MetaCyc Compound: Cd2+

Synonyms: Cadmium, Cd+2, Cd++

Superclasses: an iona cationan inorganic cationa divalent inorganic cation
an ionan inorganic ionan inorganic cationa divalent inorganic cation

Component of: dichlorocadmium

Chemical Formula: Cd

Molecular Weight: 112.4 Daltons

Monoisotopic Molecular Weight: 113.9033581 Daltons

SMILES: [Cd++]

InChI: InChI=1S/Cd/q+2


Unification Links: ChEBI:48775, ChemSpider:28935, HMDB:HMDB03638, IAF1260:1800088, KEGG:C01413, PubChem:31193

Standard Gibbs Free Energy of Formation (ΔfG in kcal/mol): -1.2482376Inferred by computational analysis [Latendresse13]

In Transport reactions:
Cd2+[cytosol] + ATP + H2O ↔ Cd2+[extracellular space] + ADP + phosphate + H+,
Cd2+[cytosol] + ATP + H2O ↔ Cd2+[vacuolar lumen] + ADP + phosphate + H+,
Cd2+[cytosol] + H+[periplasm]Cd2+[periplasm] + H+[cytosol],

Enzymes activated by Cd2+, sorted by the type of activation, are:

Activator (Mechanism unknown) of: threonine dehydrogenase [Craig88], glutathione S-conjugate carboxypeptidase [Beck03], homophytochelatin synthase [Loscos06], homophytochelatin synthase [Oven02], DAHP synthase [Huang74]

Enzymes inhibited by Cd2+, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: α-galactosidase [Burstein71], D-arabinose isomerase [Boulter73], L-fucose isomerase [Boulter73], deoxyribose 1,5-phosphomutase [HammerJespersen70], N-acetylglutamate synthase [Marvil77], acetylornithine deacetylase [JavidMajd00], 2-amino-3-ketobutyrate CoA ligase [Mukherjee87], glutamate decarboxylase A [Helmward89], glutamate decarboxylase B [Helmward89], NADPH-dependent curcumin reductase [Hassaninasab11], 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Ray80], D-arabinose 5-phosphate isomerase [Meredith03, Lim66], ubiquinol oxidase (H+-transporting) [Kita84], fumarase A [Xu12], cystathionine γ-lyase [Matsuo59], NAD+-dependent malate dehydrogenase [Gavva91], L-fucose isomerase [Boulter73], pyridoxamine 5'-phosphate oxidase [Tsuge82], pyridoxine 5'-phosphate oxidase II [Tsuge82], chitin synthase [MartinezRucobo09], N-cyclohexylformamide hydratase [Goda01], β-alanine amide amidase [Komeda04], L-proline amide hydrolase [Komeda04a], 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase [Pucci07], 3-hydroxyanthranilate 3,4-dioxygenase [Calderone02], 3-hydroxyanthranilate 3,4-dioxygenase [Muraki03], β-keto-L-gulonic acid decarboxylase [WINKELMAN61], succinate semialdehyde dehydrogenase [Chambliss92], porphobilinogen deaminase [Jones94], glycerol-3-phosphate cytidylyltransferase [Park93], L-lactate dehydrogenase [Wrba90], 4-hydroxy-tetrahydrodipicolinate reductase [Kimura75], (S)-tetrahydroprotoberberine oxidase [Amann88], arginine deiminase [Hill67], 3-dehydroquinate synthase [Hasan78], DL-methylmalonyl-CoA racemase [Stabler85], D-arabinose isomerase [Boulter73], 2-phospho-3-sulfolactate phosphohydrolase [Graham01], hydroxymethylglutaryl-CoA synthase [Middleton72], hydrogenase [Schneider79], naringenin 7-O-methyltransferase [Rakwal00], guanosine deaminase [Negishi94], 5'-GMP-nucleotidase [Bideon75], hydroxyproline 2-epimerase [Adams64], D-galactonate dehydratase [Szumilo81], δ-aminovaleramidase [Reitz70], phosphohexose isomerase [Sangwan90], anthocyanin 5-O-glucoside-4'''-O-malonyltransferase [Suzuki04a], acetyl-CoA:salutaridinol-7-O-acetyltransferase [Lenz95] Inhibitor (Other types) of: 6-hydroxy-3-succinoyl-pyridine hydroxylase [Yu15], mycophenolic acid acyl-glucuronide esterase [Iwamura12], dimethylsulfide monooxygenase [Boden11], L-allo-threonine aldolase [Kataoka97]

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: diacylglycerol kinase

This compound has been characterized as an alternative cofactor or prosthetic group of the following enzymes: NMN adenylyltransferase, methionine adenosyltransferase, adenylylsulfate kinase, carbamoyl phosphate synthetase

This compound has been characterized as an alternative substrate of the following enzymes: Zn2+:H+ antiporter, Zn2+-exporting ATPase


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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