Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Compound: carboxymethoxylamine

Synonyms: aminooxyacetate, (aminooxy)acetic acid, (aminooxy)acetate, hydroxylamine-O-acetic acid

Chemical Formula: C2H4NO3

Molecular Weight: 90.058 Daltons

Monoisotopic Molecular Weight: 91.02694303199999 Daltons

SMILES: C(ON)C([O-])=O

InChI: InChI=1S/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5)/p-1

InChIKey: InChIKey=NQRKYASMKDDGHT-UHFFFAOYSA-M

Unification Links: CAS:645-88-5 , ChemSpider:279 , PubChem:285

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -61.867588 Inferred by computational analysis [Latendresse13]

Enzymes inhibited by carboxymethoxylamine, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: canaline reductase [Rosenthal92]

Inhibitor (Mechanism unknown) of: glutamate-1-semialdehyde aminotransferase [Ilag91] , 4-aminobutyrate transaminase [Schulz90] , D-serine ammonia-lyase [Tanaka08] , alanine aminotransferase [Umemura94] , tyrosine aminotransferase [DeEknamkul87] , tyrosine aminotransferase [DeEknamkul87] , 2-aminoethylphosphonate aminotransferase [Dumora83] , β-cyano-L-alanine synthase [Comment 1] , asparagine aminotransferase [Ireland83]

Inhibitor (Other types) of: β-methylaspartate aminotransferase [Phillips72]


References

DeEknamkul87: De-Eknamkul W, Ellis BE (1987). "Tyrosine aminotransferase: the entrypoint enzyme of the tyrosine-derived pathway in rosmarinic acid biosynthesis." Phytochemistry, 26(7), 1941-1946.

Dumora83: Dumora C, Lacoste AM, Cassaigne A (1983). "Purification and properties of 2-aminoethylphosphonate:pyruvate aminotransferase from Pseudomonas aeruginosa." Eur J Biochem 1983;133(1);119-25. PMID: 6406228

Ilag91: Ilag LL, Jahn D, Eggertsson G, Soll D (1991). "The Escherichia coli hemL gene encodes glutamate 1-semialdehyde aminotransferase." J Bacteriol 1991;173(11);3408-13. PMID: 2045363

Ireland83: Ireland RJ, Joy KW (1983). "Purification and properties of an asparagine aminotransferase from Pisum sativum leaves." Arch Biochem Biophys 223(1);291-6. PMID: 6407397

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Macadam84: Macadam AM, Knowles CJ "Purification and properties of β-cyano-L-alanine synthase from the cyanide-producing bacterium, Chromobacterium violaceum." Biochimica et Biophysica Acta 786:123-132 (1984).

Phillips72: Phillips AT, Nuss JI, Moosic J, Foshay C (1972). "Alternate pathway for isoleucine biosynthesis in Escherichia coli." J Bacteriol 109(2);714-9. PMID: 4550817

Rosenthal92: Rosenthal GA (1992). "Purification and characterization of the higher plant enzyme L-canaline reductase." Proc Natl Acad Sci U S A 89(5);1780-4. PMID: 1542671

Schulz90: Schulz A, Taggeselle P, Tripier D, Bartsch K (1990). "Stereospecific production of the herbicide phosphinothricin (glufosinate) by transamination: isolation and characterization of a phosphinothricin-specific transaminase from Escherichia coli." Appl Environ Microbiol 1990;56(1);1-6. PMID: 2178550

Tanaka08: Tanaka H, Yamamoto A, Ishida T, Horiike K (2008). "D-Serine dehydratase from chicken kidney: a vertebral homologue of the cryptic enzyme from Burkholderia cepacia." J Biochem 143(1);49-57. PMID: 17977854

Umemura94: Umemura I, Yanagiya K, Komatsubara S, Sato T, Tosa T (1994). "Purification and some properties of alanine aminotransferase from Candida maltosa." Biosci Biotechnol Biochem 58(2);283-7. PMID: 7764540


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC14B.