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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Compound: EDTA

Synonyms: ethylenediaminetetraacetic acid, ethylenediaminetetraacetate

Superclasses: a non-metabolic compound

Chemical Formula: C10H13N2O8

Molecular Weight: 289.22 Daltons

Monoisotopic Molecular Weight: 292.0906655008 Daltons

SMILES: C(CN(CC([O-])=O)CC([O-])=O)[N+](CC([O-])=O)CC([O-])=O

InChI: InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)/p-3

InChIKey: InChIKey=KCXVZYZYPLLWCC-UHFFFAOYSA-K

Unification Links: ChEBI:4735 , HMDB:HMDB15109 , KEGG:C00284 , PubChem:25201827

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -176.46396 Inferred by computational analysis [Latendresse13]

Enzymes activated by EDTA, sorted by the type of activation, are:

Activator (Allosteric) of: fructoselysine 6-phosphate deglycase [Wiame02]

Activator (Mechanism unknown) of: glutathione S-transferase [Arca90] , diacylglycerol pyrophosphate phosphatase [Dillon96] , sinapoyl-CoA: glucarate sinapoyltransferase [Strack87] , cellobiose 2-epimerase [Taguchi08] , dihydropterin oxidase [Unnasch82] , glycerophosphocholine cholinephosphodiesterase [Sugimori13] , quercetin 6-hydroxylase [Halbwirth04] , L-galactono-γ-lactone dehydrogenase [Shigeoka79] , L-asparaginase [Raha90]

Enzymes inhibited by EDTA, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: hexulose-6-phosphate synthase [Kato78] , hexulose-6-phosphate synthase [Kato90] , glycerol dehydrogenase [McGregor74]

Inhibitor (Mechanism unknown) of: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase [Leppik76a, Comment 1] , rhamnulose-1-phosphate aldolase [Schwartz72, Comment 2] , UDP-3-O-acyl-N-acetylglucosamine deacetylase [Jackman99] , glycerate kinase [Doughty66] , L-rhamnose isomerase [Takagi64] , D-galacturonate isomerase [Ashwell60] , D-glucuronate isomerase [Ashwell60, Linster04] , deoxyuridine triphosphatase [Shlomai78, Comment 3] , acetylornithine deacetylase [Vogel74] , agmatinase [Satishchandran86] , cobalamin-independent homocysteine transmethylase [Whitfield70] , thiamin monophosphate kinase [Nishino72] , acetyl-CoA synthetase (AMP-forming) [Brown77] , peptidoglycan glycosyltransferase [Hara84] , α-dehydro-β-deoxy-D-glucarate aldolase [Fish66] , fructose bisphosphate aldolase [Stribling73] , murein tripeptide amidase [Maqbool12] , gluconolactonase [Hucho72] , cysteinylglycine dipeptidase [Suzuki01c] , CTP:2,3,4-saturated L-phosphatidate cytidylyltransferase [Langley78a] , ribonucleoside-triphosphate reductase [Eliasson92] , biotin sulfoxide reductase [Del79] , acid phosphatase / phosphotransferase [Thaller97] , 2',3'-cyclic nucleotide 2'-phosphodiesterase [ANRAKU64] , 3'-nucleotidase [ANRAKU64] , 8-hydroxykaempferol 8-O-methyltransferase [Jay85] , gossypetin 8-O-methyltransferase [Jay85] , gentisyl alcohol epoxidase [Priest89] , synephrine dehydratase [Manne86] , geraniol dehydrogenase (NAD+) [NOGE05] , D-serine ammonia-lyase [Tanaka11] , 3,7-dimethylquercetin 6-hydroxylase [Anzellotti00] , 3,7,4'-trimethylquercetin 6-hydroxylase [Anzellotti00] , 3,7,4'-trimethylquercetagetin 6-O-methyltransferase [De85a] , 3,7-dimethylquercetagetin 6-O-methyltransferase [De85a] , 3,7,3'-methylquercetagetin 6-O-methyltransferase [De85a] , D-fructose-6-phosphate cytidylyltransferase [Wang12b] , SAM: anol-O-methyltransferase [Kemmerer96] , 1,2,4-trihydroxybenzene 1,2-dioxygenase [Takenaka03] , 4-amino-3-hydroxy-benzoate 2,3-dioxygenase [Takenaka02] , D-xylulose-5-phosphate cytidylyltransferase [Wang12c] , trehalase [App89] , trehalose-6-phosphate phosphatase [Vandercammen89] , chitin synthase [MartinezRucobo09] , N-acetylglucosamine-6-phosphate deacetylase [Yamano96] , biotin--[acetyl-CoA carboxylase] synthetase [Tissot98] , 2-protocatechuoylphloroglucinolcarboxylate esterase [Child63] , 3-phosphonopyruvate hydrolase [Kulakova03] , phosphonoacetate hydrolase [Borisova11] , pullulanase [Dong97] , NAD+-dependent L-rhamnofuranose 1-dehydrogenase [Rigo76] , poly(3-hydroxybutyrate) depolymerase [Handrick01] , glycerol-2-phosphate cytidylyltransfrase [Wang10] , pectate lyase [Tardy97] , pectate lyase [Tardy97] , pectate lyase [Tardy97] , exotrigalacturonate lyase [Shevchik99] , digalacturonate lyase [Shevchik99] , L-galactonate dehydratase [Kuorelahti06] , galactonolactonase [Ishikawa08] , 2-keto-3-deoxy-D-glycero-D-galacto-nononate-9-phosphate synthase [Angata99] , γ-butyrobetaine hydroxylase [Vaz99] , ε-N-trimethyllysine hydroxylase [Sachan80] , nitrilotriacetate monooxygenase [Uetz92] , streptomycin 6-kinase [Sugiyama83] , 31-O-demethyl-FK506 methyltransferase [Shafiee94] , (S)-2-hydroxypropylphosphonate epoxidase [Liu03a] , parathion hydrolase [Dumas89] , carbapenemase [Rossolini98] , deacetoxycephalosporin C hydroxylase [Baker91] , deacetoxycephalosporin C synthase [Dotzlaf89] , deacetoxycephalosporin C hydroxylase [Dotzlaf87] , deacetoxycephalosporin C synthase [Dotzlaf87] , kynurenine formamidase [Kurnasov03] , D-lactate dehydrogenase [Schweiger84] , cysteine dioxygenase [Chai05] , formiminoglutamate formiminohydrolase [Kaminskas70, Magasanik71] , β-cyano-L-alanine synthase [Comment 4] , DL-methylmalonyl-CoA racemase [Stabler85] , ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6-diphosphotransferase [Rebeille97] , mandelate racemase [WeilMalherbe66] , shikimate kinase [Comment 5] , 2-phospho-3-sulfolactate phosphohydrolase [Graham01] , MtaC protein: coenzyme M methyltransferase [LeClerc96] , phosphonoacetate hydrolase [McGrath95a] , ethanolamine kinase [Wharfe79] , (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase , mannose-1-phosphate phosphatase [Rumpho83] , berberine bridge enzyme [Steffens85] , flavanone 3β-hydroxylase [Forkmann80] , NAD kinase [Turner04] , 7-methylxanthosine hydrolase [Negishi88] , 2,5-dihydroxypyridine dioxygenase [Gauthier71] , cis-4-hydroxy-D-proline dehydrogenase [Yoneya61] , vomilenine reductase [vonSchumann02] , vellosimine reductase [Pfitzner84] , L-sorbosone dehydrogenase [Asakura99] , p-hydroxyphenylpyruvate oxidase [Blakley77] , 3-keto-5-aminohexanoate cleavage enzyme [Yorifuji77]

Inhibitor (Other types) of: aspartate ammonia-lyase , 2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) [Nagahama91] , protocatechuate 2,3-dioxygenase [Wolgel90] , 2-phosphinomethylmalate synthase [Shimotohno88] , (+)-4-chloromuconolactone hydrolase [Camara08] , trans-4-carboxymethylenebut-2-en-4-olide lactonohydrolase [Camara08] , allantoate amidohydrolase [Raso07] , pyruvic oxime dioxygenase [Ono96] , alkenyl thiohydroximate-O-sulfate sulfohydrolase (epithionitrile-forming) [Burow06] , thiohydroximate-O-sulfate sulfohydrolase (nitrile-forming) [Burow06] , fructose bisphosphate aldolase [London73] , NAD-dependent formate dehydrogenase [Kearny72] , cis-1,2-dihydro-1,2-dihydroxynaphthalene-1, 2-dehydrogenase [Patel74]


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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