Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Compound: 8-oxo-GTP

Synonyms: 8-oxo-guanosine-triphosphate

Superclasses: a nucleic acid component

Citations: [Yoshimura07]

Chemical Formula: C10H12N5O15P3

Molecular Weight: 535.15 Daltons

Monoisotopic Molecular Weight: 538.9855744010999 Daltons

SMILES: C(OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])C1(OC(C(O)C(O)1)N3(C(=O)NC2(C(=O)NC(N)=NC=23)))

InChI: InChI=1S/C10H16N5O15P3/c11-9-13-6-3(7(18)14-9)12-10(19)15(6)8-5(17)4(16)2(28-8)1-27-32(23,24)30-33(25,26)29-31(20,21)22/h2,4-5,8,16-17H,1H2,(H,12,19)(H,23,24)(H,25,26)(H2,20,21,22)(H3,11,13,14,18)/p-4/t2-,4-,5-,8-/m1/s1

InChIKey: InChIKey=JCHLKIQZUXYLPW-UMMCILCDSA-J

Unification Links: PubChem:46173271

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -614.93854 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

oxidized GTP and dGTP detoxification :
8-oxo-GTP + H2O → 8-oxo-GMP + diphosphate + H+

Reactions known to produce the compound:

oxidized GTP and dGTP detoxification :
GTP + hydroxyl radical → 8-oxo-GTP + H+

Credits:
Created 22-Apr-2010 by Dreher KA , TAIR


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yoshimura07: Yoshimura K, Ogawa T, Ueda Y, Shigeoka S (2007). "AtNUDX1, an 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis." Plant Cell Physiol 48(10);1438-49. PMID: 17804481


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC13A.