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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Compound: 1-deoxy-D-xylulose 5-phosphate

Synonyms: DXP, deoxyxylulose-5-phosphate, D-1-deoxyxylulose-5-P, 1-deoxy-D-threo-pentulose 5-phosphate, DOXP

Superclasses: all carbohydrates a carbohydrate a glycan a carbohydrate derivative a sugar phosphate a pentose phosphate a pentose 5-phosphate
all carbohydrates a carbohydrate a glycan a carbohydrate derivative a sugar phosphate a sugar 5-phosphate a pentose 5-phosphate

Citations: [Herz00]

Chemical Formula: C5H9O7P

Molecular Weight: 212.1 Daltons

Monoisotopic Molecular Weight: 214.0242392178 Daltons

SMILES: CC(=O)C(O)C(O)COP([O-])(=O)[O-]

InChI: InChI=1S/C5H11O7P/c1-3(6)5(8)4(7)2-12-13(9,10)11/h4-5,7-8H,2H2,1H3,(H2,9,10,11)/p-2/t4-,5-/m1/s1

InChIKey: InChIKey=AJPADPZSRRUGHI-RFZPGFLSSA-L

Unification Links: ChEBI:57792 , ChemSpider:10462373 , HMDB:HMDB01213 , IAF1260:216273 , KEGG:C11437 , PubChem:23420274

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -266.07812 Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

pyridoxal 5'-phosphate biosynthesis I :
1-deoxy-D-xylulose 5-phosphate + 3-amino-1-hydroxyacetone 1-phosphate → pyridoxine 5'-phosphate + phosphate + H+ + 2 H2O

thiazole biosynthesis I (E. coli) , thiazole biosynthesis II (Bacillus) :
1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + a thiocarboxy-adenylated-[ThiS-Protein] → 2-[(2R,5Z)-(2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + a ThiS sulfur-carrier protein + 2 H2O

Not in pathways:
a sugar phosphate + H2O → a sugar + phosphate

Reactions known to produce the compound:

methylerythritol phosphate pathway I , methylerythritol phosphate pathway II , pyridoxal 5'-phosphate biosynthesis I , thiazole biosynthesis I (E. coli) , thiazole biosynthesis II (Bacillus) :
pyruvate + D-glyceraldehyde 3-phosphate + H+1-deoxy-D-xylulose 5-phosphate + CO2

S-methyl-5-thio-α-D-ribose 1-phosphate degradation II :
1-methylthio-xylulose 5-phosphate + 2 H+1-deoxy-D-xylulose 5-phosphate + methanethiol

Not in pathways:
1-deoxy-D-xylulose + ATP → 1-deoxy-D-xylulose 5-phosphate + ADP + H+


an N-acetyl-β-D-galactosalaminyl-[glycan] + H2O → a glycan + N-acetyl-β-D-galactosamine

Reactions known to both consume and produce the compound:

methylerythritol phosphate pathway I , methylerythritol phosphate pathway II :
2-C-methyl-D-erythritol 4-phosphate + NADP+1-deoxy-D-xylulose 5-phosphate + NADPH + H+

In Transport reactions:
a [PTS enzyme I]-Nπ-phospho-L-histidine + a sugar[out] → a [PTS enzyme I]-L-histidine + a sugar phosphate[in]


References

Herz00: Herz S, Wungsintaweekul J, Schuhr CA, Hecht S, Luttgen H, Sagner S, Fellermeier M, Eisenreich W, Zenk MH, Bacher A, Rohdich F (2000). "Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate." Proc Natl Acad Sci U S A 2000;97(6);2486-90. PMID: 10694574

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14B.