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MetaCyc Compound: 7,8-dihydroneopterin 3'-triphosphate

Synonyms: 6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin, 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin, 6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydropterin-3'-triphosphate, 7,8-dihydroneopterin 3'-triphosphate, 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate, dihydroneopterin triphosphate, H2NTP, 7,8-dihydroneopterin triphosphate

Superclasses: an organic heterocyclic compoundan organic heterobicyclic compounda pteridinea pterin
an organic heterocyclic compoundan organonitrogen heterocyclic compounda pteridinea pterin

Chemical Formula: C9H12N5O13P3

Molecular Weight: 491.14 Daltons

Monoisotopic Molecular Weight: 494.99574515689994 Daltons

7,8-dihydroneopterin 3'-triphosphate compound structure

SMILES: C1(NC2(N=C(N)NC(=O)C(N=C1C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)[O-])=2))

InChI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1

InChIKey: InChIKey=DGGUVLXVLHAAGT-XINAWCOVSA-J

Unification Links: ChEBI:58462, HMDB:HMDB00980, IAF1260:44843, KEGG:C04895, MetaboLights:MTBLC58462, PubChem:25201779

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -528.04956Inferred by computational analysis [Latendresse13]

Reactions known to consume the compound:

6-hydroxymethyl-dihydropterin diphosphate biosynthesis I :
7,8-dihydroneopterin 3'-triphosphate + H2O → 7,8-dihydroneopterin 3'-phosphate + diphosphate + H+

drosopterin and aurodrosopterin biosynthesis , tetrahydrobiopterin biosynthesis I , tetrahydrobiopterin biosynthesis II , tetrahydrobiopterin biosynthesis III :
7,8-dihydroneopterin 3'-triphosphate → 6-pyruvoyl tetrahydropterin + PPPi + H+

preQ0 biosynthesis :
7,8-dihydroneopterin 3'-triphosphate + H2O → 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + PPPi + 2 H+

Reactions known to produce the compound:

6-hydroxymethyl-dihydropterin diphosphate biosynthesis I , drosopterin and aurodrosopterin biosynthesis , preQ0 biosynthesis , tetrahydrobiopterin biosynthesis I , tetrahydrobiopterin biosynthesis II , tetrahydrobiopterin biosynthesis III , tetrahydromonapterin biosynthesis :
GTP + H2O → formate + 7,8-dihydroneopterin 3'-triphosphate + H+

Reactions known to both consume and produce the compound:

tetrahydromonapterin biosynthesis :
7,8-dihydroneopterin 3'-triphosphate ↔ 7,8-dihydromonapterin triphosphate


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon Feb 8, 2016, biocyc13.