Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites MAYBE down
12/28 - 12/31
for maintenance.
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MetaCyc Compound: 8-oxo-GTP

Synonyms: 8-oxo-guanosine-triphosphate

Superclasses: a nucleic acid component

Citations: [Yoshimura07]

Chemical Formula: C10H12N5O15P3

Molecular Weight: 535.15 Daltons

Monoisotopic Molecular Weight: 538.9855744010999 Daltons

SMILES: C(OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])C1(OC(C(O)C(O)1)N3(C(=O)NC2(C(=O)NC(N)=NC=23)))

InChI: InChI=1S/C10H16N5O15P3/c11-9-13-6-3(7(18)14-9)12-10(19)15(6)8-5(17)4(16)2(28-8)1-27-32(23,24)30-33(25,26)29-31(20,21)22/h2,4-5,8,16-17H,1H2,(H,12,19)(H,23,24)(H,25,26)(H2,20,21,22)(H3,11,13,14,18)/p-4/t2-,4-,5-,8-/m1/s1

InChIKey: InChIKey=JCHLKIQZUXYLPW-UMMCILCDSA-J

Unification Links: PubChem:46173271

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -614.93854 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

oxidized GTP and dGTP detoxification :
8-oxo-GTP + H2O → 8-oxo-GMP + diphosphate + H+

Reactions known to produce the compound:

oxidized GTP and dGTP detoxification :
GTP + hydroxyl radical → 8-oxo-GTP + H+

Credits:
Created 22-Apr-2010 by Dreher KA , TAIR


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yoshimura07: Yoshimura K, Ogawa T, Ueda Y, Shigeoka S (2007). "AtNUDX1, an 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis." Plant Cell Physiol 48(10);1438-49. PMID: 17804481


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 27, 2014, biocyc11.