and structural properties of the class-I D-fructose 1,6-bisphosphate aldolase from Escherichia coli (Crookes' strain)." Biochem J 1978;169(3);643-52. PMID: 348198

Boyer72: Boyer PD, editor (1972). "Chapter 8- Acetoacetate Decarboxylase." The Enzymes, Third Edition, Volume Six, Carboxylation and decarboxylation (nonoxidative) isomerization, Academic Press New York.

Buki85: Buki KG, Vinh DQ, Horvath I (1985). "Partial purification and some properties of tryptophan decarboxylase from a Bacillus strain." Acta Microbiol Hung 32(1);65-73. PMID: 4036551

Dowhan92: Dowhan W, Li QX (1992). "Phosphatidylserine decarboxylase from Escherichia coli." Methods Enzymol 1992;209;348-59. PMID: 1495415

Forchhammer91: Forchhammer K, Boesmiller K, Bock A (1991). "The function of selenocysteine synthase and SELB in the synthesis and incorporation of selenocysteine." Biochimie 73(12);1481-6. PMID: 1839607

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Markham82: Markham GD, Tabor CW, Tabor H (1982). "S-adenosylmethionine decarboxylase of Escherichia coli. Studies on the covalently linked pyruvate required for activity." J Biol Chem 257(20);12063-8. PMID: 6749853

OLeary68: O'Leary MH, Westheimer FH (1968). "Acetoacetate decarboxylase. Selective acetylation of the enzyme." Biochemistry 1968;7(3);913-9. PMID: 5657856

Phillips71: Phillips, A. T., George, D. J. (1971). "Urocanase (Pseudomonas putida)." Methods Enzymol. 17(2):73-79.

Satre78: Satre M, Kennedy EP (1978). "Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli." J Biol Chem 1978;253(2);479-83. PMID: 338609

Warren66: Warren S, Zerner B, Westheimer FH (1966). "Acetoacetate decarboxylase. Identification of lysine at the active site." Biochemistry 1966;5(3);817-23. PMID: 5911292

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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